• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Kimball Genetics Testing
0

2 posts in this topic

I've been reading past posts about Enterolab testing and the genetic testing but haven't seen much about Kimball Genetics. We had the celiac disease DNA test done hoping it would give us some answers -- it did, but ended up giving us more questions. Three of my children had very high IgG levels in their initial bloodwork. Only one came back with a positive biopsy. One of the children with a negative biopsy has frequent headaches with vomiting so I put her on the gluten-free diet hoping it would take care of the headaches. It didn't seem to change anything (maybe 3-4 months wasn't long enough?) To give us answers, we thought we'd find out if she carried the gene for celiac disease but hadn't developed full blown celiac disease.

We tested me, my husband and this one child. My husband and daughter tested negative for DQ2 (DQA1*05/DQB1*02) and DQ8 (DQB1*0302). They detected one of the DQA1*05 alleles in me but that alone was not enough to result in celiac disease. So...according to Kimball Genetics, neither me nor my husband has the celiac disease associated molecules necessary to result in celiac disease and therefore our children do not posess the necessary genes for celiac disease. My doctor doesn't want to put full faith in these tests and so celiac disease remains the diagnosis for my biopsy positive child.

Can anybody tell me if the Enterolab testing is more specific for possible gluten intolerance genes? (There seem to be more gene types with Enterolab).Has anybody else had a positive biopsy without a celiac gene?

I know people will say to just follow the gluten-free diet and if it works let that be enough. But I keep thinking that there may be some other factors making my children sick.

Can anything else elevate an IgG level other than gluten?

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


I was reading something yesterday (I don't remember the site) that was saying that the IgG is the least specific of all the bloodtests. Apparantly a positive IgG alone does not conclude celiac disease because people with other intestinal conditions can also have a raised IgG. Also your daughter could have gluten intolerance w/out celiac disease. I find it interesting that your biopsy positive child can't carry the celiac disease gene...are you sure? Does Kimball only test for DQ2 and DQ8? I tested w/ Enterolab and came back positive for everything w/ high malabsorption but with NO celiac genes...I have DQ1 and DQ3. I have all the symptoms but have been wondering if something other than gluten could be making me sick since I don't carry the celiac disease genes. I think obviously if your child had a positive biopsy then he/she does have celiac disease.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      107,341
    • Total Posts
      935,586
  • Member Statistics

    • Total Members
      65,004
    • Most Online
      3,093

    Newest Member
    susa
    Joined
  • Popular Now

  • Topics

  • Posts

    • I found it confusing as to whether this was gluten or free not.  However, I've not had gluten in two weeks now and at Hillshire Farms beef sausage this morning and my head is literally spinning.  I'm going to assume I shouldn't have eaten it.  It was good......but will avoid it from now on.
    • Thankyou squirmingitch that is useful info, i have decided to go ahead with the endo and biopsy but i know what you mean there are still alot of people out there who still think celiac is not serious and thinks it is a choice. I have a 11 year old daughter and i think it would be foolish not to go the whole hog with this has it would help her in later life if i have the gold standard confirmation as im sure some docs still dismiss it because they do not specialise in this subject.
    • Furthermore, getting a positive on the endoscopy will leave no doubt either in your mind nor in the minds of the rest of your family or friends. All first degree relatives of celiacs need to be tested every 2 or 3 years in the absence of symptoms & immediately if symptoms present since celiac can present at ANY age. So your parents, siblings & your children will need to be tested. Believe me, there is oftentimes a TON of pushback by family members simply because they don't want to have celiac so they stick their heads in the sand & say you're off your rocker, refuse to get tested because they say they don't have it and you don't have a concrete diagnosis so how can you be sure they need to be tested? Friends can be even more doubtful. People are really, really doubtful of people who don't have an ironclad diagnosis. I think it's stupid of them to be so negative & questioning what you know to be true but they are. I mean, when you say you are diabetic, no one doubts that you are, no one questions your diagnosis and everyone respects the implications of diabetes but that is not the case with celiacs. I think it must be that people can not conceive of never eating wheat flour again for life. They can easily accept a diabetics diet but not a celiacs. Yet they will grill you as if they are experts in celiac disease unless you can tell them you've had the full nine yards of testing & ARE, no doubt about it, celiac.
    • Hi ch88, You could try going nightshade free to see if it helps your arthritis.  It might help.  The common food nightshades are potatoes, tomatoes, peppers, eggplant, turmeric and paprika.  If you try nightshade free for one month that should be enough time to know if it helps IMHO. Sweet potatoes/yams are ok, as they are not nightshades.
    • Thankyou both of you for your advice, i will have the endoscopy will just have to wait, my blood tests were not hitting the roof with reading but a low to medium result, dont want to be one of them people who have gone gluten free with no need, however i do show typical symptons of celiac but no overwhelming symptons apart from feeling nauseous and crampy at times, and extreme tiredness. There is soooo much to learn
  • Upcoming Events