• Join our community!

    Do you have questions about celiac disease or the gluten-free diet?

  • Ads by Google:
     




    Get email alerts Subscribe to Celiac.com's FREE weekly eNewsletter

    Ads by Google:



       Get email alertsSubscribe to Celiac.com's FREE weekly eNewsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
1 1
S_J_L

Vitamin B12 Tablets Hurt!

Rate this topic

Recommended Posts

Hi everyone,

I took vitamin B12 tablets for about 1.5 to 2 weeks cos i thought it would be good for me, help with tiredness etc. However, every time i took them i got incredible bowel cramps, like ive never had before (and slight D).

Anyone know why? They are gluten-free, i checked.

It was definantly the pills as i stopped taking them and the symptoms went away, and vise versa!

I don't even get that sort of pain from eating gluten

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


Hi everyone,

I took vitamin B12 tablets for about 1.5 to 2 weeks cos i thought it would be good for me, help with tiredness etc. However, every time i took them i got incredible bowel cramps, like ive never had before (and slight D).

Anyone know why? They are gluten-free, i checked.

It was definantly the pills as i stopped taking them and the symptoms went away, and vise versa!

I don't even get that sort of pain from eating gluten

Were you taking the sublinguals?

Share this post


Link to post
Share on other sites
Were you taking the sublinguals?

What are sublinguals? These were just the ones you swallow

Share this post


Link to post
Share on other sites
What are sublinguals? These were just the ones you swallow

Riceguy is the one to tell you about the sublinguals. Basically, any B12 in a swallowed tablet is pretty much bio-unavailable to your body. So they make sublingual tablets which are very small and good tasting which dissolve under the tongue. The other way to get your B12 is through injections, which I am currently getting because I had a strange reaction to the sublinguals. I have not had any reaction to the injections so it was obviously something else in the sublingual I reacted to. Anything you are swallowing is not being absorbed (and is obviously also causing you some problems.) You can buy the sublinguals from a health food store (get methylcobalamin type); for the injections your doctor has to prescribe them.

Share this post


Link to post
Share on other sites

That's correct, mushroom. Although it's possible to absorb B12 from the pills that you swallow, the sublingual is always a better bet. After all, if you're deficient, that means your absorption isn't where it should be. Except possibly in the case of someone on a vegan diet, who must supplement anyway.

S_J_L: What was the brand? If you have a link, post it, and maybe someone will spot something which might have caused the reaction. Vitamin B12 itself won't do that, so it must have been one of the other ingredients.

Share this post


Link to post
Share on other sites
Ads by Google:


Vitamin B12 itself won't do that, so it must have been one of the other ingredients.

It is certainly possible to react to vitamin B12, though I don't know if it would cause stomach cramps specifically...would depend on how your body reacts to allergy and intolerance. I am allergic to cobalt so would likely react to vitamin B12 supplements. I avoid taking them...but my levels are fine at this point...don't know what I would do if I needed to supplement!

Michelle

Share this post


Link to post
Share on other sites
Basically, any B12 in a swallowed tablet is pretty much bio-unavailable to your body.

In this context are we talking about the general population or people with celiac?

Share this post


Link to post
Share on other sites
It is certainly possible to react to vitamin B12, though I don't know if it would cause stomach cramps specifically...would depend on how your body reacts to allergy and intolerance. I am allergic to cobalt so would likely react to vitamin B12 supplements. I avoid taking them...but my levels are fine at this point...don't know what I would do if I needed to supplement!

Michelle

Well, since B12 is a vital, necessary nutrient, I have my doubts that anyone would be allergic to it, or any other essential nutrient for that matter. The liver normally processes B12 from food into methylcobalamin (though not all of it). I'd have to believe that anyone allergic to it would have serious problems (or die) even before being born.

From Wikipedia:

Cobalt is an essential trace-element for all multicellular organisms as the active center of coenzymes called cobalamins. These include vitamin B-12 which is essential for mammals. Cobalt is also an active nutrient for bacteria, algae, and fungi, and may be a necessary nutrient for all life.

I suspect that your reaction may be to a specific form of cobalt, but the basic element itself seems to be quite essential.

Share this post


Link to post
Share on other sites
In this context are we talking about the general population or people with celiac?

I'm guessing mushroom was referring to those with Pernicious Anemia. In those cases, a sublingual (or shots) becomes necessary.

Share this post


Link to post
Share on other sites
I'm guessing mushroom was referring to those with Pernicious Anemia. In those cases, a sublingual (or shots) becomes necessary.

Yep, sorry I didn't make that clear.

Share this post


Link to post
Share on other sites


Ads by Google:


Thanks for doubting me. Maybe you can chat with my dermatologist who performed the patch tests that confirmed the allergy. :-P The body will take B12 from natural sources, and that is what I count on. It is the supplementation that is at risk. Yes, I am allergic to cobalt...which is what cobalamin supplements are made of. I am also allergic to nickel and chromium, which are also mentioned below (from http://www.acu-cell.com/nico.html):

"While estimated to be rare, dermal exposure to cobalt can - like with nickel sensitivity - trigger allergic

reactions, dermatitis and asthma, whereby hypersensitivity to nickel becomes a heightened risk factor

for cobalt hypersensitivity. Home or work-related contact sources of cobalt are pottery, paints, some

cosmetics, costume jewelry, antiperspirants, hair dyes, dental plates, etc., and also Vitamin B12 in the

form of injections (which can cause a red, itchy and tender area around the injection site) and tablets

(which can trigger eczema-like dermatitis).

In addition to nickel and cobalt, chromium is another metal whose exposure may trigger an allergic

reaction in some hypersensitive individuals, necessitating the use of gloves when handling any suspect

metals, or applying a protective coat of varnish (or clear nail polish) on items one has to touch and use."

And FYI, there is risk of having anaphylactic reactions to injections B12 in allergic people.

Well, since B12 is a vital, necessary nutrient, I have my doubts that anyone would be allergic to it, or any other essential nutrient for that matter. The liver normally processes B12 from food into methylcobalamin (though not all of it). I'd have to believe that anyone allergic to it would have serious problems (or die) even before being born.

From Wikipedia:

I suspect that your reaction may be to a specific form of cobalt, but the basic element itself seems to be quite essential.

Share this post


Link to post
Share on other sites
And FYI, there is risk of having anaphylactic reactions to injections B12 in allergic people.

True. After I had a rash reaction to the sublingual B12 my doctor made me wait 30 minutes after my first B12 shot to be sure.

Share this post


Link to post
Share on other sites

Don't know if this is much help at this point, but I have been shopping around for sublingual B12 and many brands are made with LACTOSE. Are you lactose intolerant?

Share this post


Link to post
Share on other sites
Don't know if this is much help at this point, but I have been shopping around for sublingual B12 and many brands are made with LACTOSE. Are you lactose intolerant?

I used to be really lactose intolerant (long before I realized I was gluten intolerant), but since going gluten free I am beginning to feel more comfortable with lactose; can even drink a couple of cappuchinos in a row and not have a problem. I am even getting cocky enough to consider some ice cream sometime in the near future (with Lactaid tablets at first). Gosh, it's been 20 years since I had ice cream (gluten free 18 mos.) so I'm drooling at the thought. Imagine three weeks in Italy and no gelato--what hell!

So, no, don't think it was the lactose. I broke out in an acne-type rash all over my face, and it only responded to an adult acne cream, and then it took four weeks! (And I never even had acne as a teenager!)

Share this post


Link to post
Share on other sites
Hi everyone,

I took vitamin B12 tablets for about 1.5 to 2 weeks cos i thought it would be good for me, help with tiredness etc. However, every time i took them i got incredible bowel cramps, like ive never had before (and slight D).

Anyone know why? They are gluten-free, i checked.

It was definantly the pills as i stopped taking them and the symptoms went away, and vise versa!

I don't even get that sort of pain from eating gluten

I had difficulty with some B12 due to artificial sweeteners such as sorbitol, etc...(anything with a 'tol' at the end. They would upset my digestive system for 3 days each time. Now I use Natural Factors brand. It was difficult to find sublingual, gluten free, artificial sweetner free in the Methylcobalamin form of B12.

Share this post


Link to post
Share on other sites

Thanks for doubting me. Maybe you can chat with my dermatologist who performed the patch tests that confirmed the allergy. :-P The body will take B12 from natural sources, and that is what I count on. It is the supplementation that is at risk. Yes, I am allergic to cobalt...which is what cobalamin supplements are made of. I am also allergic to nickel and chromium, which are also mentioned below (from http://www.acu-cell.com/nico.html):

"While estimated to be rare, dermal exposure to cobalt can - like with nickel sensitivity - trigger allergic

reactions, dermatitis and asthma, whereby hypersensitivity to nickel becomes a heightened risk factor

for cobalt hypersensitivity. Home or work-related contact sources of cobalt are pottery, paints, some

cosmetics, costume jewelry, antiperspirants, hair dyes, dental plates, etc., and also Vitamin B12 in the

form of injections (which can cause a red, itchy and tender area around the injection site) and tablets

(which can trigger eczema-like dermatitis).

In addition to nickel and cobalt, chromium is another metal whose exposure may trigger an allergic

reaction in some hypersensitive individuals, necessitating the use of gloves when handling any suspect

metals, or applying a protective coat of varnish (or clear nail polish) on items one has to touch and use."

And FYI, there is risk of having anaphylactic reactions to injections B12 in allergic people.

I am allergic to cobalt also and have low B12. I have had anaphylatic shock twice, Do not know what to do. I am getting weaker. I can not find any DR to help me.Have you found a solution? I had the patch test for Cobalt ,also.I get the same reaction.from others also.

Share this post


Link to post
Share on other sites

I am allergic to cobalt also and have low B12. I have had anaphylatic shock twice, Do not know what to do. I am getting weaker. I can not find any DR to help me.Have you found a solution? I had the patch test for Cobalt ,also.I get the same reaction.from others also.

I just looked in my crystal ball, and I can see organ meat in your future :ph34r: lasga. Also shell fish, octopus, pork and various other options. See here:

http://nutritiondata...00000000-w.html

Welcome to the boards and I hope you are not allergic to shell fish. :)

Share this post


Link to post
Share on other sites

I am allergic to cobalt also and have low B12. I have had anaphylatic shock twice, Do not know what to do. I am getting weaker. I can not find any DR to help me.Have you found a solution? I had the patch test for Cobalt ,also.I get the same reaction.from others also.

Can you do the injections?

I never heard of this allergy before but I have learned, from this website, that people can be allergic to anything! I agree with Shroomie, find foods with B12 and start eating them, even if you don't love them.

Share this post


Link to post
Share on other sites

Hi

I have just started to take B12 (Methylcobalamin) - it is liquid form and I put drops under tongue to absorb sublingually.

This also avoids potential absorbtion problems from damaged digestive system as sublingually is absorbed directly into the bloodstream - I think!!!

Have also read (please don't take this as a fact because I don't know that it is) that B12 swallowed is a direct foodsource for candida albicans - like sugar and yeast. That could presumably cause stomach issues if you have candida.

Share this post


Link to post
Share on other sites

In this context are we talking about the general population or people with celiac?

I'm a celiac and my B12 (with tablets, 1000mcg/2-3 per week) values were 320 (Feb,2011), 528 (Aug,2011), 609 (Dec,2011) and 693 (Mar,2012). Lab range: 208-964. My next bloodwork is in Feb.

I use Nature Made B12 which claims "Timed Release" formula that extends the vitamin absorption by the body.The last part of the small intestines is the ileum where B12 is actually absorbed. If the villis are intact there, enough absorption will occur. It did for me.

This product does contain cyanocobalamin and is gluten-free. Apparently, cobolt is not a problem to me.

Share this post


Link to post
Share on other sites


Ads by Google:


I just looked in my crystal ball, and I can see organ meat in your future :ph34r: lasga. Also shell fish, octopus, pork and various other options. See here:

http://nutritiondata...00000000-w.html

Welcome to the boards and I hope you are not allergic to shell fish. :)

still going to contain cobalt....would seem from what i read that it appears to be more dermatitis than true allergy. would be interested if lasga has been fully tested for other potential allergens..

Share this post


Link to post
Share on other sites

You are so right, frieze. Just looked up a cobalt food chart here: http://www.thecdi.com/cdi/images/documents/Cobalt_food_Feb_06.pdf on natural sources of cobalt. Seems hard to separate B12 from cobalt. Can you tell us what put you into anaphylactic shock, lasga? Was it a food source of B12 or a supplement?

Share this post


Link to post
Share on other sites

I also found this to be of interest:

Normally, B12 must be broken apart from food by acid and enzymes in the stomach. B12 must then be tied together with a protein called intrinsic factor, which is produced by cells that line your stomach. Intrinsic factor carries B12 across your intestinal wall into your blood, to be delivered to your cells. This journey across your intestinal wall requires the presence of calcium, which is suppled by your pancreas.

Pernicious anemia is a condition that involves gradual destruction of cells that line your stomach, which decreases the ability to break B12 apart from food and decreases the availability of intrinsic factor to carry B12 into the blood.

If you are deficient in B12 because you don't have enough stomach acid, enzymes, and/or intrinsic factor, you might have to receive injections of B12 directly into your blood via your muscles.

Another option is to take high oral doses of vitamin B12, which can lead to a small percent being absorbed into your bloodstream without the help of intrinsic factor. An oral dose of 1000 mcg results in approximately 10 mcg entering your bloodstream.

http://drbenkim.com/nutrient-b12.html

Have you, lasga, been tested for hydrochloric acid in stomach, and for pancreatic sufficiency? It could well be that you might need some betaine HCl and some digestive enzymes to help you break out the B12 from the foods you ingest.

Share this post


Link to post
Share on other sites

So, no, don't think it was the lactose. I broke out in an acne-type rash all over my face, and it only responded to an adult acne cream, and then it took four weeks! (And I never even had acne as a teenager!)

Mushroom were your sublinguals hydroxycobalmin? That form of b12 is known to cause acne. Also methylcobalamin is very sensitive to light and heat. Both (or each) will break down methyl to hydroxy rather quickly. All b12 supplements should be kept below 20C (about 70F) and out of light.

And FYI, there is risk of having anaphylactic reactions to injections B12 in allergic people.

From what I understand those reactions are usually from the preservatives used in the shots.

Share this post


Link to post
Share on other sites

Mushroom were your sublinguals hydroxycobalmin? That form of b12 is known to cause acne. Also methylcobalamin is very sensitive to light and heat. Both (or each) will break down methyl to hydroxy rather quickly. All b12 supplements should be kept below 20C (about 70F) and out of light.

No, it was Solgar methylcobalamin in a brown bottle, the first day I got them home from the Naturopath. No problem with the shots.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

1 1

  • Forum Statistics

    • Total Topics
      108,911
    • Total Posts
      943,458
  • Member Statistics

    • Total Members
      67,053
    • Most Online
      3,093

    Newest Member
    JAcooks44
    Joined
  • Popular Now

  • Topics

  • Posts

    • I am just curious.  As a scientist (and I am not trying to be rude), how can you determine if hydrologized wheat protein from your husband’s shampoo was actually the culprit?  If I recall at your diagnosis, you were seronegative, Marsh Stage I, gene positive,  but your doctor still  suspected celiac disease.  You improved on a gluten diet.  Other than observation, how do you really know?  Could it not be something else that triggered your symptoms?   I firmly believe that even trace amounts of gluten (under 20 ppm), can impact sensitive celiacs.  But traces of a protein within a shampoo from someone else’s hair that was rinsed?    
    • I also can't have dairy but through a series of experiments and a lot of research I think I've pinpointed my problem. It may or may not be the same for you, but I thought I'd share.  There are two kinds of beta-casein protein A1 and A2. We'll call A1 "bad casein" and A2 "good casein". The two proteins differ only in a single amino acid, but this is enough to make it so that they are processed differently in your guy. Bad casein is actually broken down into a casomorphin, which is an opioid peptide. That does not mean that milk gets you high, or is as addictive as heroin, or anything like that, it just means that it can interact with opioid receptors (which the gut has a bunch of). It's worth noting that opioids cause constipation due to their interaction with the opioid receptors in the gut, and that a lot of people feel like cheese and dairy slow things down, but any connection between the two is pure speculation on my part at this point.  Now here's where things get weird. The vast majority of milk cows in the western world are derived from Holstein-like breeds, meaning black and white cows. In a few select places, you'll see farms that use Jersey-type cows, or brown cows (Jersey cows produce less milk than Holsteins, but many connoisseurs feel it's a higher quality milk, particularly for cheese).  Holstein-like cows have A1 and A2 casein (bad and good), however, Jersey-type cows only have A2 (good casein), unless their genetic line involved a Holstein somewhere in the past, which does happen.  A company in New Zealand figured out how to test their cows for these two genes, and selected their herd down to cows that specifically produce ONLY A2 (good) casein. You might have seen it in the store, it's called A2 milk. Some people have had a lot of luck with this milk, though it still doesn't solve the problem of cheese.  I have suspected, due to trial and error and a few accidental exposures, that I have a problem with A1 casein, but not A2. In line with this: I am able to eat sheep and goat dairy without any difficulty, so at least I can still enjoy those cheeses! I am also fortunate because I'm apparently not too sensitive, as I can still eat cow-milk butter. The process of making butter removes *most* (read: enough for me) of the casein.  However, if I eat cow cheese or a baked good with milk, I get really sick. It's a much faster reaction than if I get glutened. Within minutes I'm dizzy and tired and my limbs are heavy. I have to sleep for a couple of hours, and then, over the next couple of days, I'm vulnerable to moodiness and muscles spasms and stomach upset just as though I'd been glutened (though the brain fog isn't as bad). I actually haven't tried A2 milk yet, mostly due to lack of availability (and motivation, I don't miss milk, I miss CHEESE). However, last year, when I was getting ready to go on a trip to Italy, I had a thought. Once, in the recent past, when I'd been testing dairy, I'd had a slice of parmesan cheese. Miracle of miracles, I was fine. I didn't feel a thing! I was so excited that I ran out and got some brie to eat as a snack. That did not go so well... Turns out parmigiano reggiano is made from the milk of the Reggiana variety of cow which is, you guessed it, a brown cow (they say red). I did a little more research and found that dairies in Italy predominantly use brown cows. So I decided to try something. As some of you may know, Italy is something of a haven for celiacs. It's one of the most gluten-free friendly places I've ever been. You can say "senza glutine" in the smallest little town and they don't even bat their eyelashes. You can buy gluten free foods in the pharmacy because they're considered a MEDICAL NECESSITY. If travelling-while-celiac freaks you out, go to Italy. Check out the website for the AIC (Italy's Celiac society), find some accredited restaurants, and GO NUTS. While I was there, I decided to see if I could eat the dairy. I could.  Friends, I ate gelato Every. Single. Night. after that. It was amazing. Between the dairy being safe for me and the preponderance of gluten free options, it was almost like I didn't have dietary restrictions. It was heaven. I want to go back and never leave.  So that's my story. Almost too crazy to believe.  TL;DR: Black and white cows make me sick, brown cows are my friends.
    • I'm a scientist, and I did a little research into the study. Looks valid and it was published in a respected journal.  http://www.gastrojournal.org/article/S0016-5085(17)36352-7/pdf The science looks solid. As someone who didn't have a super clean cut diagnosis before going gluten free, I'd love to see something like this become available. Then again, there's no doubt in my mind that I can't have gluten, so any additional testing would be purely academic. But like I said, I'm a scientist. I can't help myself. 
    • Update: I have tried calling the company several times and have emailed twice. I have yet to talk to a person on the phone and no one has emailed me back.    I did a little research and they were are already involved with a class action lawsuit about being labeled as salt free and one of the first ingredients is sodium chloride.  I am done with this shampoo because this whole company seems a little shady now! 
    • I've actually been glutened by shampoo with hydrolyzed wheat protein, and I wasn't even the one using it. It was my husbands! I swear I don't go around eating my husbands hair.  I am pretty sensitive though, so it's entirely believable that the trace amounts in his hair were getting onto his and my hands and then making its way to my mouth, etc. etc.  It was a slow and steady low grade glutening that eventually built up to something that I was able to recognize as more definitively "a glutening". Once we ditched the shampoo and I recovered, I realized that I'd been feeling it for weeks.  It's going to depend on your level of sensitivity, but even if you don't feel it, it could still be doing damage. Also... I second that. Starch is a carbohydrate, protein is a protein (obviously), there is no simple process that would convert one into the other. Also, as gluten is a protein, converting starch to protein wouldn't be expected to do anything to gluten ANYWAY.  Speaking as a biologist here. I call poppycock. 
  • Upcoming Events