• Ads by Google:
     




    Get email alerts Subscribe to Celiac.com's FREE weekly eNewsletter

    Ads by Google:



       Get email alertsSubscribe to Celiac.com's FREE weekly eNewsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes

Tested Negative For Celiac Gene...
0

Rate this topic

4 posts in this topic

Recommended Posts

I recently was diagnosed with late onset type 1 diabetes (at age 33).  My endocrinologist wanted me tested for Celiacs, after mentioning I've had IBS my entire life.  Here was the results:

 

Gliadin Antibody Iga - my value 47 (standard range <20) - High

Gliadin Antibody Igg, Ttg Iga, and Ttg Igg were all < 5 (standard range <20) - Normal

 

My doctor said the high value was on the "less specific" test, but may still have Celiac's.  I was then referred to a Gastroenterologist who tested me for the Celiac gene HLADQ2 &HLADQ8, both of which just came back as negative.

 

Now I'm scheduled for an Endoscopy in 3 weeks for final confirmation.  But, based on this information, is it likely that I do NOT have celiacs?  

Edited by ktmlee

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


Most people with celiac disease are DQ2/DQ8 positive, but it is possible to have it without the genes (depending on the source I've seen that between 1 and 4 percent of celiacs do not have of the main genes). I was diagnosed 4 years ago with celiac disease, then found out after the fact that I am DQ2/DQ8 negative. I am double DQ7. So is my mom, who also has celiac disease. There were a few scientific posters at the International Celiac Disease Symposium in Chicago in Sept. showing that celiac can occur in non DQ2/DQ8 individuals as well. Hope this helps!

  • Upvote 2

Share this post


Link to post
Share on other sites

I recently read in Dangerous Grains that only 90% of celiacs have the DQ2 gene and 94% have the DQ8 gene (I believe those were the numbers). It is very possible to have celiac disease without the DQ2 or DQ8 genes, most celiacs do have it though.

 

The AGA IgA is not used very often now a days because it is not a very sensitive test. It is not solely specific to celiac disease either; it is thought by some to occur in those with non-celiac gluten intolerance (NCGI) as well. Pages 10-12 of thios report discusses the tests: http://www.worldgastroenterology.org/assets/export/userfiles/2012_Celiac%20Disease_long_FINAL.pdf

 

Because you have diabetes, if you have gluten sensitivity it is probably in the form of celiac disease; diabetes is the most common partnering autoimmune disease to appear with celiac disease. :( I would guess it is celiac disease.

 

Good luck with the biopsies. i hope you get some definitive results. Kepp eating gluten until the test is complete.

Share this post


Link to post
Share on other sites

Thanks for the replies.  It makes sense why my doctor still wants the endoscopy then, since it could still be Celiacs.  Forcing myself to eat enough grains for this test has been hard though, since it doesn't help my blood sugar.  But, I guess I'll know in a few weeks time, and can go bread-free again after that!  Thanks again.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

0

  • Forum Statistics

    • Total Topics
      108,128
    • Total Posts
      939,812
  • Member Statistics

    • Total Members
      66,109
    • Most Online
      3,093

    Newest Member
    thetravelingceliac
    Joined
  • Popular Now

  • Topics

  • Posts

    • Mine didn't count past 100 - so I was over 100.  When the numbers are that high, it means you have Celiac.  Slightly elevated numbers can sometimes be caused by other things.  Welcome to the club!
    • I recently took a blood test and went over the results with my GI doctor who will be performing and endoscopy and colonoscopy on me soon. I can't remember exactly what she said, but I believe she was talking about my IGA-TTG levels. She said the normal range was under 10 but mine was 639. I think she was talking about IGA-TTG but I'm not sure. For people who have done this test what were your high levels?  Thanks! Female, 16
    • I can not help you with the Candida  issues (except to advise reducing sugar from your diet and talk to your doctor about antifungals).  I can tell you that my folate and B vitamin levels were off the chart.  No, I did not have cancer, which is what you will find if you google).  Yes, I have autoimmune  issues and maybe I have the MRTHR gene (never tested....why bother?).  Instead, I gave up all supplements even those found in processed foods.   My lab reports are all normal after a year.    I am not deficient in anything at this time.   Vitamins and supplements are a good thing, but they are not for everyone.  There is no “one-size-fits all”.   Consider changing your diet to include just whole, unprocessed foods like the ones your Great-Grandparents ate.  Eat a varied diet full of vegetables, fruit, nusts, seeds, meats, fish and grains.  See if things improve.  Work in the Candida diet into this Whole Foods diet, but find out why you think you have a Candida issue.  This should be diagnosed by a medical doctor.  Systemic Candida is rare and is usually found in people with immune-related illnesses.   If you suspect celiac disease, get tested.  It is a simple blood test.  Learn more: http://www.cureceliacdisease.org/screening/        
    • It could be celiac disease related or not.  The fact is her antibodies are still elevated.  They have come down dramatically (great job!) and she has had some  intestinal healing, but she is not completely healed.  She probably needs more time.  She is under a lot of stress which is known to affect menstrual cycles even excluding celiac disease.   She has been malnourished (think concentration camps...extreme, but you get it)  and still is based on her eating habits you described.    She  is a student who is away from home and has to deal with celiac disease every single moment on her own.    Every bite of food must be checked.  That can be exhausting!  It will get better, but it takes time.  It can take a long time to heal.   The fact that it occurred when she stopped gluten is probably a coincidence.  It probably added even more stress.  Can you imagine a life-long dietary change?  Ever dieted?  How long did the diet last?   Give it more time for her antibodies to come down.  She is still being attacked. They are not in the normal range.    Most take a year or longer to heal.  Ask anyone here.  Read through forum comments.   How about baking her some chocolate chip gluten-free cookies and shipping them to her?  Or mail a fruit basket.  You both will feel a bit better.   Hugs!!!!
    • Done and wish you luck. I moved to a full on keto/paleo diet after also. This might be why it does not come back, once you get rid of it probiotics help keep it in check as they eat the yeast.
  • Upcoming Events