• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

'eat What You Want' Pill Caution
0

36 posts in this topic

Ditto about the research, Bev and Vincent. I told Dr. Paterson how he gave me a lot of hope --- not only for myself/Celiacs, but for others. They are taking a huge risk (in terms of money) and medical advancements aren't made without risks. He really inspired me!!!!!!!!! I wish I had a video of the talk for everyone to see!!!

Vincent-I don't remember if he mentioned when the next round (Phase II) of testing will be begin. He did talk a lot about requirements for people to be able to participate (proven biopsy, etc.) but I don't recall about timeframe for testing. There were others from my Celiac group (VaBeach) that were at the Richmond meeting---I can ask at our next meeting if anyone has an answer to that. Maybe the press release that comes out Monday will address it?

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


Laura, a question:

It's my understanding that the recognition of the 33-mer that triggers the reaction occurs in the gut. So I don't understand how suppressing zonulin to 'keep the gates closed' makes any difference. Is the implication here that the immune reaction does *not* take place in the gut, but outside of the intestines?

0

Share this post


Link to post
Share on other sites

hey tarnalberry,

Yes, that is what I took from it, and from the pictures that were presented. (that the reaction occurs once the gluten has breeched barrier cells, through the tight junction). Now, I don't understand it fully, but that is the basis that the zonulin research is going on. But, yes, I do believe it is the 33-mer that triggers the reaction for Celiacs...My understanding was that it is ok until it breeches the barrier cells, and then the auto-immune cells (in Celiacs) recognize that chain as "bad."

I took this from the website of Alba Therapeutics, under "Celiac Disease"

"It is known that altered intestinal permeability (leaky gut) is a hallmark of celiac disease and tracks the severity of the disease. It is likely that zonulin-induced leaky gut is both a cause and a consequence of the disease, facilitating transport to gluten which then triggers an inflammatory process, resulting in a leak which can be blocked by zonulin antagonists."

Hope that helps?! Let me know.

0

Share this post


Link to post
Share on other sites

Wow--thanks Laura--this is all so interesting :)

0

Share this post


Link to post
Share on other sites

Thanks girl---I am just trying to present the information the best I can from what I heard and took notes on! I seriously wish everyone could have been there!

0

Share this post


Link to post
Share on other sites
Ads by Google:


Thanks girl---I am just trying to present the information the best I can from what I heard and took notes on! I seriously wish everyone could have been there!

Im gald you did!!!

BTW PLEASE link the news release when its up :D

0

Share this post


Link to post
Share on other sites

Well, I tell ya--I appreciate you taking the time to take notes and posting for us. I would love to have been there. It is exciting to think of what might come out of all this.

0

Share this post


Link to post
Share on other sites

Maybe I'm just extremely skeptical, maybe it's just because I have bad reactions to drugs, but I would still choose the diet. If others want to use it, and it really works, then I am glad for them! B)

0

Share this post


Link to post
Share on other sites

As requested:

http://www.celiac.com/st_prod.html?p_prodid=1310

Alba Therapeutics Announces Positive Celiac Disease Trial Results

Celiac.com 03/14/2006 - Alba Therapeutics Corporation announced today successful completion of Phase Ib proof-of-concept studies for its lead compound, AT1001. In a 21-patient cohort of celiac disease sufferers, the oral administration of AT1001 versus placebo control induced a significantly positive result in the trial's primary target endpoint.

"We anticipated a strong signal, however, the magnitude of the response surpassed our expectations," stated Blake Paterson, M.D., President and CEO of Alba. "We are particularly excited, as to the best of our knowledge this is the first demonstration of a desired and systemic immunological effect resulting from a physiological event at a mucosal surface."

AT1001 is an antagonist to the zonulin system -- a signaling pathway discovered by Alessio Fasano, M.D., Professor of Pediatrics, Medicine and Physiology at the University of Maryland School of Medicine, and the basis of Alba's extensive intellectual property portfolio.

About Zonulin

Zonulin is a signaling protein that transiently and reversibly opens the tight junctions ("tj") between the cells of epithelial and endothelial tissues such as the intestinal mucosa, blood brain barrier and pulmonary epithelia. Zonulin appears to be involved in many diseases in which leakage occurs via paracellular transport across epithelial and endothelial tight junctions (tj), and thus may play an important potential role in the treatment of autoimmune diseases.

About Celiac Disease

Celiac disease (celiac disease) is a T-cell mediated auto-immune disease that occurs in genetically susceptible individuals and is characterized by small intestinal inflammation, injury and intolerance to gluten. According to the National Institutes of Health, celiac disease affects approximately 3 million Americans, although the diagnosis is rarely made. The only current treatment for celiac disease is complete elimination of gluten from the diet, which results in remission for some patients.

About Alba

Alba Therapeutics Corporation is a privately held biopharmaceutical company based in Baltimore, Maryland. Alba is dedicated to commercializing disease-modifying therapeutics and drug delivery adjuvants based on the zonulin pathway. Alba's lead molecule, AT-1001, is targeted towards the treatment of celiac disease and other auto-immune illnesses.

0

Share this post


Link to post
Share on other sites

I think about the drugs that say they will cure psoriasis etc. But the side effects are heart attack etc. I think I have enough poison drugs in my system with my inhalers which I need. I do not need a pill that allows me to eat something to find out in the end it my destroy an important organ in my body or something else. I am just as happy being gluten-free than taking something which they may find out in 5 years gives you a heart attack, kidney diseased or brain tumor.

0

Share this post


Link to post
Share on other sites

While I completely understand your position on drugs, I still think it is exciting that this drug might change how other autoimmune disorders are treated (i.e., the ones that can't be controlled by diet)!!!!!!!

I think it is still important to conduct research and have break-throughs in medical technology.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      106,799
    • Total Posts
      932,534
  • Member Statistics

    • Total Members
      64,288
    • Most Online
      3,093

    Newest Member
    paacollins
    Joined
  • Popular Now

  • Topics

  • Posts

    • I am not getting enough vitamins my body needs before and after being diagnosed with celiac. Can anyone recommend great vitamins to help me get back on track. Everywhere I go the vitamins itself contains gluten or was made a gluten facility. I don't eat a lot because I am still getting sick so I need to find a way to get more nutrients into me.  Thanks!
    • It sucks when you've taken precautions and they don't pan out. Take heart however, although it feels like you're back to square one but one exposure doesn't negate all the healing that you've gone through. Eat simply and safely for now and get back on track. You should feel better soon. As for eating out, it's the same as when you learned to ride a bike. You dust yourself off, learn a lesson about that venue and get back on the bike. You need to balance risk and reward. Too far either way isn't the way to go. Hope you're feeling better soon  
    • My 9 year old daughter has the exact same marks as you. It is being dismissed as her doing it to herself. I honestly don't think she is but I do know once she gets the sores she is a chronic picker which does not help.  The main reason they say it is self inflicted is because they are only on her arms and legs - never her torso. Sorry I don't have anything for you but I was wondering where you are getting your sores?  I pulled my daughter off of gluten a year ago and they seemed to have cleared and two months ago I let her eat whatever they served at a birthday party and all the sores are back (still). 
    • Just one point on this - I'm no expert but I wonder if UTIs can present differently, depending on which section of the tract is infected?   Mine tend to be lower down in the urinary tract so I don't feel like I need to go to the loo a lot when I have one, but when I pee or afterwards it hurts, and then I get that feeling of my insides slipping out - as you put it.  My point is you may have a UTI in a different part of your urinary tract to normal.  Just a thought? 1. Diffuse pain sounds like it might be bloating. Are you drinking/eating dairy? 2. Sacroiliac joint inflammation can come about for all sorts of reasons - what you are suggesting would cause it.  However, I tend to find my pain transfers to the side of my groin and pelvis - not centrally.   Here is an interesting article which shows how it refers. http://www.massagetoday.com/mpacms/mt/article.php?id=14394 3.  I'm thinking perhaps it might be worth having a pelvic scan if you can? Internal and external. 4. Ditto - tight clothes are a distant memory! 5.  I'm no longer seeing a chiropractor.   I was in pain for months, then one day I underestimated the height of a step down and jarred my hip.  Agony!  Went to bed for four hours to sleep off the pain -  but the strange thing was my SI joint was much better for many many months after that! 6.  I agree - all this sort of stuff is highly ambiguous.  I remember when I was really concerned about my pain - which was before I had had my scan and then sigmoidoscopy - I did a lot of online research and it seems that a lot of women get unexplained pelvic pain.  So it appears we are not alone. If I were you I'd be inclined to pursue this with a GP, it might be a long journey but you should get some answers and peace of mind. I find unanswered medical questions only ever add to my pain - I think I must tense up with anxiety. Cx  
    • Thanks. Still figuring it all out. 
  • Upcoming Events