• Ads by Google:
     




    Get email alerts Subscribe to Celiac.com's FREE weekly eNewsletter

    Ads by Google:



       Get email alertsSubscribe to Celiac.com's FREE weekly eNewsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
0
karat514

Please Shed Some Insight On This Blood Test

Rate this topic

Recommended Posts

Hello all: Could you please shed some insight on this blood test.  I have the results in hand and was told things are in normal range.  It reads as follows:

 

 

Test                                                                         

 

Tissue Transglutaminase IGA

>          Transglutaminase AB (IGA)                           Flag Reference

 

                             <1  (my result)                               <4 U/ML        | CPF

 

(that is exactly how it reads.  No more no less.)

 

 

Other than being told this was normal, I have no idea if this a pretty good indicator that I DO NOT have Celiac. 

 

Thank you in advance from someone who is frustrated 

 

 

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


I share your frustration that they ran only this one test :(   They did not even run the total serum IgA which would tell us if you make normal quantities of IgA and that therefore IgA testing can be relied upon.  Doctors are in love with the tTG but it can be negative in people who will test positive on other celiac blood tests like the DGP (a newer test, and more sensitive and more specific for the development of celiac, i.e., shows results earlier and damage less likely to be caused by something else if positive).  The EMA is also a very specific test for celiac but they don't normally run this unless the tTG is positive.  But your tTG IgA will not be positive if you do not produce normal quantities of IgA - so it's Catch 22.  Is there any chance of talking whoever ordered your test to also order:

 

Total Serum IgA

Deamidated Gliadin Peptide (DGP) IgA and IgG

  • Upvote 1

Share this post


Link to post
Share on other sites

I share your frustration that they ran only this one test :(   They did not even run the total serum IgA which would tell us if you make normal quantities of IgA and that therefore IgA testing can be relied upon.  Doctors are in love with the tTG but it can be negative in people who will test positive on other celiac blood tests like the DGP (a newer test, and more sensitive and more specific for the development of celiac, i.e., shows results earlier and damage less likely to be caused by something else if positive).  The EMA is also a very specific test for celiac but they don't normally run this unless the tTG is positive.  But your tTG IgA will not be positive if you do not produce normal quantities of IgA - so it's Catch 22.  Is there any chance of talking whoever ordered your test to also order:

 

Total Serum IgA

Deamidated Gliadin Peptide (DGP) IgA and IgG

Yes, I follow up on March 12 because on Feb. 18 I had a colonoscopy.  The reason being, Dr. leaning toward IBS but wanted to rule out other things before putting me on meds.  Said that I am at an age where things could go wrong (I'm 45).  Again, just to be on safe side. 

 

After colonoscopy when Dr was speaking with my husband, he told my hubby that test went well however, he did remove a polyp and took a few biopsies but didn't expect them to be a problem.  Therefore, he handed my husband a script for Levsin for me to take. 

 

I have not started meds.  I really do not want to take it if i can improve things with my diet.  With that being said, I have been wheat/gluten free for only one week now and compared to the way I was feeling, I feel amazing!  Still not 100% but feel very healthy like. 

 

A brief history- I was told I cried the first 2 years of my life because I had colic (was born in 67).  Always very sickly and skinny.  My mom said it wasn't until I had my appendix out (via emergency surgery at the age of 8) that I started to "fill out".  Therefore, she thought I must have been born with a bad appendix.

 

In 2003 I had my gallbladder removed so, all my bowel issues over the years, I blamed it on not having a GB.  Said "issues" mostly happens right after eating, sometimes, I haven't even finished eating and I'd be running to the bathroom.  Also, first thing in the morning as soon as my feet hit the floor i'd be running to the bathroom as well. 

 

Not to mention the bloating and gas so bad I looked pregnant and it hurt to touch as well.  And the exhaustion so bad that I would ask myself "am I really that lazy?"  I forced myself to get through days.  I'd go to bed tired and I'd wake up tired no matter how much I slept. 

 

Anyway, back to the blood test.  I'm no expert, but just from what I posted above...I'm NOT impressed! 

 

Love this site!   And have a great day!

K

Edited by karat514

Share this post


Link to post
Share on other sites

Welcome to the board. That you feel much better after being on the diet a week is a good sign that you are someone who needs to be gluten free. Now on to the bad news.... If you are going to have any more testing done for celiac you need to get back on gluten. Otherwise you risk a false negative. Too bad your GI didn't do an endo at the same time he did the other scope. That is what you need for celiac diagnosis. If when you add gluten back in your body reacts badly you do have the answer no matter what the tests results.

Share this post


Link to post
Share on other sites
Ads by Google:


IBS is a symptom not a diagnosis, aka we have no idea what is going on with your gut.

Agreed.  Hence the reason why I haven't been so quick to take the meds. 

Share this post


Link to post
Share on other sites

Welcome to the board. That you feel much better after being on the diet a week is a good sign that you are someone who needs to be gluten free. Now on to the bad news.... If you are going to have any more testing done for celiac you need to get back on gluten. Otherwise you risk a false negative. Too bad your GI didn't do an endo at the same time he did the other scope. That is what you need for celiac diagnosis. If when you add gluten back in your body reacts badly you do have the answer no matter what the tests results.

Thank you.  I figured I'd just try gluten free on my own and until my follow up on the 12th.  I have to admit I feel so much better that I am not looking forward to going back to gluten even short term, but I will if I must.  Both tests done at once would have been ideal but, it is what it is. 

Share this post


Link to post
Share on other sites


Ads by Google:


If you have been gluten free for only one week, it is not too late to get back on gluten right away.  That way you will not have to do a full challenge.  If you wait until the 12th, you will probably have to eat it for an additional six weeks, which will not seem very short term to you after having experienced the benefits of being gluten free (we always feel worse when we resume eating it :( )  As a matter of fact, depending on the relationship you have with the doctor, you can even call and ask him to mail you a blood slip for the other necessary tests or just stop by his office and pick it up and have the blood drawn right now; but do get back on gluten before it's too late. :unsure:    You can tell the doctor how much better you are feeling already!

Share this post


Link to post
Share on other sites

If you have been gluten free for only one week, it is not too late to get back on gluten right away.  That way you will not have to do a full challenge.  If you wait until the 12th, you will probably have to eat it for an additional six weeks, which will not seem very short term to you after having experienced the benefits of being gluten free (we always feel worse when we resume eating it :( )  As a matter of fact, depending on the relationship you have with the doctor, you can even call and ask him to mail you a blood slip for the other necessary tests or just stop by his office and pick it up and have the blood drawn right now; but do get back on gluten before it's too late. :unsure:    You can tell the doctor how much better you are feeling already!

Oh thank you but that is not what I wanted to hear.  Lol.  I just assumed feeling better after only one week was not enough time to know for sure before I reintroduce gluten.  But if this is a gluten thing then six weeks eating gluten sounds worse.   Do I have to go crazy with the gluten or can I just have small amounts here and there? I guessing if this is a gluten issue even small amounts will make me feel like crap again. 

 

Thanks,

K

Edited by karat514

Share this post


Link to post
Share on other sites

I would eat quite a bit the first day to make up for the days you haven't been eating it, but then just the equivalent of a slice or two of bread, or a few crackers or whatever.  No need to kill yourself :D   You just have to give the antibody factory enough raw material to work with :lol:   And yes, I'm sorry, it probably will make you feel like crap - or even worse.

Share this post


Link to post
Share on other sites


Ads by Google:


Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

0

  • Forum Statistics

    • Total Topics
      108,658
    • Total Posts
      942,255
  • Member Statistics

    • Total Members
      66,586
    • Most Online
      3,093

    Newest Member
    ming1972
    Joined
  • Popular Now

  • Topics

  • Posts

    • i have panic attack since my 20s. now iam on my 40s. i just started gluten free a few weeks. i have found that i have less panic attack. last thursday i can hold my wifes hands and walk for 30 minutes without trigger my panic attack. and i can take a train or bus full of crowed people all without panic attack. i have did a food log for more than 10 years. i have found a few other things will make panic attack worse they are: alcohol (include food cooked) honey (include food cooked) most medcine this may not apply to everyone. just take note what ever you
    • What a lovely group of friends you all are. Thank you! I was devastated at this news yesterday as for nearly five years I've been living under the delusion that all was well. Several of you on this website have mentioned the annual TTG test but I trusted my consultant implicitly, and thought that testing was just the American system. Alarm bells rang a bit when some acquaintances from over the county border in Hampshire said they had an annual coeliac blood test - the TTG - whereas my doc was just checking my liver function, full blood count, and iron - although I don't doubt he had good reason to do those as my Liver Function Tests were off when I was first diagosed. Thankfully those seem to be perfect now but I want to get the TTG down. I'm going to take your advice on board and will try my hardest.    It seems that dealing with the gluten CC is first priority.  I have some savings and my husband and I are going to spend money on getting the kitchen gluten free (apart from a cookie/bread corner for them - nice idea, Icey!).  But from now on they are going to rinse everything before it goes in the dishwasher and we are not going to cook anything with gluten in our pans/crockpots etc.   Eating out is a thing of the past, at least for now.  I think there are lots of restaurants in this country that really train their staff well in all of this, but this year I've eaten in places where they are clearly making some terrible mistakes.  Crumbs in salad (chopped on a glutenous board); sliced real bread put on the same plate as 'gluten free' eggs and salmon; pasta that tasted suspiciously like pasta I used to eat, cakes advertised as gluten free, but baked in house.  I can't take these risks any more.  What is gutting (pun) is I don't know how long this has been going on.  So please, any UK Coeliacs reading this make sure you are being looked after properly.  I don't know if this elevated TTG is just this year, where I have been more relaxed and have made more mistakes, or whether it has never come down.  All I can do now is my best to try to change things.  This great piece of advice from Trents on another thread says it all really.     Bigchan, welcome to the forum! Your narrative is not an uncommon one. Many report that after going gluten free they still show inflammatory disease markers in followup testing. I wish it were the case that going gluten free is the magic bullet that we all have expected it to be at the outset of the Celiac journey. As more evidence mounts over the years from medical science studying this disease it turns out it is more complex than was first thought. Gluten may not be the only trigger of inflammation for a lot of Celicacs. And there is something called refractory Celiac disease (unresponsive to a gluten free diet, no reversal). Sorry, I don't mean to discourage you. And certainly, don't give up gluten free eating. I think there is still so much medical science doesn't know about these kind of autoimmune conditions. In the mean time, do the best you can and enjoy life. Each day is a gift. Having a condition like this can take over your life if you let it. Don't.
    • Hi TonyG, Check out the info at the vitamin D council site.  They ran tests on various vitamin D pills.  They are not all the same.  Also, oily fish is a good natural source of vitamin D. https://www.vitamindcouncil.org/about-vitamin-d/  
    • Hi, and welcome!  Please read up on (DH) dermatitis herpetiformis.  There is a lot of info on DH in the DH section of the forum.  It could be you have DH instead.
    • Twenty-two years ago, I started getting these blister fluid filled bumps on my hands and feet. They would itch and then once they popped they became scaly. I went to the doctor and dermatologist, but no one could tell me what they were. I tried some creams that they'd prescribed, but none of them helped, so I just learned to live with it. I would always hide my feet during a breakout because the sores looked so horrible. Several weeks ago, I went to the doctor because I was feeling tired all the time. I have this "fog" in my head. It's like... my vision's a little clouded (even though nothing's wrong with my eyes; I've had that checked) and it's hard to concentrate on day to day activities. When it's really bad, I feel like I can't even carry on a conversation. Plus, I was having diarrhea almost everyday.  The doctor ordered routine bloodwork and when looking in my records noticed that I'd frequently had a post nasal drip when I'd gone in for evaluations. All of my bloodwork was normal. I was ready to give up again when my primary doctor called me to schedule my routine physical. He wanted fasting labs done. Which I did and they were also normal. I decided to go gluten-free after I saw these results online, because when my daughter was going through her issues (that's a whole different story) I went gluten-free with her and the "fog" in my head actually cleared! I was about 2 weeks gluten-free when I saw my doctor and the fatigue, fog and diarrhea had subsided. The only remaining concern was the blister fluid filled bump on my foot. He took a look at it and said he thought he knew what it was! Dyshidrotic Eczema...He prescribed the strongest topical steroid and said to put it on whenever I feel an episode coming on. That's the thing, I can tell when I'm going to get it. I feel like I'm retaining water the day before... my skin feels tight. Since the diagnosis, I've been researching Dyshidrotic Eczema and it seems it's linked to allergies. I've seen a lot about nickel related allergies, but I've also seen a lot of people who've experience it posting about celiac disease or a gluten intolerance. I don't think I can even be tested accurately now that I've gone gluten-free. Does anyone have advice on how I should proceed? Has anyone experienced similar things?
  • Upcoming Events