• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Anyone Able To Interpret The Genetic Testing
0

9 posts in this topic

Today I got my genetic testing back.

It shows category #4 DQ2 heterozygous. Related risk high. Though I see there is a Very High and Extremely High category, in addition to Moderate, Low, and Extremely Low.

Specifically, DQ2.5 (HLA DQA1*05:DQB1*201) are listed.

The only blood work that came back positive was the Anti-gliadin IGA, which was 24 on a range from 0-15.

Biopsy was done a few months before they were really looking for celiac so I don't know how many biopsies were taken, but they didn't show anything abnormal.

Yes, I have many symtoms but I also have sjogren's syndrome.

Have been trying to be gluten free but am still trying to work out things like shampoos, detergents, lotions, and the like. It will probably take awhile to get thing right.

I am not feeling at all better after a few weeks gluten free. In fact, I'd say that it feels like everything I eat makes me sick and I continue to lose weight.

Have pain in my arms and tingling in my face, legs, and feet.

Thoughts?

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


This is the most common celiac gene, also nicknamed HLA DQ2. (HLA DQ2,5)

You have only one copy of the DQ2,5 gene.

If you call the lab, they might have the result of the other gene (but it would not change things, since you already have the typical celiac gene)

Those genes are just about the risk, they do not mean you are celiac. Lots of people have HLA DQ2 and will never develop celiac disease.

The positive antigliadin IgA probably means it is early or patchy celiac, and with patchy celiac they might find a spot with celiac, or not, when taking biopsies.

Did they do the more specific deaminated gliadin test that many are getting now? It is much better at catching early celiac.

1

Share this post


Link to post
Share on other sites

They did 4 different tests on blood work before the gene test. Here's what came back.

IMMUNOGLOBULIN A-SERUM normal range

GLIADIN ANTIBODY, IGA 24 (Abn: H) 0 - 15 is normal

GLIADIN ANTIBODY, IGG normal range

TISSUE TRANSGLUTAMINASE-A normal range

Annotation:

GLIADIN ANTIBODY, IGA

strict gluten free diet.

As stated, they would not do another endoscopy because they had done one 3 months earlier while checking for something else. From what I read on the biopsy report, lab only received 2 samples from the small intestines, which looked normal.

The only thing shown in the endoscopy was inflammation of the stomach. Colonoscopy showed 3 small diverticula.

Nurse for GI doc says go gluten free, regular GP says this really doesn't mean anything. It's very important to me, of course. My son came back with the same blood work, with an even higher Gliadin Antibody, IGA of 36.

0

Share this post


Link to post
Share on other sites

They did 4 different tests on blood work before the gene test. Here's what came back.

IMMUNOGLOBULIN A-SERUM normal range

GLIADIN ANTIBODY, IGA 24 (Abn: H) 0 - 15 is normal

GLIADIN ANTIBODY, IGG normal range

TISSUE TRANSGLUTAMINASE-A normal range

Annotation:

GLIADIN ANTIBODY, IGA

strict gluten free diet.

As stated, they would not do another endoscopy because they had done one 3 months earlier while checking for something else. From what I read on the biopsy report, lab only received 2 samples from the small intestines, which looked normal.

The only thing shown in the endoscopy was inflammation of the stomach. Colonoscopy showed 3 small diverticula.

Nurse for GI doc says go gluten free, regular GP says this really doesn't mean anything. It's very important to me, of course. My son came back with the same blood work, with an even higher Gliadin Antibody, IGA of 36.

Take all this paperwork to a new GI that specializes in Celiac disease.

0

Share this post


Link to post
Share on other sites

Nora has given you great advice. :)

0

Share this post


Link to post
Share on other sites
Ads by Google:






There recently was a study trying to find out why one area in the U.S. had half as many positive biopsies compared to the other half of the country, and the difference was how many samples were taken.

Now the area where they took 4 or more samples while doing endoscopy, had twice as many diagnosed with celiac compared to where they only took about 2 samples.

I guess they missed your celiac, as the most common form of celiac nowadays is patchy celiac.

Also, the antigliadin test is known to rise first, and then the ttg, in early celiac.

I would guess that if you continue eating gluten, and even increase the gluten intake, then you will get a positive ttg test, and positive biopsies, after a month or two.

Things can change in a matter of a month or two or three.

But maybe the very specific deaminated gliadin test would tell you more beforehand, as it is very specific for celiac. If it is negative, it probably would not help to do another endoscopy yet.

(here in Europe we often do a gluten challenge to get a diagnosis, if the test results are dubious)

0

Share this post


Link to post
Share on other sites

You are so knowledgeable, Nora!

Thank you for the information!

I love this group!

Debbie

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      107,324
    • Total Posts
      935,487
  • Member Statistics

    • Total Members
      64,984
    • Most Online
      3,093

    Newest Member
    Marden74
    Joined
  • Popular Now

  • Topics

  • Posts

    • I like Bakery on Mains granolas, the ones that are oat free. They have a fair amount of protein as they have nuts in them.  I also have Cream of Buckwheat if I want a hot cereal or if my tummy is off. It's has a good amount of protein and is really easy to digest.  I definately don't eat the cereals like Cheerios etc that have regular oats that are mechanically sorted. They may be fine but my reactions to even small amounts of CC is too severe to risk it.
    • Leg pain can be a symptoms of celiac or NCGS. Cause can also be from a deficiency brought on from different causes including celiac. How are her magnesium levels? And B-Vitamin Levels? Bit of a joke, doctors call their occupation a "Practice" seems they need more practice.
    • I keep my eggy flat bread in the freezer for quick fixes of eggs normally. But I do sometimes make a porridge out of almond and coconut meal, Konjac flour can be used to thicken stuff into a nice porridge wand works great with almond butter. and I sometimes make a oatmeal knock off using Miracle rice, almond milk, and a bit of coconut flour. I can not eat carbs/grains so my cereals are nut based lol. When out of the house I find MRM meal replacement powder turns into a goopy chocolatey slop of indulgence with a very acquired texture by pouring in hot coffee and topping with a sugar substitute (Flax Meal in it thickens up alot)  >.>
    • It's so frustrating how they don't order all or the right tests and then if something comes back not right--just ignore it.  With my daughter I knew something was off for some time but her blood tests -of course it was only a ttg iga and immunoglobulin a that were run-came back negative.  But in looking at previous blood tests-she had a cbc run about a year ago that showed that her MCV was high and there was no mention of it.  Makes me wonder if that along with a deficiency in her vitamin D levels can be attributed to celiac.    On a side note--she has been experiencing lots of leg pain-to the point where she is sometimes in tears because they hurt so much!  She had her endocrinologist appointment yesterday and mentioned that and he didn't think that this could be attributed to the celiac.  Is that true?  As I stated before she is having the biopsy this Tuesday but I think she is hoping that this is a symptom of the celiac so that it will resolve going gluten-free.  Any thoughts?
    • I eat oatmeal and granola made with certified gluten free oats. I have to be careful of those that are labeled just gluten free or organic oats on the label as I have had adverse reactions. I also eat Rice and Corn Chex.  If I am traveling, I can usually find them in grocery stores even in small towns. Took Chex cereal with me when I had to evacuate for hurricane.
  • Upcoming Events