This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.
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What are the major symptoms of celiac disease?
Celiac Disease Symptoms
What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic)
Celiac Disease Screening
Interpretation of Celiac Disease Blood Test Results
Can I be tested even though I am eating gluten free?
How long must gluten be taken for the serological tests to be meaningful?
The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free
Is celiac inherited? Should my children be tested?
Ten Facts About Celiac Disease Genetic Testing
Is there a link between celiac and other autoimmune diseases?
Celiac Disease Research: Associated Diseases and Disorders
Is there a list of gluten foods to avoid?
Unsafe Gluten-Free Food List (Unsafe Ingredients)
Is there a list of gluten free foods?
Safe Gluten-Free Food List (Safe Ingredients)
Gluten-Free Alcoholic Beverages
Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free?
Where does gluten hide?
Additional Things to Beware of to Maintain a 100% Gluten-Free Diet
What if my doctor won't listen to me?
An Open Letter to Skeptical Health Care Practitioners
Where can I buy gluten-free stuff?
Support this site by shopping at The Celiac.com Store.
Often drugs that end in –artan are ARBs, and they work by blocking the angiotensin receptors. I’m not sure what the exact difference is between the two medications you mention, though. Have you called the manufacturer of losartan to see if any of the fillers contain gluten? It might be a good idea to know what those fillers are.
In my drug book “dyspepsia” and “gastritis” are mentioned as side effects, but they did not drill down to the specificity of villous blunting. I did some googling, and in addition to what Knitty found, I came across this:
Small Bowel Histopathologic Findings Suggestive of Celiac Disease in an Asymptomatic Patient Receiving Olmesartan
“Although Rubio-Tapia et al are careful to avoid claiming a proven causal relationship between olmesartan therapy and the observed spruelike enteropathy, the data are highly suggestive of more than just a coincidental association.
“They further suggest that a potential mechanism for the enteropathy could relate to inhibitory effects of angiotensin II receptor antagonists on transforming growth factor β action because transforming growth factor β is important in gut immune homeostasis.
“Although anecdotal, these observations lead to the hypothesis that olmesartan, and perhaps other angiotensin II receptor antagonists, could be a cause of intraepithelial lymphocytosis in architecturally preserved proximal small intestinal mucosa.”
(One of the patients in question was offered the opportunity to do a gluten-free diet, but he/she declined.)
So, it looks like you are definitely on to something, and if this turns out to be a “thing,” would probably warrant dissemination on a wider scale.
You didn't mention what your BP is with the medication or was without it, but please let your health care provider know if you do decide to discontinue your blood pressure medication. It's often recommended not to DQ suddenly, which can cause the BP to spike in some cases.
ETA: Just because a drug can cause a particular side effect does not mean it does in your case. I just thought I'd add that, but nevertheless totally and completely understand the cause of concern in any case.
Lol funny thing me and my dietician were talking about things that could also cause villi blunting years ago. He brought up a interesting one, he had a case where someone was taking massive amounts of Metamucil several times a day, He said it was like 2-4 tsp 3 times a day and making into hot gel drinks for weight loss to feel full. Anyway what this had done "scrubbed" his intestines so much with the abrasive fiber it had actually damaged the walls and blunted the villi. He compared it roughly scrubbing with a loofah several times a day and it had like a fine sandpaper slowly eroded the insides of his intestines faster then it could heal. He says because of that he would never suggest anyone to take the full dose of psyllium husk for longer then a week straight before rotating off of it.
Not medical advice posterboy and this is a dangerous things to play with I know, but with your BP perhaps try to help regulate it with cinnamon oil, and watching and playing with your salt intakes of potassium and sodium. These tend to effect my blood flow and how I feel often. I am unsure if BP related, mine always checks great when I do check it. But Cinnamon is one thing I can not live without, I take several tbsp a day of it or a few drops of the EO. I have been doing this for over a decade, before that and when I do not, I start feeling cold, not wanting to move, and just want to curl up in blankets...no clue why if it is health, blood, neurological, or termogenic.
She may be one of those people who got diagnosed only via blood. Some tests can come back false positive. Or maybe only via biopsy and it turns out she had H. Pylori. Who knows. Absolutely could happen though.
One of the things that surprised me too was when my doc said it can weeks to months for symptoms to develop on a gluten challenge. I always had this image of getting so imminently sick that there was no question about the connection with gluten.
Yea. I hope she isn't like one of my blood and biopsy diagnosed relatives who then had a gene test that showed she didn't have one of those 2 most common genes. She was then told it was a misdiagnosis and went back to eating gluten.
She is young so she could also be in what they call the 'Honeymoon' period that used to cause doctors to think celiac could be outgrown. In young adults it can seem celiac has resolved because the person can consume gluten for a time before the antibodies start causing symptoms again.
Pure conjecture on my part.