• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Anyone Able To Interpret The Genetic Testing
0

9 posts in this topic

Today I got my genetic testing back.

It shows category #4 DQ2 heterozygous. Related risk high. Though I see there is a Very High and Extremely High category, in addition to Moderate, Low, and Extremely Low.

Specifically, DQ2.5 (HLA DQA1*05:DQB1*201) are listed.

The only blood work that came back positive was the Anti-gliadin IGA, which was 24 on a range from 0-15.

Biopsy was done a few months before they were really looking for celiac so I don't know how many biopsies were taken, but they didn't show anything abnormal.

Yes, I have many symtoms but I also have sjogren's syndrome.

Have been trying to be gluten free but am still trying to work out things like shampoos, detergents, lotions, and the like. It will probably take awhile to get thing right.

I am not feeling at all better after a few weeks gluten free. In fact, I'd say that it feels like everything I eat makes me sick and I continue to lose weight.

Have pain in my arms and tingling in my face, legs, and feet.

Thoughts?

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


This is the most common celiac gene, also nicknamed HLA DQ2. (HLA DQ2,5)

You have only one copy of the DQ2,5 gene.

If you call the lab, they might have the result of the other gene (but it would not change things, since you already have the typical celiac gene)

Those genes are just about the risk, they do not mean you are celiac. Lots of people have HLA DQ2 and will never develop celiac disease.

The positive antigliadin IgA probably means it is early or patchy celiac, and with patchy celiac they might find a spot with celiac, or not, when taking biopsies.

Did they do the more specific deaminated gliadin test that many are getting now? It is much better at catching early celiac.

1

Share this post


Link to post
Share on other sites

They did 4 different tests on blood work before the gene test. Here's what came back.

IMMUNOGLOBULIN A-SERUM normal range

GLIADIN ANTIBODY, IGA 24 (Abn: H) 0 - 15 is normal

GLIADIN ANTIBODY, IGG normal range

TISSUE TRANSGLUTAMINASE-A normal range

Annotation:

GLIADIN ANTIBODY, IGA

strict gluten free diet.

As stated, they would not do another endoscopy because they had done one 3 months earlier while checking for something else. From what I read on the biopsy report, lab only received 2 samples from the small intestines, which looked normal.

The only thing shown in the endoscopy was inflammation of the stomach. Colonoscopy showed 3 small diverticula.

Nurse for GI doc says go gluten free, regular GP says this really doesn't mean anything. It's very important to me, of course. My son came back with the same blood work, with an even higher Gliadin Antibody, IGA of 36.

0

Share this post


Link to post
Share on other sites

They did 4 different tests on blood work before the gene test. Here's what came back.

IMMUNOGLOBULIN A-SERUM normal range

GLIADIN ANTIBODY, IGA 24 (Abn: H) 0 - 15 is normal

GLIADIN ANTIBODY, IGG normal range

TISSUE TRANSGLUTAMINASE-A normal range

Annotation:

GLIADIN ANTIBODY, IGA

strict gluten free diet.

As stated, they would not do another endoscopy because they had done one 3 months earlier while checking for something else. From what I read on the biopsy report, lab only received 2 samples from the small intestines, which looked normal.

The only thing shown in the endoscopy was inflammation of the stomach. Colonoscopy showed 3 small diverticula.

Nurse for GI doc says go gluten free, regular GP says this really doesn't mean anything. It's very important to me, of course. My son came back with the same blood work, with an even higher Gliadin Antibody, IGA of 36.

Take all this paperwork to a new GI that specializes in Celiac disease.

0

Share this post


Link to post
Share on other sites

Nora has given you great advice. :)

0

Share this post


Link to post
Share on other sites
Ads by Google:


There recently was a study trying to find out why one area in the U.S. had half as many positive biopsies compared to the other half of the country, and the difference was how many samples were taken.

Now the area where they took 4 or more samples while doing endoscopy, had twice as many diagnosed with celiac compared to where they only took about 2 samples.

I guess they missed your celiac, as the most common form of celiac nowadays is patchy celiac.

Also, the antigliadin test is known to rise first, and then the ttg, in early celiac.

I would guess that if you continue eating gluten, and even increase the gluten intake, then you will get a positive ttg test, and positive biopsies, after a month or two.

Things can change in a matter of a month or two or three.

But maybe the very specific deaminated gliadin test would tell you more beforehand, as it is very specific for celiac. If it is negative, it probably would not help to do another endoscopy yet.

(here in Europe we often do a gluten challenge to get a diagnosis, if the test results are dubious)

0

Share this post


Link to post
Share on other sites

You are so knowledgeable, Nora!

Thank you for the information!

I love this group!

Debbie

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      106,433
    • Total Posts
      930,547
  • Member Statistics

    • Total Members
      63,864
    • Most Online
      3,093

    Newest Member
    Shanna
    Joined
  • Popular Now

  • Topics

  • Posts

    • Learn more about testing for celiac disease here: http://www.cureceliacdisease.org/screening/ You do have to be on a gluten diet for ANY of the celiac tests (blood and biopsy) to work.  While the endoscopy (with biopsies) can reveal villi damage, many other things besides celiac disease can cause villi damage too: http://www.cureceliacdisease.org/faq/what-else-can-cause-damage-to-the-small-intestine-other-than-celiac-disease/ So, both the blood test and endoscopy are usually ordered.  There are some exceptions, but those are not common.  
    • Exactly what are your allergy symptoms?  Were they IgG or IgE?  Allergy testing as a whole is not super accurate -- especially the IgG.  Were you on any H1 or H2 antihistamines for the last five days  when you were tested?   As far as celiac testing, four days without consuming gluten probably would not impact testing.  
    • I've been seeing my dr for a few weeks now about my stomach issues. We've ruled out the gallbladder and h-pylori and today I had the celiac blood tests done. From the reading I've done the past two days, it seems to me that it's highly likely that I have it. I've had digestive issues for years, but they've gotten progressively worse over the past 6 months or so. Pain and nausea when eating, bloat, eternal constipation, dh rash, at it's worse, tight cramp-like pain in a fist under my sternum, radiating through my back and around my right side keeping me up at night. Also heartburn/reflux and trouble swallowing, etc. 

      Anyway, about 2 months ago, I needed a change. I didn't go to the dr immediately because it seemed pointless. (I've mentioned stomach ache when eating to drs before and been blown off.) So, I started the Whole30 elimination diet (takes out soy, grains, dairy, peanuts, and leaves you basically eating meat & veggies). Figured it would show me what I needed to take out of my diet and hopefully feel better. It worked- I felt great! And it seems that grains and gluten are my biggest offenders. But, now I've been off gluten prior to celiac testing. It's been 7 weeks. After 4 weeks I tested steal cut oats, that I later found out were probably glutened. And then nothing until yesterday. Yesterday I had 2 pieces of bread and a muffin and today I had two pieces of bread and then the blood test. Is this going to be enough to show up on the tests? My dr said that it would probably show up, since I had some yesterday and today and was currently having symptoms. But, google seems to say that I should be glutened for 2 wks straight before testing. Has anyone tested positive after just a little gluten? If it's negative should I insist on doing it again after weeks back on gluten? I feel awful, but do want clear answers. Obviously, gluten's not going to be a part of my life any more either way. 
    • So just to clarify  had not consumed any gluten for about 4 days before testing. I was assured by my allergist that it wouldn't affect the test. But what was alarming was that she retested my food allergies (my most recent reaction was two weeks ago) and every food allergy I have came back negative. I don't understand how that is possible. These food allergies developed when I was 20 and I am almost 24 now.
    • Thanks! You too! I have learned from this experience to take charge of my own health. It's nice at least that we can try the gluten-free treatment without a firm diagnosis or a doctor confirming the disease. I've also felt some of the gluten withdrawal symptoms, and my stomach pain ebbs and flows, but I'm determined to stick with the gluten-free diet to see what a difference it makes. Gemini, thank you! This was really validating and useful for me to hear. I've felt so confused through this process and just want some answers. If the biopsy results do come back negative, I'm going to follow your advice and do the gluten-free diet with repeat blood testing after a while. If they come back positive, well, then I'll have my answer. I'm supposed to get them back next week.
  • Upcoming Events