• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Newbie Here With One Celiac Test To Be Positive-Need Help!
0

7 posts in this topic

Hi, I have stalked around on this forum for a while and finally decided to sign up today and ask all of you seasoned celiacers a question about my lab work. I have had some serious neurological issues, mainly my eyes being very sensitive to light and feeling dizzy, so my neurologist ran a panel of blood work on me and besides a low Vit. D, a slight titer of dsDNA which is so low considered neg. only one came back positive. This was the Deamidated Gliadin Peptide IgG. It was weakly positive at 24. 30 being strong postive. So I googled what Deamidated Gliadin Peptide was and a whole slew of celiac articles popped up. I had a biopsy in 2008 which I was told was negative for celiac disease, but I think my Gastro only took one biopsy. I want to be realistic here and not keep barking up the same tree if I don't have celiac disease, but I was shocked to see the DGP IgG positive. Do you guys think this test could correlate with other possible diseases? They did do other celiac tests like the IgA and Ttg test which were in normal ranges.Endomysial test also normal.

I guess what I want to know is, with this one test being positive, should I look further into celiac disease or should I not worry about it? Thanks for any input in advance. :rolleyes:

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


Was this one of the articles you read?: (excerpted in part)

http://drrodneyford.com/extra/documents/279-gliadin-antibody-confusion-same-name-different-test.html

"The old gliadin test. In the 1990s, the gliadin antibody test was developed. Although most celiacs had a positive IgG-gliadin antibody test, high levels of this antibody were found in about 10% of the normal population. Consequently, gliadin testing was considered non-specific” from the point of view of diagnosing celiac disease. Mistakenly, this led to IgG-gliadin being maligned as a useless and non-specific test .

Gluten sensitivity. The reality, however, is that an elevated IgG-gliadin antibody specifically means that the person is immunologically reacting to gluten. International research, including my own, has demonstrated that high gliadin anybody levels are frequently associated with clinical disease without the gut damage of celiac disease. This is now known as non-celiac gluten sensitivity, or the gluten syndrome.

Because of the poor predictive value of IgG-gliadin antibodies to detect celiac disease, this old gliadin test has been widely abandoned in the medical community – to the extent that most laboratories do not offer to do this test. But this is about to change.

DGP. This new deamidated gliadin peptide (DGP) antibody is the next big step along the journey. It is more sensitive and specific than EMA or tTG for the diagnosis of celiac disease. Unfortunately, its name is now being confused with the early old gliadin test.

Nicknames

Shortening names is universal, we call these nicknames. Whenever I am in Australia, I introduce myself as Rodney, but my friends call me Rod .

The same name strategy is being used for the DGP test. Instead of its full name, it has been shortened to the gliadin test – the identical name for the old gliadin test. But they test for very different things:

The new DGP gliadin test accurately indicates the gut damage of celiac disease.

The old IgG-gliadin antibody test indicates immunological reaction to gluten, and can help diagnose the gluten syndrome.

This is how to interpret what these gliadin antibodies mean:

A positive old test (IgG-gliadin antibody) usually means gluten sensitivity.

A positive new test (DGP-IgG and DGP-IgA) means celiac disease.

A negative old test usually means that gluten is unlikely to be a problem.

A negative new test means that celiac disease is unlikely at the time of the test, but it does not rule out gluten sensitivity."

I have heard Dr. Ford speak, and I believe that with a weakly positive DGP you should have another Endoscopy, this time with enough biopsy samples to have a hope of finding the disease. This is if you absolutely have to have the official diagnosis. If it were me, I would consider that I had celiac disease and put an end to it. I would definitely not dismiss it.

0

Share this post


Link to post
Share on other sites

Wow, thats alot more cut and dry, and seems to be very specific for celiac. I am a little shocked to be quite honest and thought with the neg biopsy from 5 years ago that I had a different unknown disease. I haven't gone completely gluten-free because I think I have been in denial somewhat. I honestly don't know if I could go through another biopsy, and maybe I should just really accept that I should cut out the gluten and be serious about it. I don't mean to sound like a baby here, but going gluten free has been harder than I thought it would be and so I waiver with cutting it out. I guess this article really explains what my blood test meant. I just wish my doctor who ran the test would have taken the result seriously and talked to me about it. Thank you for such an in depth answer, it was extremely helpful.

0

Share this post


Link to post
Share on other sites

hi! i had a full celiac panel done by Labcorp, and my DGP igG was also the only thing that came back positive. For my lab, a strong positive was greater than 30 and I scored a 43. I've been researching info to get ready for my follow-up GI appointment and found this article to be very helpful http://www.worldgastroenterology.org/assets/export/userfiles/2012_Celiac%20Disease_long_FINAL.pdf

page 8 gives a clear cut diagram that says if you test positive for either ttG igA/EMA or DGP igG, a small bowel biopsy is warranted. I plan on giving my GI a copy at my next apt. Hope you find it helpful!

0

Share this post


Link to post
Share on other sites

hi! i had a full celiac panel done by Labcorp, and my DGP igG was also the only thing that came back positive. For my lab, a strong positive was greater than 30 and I scored a 43. I've been researching info to get ready for my follow-up GI appointment and found this article to be very helpful http://www.worldgast..._long_FINAL.pdf

page 8 gives a clear cut diagram that says if you test positive for either ttG igA/EMA or DGP igG, a small bowel biopsy is warranted. I plan on giving my GI a copy at my next apt. Hope you find it helpful!

Thanks for the info, I am excited to read it! Have you gone gluten-free and feel better and do you have any symptoms?

0

Share this post


Link to post
Share on other sites
Ads by Google:


here's a link to the thread about my test results and questions

my main one is continuous bloating and frequent constipation, but in the WGO paper, they are listed in the non-classic symptoms portion on pg. 7.

i've tried gluten free for three weeks and things started to improve, but then I read that you needed to be on gluten for the testing, so i started eating it again.

0

Share this post


Link to post
Share on other sites

Jen, what did you end up being diagnosed with?  Did you get an EGD done?  Hope you're feeling better!!

0

Share this post


Link to post
Share on other sites




Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      107,341
    • Total Posts
      935,594
  • Member Statistics

    • Total Members
      65,009
    • Most Online
      3,093

    Newest Member
    werstern101
    Joined
  • Popular Now

  • Topics

  • Posts

    • i just read my BODY FORTRESS vanalla whey protein powder and it says GLUTEN FREE on the jug--SO GLAD
    • You're welcome ritamichelle. Yes, if you are biopsy confirmed then it will be much easier to get your daughter tested. 
    • I agree that In people that have celiac there usually is a trigger. It can be physical or emotional stress as the article states. I wonder though if the people they say 'don't have the genes' are folks that simply have rarer ones. There is research on more genes. I discovered it when I was writing a paper for a class. It was a very long time ago in 'computer age' and my bookmarks died along with the computer I was useing. But it is out there on peer reviewed sites like Lancet, NIH etc. Since celiac was rarely tested for even a couple decades ago there are many folks that may have celiac in their family but it was never known. That was the case in my family. I am confident about that.  I always wondered why my Mom seldom left the house, spent a lot of time in the bathroom, was tired all the time and was always holding her hands the way she did.  Then I became her.  We have so much to learn about celiac. Personally I dislike the term 'NCGS' because it makes folks think at times they don't need to be as strict and it isn't as serious. Too many are told that their biopsies are negative and they then get the NCGS label if they had positive bloods.  I consider celiac to be a spectrum disorder. Not all celiacs have gut impact or at least haven't developed it yet. I had the neuro impact and DH from shortly after I was impaled as a young child. It was many years before any severe GI issues arose.  
    •     http://www.takepart.com/article/2014/08/11/coffee-adulterated https://www.thetimes.co.uk/article/how-was-your-morning-coffee-did-it-taste-like-mud-v6rfdmrrr92 http://grist.org/food/coffee-taste-like-dirt-thats-because-it-might-be/ " Using liquid chromatography, which identifies the individual chemical components of a mixture, the Brazilian scientists found wheat, soy bean, brown sugar, barley, corn, and rice commonly interspersed with the grounded coffee they tested. Large amounts of wood and dirt were also prevalent, an issue not only for purists who prefer to drink their coffee black, but for those with potential allergies to the unknown additives. As TIME reports, the scientists are identifying the rogue coffee with increasing accuracy:" http://www.bodyandsoul.com.au/health/health-news/is-there-wheat-hidden-in-your-coffee/news-story/a3d53a7c36b76156f08d89eab6a396b3   -----   I have also read other references to coffee upsetting those with celiac.   Personally I have a family history of officially diagnosed celiac even though I have never been diagnosed myself..then again Ive never been properly tested. My drs just keep saying the following symptoms are anxiety and wont refer me to a gastroenterologist for:   Loss of bowel control, pale coloured stools, severe bloating, passing undigested food, ataxia, vertigo, migraine headaches, feeling feverish, repeated ulcers on my tongue and in my mouth, feeling generally ill and sleep issues (mostly falling asleep when I dont want to but rarely insomnia).   Because they insist its anxiety as routine blood tests are normal they wont refer me to a gut dr. They did do a blood test for celiac once on my request but it came back negative. This does not phase me when it comes to my suspicians that gluten is an issue for me because:   1 I was on a gluten free diet at the time, hence why i was well enough to crawl to the gps office. 2 I have a family history of celiac 3 MY symptoms are alleviated by a gluten free, dairy free, oat free, corn free diet..and lately, coffee free it seems. Coffee has indeed become a problem for me recently. 4 I could not tolerate gluten based baby foods as an infant. I was admitted to hospital as a baby for being underweight because I was vomitting all my food up. They put me on gluten free formula and i was fine, stopped being sick and gained weight. I could have grown out of it but considering the symtpoms i get on a gluten based diet, i really doubt it.   -----   When it comes to the coffee, food manufacturers will do most anything to make profits if they think they can get away with it. We live in a world where money is most important and if they do get caught...they can always claim they have no idea how the barley got in there!    
    • If you have had a sleep study and been diagnosed, you have sleep apnea. It's definitely different than waking up to go to the bathroom. Are you using your cpap every night for The entire night. Naps too? SA can actually cause death so it's very Important for you to use it every time you sleep. Do you follow up with your doctor yearly? Sorry to sound like the SA police, but I know someone who died from it. He wasn't using his cpap anymore, thought it was uncomfortable.     What Is Sleep Apnea?   Sleep apnea (AP-ne-ah) is a common disorder in which you have one or more pauses in breathing or shallow breaths while you sleep. Breathing pauses can last from a few seconds to minutes. They may occur 30 times or more an hour. Typically, normal breathing then starts again, sometimes with a loud snort or choking sound. Sleep apnea usually is a chronic (ongoing) condition that disrupts your sleep. When your breathing pauses or becomes shallow, you’ll often move out of deep sleep and into light sleep.
  • Upcoming Events