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      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes

Kimball Genetics Testing
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I've been reading past posts about Enterolab testing and the genetic testing but haven't seen much about Kimball Genetics. We had the celiac disease DNA test done hoping it would give us some answers -- it did, but ended up giving us more questions. Three of my children had very high IgG levels in their initial bloodwork. Only one came back with a positive biopsy. One of the children with a negative biopsy has frequent headaches with vomiting so I put her on the gluten-free diet hoping it would take care of the headaches. It didn't seem to change anything (maybe 3-4 months wasn't long enough?) To give us answers, we thought we'd find out if she carried the gene for celiac disease but hadn't developed full blown celiac disease.

We tested me, my husband and this one child. My husband and daughter tested negative for DQ2 (DQA1*05/DQB1*02) and DQ8 (DQB1*0302). They detected one of the DQA1*05 alleles in me but that alone was not enough to result in celiac disease. So...according to Kimball Genetics, neither me nor my husband has the celiac disease associated molecules necessary to result in celiac disease and therefore our children do not posess the necessary genes for celiac disease. My doctor doesn't want to put full faith in these tests and so celiac disease remains the diagnosis for my biopsy positive child.

Can anybody tell me if the Enterolab testing is more specific for possible gluten intolerance genes? (There seem to be more gene types with Enterolab).Has anybody else had a positive biopsy without a celiac gene?

I know people will say to just follow the gluten-free diet and if it works let that be enough. But I keep thinking that there may be some other factors making my children sick.

Can anything else elevate an IgG level other than gluten?

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I was reading something yesterday (I don't remember the site) that was saying that the IgG is the least specific of all the bloodtests. Apparantly a positive IgG alone does not conclude celiac disease because people with other intestinal conditions can also have a raised IgG. Also your daughter could have gluten intolerance w/out celiac disease. I find it interesting that your biopsy positive child can't carry the celiac disease gene...are you sure? Does Kimball only test for DQ2 and DQ8? I tested w/ Enterolab and came back positive for everything w/ high malabsorption but with NO celiac genes...I have DQ1 and DQ3. I have all the symptoms but have been wondering if something other than gluten could be making me sick since I don't carry the celiac disease genes. I think obviously if your child had a positive biopsy then he/she does have celiac disease.

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