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      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Totally Confused On Genetic Test Results- Please Help?
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Hi,

I'm in the middle of a horrifyingly bad gluten challenge in preparation for my biopsy, etc., so please excuse any confused-sounding bits of this.

Before subjecting me to a gluten challenge, I had the genetic testing done. I don't entirely understand the results, but the gist is that I'm positive for one of the types:

HLA-DQ2 (DQA*05/DQB1*02) - Positive

HLA DQ8 (DQA*03/DQB1*0302) - Negative

HLA-DQA1* - 02

HLA-DQA1* - 05

HLA-DQB1* - 0201

HLA-DQB1* - 0202

If anyone out there actually understands this, I would really appreciate more insight.

The real confusion is coming from my parents. My dad also demonstrates symptoms similar to mine. The cause of my symptoms HAS been diagnosed as EITHER celiac or non-celiac gluten intolerance.

However, when my dad went in to get tested, too, they had him also do the HLA test and he came back negative. (My mom is negative, too.) I wanted to know how it's possible for both my parents to be negative, but then I'm positive. Does anyone understand the genetic component better?

I'm trying to encourage my dad to pursue this because he's having some symptoms that are troubling (i.e. serious brain fog) and I would like to see if I can get him some help before it gets worse.

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Hi lobbyart - Did your parents go through the same doctor/lab for testing that you went through? You seem to have 1 copy (alpha and beta chains) of DQ2.5 and 1 copy (alpha and beta chains) of DQ2.2. Each parent has the capacity to give you 1 copy. Since you have 2 copies, both of your parents have at least 1 copy of DQ2. They cannot skip generations! Somewhere along the line, I'd wonder about the validity of tests... and whether you could get your hands on the exact results of your parents' gene tests...?

Good luck, keep us posted!

Laura

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Hi lobbyart - Did your parents go through the same doctor/lab for testing that you went through? You seem to have 1 copy (alpha and beta chains) of DQ2.5 and 1 copy (alpha and beta chains) of DQ2.2. Each parent has the capacity to give you 1 copy. Since you have 2 copies, both of your parents have at least 1 copy of DQ2. They cannot skip generations! Somewhere along the line, I'd wonder about the validity of tests... and whether you could get your hands on the exact results of your parents' gene tests...?

Good luck, keep us posted!

Laura

Thank you so much, Laura. Those results were unreadable to me! I really appreciate your help on this. So that would make me homozygous for DQ2?

I wish they'd just give us plain english... :)

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Yes, you are homozygous for DQ2.

To be honest, I don't think many doctors know how to read the results, either. :ph34r: For the ones that do know how, I think it makes them feel good to be able to read the jargon... :lol:

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