• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Help With Results Pls
0

5 posts in this topic

Recommended Posts

Guest christyworthington   
Guest christyworthington

Hi all,

I recently had blood work done on my 2 children. My Daughters came back as follows

GLIADIN AB IgG 67 (moderate to strong positive)

GLIADIN AB IgA 7 (negative)

ENDOMYSIAL IgA AB 3 (negative)

Could somebody please help me interpret these results and advise me of any other tests that may or may not be needed to determine if she is celiac or not.

I have discussed this with the Doctor but would like to hear some opinions if possible.

Many thanks in advance

Chris

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


celiac3270    4

Okay...there's some stuff on Celiac.com on interpreting stuff, but I couldn't get through it, so I found another site...........which I also can't get through.... :) ....they make this stuff hard to understand: :)

1. Serological

a. The blood tests recently developed for the detection and screening of celiacs and their relatives are a useful aid to diagnosis and monitoring. The tests have a clinical utility in:

Screening at-risk populations to identify biopsy candidates

Providing information to support a diagnosis of celiac disease

Monitoring adherence to a gluten-free diet

b. There are two classes of antibodies seen in untreated celiac disease: Antibodies directed against a fragment of gluten called gliadin and antibodies directed against some tissue in the body itself, endomysial (the covering of muscle), and reticulin (the framework for kidney and liver). There are other types of antibodies to the body's own tissues.

The actual tests are done using blood from the patient. The blood cells are removed. The gliadin test is usually an automated machine read test. While this means there is little room for interpreter error, there are no standardized tests, normal ranges, or even standardized methods in use in the US.

The endomysial tests are more dependent on the experience and ability of a pathologist in looking at a pattern of staining produced by the patient's serum on a slice of monkey esophagus or human umbillical cord. While this test is done in a similar way in most labs there are differences in how these are interpreted.

c. How good are these tests?

If all of the tests are positive then they are pretty accurate, GT 95% right. However, there are several reasons and circumstances when they are not so accurate. IgA and IgG are two different varieties of antibodies we have in our immune systems. The IgA gliadin and IgA endomysial tests are the most accurate and also become negative relatively quickly after stopping gluten (3-6 months). The IgG is not as specific (it can be positive in non celiacs). However it is important to do both, as about 4% of celiacs have low enough levels of IgA to make the IgA tests inaccurate.

These tests can only be given to a patient that is consuming gluten. The amount and time require for a gluten challenge varies and is a factor for consideration when scheduling the test.

Negative results do not indicate that the patient will never develop Celiac Disease, only that it is not currently a factor. HLA typing can be used to determine if a person has the genetic factors that are associated with celiac disease; without these genetic factors celiac disease is very unlikely to ever develop. For more information, access the file CELIAC CEL-HLA with the GET command from listserv@maelstrom.stjohns.edu.

Needless to say the interpretation of mixed results (i.e. some positive and some negative) is complicated. Also the interpretation and use of these tests in infants may be different, due to lower levels of IgA.

Okay, then there was a table I found in the FAQs of this site, which tells you how important each of the tests are for telling you "yes" or "no" with celiac disease:

Each of these three tests provide a certain degree of reliability for diagnosing celiac disease. Of these, endomysial antibody is the most specific test. The following table is taken from our studies (Lerner, Kumar, Iancu, Immunological diagnosis of childhood coeliac disease: comparison between antigliadin, antireticulin and antiendomysial antibodies).

Share this post


Link to post
Share on other sites
gf4life    5

Most doctors would say the results are negative and not test further, others are willing to do the biopsy just to be sure. All three of my kids tested similar to your daughter. All had positive IGG only, negative on everything else. While waiting for the follow-up appointment (two months later) I had the kids tested through Enterolab. All three tested positive on Gliadin IgA and tTg stool tests and have genes that cause either Celiac or gluten intolerance. With this information and the improvement on the diet the doctor and I agreed not to do a biopsy on any of them. This means that they are getting healthy, but do not have an official diagnosis.

I personally tested negative on all the blood tests including the biopsy, yet positive on the stool tests. I was not too surprised at the negative test results given that I had previously been on a gluten free diet and being gluten free before testing can mess things up for future testing. I feel so much better off gluten and was getting sicker everyday on gluten. So I know that is my problem.

As for whether you should ask fo rmore testing, that is a decision you have to make, but from my personal experience even a positive IGG blood test suggests further testing would be a good idea.

Do you mind me asking what your daughters symptoms are, and how you came about getting them tested? Do other family members have it? Just curious.

God bless,

Mariann

Share this post


Link to post
Share on other sites
GEF    0

Hello Chris.

I'm sure it will be of some comfort to know that you're not the only one who's wondering about what your results mean. I too am IGG positive only. I had an endoscopy and it was normal, so at least I know I'm not celiac. It still doesn't rule out gluten intolerance though. I'm still in the process of getting tests done with my doctor, but from what I've heard is that if you're IGG is positive, it might not be celiac, it could be something else causing that anti-gliadin to show up. There are many, many people that will tell you that it took a while for the other anti-gliadins to show up in their blood, or even for an endoscopy to show any signs of damage to the intestine. I know how you're feeling, believe me... keep searching, keep asking until you get your answers. My family is pre-disposed to auto-immune disease (lupus)... if you have anything of the sort in your family, see if your doctor can run an ANA. If I test positive, I'll probably have to go gluten-free anyway... I just really would like to know where the root of the problem is. Anyhow, keep searching, keep asking questions and I hope you'll get some answers and feel better soon.

Gretchen

Share this post


Link to post
Share on other sites
Guest christyworthington   
Guest christyworthington
Do you mind me asking what your daughters symptoms are, and how you came about getting them tested?  Do other family members have it?  Just curious.

God bless,

Mariann

Thankyou for your replies.

My daughter does not really present any symptoms continuously. She has in the past suffered nausea and diarrohrea *sp. The test are more for peace of mind really.

I hadn't really noted how serious the disease was until i found this site. Growing up all my mum told me was, not to eat flour it will make you ill.

Thanks again

Chris

Share this post


Link to post
Share on other sites
Ads by Google:


Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

0

  • Forum Statistics

    • Total Topics
      107,883
    • Total Posts
      938,465
  • Member Statistics

    • Total Members
      65,788
    • Most Online
      3,093

    Newest Member
    KaitlinP
    Joined
  • Popular Now

  • Topics

  • Posts

    • Sorry to hear about the loss, bread is a pain for some, Canyon house makes one many swear by...I have 2 issues with it so I can not even try it. I been using Julian Bakery Bread for awhile, the seed one was wonderful even toast like gluten bread, while the coconut one made the most amazing french toast, and the almond one was great toasted with mashed avocado. I recent perfected a sandwich bread for my bakery, so will be making my own grain free, starch free, 1 net carb bread loafs for myself.
      NOW a bit more on this topic, I am currently converting it to a sugar free German chocolate cake loaf for testing this weekend (these are going to be bakery item only for my store)
    • Hi everyone! I am a 23 yo female and was diagnosed Celiac in January 2016 and have been gluten free since then. My IgA levels are down to 4 and my Celiac is very under control. However, I recently have been dealing with a lot of unexplainable pain and discomfort that no one can seem to explain to me and wanted to see if anyone has experienced anything similar. For about a year, I have been occasionally getting severe abdominal pain that seems to be concentrated in my rectum. It starts by feeling overall icky, crampy and sort of like I have "twinges" in my rectum. It feels like maybe I need to have a bowel movement but I dont, and if I do it doesn't help the pain. So I feel bad, and then all of a sudden I feel like I am being stabbed in my rectum. The stabbing comes and goes but causes me to like roll around on the floor it is so painful. This sometimes only happens once and is over in 20 seconds, but generally it is an all day thing and lasts like 8-10 hours. These generally have been coming 2-3 times per month one day apart. They seem to come about every four weeks (not during my period or ovulation though) and naproxen and heat helps some, so I thought it was maybe OB/GYN related (they also started shortly after I switched for BC pill to an IUD) but I have seen two OB/GYNs and both have no idea and think it is gastrointestinal, maybe gas pain of some sort that is possibly triggered by hormones related to my cycle. However my gastroenterologist is also stumped and thinks its related to my uterus cause it seems to be somewhat cyclical. Anyway they're horrible and I can't figure out what they are, they don't seem to be related to what I eat (though I should probably start tracking) or a particular time of day. Sometimes they seem to come while I am exercising, but sometimes they wake me up in the middle of the night. I should also add that I have no GI symptoms involved with these painful episodes, my bowel movements seem completely normal, no gas or anything either. Also, the last two days, I have woken up in the middle of the night with the feeling of being bloated and crampy. Not painful per say but extremely unpleasant. Again, I'm not on my period so idk what is causing this, especially cause both times it woke me up and I am a deep sleeper. Now, for the last 30 minutes I have been having non-painful muscle spasms in my left lower abdomen. It feels like a flutter, if I put my fingers against the spasm I can feel it distinctly. Again it doesn't hurt, but feels weird and I've never had a muscle spasm there before. If anyone has ever had any of these symptoms before or has any idea what me going on I'd be very grateful! Is it possible its related to glutening? Since I caught my Celiac really early I don't really know what my symptoms of being glutened are, the few times I know I have been I don't get diarrhea but instead extreme bloating, acid reflux, and overall feeling really crappy and anxious. I have a whole host of health issues these days that have been causing me a lot of stress (I'm in medical school and don't have time for these debilitating pains!) and it would be awesome to have some answers.   Thank you all, K
    • Thank you!   I see a Dietician early next month and figured I will need to be more strict early on.    There is so much to learn.  I am grateful for the apps available that allow me to scan UPC's to find out what is and is not gluten-free, but will be confirming by reading labels  too.   I cleared out quite a bit of space in my cupboard today.  It is only me in the house since I lost my husband earlier this year so it will be easier to control what is in the house.    He loved bread as much as me so it would have been much harder with the 2 of us here
    • Welcome to the board. Many of us keep safe gluten free snacks on hand for times when we are away from home.  In addition to what Karen mentioned fruits, nuts, hard boiled eggs etc. If it is a long trip a cooler can keep stuff fresh for you and they make ones that you can plug into your car. How were you diagnosed? Many folks carry the genes but don't develop celiac. You should have had a celiac panel blood test and an endoscopy. If you are new to the lifestyle then do check out the Newbie 101 threead at the top of the Coping section. it has a lot of info to keep you safe.
    • If you are super sensitive (or have become super sensitive) there is an oats purity protocol used by just a few companies. The fields do not grow gluten containing grains for 4-5 years before the oats are planted, the fields are walked several times a season for any plants not belonging to be pulled by hand, and all the equipment and facilities used to harvest are dedicated equipment. It's a bit pricey, but it produces the only oats that I don't react to (although I have not tried all certified gluten free oats).  There are a couple variations of magnesium. Some cause loose stools so check the source of magnesium (and make sure it's gluten-free). Calm I've used with no problem. If you are stressed, you will burn through magnesium faster.  Roommates create some complications. I had a shared kitchen for a vacation this past year, and I was constantly cleaning. I'm so used to my gluten-free kitchen I became very aware of sinks being used to pour pasta water in, bread crumbs left from a cut sandwich, and how much gluten a simple sponge can be exposed to. I kept my sponge to clean my area in a ziplock bag next to the sink. And if I was cleaning fruit or veggies, I filled a large bowl with water to use so I wouldn't have to always be cleaning the sink. If you have wooden utensils, make sure they aren't be accidentally used. A friend was getting cross-contaminated from shared condiments.  My celiac reactions for cross contamination are not gastro but neurological so I can't offer much with that. A proper glutening is the only thing that gives me gastro symptoms, and it is the most painful experience! In either case, I drink lots of water. I will drink a gallon on those days. Throw some Calm in there, but force fluids. I also use Ultima Replinisher (which I typically use after exercise) if I'm forcing fluids, and I drink mugs of warm broth if my gut is really not doing well.  Hang in there, C. Hope you feel better soon.     
  • Upcoming Events