• Ads by Google:
     




    Get email alerts Subscribe to Celiac.com's FREE weekly eNewsletter

    Ads by Google:



       Get email alertsSubscribe to Celiac.com's FREE weekly eNewsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes

Lactulose/mannitol Test For Leaky Gut
0

Rate this topic

11 posts in this topic

Recommended Posts

Hi, everyone. I'm brand new to the forum. I have a question for you. (I've searched the forums for a topic that might already have answers to my question, but could not find one.)

Have any of you had a lactulose/mannitol test to determine whether or not you have a leaky gut? I just got the results back from my test, and it's pretty scary. The percentage of lactulose recovered in my urine was 2.45. That's much higher than normal. The percentage of mannitol recovered was 26, which is also quite high. The lactulose/mannitol ratio was .09, again fairly high.

I'm just curious if any of you have had this test done and, if so, how your results compare to mine.

I have not (yet) been diagnosed with celiac disease, but I am almost certain I have it. After elminating gluten (and casein) from my diet 10 months ago, my depression/anxiety cleared up completely. It was amazing. I've been on the paleo diet (lean meat, fresh fruit and vegetables) ever since, and haven't had any problems. Except for eczema and shortness of breath after eating citrus fruits and tree nuts -- and so I've elminated them as well.

I've asked my doctor (a family practitioner) if he can find another lab that will perform this same test. I just want to confirm the results. If confirmed, I guess I'll start looking for ways to heal the gut -- I've heard glutamine, fish oil, and acidophilus are all helpful. Any other treatments you've heard of?

Thanks much!

Scott

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


Hi Scott, just wanted to welcome you to the boards. I have not had that test but it seems like something I should look into.

Share this post


Link to post
Share on other sites

I had the test several years ago. I will be having a new test in a couple of weeks.

Glutamine is said to be the best 'gut' healer. It worked for me but I am no longer allowed to take it so I will probably have problems again. Claire

Share this post


Link to post
Share on other sites
I had the test several years ago. I will be having a new test in a couple of weeks.

Glutamine is said to be the best 'gut' healer. It worked for me but I am no longer allowed to take it so I will probably have problems again. Claire

Claire, do you mind if I ask why you're no longer able to take it? Did you develop some type of allergy to it?

Thanks,

Scott

Share this post


Link to post
Share on other sites

I have heard of the test, seems like it is growing in popularity for its ability to measure intestinal effects in individuals w/o classic biopsy or w/o being invasive...

Share this post


Link to post
Share on other sites
Ads by Google:


Have any of you had a lactulose/mannitol test to determine whether or not you have a leaky gut? I just got the results back from my test, and it's pretty scary. The percentage of lactulose recovered in my urine was 2.45. That's much higher than normal. The percentage of mannitol recovered was 26, which is also quite high. The lactulose/mannitol ratio was .09, again fairly high.Scott

Welcome Scott-

I'm pretty new also 6 months gluten-free and now trouble with dairy and my chiropractor thinks I have leaky gut. still trying to wrap my head around what that is...I'm embarrased to say I don't know what mannitol is??

Can you help me here so I don't have to do a search?

Does the dr have to order the test?

I feel that acidophilus is so helpful for me been taking it for many years.

Thanks much!

Judy in Philly

Share this post


Link to post
Share on other sites

Hope the following will be of help:

Causes of Leaky Gut Syndrome / Intestinal Permeability

• Chronic stress

• Intestinal infections

• Small intestine bacterial overgrowth

• Environmental contaminants

• Excess alcohol

• Poor diet

• NSAIDS and other medications

Testing

The standard test for leaky gut syndrome is the mannitol and lactulose test. Both are water soluble molecules that the body can't use. Mannitol is easily absorbed by people with healthy intestinal linings. Lactulose is a larger molecule and is only slightly absorbed. A person drinks a solution contain both mannitol and lactulose. Urine is collected for six hours and the amount present in urine reflects how much was absorbed by the body. A healthy test shows high levels of mannitol and low levels of lactulose. If high levels of both molecules are found, it indicates a leaky gut condition. If low levels of both molecules are found, it indicates general malabsorption of all nutrients.

Source http://altmedicine.about.com/od/healthcond...estLeakyGut.htm

This article fails to mention Celiac -i.e. gluten - as a cause of LGS. Big omission!

As you can see here - this test also will show malabsorption - probably more accurately than some of the lab tests do.

A GI specialist can order the test. Some GPs will also - if they happen to know what it is.

Scott: to answer your question: I stopped taking L-glutamine because the glutamates are iffy for people with neurological problems - specifically cerebellar damage. As I have cerebellar ataxia this product was discontinued. In cases of cerebellar damage it is uncertain whether the brain will or will not process glutatmates properly. I am being on the safe side. Claire

Share this post


Link to post
Share on other sites


Ads by Google:


Thanks so very much Claire and Jen

Judy in Philly :)

Share this post


Link to post
Share on other sites

Where can I have the lactulose/mannitol test for leaky gut syndrome performed? I'm in Akron, Ohio, but willing to travel if necessary. My physician told me any gastroenterologist could order this test, then her staff referred me to a gastroenterologist who didn't know this test existed.

Share this post


Link to post
Share on other sites


Ads by Google:


Where can I have the lactulose/mannitol test for leaky gut syndrome performed? I'm in Akron, Ohio, but willing to travel if necessary. My physician told me any gastroenterologist could order this test, then her staff referred me to a gastroenterologist who didn't know this test existed.

Just an FYI - this thread is from 2006. I don't think any of these members have been on in a few years.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

0

  • Forum Statistics

    • Total Topics
      108,110
    • Total Posts
      939,729
  • Member Statistics

    • Total Members
      66,097
    • Most Online
      3,093

    Newest Member
    GlutenMama
    Joined
  • Popular Now

  • Topics

  • Posts

    • Hello and welcome You've found a good site for advice and support.  Google suggests there is a link between EoE and Celiac, but at the moment that seems to be as much as anyone knows: https://www.emaxhealth.com/12410/celiac-disease-increases-risk-eosinophilic-esophagitis https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-13-96 Although it's not true that having one means you have the other.  You may want to read this thread for the experiences and ideas of others here who have experienced Burning Mouth Syndrome: https://www.celiac.com/gluten-free/topic/106704-burning-sensation-in-mouth/ There were lots more gluten and BMS articles, so if a direct link hasn't been made, there's food for thought there along with some interesting thoughts on B and Iron deficiencies and possible additional food intolerances. No please don't. If the biopsy is inconclusive they may want a second one or further blood tests (you don't mention if they already did these?). Once you eliminate gluten from your diet these tests are inaccurate. That's not to say you shouldn't trial the diet, just make sure with your doctor you only do so once tests are complete. I'd add that even if you test negative you have nothing to lose from trialling a gluten free diet and as someone who did test negative I highly recommend you do, but only once testing is done! In the meantime, start a food diary. Log what you eat, when, and how you feel. Just short notes but make it a habit and try to capture everything you put in your mouth.  Build a record that you can use to find patterns. Maybe a trigger for the BMS will become apparent over time. Best of luck    
    • Funny you should ask about Lectins because I am currently recovering from a recent run in with some pinto beans.  After reading soaking longer than overnight helps break down those Lectins, I soaked them for twenty-four hours  Then I cooked the spots off them!  And still, they have wreaked havoc in my tummy.  Ugh!   So while recuperating, I did some research.  While cooking can break down some of the lectins, the only way to get rid of them completely is to cook them in a pressure cooker.  I was surprised to find that Lectins are histamine releasers!  Lectins make Mast cells release all their histamine.  Aha!   The red wine and balsamic vinegars and the bottled lemon juice are all high in Sulfites.  Sulfites are histamine releasers, too.  Apple cider vinegar is lower in Sulfites.   Lectins stimulate the autoimmune system: https://www.ncbi.nlm.nih.gov/pubmed/25599185 More on Lectins and autoimmune diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115436/ And for Enis' affinity for chocolate nibs...(as well as my own)... Chocolate is a source of copper.  Copper deficiency causes neuropathy.   My neuropathy has gotten worse recently and my chocolate cravings have increased.  Hmmmm...... https://www.ncbi.nlm.nih.gov/pubmed/19901719 More info on copper http://lpi.oregonstate.edu/mic/minerals/copper So...I'm wondering if I've neglected taking copper along with my calcium and magnesium.  I'm starting supplementing this week. Is copper in any of your protein powders, Enis?   I hope this helps.
    • I have neuropathy. Mine is worse with cold. My hands and toes get so bad I cry. I don't know what to do to make it better but just wanted you to know you aren't alone. I hate feeling alone with this disease.
    • Just recently found this article about a woman suffering from neuropathy which was caused by copper deficiency caused by Celiac Disease. https://www.ncbi.nlm.nih.gov/pubmed/19901719 Copper deficiency myeloneuropathy due to occult celiac disease. "...the authors suggest that some cases of ataxia associated with celiac disease are likely due to copper deficiency myeloneuropathy."
    • Do EoE and celiac disease generally come in tandem?  Does having one necessarily mean having the other? Had an EGD today expecting to have an entirely different outcome.  A short history: Lap Band placed 10 yrs ago with a weight loss of 173-ish lbs. Am a 47 y/o F experiencing uncontrolled vomiting, several times a day, and abnormal, unwanted continued weight loss. Too thin IMO, at 133. Experience random and lengthy bouts of burning (scalding,  really)  mouth syndrome (which I believe is a diagnosis recognized only by those experiencing it, and has not an official diagnosis of anything... yet). At the urging of my children and my parents alike, all of whom see me wasting away before their very eyes, and concerned for my well-being (if not my life),  I began looking for answers. Assuming my answer would sound something like this... "let's remove your lap band immediately". Problem solved.  Not so.  Lap and in perfect condition and placement, and not the cause of any restriction whatsoever, as all fluid was removed 3 yrs ago. Food from over 12 hours previously ingested was still hanging out in the lower portion of my esophagus.  Dr. susoects a high concentration of eosinophils and EoE and/or celiac disease is also suspected.  4 samples have been sent for biopsy.  I knew nothing of either of these two diseases until 2 hours ago, and I am, at best, confused.  Lots of info to digest. Should I begin eliminating wheat, dairy, eggs... Etc. prior to biopsy results? Or wait for Dr. orders? History of Grave's (mom), and Hashimoto's (sister). I've had asthma and chronic bronchitis and pneumonia since childhood. Any  and all info/help/suggestions are more than welcome. Also, feel free to let me know if I'm way off base and prematurely/overly concerned.  I'd be ok with that too, as I tend to overthink things.    Thanks! 
  • Upcoming Events