• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Finally Got Some Test Results - Questions
0

11 posts in this topic

Hi, I had posted about a month ago and since then have had more testing done. My initial test, requested by me, was just an IgA which came back negative at 172 out of a ref range of 61-356. I then requested further testing since I was still getting no other answers and they ran the genetic typing which was positive.

So after that, they ran more testing. My doctor just called and told me that my IgA still came back normal but my IgG came back weakly positive at 25 with <20 being normal.

I'm now being referred for a biopsy. Is this typical that celiac is expressed with a pos IgG and neg IgA?

Also, I have been feeling great for the past two weeks (on a typical, gluten containing diet) so I had convinced myself that it was all just stress and this result came as kind of a shock since I've been feeling so good lately.

I'm definitely not as scared of the idea of celiac anymore, after worrying about other possibilities, but I'm just kind of perplexed as to the results.

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


Which IgA and IgG tests were run? The total serum IgA or IgG tesst simply test whether you have enough Immunoglobulin A or G in you system to get an actual positive celiac test (on the ttg, DGP, EMA or AGA tests).

 

To me, based on your lab ranges, it looks like you had the total serum IgA test done (you have normal levels so you could have further ttg IgA, EMA IgA, EMA IgA or AGA IgA tests done), and possibly a ttg IgG (which came back slightly positive). There is a chance something else is causing your slightly elevated (ttg?) IGg so it's a good idea to get more testing (biopsy or blood) done. Personally, I feel that if you have celiac symptoms and have a slightly positive test, chances are that it's celiac, but I understand that "need to be sure" before you overhaul your diet.

 

And yes, there are many around here who just had positive (ttg?) IgG or DGP IgG tests with a normal (ttg?) IgA. It's not uncommon; that's probably why they do both test versions. There are some who have totally negative blood work and then have a positive biopsy and then vice versa.  Hopefully celiac testing will be improved soon so gettin a diagnosis won't be such a process!

 

Good luck with the biopsy.

0

Share this post


Link to post
Share on other sites

I second what nicole said...if you are unsure which tests are which - feel free to post everything written on your results and we can help interpret them.

Good luck to you :)

0

Share this post


Link to post
Share on other sites

Thanks!  I feel like my doctor knows very little about these tests and I had to tell him what should be tested, so I'm not absolutely positive on the results as I've only talked to him on the phone.  He is sending me a copy of the results though.  The initial test that came back negative was a "Celiac Disease Cascade IgA" which lists Immunoglobulin A, S at 172, which was listed as "negative serology."

It appears this is the test they ran most recently, as Mayo was the lab that did it.  http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/89031

So it isn't weird that I've been feeling better recently while eating gluten?

Also, since I did get the positive genetic test, this means that my little boys should be tested too, correct?  Would I need to have them get just the regular blood test or the genetic typing?

Edited by Bbec
0

Share this post


Link to post
Share on other sites

Similar results for me-- everything on the Celiac Panel came back as normal/negative but the IgG  (ANTIGLIADIN ABS, IGG 31 units (0-19).  From what I've read, that should mean that Celiac most likely isn't the source of my problems but the replies on this thread suggest that it still could be.  Just curious what other tests might be recommended to further explore the reason for the eleveated IgG antiobdy? I expect to feel better once I go Gluten free, but my concern is that there could be another cause (autoimmune or otherwise).  My doc is helpful but also doesn't seem to know much in this area.  For those of you that had similar lab results (positive IgG but normal IgA), what other causes did you explore before settling on Celiac (or Gluten Sensitivity) as the most likely cause?

0

Share this post


Link to post
Share on other sites
Ads by Google:


Thanks!  I feel like my doctor knows very little about these tests and I had to tell him what should be tested, so I'm not absolutely positive on the results as I've only talked to him on the phone.  He is sending me a copy of the results though.  The initial test that came back negative was a "Celiac Disease Cascade IgA" which lists Immunoglobulin A, S at 172, which was listed as "negative serology."

It appears this is the test they ran most recently, as Mayo was the lab that did it.  http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/89031

So it isn't weird that I've been feeling better recently while eating gluten?

Also, since I did get the positive genetic test, this means that my little boys should be tested too, correct?  Would I need to have them get just the regular blood test or the genetic typing?

 

I still think that IgA could just be your Total IgA Serum test... not sure though. I;m afraid I couldn't see or understand where in that article they refered to your test. Oh well. Post your results when they arrive in the mail and there are many around here who could help you figure them out.

 

I agree that it's a good idea to test your kids. If possible, I would do both types of tests. Just be aware that the blood work on young kids (up to preschool age) can often show a false negative because they haven't had time to build up the antibodies yet. also, remember that celiac can manifest itself at any time in a person's life so if they test negaive at age 5, it doesn't mean they'll still be negative at age 6. If you have them on a "glutenous" diet, you'll need to keep on eye on them.

 

... My kids tested negative, but since I have celiac and needed to go gluten-free I made them gluten-free too just to be on the safe side; I was actually happy to see health improvements in 2 out of 3 of my kids, and they ALL had a growth spurt after being gluten-free for 2 months... could be a coincidence or maybe not. Anyway, having the whole family eat gluten free is something to consider for health and,,, for ease of cooking! LOL

1

Share this post


Link to post
Share on other sites

Similar results for me-- everything on the Celiac Panel came back as normal/negative but the IgG  (ANTIGLIADIN ABS, IGG 31 units (0-19).  From what I've read, that should mean that Celiac most likely isn't the source of my problems but the replies on this thread suggest that it still could be.  Just curious what other tests might be recommended to further explore the reason for the eleveated IgG antiobdy? I expect to feel better once I go Gluten free, but my concern is that there could be another cause (autoimmune or otherwise).  My doc is helpful but also doesn't seem to know much in this area.  For those of you that had similar lab results (positive IgG but normal IgA), what other causes did you explore before settling on Celiac (or Gluten Sensitivity) as the most likely cause?

 I know that a slightly elevated ttg IgA can be liked with thyroid disorders as well as ecoli.  I'm afraid I don't know much about other diseases that cause a positive AGA IgG  but I found a couple of links with more info:

http://www.ncbi.nlm.nih.gov/pubmed/9553358?dopt=AbstractPlus

http://www.celiacdiseasecenter.org/c_doctors/C05-Testing.htm

0

Share this post


Link to post
Share on other sites

I got the results in the mail. Here is what it says:

Celiac gene pairs present? Yes

Celiac disease possible. Consider biopsy.

Gliadin (deamidated) Ab, IgA, S <10.0 Ref <20 negative

Gliadin (deamidated) Ab, IgG, S 25.9 Ref <20 negative. Interpretation: weak positive (20-30)

Immunoglobulin A (IgA) 147 Ref 61-356

Tissue transglutaminase Ab, IgA, S. <1.2. Ref <4 negative

Tissue transglutaminase Ab, IgG, S. 2.5 Ref <6 negative

Thanks for your continuing help!

0

Share this post


Link to post
Share on other sites

I got the results in the mail. Here is what it says:

Celiac gene pairs present? Yes

Celiac disease possible. Consider biopsy.

Gliadin (deamidated) Ab, IgA, S <10.0 Ref <20 negative

Gliadin (deamidated) Ab, IgG, S 25.9 Ref <20 negative. Interpretation: weak positive (20-30)

Immunoglobulin A (IgA) 147 Ref 61-356

Tissue transglutaminase Ab, IgA, S. <1.2. Ref <4 negative

Tissue transglutaminase Ab, IgG, S. 2.5 Ref <6 negative

Thanks for your continuing help!

Hi Bbec

 

i also only had a high DGP igG number and everything else fell into the negative range, and I'm not igA deficient.  here's the link to my main thread, so I hope it is helpful  :) http://www.celiac.com/gluten-free/topic/99439-need-help-with-tests-results-please/  

0

Share this post


Link to post
Share on other sites

I got the results in the mail. Here is what it says:

Celiac gene pairs present? Yes

Celiac disease possible. Consider biopsy.

Gliadin (deamidated) Ab, IgA, S <10.0 Ref <20 negative

Gliadin (deamidated) Ab, IgG, S 25.9 Ref <20 negative. Interpretation: weak positive (20-30)

Immunoglobulin A (IgA) 147 Ref 61-356

Tissue transglutaminase Ab, IgA, S. <1.2. Ref <4 negative

Tissue transglutaminase Ab, IgG, S. 2.5 Ref <6 negative

Thanks for your continuing help!

 

I think your DGP IgG positive shows that something is up. Usually it is celiac causing it. I would strongly considerfollowing the gluten-free diet, or having the biopsy... and then following the gluten-free diet.  ;)  That's the beauty of the gluten-free diet is that it can't hurt in any way unless you subssist on junk food but that's not good on any type of diet.  Good luck.

0

Share this post


Link to post
Share on other sites

My doctor referred me for a biopsy but the soonest I can be seen is the end of April.  sigh.  I guess I just get to wait until then to find out if it's really celiac.  Are there other things that can trigger a higher IgG number?

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      106,776
    • Total Posts
      932,357
  • Member Statistics

    • Total Members
      64,251
    • Most Online
      3,093

    Newest Member
    cmatott
    Joined
  • Popular Now

  • Topics

  • Posts

    • These are all low in fermentable carbs, but limit amounts to see what is tolerated (for us, 2 tortillas, two biscuits, one sandwich round) and don't load up on lots of baked goods in a day  I try to limit it to one baked good per day   Tortilla/ flat bread:  http://comfybelly.com/2013/04/tortillas-and-a-book-giveaway/#.WScABoFOmEc Sandwich Rounds (good with peanut butter): http://comfybelly.com/2013/08/sandwich-rounds-using-almond-flour/#.WScAm4FOmEc Biscuit (these are amazing. Make them sweet and serve with strawberries and coconut cream, savory and make sausage sandwiches, etc): http://healthyindulgences.net/2008/08/easy-low-carb-gluten-free-biscuits/
    • Thank you so much for sharing... we struggle with my daughters diet but it has only been 10 months so we are still learning the ropes. 
    • Also want to say that a lot of gluten free  recipes are not good for SIBO- too many starches. Also large quantities of almond flour or coconut flour have too much fermentable fibers so be careful with Paleo/SCD recipes too.  It's a bit of a balancing act in what you make and how much is eaten (that's why I like fast Tract- you can qualify things and it works).
    • My daughter is now 11 and we are finally on top of her SIBO (since she was 8).  Diet is super important. I know it's hard with kids, but a diet low in fermentable carbs is key. Especially when SIBO appears to be chronic.  I suggest looking into the Fast Tract Diet. There is a book and an app. Using glycemic index, fiber, and total carbs, the diet tells you the fermentation potential of different foods. There is a point system. The goal is to keep your fermentation potential points between 20-30 per day when you are experiencing SIBO symptoms, and then slowly increase to 40 points for the long term maintenance.  It is important to note that Fast Tract is not strictly gluten free. So you have to choose that yourself.  This system has worked very well for my daughter.  She also takes Atrantil daily and her GI at U of C suggested once a month going on a preventative herbal antibiotic.  Honestly, this is the best she has felt in years. Avoiding gluten is key...this is the other part of the equation. Incidentally, since gluten affects her nervous system, I think it has affected her motility, hence the SIBO.  So, diet is important and kids are difficult. Avoiding most grains is important since they are super high in fermentable carbs. BUT, there are some grains that are lower in fermentable carbs that help:  Jasmine Rice (cook in water like pasta and drain. Do not use left over because cooling causes resistant starches to form and that is aweful for SIBO).  Also mashed Red Potatoes (soak in salt water for 30 minutes to get most starch out, then rinse well, boil, drain, mash.  Again don't cool and reheat because of resistant starch). I have a terrific biscuit recipe and tortilla/flat bread recipe that I can post too. 
    • I hear ya. I spend all day in the bathroom *thinking* something's going to happen. lol  
  • Upcoming Events