Ana Test (autoantibody Tests): Are Celiacs Positive? in Celiac Disease Pre-Diagnosis, Testing & Symptoms Posted September 1, 2010 · Report to Admin Not only do I have a very high ANA but also have a very high Rheumatoid Factor. However, I have absolutely no symptoms or signs of the diseases that spike these 2 tests. As I prefer not to be micro-managed by the AMA and have endless doctor appointments, for now, I am choosing to stay strictly gluten-free and do nothing else. If symptoms develop, then it might be appropriate to see a Rheumy but not now. I have the same thing. My ANA has been 1:1280 for 5 years. Rheumatoid factor is 27, Anti-smooth muscle antibody is 57. These are very high titers and the docs are expecting MCTD or autoimmune hepatitis to develop, but so far I only have microscopic colitis and gluten intolerance (not confirmed celiac yet). I'm gluten free hoping it will stop hepatitis before it starts (preventing a life of full-time steroids or liver transplant). I get bloodwork by my PCP every 6 months to monitor antibodies and chemistry, and am seeing a celiac specialist who may be able to shed more light. The antibodies were first found due to a itchy post-partum rash, malar rash on my face, and sun sensitivity, but it all went away when I stopped nursing at a year. Had another pregnancy and no problems (except colitis a year later). I feel like a ticking time-bomb, but try to ignore it.