• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Low Iga
0

9 posts in this topic

My 2 1/2 year old son had some blood work done to rule out Celiac since he's underweight and not gaining and actually gone down in weight over the last few months. He's 26lbs and 36in. His IgA came back low, about 39 and our lab range is 66 to 436. What does a low reading like his mean?

Thanks,

Megan

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


Selective IgA defiency is 10-20 times more common in patients with celiac disease than in the general population. Many of the tests for Celiac Disease are based on measuring levels of certain specific types of IgA antibodies (like antigliadin-Iga or endoymysial-IgA) - but if your *total* IgA is low then you will not tend to have enough IgA antibodies to make these tests positive - thus the phenomenon of false negatives.

That's one reason why "serum IgA" or "Total IgA" is included in some labs' panels for Celiac disease. If it comes back low, it is supposed to be a warning sign to the physician that the other test results in the panel cannot be trusted and he/she needs to seek an alternate method of diagnosing. A low serum IgA should tend to point the physician in the direction of suspecting Celiac Disease, not ruling it out.

The issue of low or absent IgA can be considered an autoimmune condition just by itself, but sometimes it occurs with other autoimmune conditions like Celiac Disease.

I assume the lab's ranges of normal were age-based and your child was still low?

0

Share this post


Link to post
Share on other sites

I think that children tend to be low in IgA anyway, which makes the Celiac tests done on children so inconclusive.

I had a low IgA (19) and the range was 80-200something. The doctor said it was fine. (She is not too Celiac savvy though) Since then, I have read that somewhere around 30% of the population is IgA deficient, so if you are being tested for Celiac and your IgA is already low, your test will most likely turn out negative since you are not producing within normal ranges anyway. This made a lot of sense to me and could be the case of your son.

I read that in "Living Gluten-Free for Dummies" by Danna Korn. (in case you are wondering) who is the founder (I believe) R.O.C.K.

0

Share this post


Link to post
Share on other sites

Good points and info! I reread my post and I definitely don't want to scare you or make you jump to the conclusion that your child has selective IgA deficiency - which lots of people live with just fine anyway. It's just something I would ask your doctor about, as I definitely think low IgA can skew other IgA-based test results, like the last poster mentioned.

0

Share this post


Link to post
Share on other sites

I certainly don't mean to tread on the thread... but, does anyone have any clue what it means when the IgA levels are far off the other end.... much *higher* than the normal range?

That happened with my son, who was 8 at the time of his testing. The high end of the reference range was about 100 LESS than what my son's actual level was.

I've never found anyone knowledgeable enough, with regards to IgA, to ask!

0

Share this post


Link to post
Share on other sites
Ads by Google:


does anyone have any clue what it means when the IgA levels are far off the other end.... much *higher* than the normal range?

I don't know. I did a quick search for two phrases, "elevated serum iga" and "hyper iga" and came up with lots of links that referenced a variety of autoimmune things. So you might just try searching for these phrases and reading the first few pages of links that come up.

Good luck!

0

Share this post


Link to post
Share on other sites

Well, I am really confused. I know the IGA says 39 (range 66-436), then under TTGA there is nothing, which I guess it means it is not back yet, it was a send out test, and then it says CELIA and under that IGA, Serum and it is 33 range 14-122. So is there something different with CELIA IGA, Serum as compared to IGA?

Thanks!

Megan

0

Share this post


Link to post
Share on other sites

This site may be helpful for you

http://www.celiacdiseasecenter.columbia.ed...C05-Testing.htm

The blood tests that comprise the Celiac panel are:

Anti-gliadin antibodies (AGA) both IgA and IgG

Anti-endomysial antibodies (EMA) - IgA

Anti-tissue transglutaminase antibodies (tTG) - IgA

Total IgA level.

If you are confused with the results, it may be worth it to call the doctor and ask to speak to the nurse. Specifically ask what tests where run, and for each tests, what were the reference ranges and the result of the test. Lab tests pages can be very confusing to read!

0

Share this post


Link to post
Share on other sites

I agree, you need to speak with your DR to help with the interpretation of the results. I find it sad that DR's just give the results to people and don't feel the need to offer any explanation... mine did just that. In her case, I'm not sure that she herself knew what they meant. :(

I found more information by doing exactly what you are... googling and posting on this forum. Sometimes, we have to really seek the answers to help figure out what is wrong with us. I hope you find your answers.

Liz

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      106,434
    • Total Posts
      930,553
  • Member Statistics

    • Total Members
      63,865
    • Most Online
      3,093

    Newest Member
    nikkita
    Joined
  • Popular Now

  • Topics

  • Posts

    • I'm still really new to all this but is it common to have trouble with sleep? I swear since my symptoms got really bad a few months ago I can't get 1 good nights sleep, like a 5 hour stretch is doing real good. Wake up at 3am wide awake almost every night. Told my doctor and they've recommended melatonin, that doesn't work. Tried chamomile and lavender tea, no help. Tried zzquil, that will knock me out but maybe for like an extra hour then I'm really drowsy the next morning from it. I don't know what to do.
    • I have 2 copies of DQ9. One from each parent.
    • Obviously from the outside it's difficult to comment, but if I were you I'd leave allergies for now and pursue definitive celiac testing via your doctor and preferably a gastroenterologist. They're the first port of call for digestion issues. If you do wind up being celiac it's possible that other allergies or intolerances would resolve or improve in any case once you've been on the diet for awhile. That's been my experience.   Ps note that wheat allergy is completely different and unrelated to celiac or non celiac gluten sensitivity. 
    • Thank you ps, it may be better if the thread title was changed as we now have two 'overwhelmed' topics. If it were 'Bile ducts and celiac?' then it may attract more users with direct experience?
    • Hello and welcome Maybe? From reading others accounts there's a big variation in how quickly gluten antibodies respond to the gluten diet. I did similar to you and my doctor said that 1 week back on should be enough to show up in a test, but he didn't know what he was talking about sadly... The 2 week figure refers to the endoscopy, for blood testing 8-12 weeks on gluten is more normal.  Basically if it comes back positive fine you have your answer. If its negative it may be a false negative due to your going gluten free beforehand. If you want to pursue a diagnosis then yes. Don't go off gluten again until you confirm that all testing is complete.  Keep a journal noting any symptoms, that may be useful to you later. More info here: There's some good info in the site faq: https://www.celiac.com/gluten-free/announcement/3-frequently-asked-questions-about-celiac-disease/ I know how you feel! Partway through my gluten challenge I knew that too results notwithstanding. Fwiw I think you've found your answer. Good luck!
  • Upcoming Events