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      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Does Anyone Know?
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4 posts in this topic

I was wondering if anyone knew the mechanisms of action that causes ingesting gluten to lead to things like joint and muscle pain with one glutening. I could see over a long period of time, but how does it do it all at once? I don't know if this is known, but I thought I would just ask my question anyway.

Thanks.

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my only guess is that the antibodies produced during the digestion of the gluten lash out at everything they come in contact with.

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Great question. I hope someone can find a scientific article with some solid facts, but I don't know if research has gone quite that far... at least the placebo controlled/double blind types of studies.

Based on what I've read, I have a couple of guesses. Note the word guesses. Sorry. (They aren't totally blind guesses, though!)

-Inflammation. We know that gluten causes inflammation of the gut. Having an auto-immune disease means that we react (and over-react?) to normally "safe" substances. This is an article on inflammation in general. I don't know the mechanism, but I wouldn't be surprised if the inflammation does not limit itself to the gut.

http://www.huffingtonpost.com/dr-mark-hyman/is-your-body-burning-up-w_b_269717.html

-This might be more controversial, but intestinal permeability ("leaky gut") could play a role - substances cross over the gut barrier that are not supposed to, leading to multi-systemic issues. Traditional western medicine is starting to recognize and research intestinal permeability, and some studies indicate that inflammation leads to permeability. That pretty much "allows" the gluten dominos to start to fall and reach other body parts.

-This article: http://charlotteceliacconnection.com/files/Celiac_Mechanisms_Neurologic_Review_Cellular.pdf is a bit scientific, but it explores the neurologic connection in Celiac. What it comes down to is that there is a lot they don't know. It's not about joint/muscle pain per se, but more related to brain/nerves:

"While advances have been made in understanding the pathogenesis of the intestinal lesions in celiac disease, the patho- genesis of the neurologic manifestations has yet to be elucidated. Current data point to molecular mimicry and intermolecular help as two possible mechanisms that could explain how ingested gluten can result in damage to the neuraxis." In other words, they are starting to understand fully how the gut gets messed up, but they're trying to figure out why the rest of it happens.

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Thanks for your reply. I was suspicious that the answer was going to be that we really don't know yet how it happens. But since I was having intense joint pain from being glutened, I thought I would ask and see if I was surprised that we did know. Thanks for looking into that for me, I will give the articles you suggested a look.

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