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Showing content with the highest reputation on 03/02/2019 in all areas

  1. 1 point
    Celiac.com 02/20/2019 - Pharmaceutical company ImmusanT is developing a celiac disease vaccine called Nexvax 2. Many vaccines provide long-term or permanent protection against disease after just one, or several doses. Because celiac disease is not caused by a virus, like polio, but is a response to the presence of an antigen (similar to an allergen that triggers an allergy), the approach to creating a vaccine like Nexvax 2 is different and, in some ways, easier, than creating a traditional vaccine, like the HPV vaccine. Nexvax 2 is a vaccine in much the same way that allergy shots are, but not in the way the polio vaccine is. Celiac Vaccine is Similar to Allergy Shots Unlike traditional vaccines, such as the polio vaccine, or the measles vaccine, Nexvax 2 does not inject a small dose of dead or weakened virus, or any virus fragment, into the patient to achieve disease immunity. Allergy shots work by desensitizing the body’s reaction by strengthening the immune system, thereby reducing or eliminating reactions to certain allergens. Nexvax 2 would work in a similar manner to allergy shots. It would build tolerance levels until there was little or no immune reaction to gluten exposure. Anyone who’s ever had allergy shots knows that their effectiveness can range from person to person. Some people get minimal relief, though most see good to excellent results. Many experience tremendous relief, and see their symptoms disappear. Nexvax 2 Faces Easier Path to Approval Because Nexvax 2 works less like a traditional vaccine, and more like allergy therapy, the process for testing and approval is potentially easier and shorter; several years, rather than a decade or more. The hope is that, once treated with Nexvax 2, “the immune system, now seeing these fragments of gluten in a different way, might learn to tolerate gluten," said Benjamin Lebwohl, director of clinical research at the Celiac Disease Center at Columbia University. Certainly, the ability to reduce or neutralize the body’s reaction to gluten in people with celiac disease would be a major breakthrough in the treatment of celiac disease. Benefits for celiac patients could include a reduction in severity of gluten contamination symptoms, and potentially an elimination of symptoms entirely. Nexvax 2 treatment, if successful, could allow some people with celiac disease to safely consume wheat. That is potentially huge news. Phase two clinical trials of the Nexvax 2 are slated for completion by the end of 2019. Read more: Promising Celiac Vaccine Nexvax 2 Begins Phase Two Trials
  2. 1 point
    You are perfectly free to be fearful and reactionary against a potential celiac vaccine. Whether you try such treatment or not is entirely up to you. However, the fact is that, if the treatment works as described, many people with celiac disease could have their sensitivity levels reduced or eliminated. That's potentially huge and beneficial to large numbers of people with celiac disease. Spewing fear and misinformation won't do much to change that reality, or to strengthen your objections.
  • Posts

    • I recently started a medication that's known to cause hypothyroidism, and in me, it has. As I increased the dose, my TSH went higher, in an almost lockstep fashion. On the most recent set of blood tests, after my TSH had gone over the threshold, my GP decided to chuck a coeliac test in there since hypothyroidism can be linked to coeliac disease, even though it seems pretty much certain the hypothyroidism is caused by the medication. So essentially this test result was something neither he nor I were in any way prepared for. He's referred me to gastroenterology and ordered the same blood test again to check it wasn't a dodgy result, but what are the chances I don't have coeliac disease, with a tTG-IgA result of 128? I already have to follow a type 2 diabetes diet and an MAOI diet; I don't want to have to be gluten-free too!
    • TDZ, that is interesting that you mention weed-eating as coinciding with the start of your husband's rash, as about 12 years ago I had a possibly similar experience.  It was in the spring (meaning late May here in SC Alaska), and I was cutting the lawn.  Rather than bagging up all the lawn clippings, I would just take the filled bag off the mower, walk into the woods behind the house, and pull out the clippings with my hand and then scatter them around (so that they didn't just all rot and fester in one stinking pile).  Well, the next morning I woke up with (mainly) the thumb and index finger of my right hand, and all the skin in-between, being red and inflamed and VERY itchy.  Soon the itching spread, and turned into tiny red bumps.  Then it became painful and highly sensitive, like a burn, and looked that way, too.  After four or five days, little areas of skin starting loosening up and peeling, and before long pretty much the entire skin of my right hand was peeling off, just like a glove!  I did go to a doctor and had a skin biopsy done, but nothing was determined, and the doctor was stumped. Years after that, I was talking to an acquaintance who was a botanist, and she casually mentioned about how the wild buttercups that are a common weed here are severely poisonous, and caustic, and how their juices can burn the skin to the point of it sloughing off.  And as it happens, those same buttercups were all through my lawn that year when I had my skin incident!  Now, I'm not saying that you might have those same plants in your yard, but there are any number of other plants that could react similarly, especially to somebody whose skin and immune systems are already compromised --- any plants in the carrot/celery family, for example, can play Hell on the skin, and we have at least two such wild plants here in Alaska that have repeatedly caused me great grief.  In fact, I have seen groundskeepers here who while weed-whipping will wear full hazmat suits, as the juices from one of those carrot family plants (Cow parsnip) is well known for causing serious skin burns, rashes and even permanent scarring.
    • Not a clue, other than normal eating. He ate a fair amount of bread, and pasta and pizza and such. Right before the massive outbreak in November, there was a peppermint/chocolate-drizzled popcorn that I got at Walmart, and it gave both of us horrible diarrhea, and within a few days he was covered with more rash than ever before. Might have been unrelated, but it's the only unusual thing that times out right for any causality. Otherwise, he wasn't eating anything different. The first thing that I suspect started it was weedeating the yard a couple of years ago -- I'm seeing that wheat allergies correlate with grass allergies, because wheat is a grass and is related to lots of things. That one particular day, he started getting the rash and thought he must be allergic to a particular plant that we had noticed and hadn't ever had before, and it really never completely went away after that -- ebb and flow, but no remission, and then gradually getting worse and worse and spreading to other areas. So maybe that was the initial sensitization, and then the gluten continued it. Just a guess, though.
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