• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Dgp Question....
0

5 posts in this topic

We got results of my 12-yr-old daughter's blood work today. Everything was in the normal ranges except for the DGP, which was 37 units (<20 antibody not detected)(>or=20 antibody detected). Her CBC showed no abnormalities or deficiencies, so the doctor said he recommends eating gluten-free, but he will not diagnose her with celiac. He believes that she does not have full-blown celiac disease since there is no indication of malabsorption. Since the DGP is so specific, is it enough to go on to diagnose? Or is an endoscopy required as well?

I originally took her in because I suspected spots on her legs to be DH. They could not do a biopsy on the day we were there because of scheduling, so we set it up for today. Of course, the lesions healed beyond the point of getting a positive result (on adjacent skin), so I cancelled the biopsy. With no DH and no endoscopy, but a positive DGP, is the doc correct in NOT diagnosing her?

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


It is my personal opinion that he should do the endoscopy with a positive DGP, even with normal bloodwork and tTG. The DGP is very specific for celiac disease (i.e., nothing else that we know of elevates it, unlike the tTG). Dr. Rodney Ford (world eminent pediatric GI - here in Christchurch) believes that every child who has an elevated DGP will eventually develop celiac, whether or not they actually have it at the time of testing. I heard him speak on this subject about a family with one child with celiac and two with elevated DGP but negative biopsies. Within two years, both these other two children had celiac disease. So it is possible that the endoscopy would not turn up positive either, but I think it should enter into the picture. Many celiacs with negative tTG's have tested positive on biopsy.

So to answer your other question, if your doctor does not plan to follow up on this result, I would either wait until she has an active skin lesion and get it biopsied, or take her straight gluten free. I personally do not believe it is worth continuing to give her rat poison so the doctor can become convinced. He was supposed to pay for his own education :P Not all doctors are Dr. Rodney Ford :(

0

Share this post


Link to post
Share on other sites

She may not have the worst symptoms of celiac disease yet, but that doesn't mean she wouldn't develop worsening symptoms over time if she continues to eat gluten. Her doctor isn't thinking quite right. He needs to consider the idea of preventative care once in awhile. Does he take his car to the shop when the check engine light comes on? Or wait until the engine falls out before talking to a mechanic? Grrr is a legal word here, so Grrr!

0

Share this post


Link to post
Share on other sites

I was diagnosed with just blood work so I'm biased on simply accepting a positive blood test as indicating celiac. Those DGP tests are fairly specific to celiac disease as far as I know.

If the doctor is implying that her disease hasn't progressed much yet, then great! Although I have no idea how he can tell that from the blood work.... either way, she should go gluten-free once her testing is complete. Good luck.

0

Share this post


Link to post
Share on other sites

I just excerpted this for another poster, so thought I would pop it in here, too. :)

http://drrodneyford.com/extra/documents/279-gliadin-antibody-confusion-same-name-different-test.html

The old gliadin test. In the 1990s, the gliadin antibody test was developed. Although most celiacs had a positive IgG-gliadin antibody test, high levels of this antibody were found in about 10% of the normal population. Consequently, gliadin testing was considered non-specific” from the point of view of diagnosing celiac disease. Mistakenly, this led to IgG-gliadin being maligned as a useless and non-specific test .

Gluten sensitivity. The reality, however, is that an elevated IgG-gliadin antibody specifically means that the person is immunologically reacting to gluten. International research, including my own, has demonstrated that high gliadin anybody levels are frequently associated with clinical disease without the gut damage of celiac disease. This is now known as non-celiac gluten sensitivity, or the gluten syndrome.

Because of the poor predictive value of IgG-gliadin antibodies to detect celiac disease, this old gliadin test has been widely abandoned in the medical community – to the extent that most laboratories do not offer to do this test. But this is about to change.

DGP. This new deamidated gliadin peptide (DGP) antibody is the next big step along the journey. It is more sensitive and specific than EMA or tTG for the diagnosis of celiac disease. Unfortunately, its name is now being confused with the early old gliadin test.

Nicknames

Shortening names is universal, we call these nicknames. Whenever I am in Australia, I introduce myself as Rodney, but my friends call me Rod .

The same name strategy is being used for the DGP test. Instead of its full name, it has been shortened to the gliadin test – the identical name for the old gliadin test. But they test for very different things:

The new DGP gliadin test accurately indicates the gut damage of celiac disease.

The old IgG-gliadin antibody test indicates immunological reaction to gluten, and can help diagnose the gluten syndrome.

This is how to interpret what these gliadin antibodies mean:

A positive old test (IgG-gliadin antibody) usually means gluten sensitivity.

A positive new test (DGP-IgG and DGP-IgA) means celiac disease.

A negative old test usually means that gluten is unlikely to be a problem.

A negative new test means that celiac disease is unlikely at the time of the test, but it does not rule out gluten sensitivity.

0

Share this post


Link to post
Share on other sites
Ads by Google:


Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      107,332
    • Total Posts
      935,536
  • Member Statistics

    • Total Members
      64,994
    • Most Online
      3,093

    Newest Member
    Daisy Charlize
    Joined
  • Popular Now

  • Topics

  • Posts

    • LOL, re: trousers vs. pants.   Here in the US, trousers are a specific kind of pants/slacks, with a looser fit and often with pleats in the front.   I also read that Vit D helps digestion;  can't recall the links, but likely within Gundry's writings about lectin.   My Dr. just told me to resume 2000 IU per day, and I do think it's made a slight difference. Have also read that bone broth is helpful, its gelatinous nature supposedly coats the stomach.   I know bone broth has not been formally studied much, but again, probably can't hurt and might help.
    • I'd try the gluten free diet for a few months to see if that helps at all. Can't hurt. If it doesn't help I'd try a low FODMAP meat and veggies diet.
    • A good amount of the neurological effects from celiac are also related to nutrient deficiencies caused by malabsorbtion from damaged intestines and the fact that most gluten-free foods are not fortified and your net eating many grains. You sound good about the CC and everything and seem to be taking percations goods, I still use freezer paper for a clean safe work surface even in my gluten free home lol. Anyway top things to look for and consider are magnesium and B vitamin deficiencies . I take my in a drink to avoid pills and the sublingual forms are more easily absorbed by the body. I normally suggest 2 brand or forms of magnesium and you need to find the one that works for you there. They are Natural Vitality Calm, a magnesium citrate in a powder, you add it to a warm drink let it fizz and drink it. Magnesium citrate can be a bit harsh on some peoples guts, I suggest you start off with 1/4 tsp and work your way up to the full dose over a week, if you get D then your taking too much and need to back down or the citrate version might be too rough for you. In which case I suggest Doctors Best, bit more off tasting and mixes best with a juice but with the powdered form of it you do not have to worry about digestion issues, I just found the citrate to seem to help with my nerve issues more. B Vitamins, I take Liquid Health Stress & Energy and the Neurological Support, I take 1 tbsp of each 2-3 times a day before meals. Really helps with everything and being in liquid forms I just add to tea and drink it. There are many other vitamins to look into and we each have ones we have issues with more then others, getting tested might help, NOTE magnesium and B vitamins sometimes show normal but you will still find you need supplementation...bit of a odd thing I found. Yeah the neurological effects are  huge thing with me as my issues with this disease cause my immune system to attack my nervous system and brain....accumulated brain and nerve damage over the years. Had a whole mental trauma issues with them, my gastro issues back then were mostly just constipation. NOW days I get the Vomiting, D, gas, bloat, and then constipation for a week along with neurological issues which NOW if I get exposed to eating straight gluten (happened twice in 3 years to this extent) I loose motor control and collapse unable to move, normally while vomiting violently to the point of blood coming up (this was what happened last June 2016 after eating out).  
    • Started thinking the only cereal I allow in my house is Vans, they have a cinnamon one that is like a captain crunch with cinnamon, and a strawberry O type that I keep in stock for a friend that comes over sometimes and for my cousins littler girls who I end up babysitting sometimes. There was a coconut flake (corn flake knock) off I used to eat, but the company discontued it. There is a stuff called progranola from julians bakery made without grains that looks great but is a bit expensive at $9 a bag.
    • I would add your pharmacist to that that list and double check when getting a script filled that they checked to make sure it is safe. You will also need to tell any romatic partners as if they are gluten consumers they should brush their teeth before any kissing.
  • Upcoming Events