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      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

What Is The Igg Blood Test?
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4 posts in this topic

Once diagnosed, one of the first thing my doctor told me to do was to get my kids tested.

So, we ran an IGA test, which for both kids came back normal. Thank God for that right now.

At the same time an IGG test was run.....Normal is below 20 or 30. One child was in the high 80s and one was 120. That is very high! What does it mean?

I ran into a brick wall trying to get an explanation of this test. Both the allergist that ordered the test as well as the pediatrician, could not tell me the signficance of this test. Take about one FRUSTRATED mom! I was about to blow my top!

I finally called my GI doctor and asked the nurse. She said it just showed that they carried the gene and that I did not need to worry about anything at this time. But, that they would need to be monitored over the years.

Now, subject #2, if they carry the gene....I have read that I should put them on a gluten-free diet to avoid celiac disease. Anyone know anything about that?

I am still confused, so any input would be appreciated.

Man, I wish the main stream medical people knew about celiac disease. I have found that close to no one but the GI folks have a freaking clue.

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I had the same experience as you with my children. All three tested negative on the IgA tests and positive on the IgG only. I kept being told that this means they probably don't have celiac disease. Well, probably is not good enough for me when it comes to my kids health, but I did not want to put them on the diet if they didn't have to be on it. I got them to a pediatric GI who wanted to gene test them, but my insurance wouldn't pay. I looked into using the lab that the doctor wanted, but it was going to be $750 per child, so I opted for Enterolab testing at $350 per child. All I wanted was a YES or NO answer.

I got their results back yesterday. My daughter carries the gene that I have that causes celiac disease, both my boys carry different genes that predispose them to gluten intolerance. But the clincher is that they are all producing positive IgA antibodies to gliadin and tissue transglutiminase (the two top gluten intolerance tests), and they are all also producing antibodies to casein (meaning they are intolerant to dairy as well, so am I by the way). So now I can rest assured that I am doing the right thing by putting them on a gluten-free/dairy-free diet. Only my daughter has a chance of developing full blown celiac disease, but the others also have the auto-immune response to gluten and although they wouldn't get as much damage in their intestines they would still suffer from many ailments caused by gluten. Now they don't have to.

If you are interested in the Enterolab testing you can find out more about it at http://www.enterolab.com They test the stool, which is a more sensitive test, since the antibodies are produced in the intestine and some are eliminated in the stool. They only cross over into the blood when the damage to the intestines is really bad. They also run a gene test which is much cheaper, but if you already know they have the gene then you wouldn't need that. The stool test is cheaper without the gene test.

I just didn't want to wait until my kids were severely ill with very damaged intestines before getting them diagnosed. I wanted to be able to help them avoid further illness caused by gluten.

I hope this helps you a little bit. The doctors always say that they IgG test is not specific for Celiac, but they don't seem to know what a high IgG reading might indicate. I just see it as an inconclusive test result and it warrants further testing. They can't rule out gluten intolerance based on one blood test. Your kids just don't have severe damage enough to produce IgA antibodies, and they may never get that much damage, but do you really want to wait around and see if they do?

God bless,

Mariann

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Thanks Mariann. It helps to get a clue from someone else. I will be checking into this much more.

I appreciate your help.

Lisa

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My daughter also tested positive to only the IgG gliadin. I have been researching this topic on the web.

I found one site at http://www.aal.xohost.com/ipe.htm that talks about intestinal permeability (a.k.a leaky gut). They claim that people with a leaky gut will test positive for IgG and IgA (gliadin and casein) antibodies. Interesting huh?

There is also an article on this site (celiac.com) that talks about Candida (which is one cause of leaky gut) being a trigger for Celiac disease

http://www.celiac.com/cgi-bin/webc.cgi/st_prod.html?p_prodid=859&sid=8f3Ivt0mJK4O2R5-44103066815.c9 ://http://www.celiac.com/cgi-bin/webc....44103066815.c9 ://http://www.celiac.com/cgi-bin/webc....44103066815.c9

Apparently, Candida looks a lot like gliadin.

This may explain why some people continue to get positive IgG and IgA gliadin results and still have symptoms despite being gluten-free.

There is a test for leaky gut. For more information check out http://www.gsdl.com/assessments/ip/

Lisa

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    • Yes you are correct. Interestingly my genes in the US are thought to be more associated with RA. Which is something they thought I had prediagnosis. In the Middle and far East they are more likely to be associated with celiac and they are rare genes in Caucasians which I am according to my parents known heritage. I always caution folks not to take the gene tests as absolute proof they can't have celiac because I had one child who had positive blood and biopsy, did well on the diet, then got genes tested in young adulthood and was told they could never be celiac. Of course that resulted in her abandoning the diet. I worry but hope someday doctors will realise we still have a lot to learn about the genetics of this disease. PS While I still have some deformity in my hands my joint pain resolved after a few months on the diet.
    • It seems like you really need a concrete or near concrete answer so I would say maybe you ought to get the gene testing. Then you can decide on the gluten challenge.   Thanks! I am convinced our dogs are there waiting for us. Meanwhile they are playing, running, laughing, barking & chasing. I have another favorite quote dealing with dogs: "If a dog will not come to you after having looked you in the face, you should go home & examine your conscience."  ~~~ Woodrow Wilson ~~~
    • I can't help thinking that all of this would be so much easier if the doctor I went to 10 years ago would have done testing for celiac, rather than tell me I probably should avoid gluten. He was looking to sell allergy shots and hormone treatment, he had nothing to gain from me being diagnosed celiac. I've been messing around ever since, sort-of-most-of the time being gluten free but never being strict about it. I really feel like three months of eating gluten would do my body a lot of permanent damage. I've got elevated liver enzymes for the third time since 2008 and no cause can be found which might be good, I guess. I wonder if it would be reasonable to do the HLA testing first, to decide if I really need to do the gluten challenge. If the biopsy is negative, that is. Squirmingitch, love your tag line about dogs in heaven. We lost the best dog ever last December. I sure hope all my dogs are there waiting for me!
    • Most (90%-95%) patients with celiac disease have 1 or 2 copies of HLA-DQ2 haplotype (see below), while the remainder have HLA-DQ8 haplotype. Rare exceptions to these associations have been occasionally seen. In 1 study of celiac disease, only 0.7% of patients with celiac disease lacked the HLA alleles mentioned above. Results are reported as permissive, nonpermissive, or equivocal gene pairs. From: http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/88906  
    • This is not quite as cut & dried as it sounds. Although rare, there are diagnosed celiacs who do not have either of those genes. Ravenwoodglass, who posted above, is one of those people. I think she has double DQ9 genes? Am I right Raven?  My point is, that getting the gene testing is not an absolute determination either way.
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