• Ads by Google:
     




    Get email alerts Celiac.com E-Newsletter

    Ads by Google:



       Get email alertsCeliac.com E-Newsletter

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Test Results Pointing To Early Stage Celiac?
0

6 posts in this topic

Just got the results of my tests. This reeks of very recent development of celiac disease to me. Any ideas? With the marginally positive IgA and somewhat high negative IgG, also note the borderline negative transglutiminas IgA at 3. Of other note all bloodwork at my general physician in Decmember was normal including RBC, hemoglobin, iron, calcium, and thyroid. I have had IBS symptoms on and off for 15 years or more, have not really noticed any glaring symptoms change in recent times. I did have a period in December of 5-7 days of pretty nasty gas and bloating but no diarrhea. In the last 3-4 days the same pattern resurfaced and now appears to once again be improving. Is this cyclical symptom pattern somewhat common in celiac? I was eating some pretty horriblly glutened foods for Xmas and the entire last 6 weeks since the first flareup and no symptoms whatsoever til the same thing came back last week.

Deamidated Gladin IgA - 20

Weak positive 20-30

Demidated Gladin IgG - 15

Negative 0-19

Transglutiminase IgA - 3

Negative 0-3

Transglutiminase IgG - <2

Negative 0-5

Endomysial Antibody IgA - 174

Normal range 91-414

C-Reactive Protein - 0.7

Normal range 0.0-4.9

0

Share this post


Link to post
Share on other sites
Ads by Google:
Ads by Google:


This reminds me of my blood work, only my DGP IgG is weakly pos at 24. Does your doctor have any input about the weak pos. DGP IgA? There is a poster here that has great info with the screen name Mushroom who forwarded me an article by Dr. Ford explaining deamidated gliadin peptide tests and they seem to be pretty specific for celiac disease.

0

Share this post


Link to post
Share on other sites

This reminds me of my blood work, only my DGP IgG is weakly pos at 24. Does your doctor have any input about the weak pos. DGP IgA? There is a poster here that has great info with the screen name Mushroom who forwarded me an article by Dr. Ford explaining deamidated gliadin peptide tests and they seem to be pretty specific for celiac disease.

No, didn't have the follow up yet so no specific one on one conversation. I've come across some research that shows surprisingly these are not exactly the breakdowns you want to see as a potential celiac. Although most argue a non positive EMA that falls decently within normal range means less intestinal damage and the likelihood you've caught the condition much earlier on, some think the lesser fight put up within the intestines and hence lower EMA # increases the risk of malignancies to develop. I was told by a family member who is a general practitione to wait 90-120 days and do the blood test again and see if the #s increase any, she has advised me not to go through the invasive endoscopy procedure just yet based on those #s and my otherwise normal supplementary blood work.

0

Share this post


Link to post
Share on other sites

Blood tests are often difficult to interpret, with the one weak positive it makes it even more difficult. That is what sucks about Celiac, often the diagnosis is up in the air and not so clear cut.

I am not sure what you are speaking about with the Endomysial, the range you provided makes me think that you have mistaken that for your total serum IgA? There is no "falling decently in range" endomysial, and endomysial can't be "below range". It is listed as a titre, 1:5 and below is considered negative, above will be reported as positive.

The theory of a low EMA, which again does not exist, provides a greater increase of malignancy does not make sense. If you have a positive EMA it is showing damage to the intestines, the higher the titre the higher the damage, the higher the damage the greater the risk increase of malignancy. A negative EMA is a good thing.

The advice of retesting in three months sounds great, keep on top of it and make note of any symptom changes. If it provides you with any comfort I had a weak positive deamidated IgG of 11 (>10) and TTG 16 (>10) after a bout of Salmonella. I got biopsied months later in which my intestines were perfectly healthy and the next blood test 4 months after the previous was negative. Good luck!

0

Share this post


Link to post
Share on other sites

I expressed my desires about the blood test and was sort of rebuffed. Doc claims that the borderline IgA and negative EMA in no way is a guarantee the disease is recent at all, said someone with the disease for 18 years can have a 21 IgA and negative EMA while someone only having it for 18 months can have a 40 IgA and 600 EMA...no guarantee that the #s suggest duration. I countered with the normal calcium/vitamin/iron levels on the generic blood workup and he said THAT could hold some water about this being recent but still said there are plenty of patients with the illness for decades who do not suffer the iron or vitamin deficiencies.

0

Share this post


Link to post
Share on other sites
Ads by Google:


I also agree that doing follow up blood work would be good. I have also wanted to see what my DGP would be. There is one study I found online that claims that the dgp can sometimes be falsely pos. And fall without taking gluten out of the diet. This is where the confusion sets in because many studies also show that dgp is extremely sensitive and accurate in detection of celiac. You may want to experiment with a gluten-free diet just to see if you begin to notice any difference. I have been gluten-free for about a week now faithfully and the change is astounding. I hope I continue feeling better. I really am curious as to what next step you will take and please update us! :)

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      107,339
    • Total Posts
      935,566
  • Member Statistics

    • Total Members
      64,999
    • Most Online
      3,093

    Newest Member
    Con Smith
    Joined
  • Popular Now

  • Topics

  • Posts

    • Yes you are correct. Interestingly my genes in the US are thought to be more associated with RA. Which is something they thought I had prediagnosis. In the Middle and far East they are more likely to be associated with celiac and they are rare genes in Caucasians which I am according to my parents known heritage. I always caution folks not to take the gene tests as absolute proof they can't have celiac because I had one child who had positive blood and biopsy, did well on the diet, then got genes tested in young adulthood and was told they could never be celiac. Of course that resulted in her abandoning the diet. I worry but hope someday doctors will realise we still have a lot to learn about the genetics of this disease. PS While I still have some deformity in my hands my joint pain resolved after a few months on the diet.
    • It seems like you really need a concrete or near concrete answer so I would say maybe you ought to get the gene testing. Then you can decide on the gluten challenge.   Thanks! I am convinced our dogs are there waiting for us. Meanwhile they are playing, running, laughing, barking & chasing. I have another favorite quote dealing with dogs: "If a dog will not come to you after having looked you in the face, you should go home & examine your conscience."  ~~~ Woodrow Wilson ~~~
    • I can't help thinking that all of this would be so much easier if the doctor I went to 10 years ago would have done testing for celiac, rather than tell me I probably should avoid gluten. He was looking to sell allergy shots and hormone treatment, he had nothing to gain from me being diagnosed celiac. I've been messing around ever since, sort-of-most-of the time being gluten free but never being strict about it. I really feel like three months of eating gluten would do my body a lot of permanent damage. I've got elevated liver enzymes for the third time since 2008 and no cause can be found which might be good, I guess. I wonder if it would be reasonable to do the HLA testing first, to decide if I really need to do the gluten challenge. If the biopsy is negative, that is. Squirmingitch, love your tag line about dogs in heaven. We lost the best dog ever last December. I sure hope all my dogs are there waiting for me!
    • Most (90%-95%) patients with celiac disease have 1 or 2 copies of HLA-DQ2 haplotype (see below), while the remainder have HLA-DQ8 haplotype. Rare exceptions to these associations have been occasionally seen. In 1 study of celiac disease, only 0.7% of patients with celiac disease lacked the HLA alleles mentioned above. Results are reported as permissive, nonpermissive, or equivocal gene pairs. From: http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/88906  
    • This is not quite as cut & dried as it sounds. Although rare, there are diagnosed celiacs who do not have either of those genes. Ravenwoodglass, who posted above, is one of those people. I think she has double DQ9 genes? Am I right Raven?  My point is, that getting the gene testing is not an absolute determination either way.
  • Upcoming Events