• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Test Result Interpretation Help Please!
0

4 posts in this topic

Hi,

I am new here. My 5 yr old son was negative for all celiac disease bloodwork in 2010 and July 2012. He used to have mild GI symptoms that improved drastically after determining he is lactose intolerant, but he still had some ongoing, occassional issues until I realized that he also has an issue with fructose. I'm happy to report that since I started limiting his fructose intake in August, all of his symptoms have completely resolved and he is doing well, gaining weight, and growing :) I should mention that he was borderline anemic in July (10.8hgb) that has gone up to 12.2 with a low dose iron supplement. Likewise, since I started limiting his fructose, his appetite has increased tenfold (he never was hungry before!) and he is the happiest I've ever seen him. All of this has really made me believe in the fructose malabsorption diagnosis.

We have seen 2 GIs (NJ/NYC) and both were not concerned with celiac disease any longer; they felt we had ruled that out. Both agreed that if I saw complete resolution of symptoms with the new low fructose diet, that is it. However, my pediatrician decided to throw a wrench in the works and said, "Why don't we do the DNA testing for celiac disease? It will show us for certain that he doesn't have the gene and you can forget about it." Well, now I get these results. And of course, the pediatrican doesn't know how to interpret them other than to read the paper to me and tell me that not everyone with the gene will get celiac disease. I'd also like to know what these results may mean for my other 2 children (healthy).

Please help! I'm waiting to hear from the specialist.

Thank you so much in advance.

Lab Corp results:

Celiac HLA-DQ Result

DQ Alpha 1 01, 03

DQ Beta 1 03:02, 05

Interpretation:

These genes are permissive for celiac disease. The absence of HLA celiac permissive genes would make the presence of celiac disease unlikely. However, these genes can also be present in the normal population.

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


I'm not the gene person, I'm just bumping this up and hoping someone else more literate sees it. But, I think that means he's got the DQ2 gene, just like 30% (roughly) of the population. However, having the gene does not mean one automatically goes on to become celiac, it just means that the person is capable of it. Most celiacs have DQ2, but, obviously, not all DQ2's have celiac, or we'd see nearly a third of the population having a "gluten" problem with their digestive enzymes not being able to handle wheat family proteins. Also, one does not HAVE to have the DQ2 genes for celiac, there are the DQ8 genes, and there are a few rare people with more unusual types (DQ1 and they are celiac) or which seems to predispose them for what can only be called gluten intolerance (shorthand for "had bad symptoms, flunked the tests, responded to diet anyway.)

So don't panic, but be aware of the symptoms for celiac and gluten intolerance, and be vigilant.

http://en.wikipedia.org/wiki/HLA-DQ2

0

Share this post


Link to post
Share on other sites

Thank you so much for responding, Takala. This is all very confusing and I'm so eager for answers. From what I've read today, I thought that having the combination of A1*03 with B1*0302 gives him DQ8.

I am reading his results as:

A1*03

A1*01

B1*0302

B1*0305.

I don't know at all if this is correct, but I am trying. If I look at it this way, that one gene combo I mentioned above =DQ8. I don't know what to make of the other 2 (A1*01 and B1*0305).

I didn't see anything for DQ2, but again, I am new to this. I'm not sure what to look for! I do know that DQ2 and DQ8 are both higher risk genes for Celiac.

Thanks again-

0

Share this post


Link to post
Share on other sites

Ok, so the GI nurse just called me and told me that he has DQ2 and DQ8. I don't know how she got DQ2 (can someone please help explain it?)

She said that since all his current bloodwork is negative for Celiac, they will not do anything now and instead will re-test him every few years.

Any advice? Help? Please!

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      106,779
    • Total Posts
      932,367
  • Member Statistics

    • Total Members
      64,252
    • Most Online
      3,093

    Newest Member
    cmatott
    Joined
  • Popular Now

  • Topics

  • Posts

    • Hi all- im so sorry you are suffering from this gluten nightmare.....  here's my story in a nutshell. Any friendly advice is much appreciated. I am 41, female, healthy weight, ex smoker.. even quit alcohol 10 months ago because of AI disease. Been DX'd with 1) Sjogren's Syndrome and 2) Relapsing Polychondritis. For those that don't know, RP is an AI disease where the body destroys its cartilage. Its pretty aggressive and there is no cure. It is fatal for alot of ppl when the airways collapse. Ive had chronic inflammation for probably 10 years but it is getting progressively worse. It didn't dawn on me until a few weeks ago that gluten intolerance may be driving this. I am in between doctors. I have a new patient apt w/ a new internal med doc 06/28/17. Id planned to ask her then to please test me for celiacs. (going back onto gluten to test this makes me ill thinking about it) My brother and mother have it. I feel good and have plenty of energy. I am a healthy weight. I run, I bike, I walk, I take an hour long aerobics class 3 days a week. I have NO digestive issues. My 10 page labs are green across the board, except for high inflammation. Ive started researching this issue. Ive had more injections in the neck and back and wrists than I can remember. Ive had ablations, exploratory surgeries, botox, trigger point injections.. even a level 2 cervical fusion due to high inflammation in the spine and OA destroying the discs. I have reduced gluten as much as humanly possible. I quit drinking. I take a good quality probiotic and fish oil. My hormones are all good- I take sublinguals for those. My thyroid is perfect. My periods are perfect. My skin is clear. Ive stopped eating dairy, corn and soy. I pretty much currently live off big homemade green salads with olive oil, I make my own soap (which I use as shampoo) I make my own laundry detergent..I even started eating several fork fulls a day of fermented cabbage (ughh) because of the healthy benefits to the gut. Its only been a few weeks. Am I just impatient? What gives? My eyes, wrists and spine are absolutely on FIRE. XXOOO   Tracy
    • This is really tough.  There is still a lot of research needed in diagnosing (or dismissing) celiac disease.  It shouldn't be months/years of misery and uncertainty. A couple of years ago Dr. Marsh (THE Dr. Marsh of the Marsh biopsy rating system) criticized the US celiac community for not recognizing an increase in IELs as early celiac disease. He asked if these doctors would like to be responsible for the oseoperosis or lymphoma of the undiagnosed patients.  I have also seen that it can take months for antibodies to rise.  There was a paper (2015) that looked at gluten challenges in diagnosed celiac patients.  These are folks with confirmed celiac  and for some it took over 3 months for blood tests to show anything. I hope the strict gluten-free diet works for you. I hope to hear you report back in a couple of months.  I'm undergoing my gluten challenge right now. Week 2. It's just really tough. 
    • My 13 and 7 year old have Celiac Disease and my 4 year old has the genes.  I have a double dose of the genes so no matter what my children will get a gene that could develop into the disease.  I hope that my youngest son doesn't ever develop the disease, but his dr said it could activate later in life.  My kids are thriving, they have normal lives, they are smart and have gained knowledge about food that they can carry with them throughout their life.   They really don't let anything stop them from living a normal life.  I think you'll have the upper hand if you choose to have kids.  You'll have the knowledge of what to do to keep them safe if they do have Celiac Disease.  You'll be able to relate since you were young when you were diagnosed.  How was it for you growing up? 
    • My 7 year old son has this happen.  I too get highly angry, like could flip a vehicle kind of angry.  It's hard for the little ones to understand what is going on at the time, only knowing that they can't control themselves....  The glazed crazy look in his eye are always a tell.  Sleep helps, along with lots of water the following day.  The next day we talk about everything and try to figure out what could have glutened him.  We've had talks with our school and teachers letting them know that our son is to not eat anything unless we bring it.  I think the last time this happened to him was from using shared supplies after a treat party.  Now he's very cautious of putting his hands to his lips or mouth.    Now as far as chips, my kids stick with Kettle Brand Chips.  They are certified.  Potatoes aren't my friend so I can't really say if they taste great.     
    • Exactly!! Scuff, are you doing the gluten challenge?  How far along are you?  
  • Upcoming Events