Positive Blood / Neg Biopsy? in Post Diagnosis, Recovery & Treatment of Celiac Disease Posted August 1, 2007 · Report to Admin So hear me out here.... Have had a positive blood test a few times...I believe its the IGg that was positive cause my PC says its the less sensitive anti-body of the two. Went for an endoscopic biopsy which came back negative...so...based on convential wisdom, no positive biopsy, no celiac disease and no change to my diet. Not long after this I came down with a WICKED painful intestinal infection diagnosed as mesenteric penniculitis (sp? / say that three times fast!!)....which is an inflammation of the 'fat" around the intestine. Lasted a few weeks and lost a lot of weight...like 15+ lbs. One of the suspected causes of this type of infection is an auto-immune response...so celiac is a possibility...but drs couldnt say for sure what caused it (idiopathic). After that was done I started having some very persistant new symptoms including - - Intense light-headedness / dizziness - lots of gas - floating stool - occasional night sweats Based on what I've read....all very much indicative of celiac problems. Had another biopsy recently which still came back negative...BUT...recently found out that there is a family history of celiac (aunt, cousins, etc.). So my question is this.... Can you have a negative biopsy and STILL have celiac disease??? Appreciate your input. Tigano, I am one of the many posters here whom I know also had a positive blood and negative biopsy. I don't want to discourage you but based on your post everything seems to point to celiac. In my case it's harder to accept since I'm a Filipino with no one in the family having this disease. Celiac is unknown to my country and if you have celiac you will only be diagnosed with IBS like what happened to me. I just got proper diagnosis outside Philippines. I was diagnosed by a GI doctor through blood and he said there is no need for a biopsy since I'm positive with lga and I have a raised ttg. Not satisfied I went to another doctor who did the biopsy that came out negative. He told I have no celiac and said "go back to your normal life and eat". I hesitated at first but later on I did some gluten challenges, it didn't make me sick in the beginning but later on all my symptoms of bloating and gas came back. So that's it, gluten free!!!