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      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
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bayba792

Son's Prometheus Test Results

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I have posted on here several times and you all have been so kind and patient with me. I just received my son's Prometheus test results and would like some clarification.

 

This is my son's test results:

 

DGP IgG 0.4 EU/ml - <4.9 EU/ml

DGP IgA 1.7 EU/ml - <6.1 EU/ml

TTG IgA 0.6 U/ml - <10.3 U/ml

EMA IgA NEGATIVE - NEGATIVE

TOTAL IgA 209 mg/dl   41-395 mg/dl

 

CELIAC RISK HAPLOTYPE DETECTED:

 

DQ2.2 (HLA DQA1*0201:DQB1*0202) AND DQ8 (HLA DQA1*03:DQB1*0302)

 

CATEGORY #       DQ GENOTYPE     INCREASED RISK    RELATIVE RISK

        6                      DQ2/DQ8                    14X                      VERY HIGH

 

My son has been gluten-free for 5 months before this test was done so the Dr said that she would expect the serological markers to be negative.

 

This was my husband's results to the same test:

 

Deamidated Gliadin Peptide Antibody,
IgG (DGP IgG) 9.2 EU/ml + <4.9 EU/ml
Deamidated Gliadin Peptide Antibody,
IgA (DGP IgA) 15.0 EU/ml + <6.1 EU/ml
Anti-Human Tissue
Transglutaminase IgA (TTG IgA) 2.3 U/ml - <10.3 U/ml
Anti-Endomysial IgA IFA (EMA IgA) Negative Negative
Total Serum IgA
By Nephelometry (TOTAL IgA) 308 mg/dl <3 Yrs: 8-220 mg/dl
3-13 Yrs: 41-395 mg/dl
>13 Yrs to adult: 44-441 mg/dl
Celiac Risk Haplotype: DQ8(HLADQA1*03:DQB1*0302)AND OTHER NON-RISK
ALLELES.
Category # DQ Genotype Increased Risk Over General Population Relative Risk
------------------------------------------------------------------------------
3 DQ8 HETEROZYGOUS 2X MODERATE
------------------------------------------------------------------------------
 
sorry so long but from what I understand is that I carry DQ2 and that is why my son has both? Do I need to be tested and also my 5 year old son? We have no GI problems when we eat gluten but we are completely gluten-free in the house and I do not cheat because I have noticed improvements other than GI clear up on gluten-free diet but I notice that if my youngest son eats gluten at school (cupcakes when it's someone's birthday) he gets a rash on his butt cheeks and under his testicles, could this be related?
 
Thank you!!!!
<3 <3 <3

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Whether you get yourself and your son tested is up to whether you want to spend the money and go through the trouble but yes, the gluten sensitive/celiac genes are in your family and it is probably good for all of you that you are gluten free. For your 5 year old, from my perspective with my children now in their twenties, I no longer have any control over their health. Looking back, if they had had the gene tests back when they were little I would have got them so that they would maybe take being gluten free more seriously.

 

From my interpretation of the test results, which I am an amateur by the way, it does seem you have the DQ2 gene and your husband has the DQ8 but heterogenous which means he also has a non-gluten gene. IF you also have one gluten gene and one non gluten gene then your 5 year old has a 1/4 chance of having NO gluten genes, if that makes sense. But that also means he has a 75% chance of having at least one. So if you don't get him gene tested, it would be good to watch him for symptoms. Also, living in a gluten free home could potentially protect him from getting sick later. However, you will rapidly lose control as he grows, goes to school, etc.

 

I don't think it would be worth it to go on gluten to try to tease out a diagnosis, but in my opinion, getting the test and having the information to give your child is a good idea. Then as he becomes an adult and has to make his own food choices he will at least know if he is at risk of celiac disease or gluten related problems.

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I agree with Lock. I think having them tested does make for better choices in the future. 

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Yes, you and your 5 year old should be tested, your son especially and his test should be repeated every few years if it is negative.

I hope your husband is going gluten-free after those positive tests.

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Thank you so much for responding. I will get my 5 year old son tested, I was under the impression that he would have both like my oldest so it would be good to find out. I called my son's doctor and made an appointment for the testing.

 

nvsmom, my husband was gluten free for 3 months before this test so the GI specialist is keeping a close eye on him because of his numbers. He wants to see my husband in 3 months to see if his numbers come down more. He is feeling excellent now that he is gluten free. 

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Glad he is feeling good. It takes a while for those numbers to come down, doesn't it?

Good luck with all the testing. :)

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