• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Antibody Tests For Celiac Disease
0

9 posts in this topic

I've been looking for a better test than IgE, since that is immediate response, and the one the docs always want to give us. Since celiac disease is autoimmune, that doesn't make sense. What also doesn't make sense to me is having an IgA test done, being it only indicates having an unspecified auto-immune disease. Since I have already been diagnosed having Hashi's, this test would not make sense, as I already know I have an auto-immune disease, so I got to thinking, what test did they give me to determine the thyroid test, specifically? I looked it up, and it was a thyroid antibody test. That led me to wonder why there isn't one for intestinal antibodies....or was there? Googled it, and came up with PubMed article with a study on:

Intestinal anti-tissue transglutaminase antibodies in potential coeliac disease.

As a result of the data collected in this study, it shows "the measurement of intestinal anti-TG2 antibodies may prove useful in clinical practice to predict evolution towards mucosal atrophy in potential coeliac patients and identify patients with gluten sensitivity." Thoughts, anyone???

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


I've been looking for a better test than IgE, since that is immediate response, and the one the docs always want to give us. Since celiac disease is autoimmune, that doesn't make sense. What also doesn't make sense to me is having an IgA test done, being it only indicates having an unspecified auto-immune disease. Since I have already been diagnosed having Hashi's, this test would not make sense, as I already know I have an auto-immune disease, so I got to thinking, what test did they give me to determine the thyroid test, specifically? I looked it up, and it was a thyroid antibody test. That led me to wonder why there isn't one for intestinal antibodies....or was there? Googled it, and came up with PubMed article with a study on:

Intestinal anti-tissue transglutaminase antibodies in potential coeliac disease.

As a result of the data collected in this study, it shows "the measurement of intestinal anti-TG2 antibodies may prove useful in clinical practice to predict evolution towards mucosal atrophy in potential coeliac patients and identify patients with gluten sensitivity." Thoughts, anyone???

0

Share this post


Link to post
Share on other sites

ahhh....missed an important part of the study.... [[[biopsy]]] which means, this is not a blood test. how frustrating that they can obtain an antibody test from your blood for thyroid, but not for intestinal, because it needs to be from the mucosa and not the blood...ahhhh...okay.

0

Share this post


Link to post
Share on other sites

opps, looks like I hit the reply button to my own post :rolleyes:

0

Share this post


Link to post
Share on other sites

I had an Elisa test. I believe it looked for IgG, total IgA and IgE. I had IgG antibodies to Pracitically everything I was eating. I could not cut out eatting everything, so I am doing a rotational diet and eating them all.

0

Share this post


Link to post
Share on other sites
Ads by Google:


I'm confused - have you had a complete celiac antibody panel?

Total IgA

tTG - both IgA and IgG

EMA

DGP - both IgA and IgG

0

Share this post


Link to post
Share on other sites

I'm confused - have you had a complete celiac antibody panel?

Total IgA

tTG - both IgA and IgG

EMA

DGP - both IgA and IgG

No, I've been wondering whether I should, as from what I understand it doesn't diagnose celiac disease specifically, only that I would have an auto-immune disease? If this is the case, then it would come up positive because I have auto-immune thyroid disease and it would be a waste of my money. If this is specific, I would get it done in a heartbeat, but from my reading, the only test that is specific are the intestinal and dh rash biopsies?

0

Share this post


Link to post
Share on other sites




No, I've been wondering whether I should, as from what I understand it doesn't diagnose celiac disease specifically, only that I would have an auto-immune disease? If this is the case, then it would come up positive because I have auto-immune thyroid disease and it would be a waste of my money. If this is specific, I would get it done in a heartbeat, but from my reading, the only test that is specific are the intestinal and dh rash biopsies?

I am currently traveling so I have no access to specific research, but you should keep researching or perhaps someone else will chime in with some papers for you to read.

0

Share this post


Link to post
Share on other sites

Below is from Lab Tests Online ( http://labtestsonline.org/understanding/analytes/celiac-disease/tab/sample ):

Common tests for celiac disease include:

  • IgA class of Anti-tissue Transglutaminase Antibody (anti-tTG): Tissue transglutaminase is an enzyme that causes the crosslinking of certain proteins. Anti-tTG, IgA is the most sensitive and specific blood test for celiac disease but may be negative in children under 3 years old. The IgG class of anti-tTG may be ordered as an alternative in those who have a deficiency of IgA. Although "tissue" is in the name of these tests, they are measured in the blood.
  • Anti-Gliadin Antibodies (AGA), IgG and IgA classes: Gliadin is part of the gluten protein found in wheat (similar proteins are found in rye, barley, and oats). AGA is an autoantibody directed against the gliadin portion.
  • Quantitative immunoglobulin A (IgA): Used to determine if someone is deficient in the IgA class of antibodies and whether the IgG class of autoantibody tests should be performed.
  • Deamidated Gliadin Peptide (DGP) Antibodies, IgA: Anti-DGP test is a relatively new test that may be positive in some people with celiac disease who are anti-tTG negative, including children less than 3 years old.

Other tests less commonly performed include:

  • Anti-Endomysial Antibodies (EMA), IgA class: Endomysium is the thin connective tissue layer that covers individual muscle fibers. Anti-Endomysial antibodies are developed in reaction to the ongoing damage to the intestinal lining. It has been found that tTg is the substance detected in this test. Almost 100% of patients with active celiac disease and 70% of patients with dermatitis herpetiformis (another gluten-sensitive condition that causes an itchy, burning, blistering rash on the skin) will have the IgA class of anti-EMA antibodies. The test is more difficult to do and interpret properly than anti-tTg.
  • Anti-Reticulin Antibodies (ARA), IgA class: Anti-ARA is not as specific or sensitive as the other autoantibodies. It is found in about 60% of celiac disease patients and about 25% of patients with dermatitis herpetiformis.
  • Anti-Actin (F-actin), IgA class: The F-Actin antibody test may indicate increased intestinal damage.

As I understand it, ttg IgA can come up positive in thyroid patients but the other tests are not linked to thyroiditis. The EMA IgA shows a reaction to ongoing damage to the lining of your intestines, meaning if you have a positive test there has been a LOT of damage done; I believe the EMA IgA is extremely specific to celiac disease BUT there are a few other more rare health issues that can cause extensive damage to the gut as well. It you end up with a couple of positive tests, chances are it's celiac.

TPO Ab, which is used to diagnose Hashimotos, is not just specific to Hashimotos either; it is also used to diagnose other health problems as well... like the celiac tests can do as well.

But, I find that if it looks like a duck, and quacks like a duck, it's probably a duck. Those tests usually point to one disease, not always but when you consider symptoms and history, it gives you a better idea of what a test result indicates.

This is just my interpretation, but I hope that made sense. :) Best wishes to you.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      107,377
    • Total Posts
      935,763
  • Member Statistics

    • Total Members
      65,067
    • Most Online
      3,093

    Newest Member
    pauline11
    Joined
  • Popular Now

  • Topics

  • Posts

    • Thanks so much, friends!  JMG, I'll try to get hold of that licorice, almost everything I read gives it glowing reviews.  I miss Bertie Bassets licorice (it contains wheat) so it will be nice to have some licorice again.  Thanks Whitepaw for those ideas, I must admit I'm getting rather fed up with my low fat menu but it seems the best way to keep the pain at bay so it is nice to have something else to cook.  I don't know if I have picked up another intolerance, but you could be onto something there.  And I know what you mean icelandgirl, we've been through so many tests and treatments it all becomes a blur!  My doctor isn't expecting to see me again unless things aren't better within the month, but I might bring my gastro appointment forward if needs be. Actually, in the end yesterday didn't go quite as badly as I'd envisaged it would, which makes me think that some of my pain, bloating and nausea are down to the ompremazole - it does warn that can happen on the packet.  When it says 1 in 10 people get these symptoms I always seem to be that 1 in 10!  I don't have any more burning pain or acid reflux (at least yet) but  I'm still losing weight which slightly troubles me.  That said, when I think of how I normally eat I must be down at least 500 calories a day.  JMG will know from another thread that I have a sweet tooth and at the moment the thought of eating a bar of chocolate makes me feel very sick indeed... Oh no - hope that doesn't mean I have developed a chocolate intolerance! I bought some 10g ompremazole tabs yesterday from Boots, having had nothing yesterday, and I've taken one at breakfast time.  So far so good.  I think I might take these for a few days then taper off. Thank you so much guys for accompanying me on what would otherwise be a lonely journey.  
    • Update: I have been taking Chanca Piedra (specifically, Royal Break-Stone, by Whole World Botanicals) on an empty stomach in the morning for the liver-gall bladder and surprisingly my lips are almost normal. I know the peeling lips may be caused by different issues but I hope this info helps someone.
    • Hi Cristiana, I'm so sorry that you are still not feeling well.  When do you go back to your Dr? I wish I could help more, but it's so hard to know what was what when I was on the PPI.  I was diagnosed with celiac and h. Pylori on the same day so I was already feeling awful.  Then I was put on 2 antibiotics with the  PPI.  I do remember feeling terribly nauseous, but just assumed it was the antibiotics.  When I started tapering, I still wasn't feeling well.  It really took months before I started to feel decent.  But I assume that it was the celiac. I really hope you start to see some improvement...((((hugs))))
    • @scorpio it has now been almost 2 years and I am curious if you ever found something that worked for you. My boyfriend suffers from EC as well and I am desperate to find a resolution for his sake. He's been dealing with it for over a year now and it is taking a toll on his work and social life.   Any updates would be helpful
    • I am going through the diagnosis stage as well. My family has strong history for celiac disease, and while I always had discomfort and other symptoms ( some of which i didnt know about) I wasn't tested until recently because I was DEATHLY afraid of needles. The results are highly positive but I am still getting a biopsy in early August. From what I have learned about it is that the endoscopy is beneficial to looking for not only signs of celiac but also other diseases that have similar symptoms to celiac. Because of your mixed result it wouldn't hurt to get a biopsy but it really is personal preference. I understand what you are going through and didn't like the idea much either but I really think it is something that can help you in the long run. P.S. There are lots of testing being done for new medications or other ways to "cure" celiac other than a gluten-free diet. It is my understanding that this can only be covered by insurance with a confirmed diagnosis (biopsy) but I don't need to get into that. The bottom line is that a biopsy is confirmatory especially since the doctors could see in the intestine, so to me, I feel better knowing that there's no chance of going gluten-free for nothing.
  • Upcoming Events