• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Questions About Cyrex
0

10 posts in this topic

As some of you know I've been doing a gluten challenge after being gluten free for a year (on GAPS for most of it). My doctor did order a standard panel for me, but now I'm considering getting the cyrex array 3 instead.

My doctor ordered:

Total IgA

Anti Gliadin IgA

Anti Gliadin IgG

Anti tTG IgA

Anti EMA IgA

She couldn't order the Deamidated Gliadin Peptide test.

Looking at the cyrex array, I see that there is

Deamidated Alpha Gliadin 33 MER IgG ( CPT CODE : 86001-59 )

Deamidated Alpha Gliadin 33 MER IgA ( CPT CODE : 83516-59 )

Are these the same as a Deamidated Gliadin Peptide test? The array also offers other tests which I would find interesting as part of the array - the gluteomorphin, for example. However, the Anti-endomysial Antibody test and the total IgA do not seem to be included.

I KNOW that gluten is a problem for me. The main reason I want the celiac screening is so that I can be aware of whether I have autoimmune gut damage going on as a part of my intolerance, for family reasons and emotional reasons. A smaller side-note... if I don't have indications of autoimmune issues, I may be ok with eventually basing my level of allowable cross-contamination on symptoms rather than absolute avoidance, as I do for my son.

I am leaning toward going with the cyrex array 3 and then if all my IgA numbers are low, getting the total IgA tested, if Deamidated Alpha Gliadin is the same as the Deamidated gliadin peptide test.

But I did want the EMA test. I have a call out to my doctor to find out the cost of the tests ordered, since I have to pay for everything out of pocket. Doing the tests in a phased approach is not possible because I need to stop eating gluten ASAP!!!

What do you think?

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


The Cyrex array does look interesting. The Deamidated Alpha Gliadin 33 MER is the test you're wanting, the one often called DGP.

You might also look at the panels this company offers. They have a celiac panel with total IgA, EMA, TTG, and DGP. There is also DGP IgG and IgA available alone if you just want to supplement what your Dr. has ordered.

http://www.ineedlabs.com/Celiac-Disease-Comprehensive-Antibody-Profile.html

http://www.ineedlabs.com/Gliadin-Antibody-Profile-IgG-IgA-EIA.html

EMA is going to be relatively expensive. It is a hand-read histological test that checks whether your antibodies bind to monkey esophagus so it's much more labor-intensive than an ELISA like TTG or DGP. Cyrex looks to be only running ELISAs which is why they are not offering it. I'm not sure I would order EMA if I were paying out of pocket. DGP is more sensitive, and TTG has been identified as the main antigen in endomysium.

0

Share this post


Link to post
Share on other sites

Yeah, I've looked at all their panels! They also have a panel for assessing cross-reactive foods, and another to determine the specific causes of leaky gut... but funds are limited.

Since the Cyrex test does include DGP (thanks for clarifying), I am very much leaning toward it. I think this whole panel is only about $360. My dr's office still hasn't called me back about costs or ordering from Cyrex (which I'm sure will require a bunch of extra paperwork) but I am thinking that's the direction I'm going to go, rather than with the EMA.

Do you think the idea of only ordering the total IgA if IgA numbers come back low is a good idea? I'm assuming it doesn't matter whether I'm eating gluten or not for that one.

0

Share this post


Link to post
Share on other sites

Do you think the idea of only ordering the total IgA if IgA numbers come back low is a good idea? I'm assuming it doesn't matter whether I'm eating gluten or not for that one.

I think it's fine if you don't mind being stuck twice. Personally I'd be on pins and needles wondering about IgA if everything came back low so I'd get the total IgA at the same time. :lol: Gluten won't matter for total IgA.

0

Share this post


Link to post
Share on other sites

Yeah, I've looked at all their panels! They also have a panel for assessing cross-reactive foods, and another to determine the specific causes of leaky gut... but funds are limited.

Since the Cyrex test does include DGP (thanks for clarifying), I am very much leaning toward it. I think this whole panel is only about $360. My dr's office still hasn't called me back about costs or ordering from Cyrex (which I'm sure will require a bunch of extra paperwork) but I am thinking that's the direction I'm going to go, rather than with the EMA.

Do you think the idea of only ordering the total IgA if IgA numbers come back low is a good idea? I'm assuming it doesn't matter whether I'm eating gluten or not for that one.

I ordered the Celiac Panel from ineedlabs.com and it was 200 dollars for the panel which included EMA. AND I didn't need a doctor to order it. They use LabCorp.

0

Share this post


Link to post
Share on other sites
Ads by Google:


http://www.ineedlabs.com/Product-search.html?keyword=celiac

I see! I've been scared to use these kinds of services. I found another one that offered the cyrex labs without a doctor, but they had typos and grammar errors all over and were trying to sell some digestive enzyme to deal with being glutened, so I just couldn't trust them.

I'm glad to hear you had a positive experience with i need labs. They don't have all the tests cyrex does, but they do have total iga, ttg, ema, dgp, antigliadin igg and iga. I wish my partner would come home and discuss it with me already!

My doctor's office still hasn't gotten back to me... but it finally occurred to me that my (new) naturopath could also order these tests for me just as easily, and I can get her on the phone or by email, no problem!

I'll be happy to be thinking straight again.

0

Share this post


Link to post
Share on other sites

Yay! I just got a call back from my dr office. I can get the panel listed at the top for $169.36 + a 15.96 fee. Blood draw scheduled for 11:10 AM.

I found the deamidated gliadin peptide test available for $89 online. I'm considering ordering it.

OR, I could order this celiac panel for $177.25 but It doesn't inlcude the anti gliadin IgA or Igg, but does include the EMA, DGP, tTG, and total IgA.

I could get a blood draw with that tomorrow if I want to.

Which would you do?

The cyrex test did have more things listed and I've heard (but not confirmed) that it's about $360. I'm now thinking I'll skip it, since it would be more hassle to order and I'm not convinced of the value added.

0

Share this post


Link to post
Share on other sites

Great!

That's a tough call what to get. Since you know you're gluten intolerant and it's autoimmunity you are concerned with, how would you even interpret the old anti-gliadin? It's not very specific for celiac autoimmunity.

0

Share this post


Link to post
Share on other sites

Good news! I called the lab at my doctor's office and asked if they could now order the DGP or just let me order some of the tests in their panel so I could order the rest online. It turns out that since my celiac panel was ordered 2 months ago they have changed what's in it. Now their standard screening includes the DGP test! Progress :)

As for interpreting the old anti gliadin - I guess it's just one more piece of validation I might be able to get to help me with my hypochondria about having hypochondria rather than anything physically wrong with me. :rolleyes:

1

Share this post


Link to post
Share on other sites

That is good news. I hope you get the positive test you're looking for. Good luck!

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      106,803
    • Total Posts
      932,560
  • Member Statistics

    • Total Members
      64,296
    • Most Online
      3,093

    Newest Member
    igone02@verizon.net
    Joined
  • Popular Now

  • Topics

  • Posts

    • Ken, I have the same thing. Did you ever find a reason or solution? I'm tired of shampoos and creams that only work short term. My problem cropped up after I had gone gluten-free. Thanks!
    • Hi, I recently was tested (blood) and got a positive for celiac disease. I'm 31 and have had 3 kids, and no longer have the urge to urinate. I birthed all of my children naturally, no c-sections, no surgeries. I thought perhaps there was some trauma during the birth and attributed it to that. But have come across a few things online saying that bladder problems can be related to celiac disease? I have been to a few doctors for this problem, including a very confused urologist (I asked him about my stomach bloating issue with pictures of it- before having any clue it was from celiac!) and he wanted to run some tests but I have not been back. I had multiple (or perhaps just one very bad) urinary infections which would not go away for about 6 months. The last round of harder antibiotics finally killed it off. Has anyone else had this problem? I have not met with a GI yet to ask, I'm super poor right now! hah.
    • You're right on the extremes, I'm sitting in a gluten-free food festival right now and still unsure if to eat anything which I guess means I've hit the extreme end of the scale. Seem to be noticing the recovery pattern over the course of 6 weeks or so after a gluten hit. Will be very interesting to see what the blood test readings come out like when I eventually get them done again. And thanks for the good wishes
    • Your getting plenty of proteins for once and I would drop the L-glutamine supplement what brand is it? Paleo Protein as in the brand? They were not gluten free last I checked, I got sick from it 2 years ago or so when they changed to a non dedicated facility.
    • Very interesting. However, my positive on the DGP test is on the combined assay. When separated into IGA and IGG they are within normal range. Twice the IGA was a point or two above normal range, which can be easily disregarded per University of Chicago.  Much of the research done on NCGS is showing activation of cells which are different then in celiac. Placing it still in a gluten related illness spectrum, but an entirely different kind of mode of transport, if you will, then celiac disease. Odd, because I am pretty sure I read that 1st degree relatives of celiacs have a higher prevalence of NCGS suggesting it is, in part, that they are related. But I cannot recall where I read that.  I think my specialist doc is following the right track given that all of this began at the tail end of a 6 week challenge in 2015/16 and I have an increase in IELs.  which, as I've stated before, is a very non-specific finding however. Symptoms continued On a gluten free diet for me months after.  however I was only on it for that 3 months after they found some inflammation. So maybe I didn't give it long enough.  Or like I said, maybe it's something else. We shall see! 
  • Upcoming Events