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@knitty kitty it’s hard for me to figure out what causes the reactions in multivitamins for me - I found out through individual supplements that I can’t do methylated forms - methyl folate and methyl cobalamin both gave me hives. It’s really tedious trying out each form of vitamin individually but I do taken b2 and b6 too for nausea/vertigo. I can’t tolerate b3 bc it gives me nausea and hives. I actually feel pretty good where I’m at now and kind of have supplementation fatigue - it’s so much work doing trial and errors that I’d like to hold my course for a bit.
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By knitty kitty · Posted
@Celiac16, Thiamine (any form including Benfotiamine) needs magnesium to make life sustaining enzymes. Taking Thiamine without sufficient magnesium means the body cannot use Thiamine properly. I understand how magnesium can make you feel "knocked out" but that goes away with continued supplementation. When I first started supplementing magnesium, I took it at bedtime, too. Magnesium helps muscles relax, so feeling really knocked out was a sign to me I was deficient. I kept taking it. Magnesium doesn't knock me out anymore since my deficiency was corrected. Thiamine chelates heavy metals like Lead and Cadmium. Thiamine binds irreversibly with dangerous heavy metals like Lead and Cadmium, so they can be removed from the body through the digestive tract. Thiamine combines with chromium to form an enzyme. Thiamine and chromium separately both help regulate blood glucose levels and use of insulin. Thiamine and Selenium are both utilized in the thyroid. Enzymes made with manganese are used after thiamine enzymes inside cells. Thiamine interacts with each of the other B vitamins. Each of the B vitamins is needed at different points in the production of energy for cell metabolism. You are doing yourself a disservice by not supplementing with the other B vitamins and magnesium as well as Thiamine. Insufficiencies in the other B vitamins can affect how well Thiamine is utilized in the body. Some people don't like a B Complex supplement because Nicotinic Acid or Niacin Vitamin B 3 causes flushing. Flushing is temporary, and goes away with continued use. I've heard it said, the worse the flush, the more your body needs the niacin. As deficiency levels are corrected, the flushing ceases. If you don't like B Complex, take each of the eight B vitamins separately. Vitamins A, D and C are important as well. Vitamin D helps regulate inflammation. Vitamin A and C help in healing. Have you been referred to a Nutritionist? References: Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/ Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019700/ Effects of Combined Dietary Chromium(III) Propionate Complex and Thiamine Supplementation on Insulin Sensitivity, Blood Biochemical Indices, and Mineral Levels in High-Fructose-Fed Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510416/ -
By knitty kitty · Posted
@Moodiefoodie, Sorry you are having such problems. Gluten exposure, illness and vaccinations are situations in which there is a higher demand for Thiamine Vitamin B1. We need more Thiamine when we have an immune response, whether it is caused by a cold or an inoculation to promote an immune response as with vaccines, or upon exposure to gluten and our autoimmune response to gluten. Thiamine stores can be depleted within three days to three weeks. Subclinical Thiamine deficiency can exist for years. A twenty percent increase in dietary thiamine causes an eighty percent increase in brain function, so symptoms may mysteriously wax and wane. With illness, vaccinations, and gluten exposure, the demand for Thiamine increases, and symptoms flair. Thiamine has antibacterial properties. Thiamine has analgesic effects, especially when taken with Pyridoxine B 6 and Cobalamine B12. Thiamine has been shown to reduce inflammation in joints. The Gluten Free diet can be low in Thiamine. Gluten free processed foods are not enriched with vitamins like gluten containing products. Eating a diet high in these carbohydrates can also increase the demand for Thiamine. This is High Calorie Malnutrition. Supplementing with Thiamine, the rest of the B vitamins, and magnesium is beneficial in correcting nutritional deficiencies as occurs in Celiac Disease. References: Thiamine and benfotiamine: Focus on their therapeutic potential https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682628/ Long-Term Treatment by Vitamin B1and Reduction of Serum Proinflammatory Cytokines, Hyperalgesia, and Paw Edema in Adjuvant-Induced Arthritis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102562/ Thiamine deficiency disorders: a clinical perspective https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451766/ Hiding in Plain Sight: Modern Thiamine Deficiency Chandler Marrs and Derrick Lonsdale https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/ The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316433/
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