Posterboy

Nacina,

Knitty Kitty has given you good advice.

But I would say/add find a Fat Soluble B-1 like Benfotiamine for best results.  The kind found in most Multivitamins have a very low absorption rate.

This article shows how taking a Fat Soluble B-1 can effectively help absorption by 6x to7x times.

https://www.naturalmedicinejournal.com/journal/thiamine-deficiency-and-diabetic-polyneuropathy

quoting from the article....

"The group ingesting benfotiamine had maximum plasma thiamine levels that were 6.7 times higher than the group ingesting thiamine mononitrate.32"

Also, frequency is much more important than amount when it comes to B-Vitamin. These are best taken with meals because they provide the fat for better absorption.

You will know your B-Vitamin is working properly when your urine becomes bright yellow all the time.

This may take two or three months to achieve this.......maybe even longer depending on how low he/you are.

The Yellow color is from excess Riboflavin bypassing the Kidneys.......

Don't stop them until when 2x a day with meals they start producing a bright yellow urine with in 2 or 3 hours after the ingesting the B-Complex......

You will be able to see the color of your urine change as the hours go by and bounce back up after you take them in the evening.

When this happens quickly......you are now bypassing all the Riboflavin that is in the supplement.

The body won't absorb more than it needs!

This can be taken as a "proxy" for your other B-Vitamin levels (if taken a B-Complex) ...... at least at a quick and dirty level......this will only be so for the B-1 Thiamine levels if you are taking the Fat Soluble forms with the Magnesium as Knitty Kitty mentioned.

Magnesium is a Co-Factor is a Co-factor for both Thiamine and Vitamin D and your sons levels won't improve unless he also takes Magnesium with his Thiamine and B-Complex.

You will notice his energy levels really pick up.  His sleeping will improve and his muscle cramps will get better from the Magnesium!

Here is nice blog post that can help you Thiamine and it's many benefits.

I hope this is helpful but it is not medical advice

God speed on your son's continued journey

I used to be him. There is hope!

2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the grace of God,

9 hours ago, Acacia Voynar said:

Can I have a B vitamin deficiency when labs show elevated B vitamin levels?  How/why does that happen?

Acacia,

I saw this topic......after logging to respond to another thread that had a lot of activity in my feed.

Yes you can. It is common in SIBO.

I don't participate as much as I used to because life has taken me in a different direction, but Scott has given you an excellent resource in Knitty Kitty.

I am not going to follow this thread........I just don't have the time to keep up with it right now.....but I wanted to point you in the right direction.

See this article about why this is so....

https://www.merckmanuals.com/professional/gastrointestinal-disorders/malabsorption-syndromes/overview-of-malabsorption#:~:text=A combination of low B12 and high folate,intestinal bacteria use vitamin B12 and synthesize folate.

quoting the article...

 "A combination of low B12 and high folate levels is suggestive of SIBO, because intestinal bacteria use vitamin B12 and synthesize folate."

SIBO commonly happens when you have low stomach acid......it (Low Stomach Acid) is not uncommon in GI diseases......and doctor's don't associate the too......in fact they commonly get it wrong.

Search for the Posterboy on Celiac.com and you will find my story of how I suffered with it for years.....going misdiagnosed.....especially the posterboy blog entries.. ...read them to your heart s contents......that is why I wrote them......to help others when I couldn't always be here....

Knitty Kitty is an excellent resource on this site for B-Vitamin deficiencies and their many faces IE disguises showing up as various diseases like SIBO as mentioned above etc......

Thiamine and Niacinamide (Vitamin B3) is very important in the treatment of SIBO and low stomach acid.

See this article about the SIBO in Celiac disease article...

 https://www.omicsonline.org/open-access/small-intestinal-bacterial-overgrowth-sibo-2161-069X.1000225.php?aid=31428

Here is their summary paragraph about this connection....

quoting....

"Celiac disease: Patients with celiac disease who have persistently symptoms that do not respond to a strict gluten free diet may have underlying SIBO [19]. This is due to the fact that underlying chronic inflammation of the small intestinal mucosa predisposes to bacterial overgrowth and untreated SIBO is one reason why this patient population may have persistent symptoms. In celiac disease, a prevalence rate of SIBO as high as 66% has been reported [2]."

I hope this is helpful, but it is not medical advice.

Good luck on your continued journey.

Posterboy by the grace of God,

7 hours ago, knitty kitty said:

@Beverage, 

Thanks for sharing!  This is really interesting!  I had to satisfy my curiosity and learn more, and found this...

Lactobacilli Supplemented with Larch Arabinogalactan and Colostrum Stimulates an Immune Response towards Peripheral NK Activation and Gut Tolerance

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352398/

I don't do well with the gummy gluten free breads, either!  

I'm going to give this a try! 

Thanks!

 

Beverage and Knitty Kitty,

I agree that is good research.  I have been looking for a dietary fiber that agrees with me....

I take Glucommanan from time to time......but I somehow havent taken a liking to it the way I thought I would....

I will definitetly look that up at the Vitamin Shop (to see if they have it)......or my local supplement shop to see if I can order it.

Since Knitty Kitty mentioned the Natural Killer (NK) connection....

I though I would sight this research (though when I get time I want to post in a separate thread) or the Magnesium thread......

But it could be helpful too here as well....

If you  have Natural Killer cell problems then you have  Magnesium issues!

See this research

Entitled "Mg2+ (Magnesium) regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D"

https://pubmed.ncbi.nlm.nih.gov/23846901/

IT is truly amazing all the ways Magnesium help make and keep us healthy!

It also explains how and why EBV is associated with Celiac disease and seven other auto-immune diseases becasue we get low in Magnesium and the NK cells become Cytoxic.

See this research about it entitled "Epstein Barr virus linked to seven serious diseases" including Celiac disease.

https://medicalxpress.com/news/2018-04-epstein-barr-virus-linked-diseases.html

I hope this is helpful but it is not medical advice.

2 Timothy 2:7  “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the grace of God,

To All,

At least you think.....I came up with this on my own.....I didn't I just went out and found the research that confirms my hypothesis.

Showing it is a "Working Theory".....that time has forgotten.....IMO who's time has come again.....to discuss and time for it to rediscovered because patient's can't wait another 15 or 20 years for the doctor's to figure it out and do more studies on this topic.

Once upon a time.....they knew this -- that Nicotinic Acid aka Niacin today or Vitamin B3 was used to treat DH succesfully nearly 20 years before DH was even associated with Celiac disease.

I am quoting this because it is the best article I know about it currently....

https://www.jidonline.org/article/S0022-202X(15)50482-X/pdf

IF some intrepid researcher want to find more up to date research about it.....

@Blue-Skyor @knitty kittyI would like to see it....

I currently don't have the time to do more research on the topic but IMHO this is conclusive enough for me!

Trialing Niacinamide (the natural non-flushing form of Niacin) or a small dose Niacin say 100mg with meals is all somebody would have to do....in those who have DH to see if goes into remission....

Then add a B-Complex or a Multivamint or a Multivain in the morning and B-Complex at night for 3 or 4 months is all it would take to see IF first the DH rash doesn't go away (go into remission) and your GI symptom's don't improve in 2 or 3 months....

Blue Sky and/or Knitty Kitty go back and read this blog post if you haven't read it already......and it summarizes this Niacinamide protocol for NCGS and/or Celiac disease well....

YOU dont' have to take it for years at HIGH doses......6 months seems to be  "Goldilocks" amount of time....

Often a 100 count bottle of a B-Complex is enough to put DH in remission!.....but I do recommend it twice a day or 3/day with meals for best results....

But over the years I've found it is best to be conservative and takea 300 count bottle (about a 3 or 4 month supply) of either a B-Complex or just Niacinamide by itself to confirm this working Theory .....to build up your livers (bodys) reserve.....against future stress(es)....

IF you have DH......you will want to trial the Niacinamide to see if it puts the DH in remission otherwise if you just have GI problems like NCGS or Celiac disease without Skin Isuuses like DH, Acne, Psorsias, Eczema etc then just trailing a B-Complex should be enough to help your GI problems.....

Obviously there are others thing you can add to that to support your lingering symptom's.....

Becasue you will still have "Overt (Hidden) Vitamins Deficiencies" without Obvious Symptom's....

Like Vitamin D, and Magnesium Citrate and/or Magnesium Glycinate....

The ONE B-Vitamin you should add to this B-Complex regimen is Thiamine as Benfotiamine or another high quality Fat Soluble B-1 Thiamine supplement......because Thiamine is important in Celiac disease as well...

But is usually not the trigger for Skin issues....but as I said before and above.....YOU will also be low in B-1 and your other B-Vitamins like B2, and B6 and Tryptohan etc......if you have (also) developed Pellagra in addition to your Celiac disease or if you prefer your Celiac disease (due to low nutritent absorption) has also triggered Pellagra to COME to the surface via the DH diagnosis!

Until the liver is full of it's reserve STRESS will continue to be a problem for you.

IF you have a STRESS problem.....you have B-Vitamin problem!

I will quote again.....Prousky full citation for anybody who has the interst and time to read it....

He explains better than I can what a Vitamin Dependency is.....not a Vitamin deficiency...

Entitled "Is Vitamin B3 (Niacin) Dependency a Causal Factor in the Development of Hypochlorhydria (Low Stomach Acid) and Achlorhydria (NO Stomach Acid)"

http://orthomolecular.org/library/jom/2001/pdf/2001-v16n04-p225.pdf

Again I am sorry, I rambled (a little) but I stayed on topic (more I think this time).....but I had alot of "Ground to Cover" as they say.

Then report back when it helps you! and let other's know.....your Pellagra being diagnosed as DH in Celiac disease got better/went in to remission when you took some Niacinamide for your DH symptom's....

Or just a B-Complex if your prefer to take it that way......but you will only know IF it is the Niacin portion of the B-Complex that helped your DH.....if you only trial the Niacinamide alone or the Flushing Niacin form (though many (may find) the flusing uncomfortable....at first......I find it nicely relaxing and comforting.....once you know what it is....see this article on how to tritrate up Niacin as Nicotinic Acid to help Seasonal Allergies......So I won't have to type soo much......(again and again).....and this reply is already getting too long for even me!

http://getwellstaywellathome.com/blog/2015/06/seasonal-allergies-and-the-niacin-flush/

Again if you have GI problems.....and NO DH symtpom's.....a B-Complex will do just Fine!......but if you DH trial only the Niacinamide for 3 months THEN add a B-Complex to that regimen.....to address your remanig B-Complex deficiencies....for another 3 months......UNTIL your urine GLOWS.....then you can cycle off the B-Complex......because your are now bypassing Riboflavin aka Vitamin B-2 thorugh your kidneys......and you have refilled your liver!

One Final Note: Niacin works much better on the Itching of DH than Niacinamide does!

IF itching is your main complaint then Niacin aka Nicotinic Acid is the form you want to take.

See this article about why the "Niacin Flush" is good for us!

http://www.life-enhancement.com/magazine/article/3396-why-the-niacin-flush-may-be-surprisingly-beneficial-to-your-health

It is the release of Prostaglandins that build up in the skin that relieves the Itching of DH.

Here is an article about it....

Entiltled "Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid" aka Niacin

https://pubmed.ncbi.nlm.nih.gov/2475889/

And this one shows how Niacin via this Prostaglandin recepter helps UC in the same way!

Entitled "Niacin ameliorates ulcerative colitis via prostaglandin D2-mediated D prostanoid receptor 1 activation"

https://www.embopress.org/doi/full/10.15252/emmm.201606987

IT is also why Slow Release Niacin as Inositol hexanicotinate is not as healhty for you as quick release Niacin.....

and Why Niacinamide will not quickly help the Itching of DH......because you don't release the build up Prostraglandins in the skin.....triggering unberable itching!

I have to stop for now!

Again, I hope this is helpful but this is not medical advice.

2 Timothy 2:7 "Consider what I say; and the Lord give thee understanding in all things.", this included.

Posterboy by the grace of God,

To All,

This is just a follow up to the STRESS that happens before a Celiac disease diagnosis.

This is what you would expect IF your B-Vitamins are important for your Stomach Acid production......and the commonly low Stomach Acid in NCGS/Celiac disease patients.

See this research about it....

Entitled "Gastric morphology and function in dermatitis herpetiformis and in coeliac disease"

https://pubmed.ncbi.nlm.nih.gov/3992169/

This article shows (IMO) shows that NO Stomach acid aka Achlorhydria is predictive of DH in Celiacs....

I hope this is helpful but it is not medical advise.

As always  "Consider what I say; and the Lord give thee understanding in all things.", this included.

2 Timothy 2:7

Posterboy by the Grace of God,

Grossi Et Al,

I knew about this.....but didn't think about it at the time.

NOT Only can Stress makes Celiac symptom's worse.....IT might even be the trigger for Celiac disease.

STRESS is Common before a Celiac diagnosis.....

See this article about it....

Here is another article that expalins how Stress can be a trigger for Celiac disease.

https://www.verywellhealth.com/can-pregnancy-trigger-celiac-disease-562302

As I like to think about it.....FIRST Comes baby, then comes GERD/ NCGS/Celiac disease symptoms....

I hope this is helpful but it is not medical advice.

Posterboy,

17 hours ago, Blue-Sky said:

Niacin in any form can cause diabetes and insulin resistance when taken at "therapeutic" dosages. There are a few warnings about it on the government health page.

https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/

You can also get elevated liver enzymes if someone is eating a western diet. Niacin depending on the dosage could potentially aggravate that.

Since the body can't keep minerals like zinc, magnesium and selenium very long, and they are lowered by stress I take extra of those, along with a multivitamin as malabsorption is common with Celiac disease.

Tryptophan is another healthy way of aiding in gut repair and boosting niacin levels.

Very few people probably take therapeutic dosages of niacin. A lot of people take multivitamins though and those people tend to eat healthier to start with.

Blue Sky,

No one mentioned taking Niacin or Niacinamide in "Therapuetic Doses"......

For those who haven't had time to read the link they posted it is doses between 2 to 3 gram a day for 2 or 3 years etc...

But the use of Niacinamide or Niacin for 3 months (In divided doses IE with Meals is best) has shown marvelous results.....and not just Niacin but other B-Vitamins as well....Like Thiamine for example.

See this nice article about to  use B-Vitamins to help treat Pyschiatry issues

Entitled "Understanding nutrition, depression and mental illnesses"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738337/

quoting their paragraph on B-Vitamins...

"B-complex vitamins

Nutrition and depression are intricately and undeniably linked, as suggested by the mounting evidence by researchers in neuropsychiatry. According to a study reported in Neuropsychobiology,[42] supplementation of nine vitamins, 10 times in excess of normal recommended dietary allowance (RDA) for 1 year improved mood in both men and women. The interesting part was that these changes in mood after a year occurred even though the blood status of nine vitamins reached a plateau after 3 months. This mood improvement was particularly associated with improved vitamin B2 and B6 status. In women, baseline vitamin B1 status was linked with poor mood and an improvement in the same after 3 months was associated with improved mood."

So, to summarize a B-Vitamin plateau is reached after 3 months......essentially what is "Homeostasis" or balance from which the patients mood improved.....

And seemingly suprising to them.....(But not to me).....that Riboflavin and B6 was particualrly associated with a healthy mood (and presumbly mind)......because they are in the Kyneureine Pathway that allows us to synthesize or own Niacin....

For others who are following this thread.....this thread also might be of help.....because it expalins the best form of Niacin and/or Niacin to take....

And it is worth noting here again (In case you missed above).....at even up to the length of 1 year at a rate of 10x the RDA for the B-Complex the regimen only produced good and healthy results in mind and body!

I hope this is helpful but it is not medical advice.

Posterboy,

To all,

Here is the study on Niacinamide as potential treatment for Psorsias.

Entitled "Nicotinamide: a potential addition to the anti-psoriatic weaponry"

And yet.....everybody seems to have forgotten the role Niacin can play in healthy skin....

https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.03-0002hyp?journalCode=fasebj&legid=fasebj%3B17%2F11%2F1377&related-urls=yes

And not suprisingly it (Niacin) does this by down regulating "Antibodies" to Psorsias in the body.

quoting from the abstract....

"Nicotinamide is an inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1) that, through enhancement of nuclear kappa B-mediated transcription, plays a pivotal role in the expression of inflammatory cytokines, chemokines, adhesion molecules, and inflammatory mediators. Through interaction with CD38 and inhibition of IL-1, IL-12, and TNF-α production, nicotinamide produces a mild TH2 bias."

Th2 Bias.....is homeostasis or a quieting or our immune system......and that is exactly why it can help "Auto-Immune" conditions by restoring our immune system to a state of balance.

I hope this is helpful but it is not medical advice.

Posterboy,

17 hours ago, Blue-Sky said:

Since the body can't keep minerals like zinc, magnesium and selenium very long, and they are lowered by stress I take extra of those, along with a multivitamin as malabsorption is common with Celiac disease.

Blue Sky,

I know your focus is on Zinc.....I looked it up once....how long does Zinc stays in the body.....I want to say about 20 days.

You mentioned the other Minerals as well do you know their Half Lifes as well?

I would be interested in knowing how long our body can hold Minerals in reserve......I tend to think our mineral reserve was longer than 20 days......but I think (if my memory serves me correctly)......I looked up the Zinc once bfore and was suprised by how quickly we can become low in Zinc and/or our other minerals....

If approx. 20 days is a good number then it can be a predictor/proxy of 1) low stomach acid and 2) a predictor of low Niacin levels....

Because Niacin helps control iron and Zinc levels in the liver.....leading to deficiency in they body.

See this research about it

Entitled "Effect of nicotinic acid on zinc and iron metabolism"

https://pubmed.ncbi.nlm.nih.gov/9353874/

quoting from the absract

"When mice were fed with nicotinic acid-deficient, -adequate and -excess synthetic diets for four weeks it was observed that, in comparison with the nicotinic acid-deficient diet, percent zinc absorption, intestinal zinc, percent haeomoglobin and liver iron increased significantly under nicotinic acid-adequate and -excess conditions. The results obtained suggested that nicotinic acid, in addition to its known effect on growth and metabolism, may be playing an important role in enhancing zinc and iron utilization."

Low Iron is common in Celiac's and I don't think almost anybody knows that too can be a sign of low Niacin levels....

I hope this is helpful but this is not medical advice.

Posterboy by the grace of God,

14 hours ago, Rogol72 said:

This is very interesting. So what is the therapeutic dose of Niacin to correct a deficiency or a subclinical deficiency? Is it a case that the cells need to be saturated with Niacin to be of significant benefit as is the case with Thiamine? Is there a helper mineral or nutrient that helps Niacin to do it's thing similar to Thiamine and Magnesium?

Rogol72,

These are great questions!

Yes and No is the answer.....I saw from another thread on DH you have had flare up in the past....

I see you are aware of this thread......so I am quoting this thread for the others who might also come across this thread....

It explains in  more detail how this happens.....

To answer your question.....So now Niacin or Niacinamide does not need other Vitamins/Minerals for it too work....in and of itself?

But Yes, Niacin needs other Vitamins and Minerals etc. for the body to synthesize it etc.

@knitty kittyknows alot of these same things too.....

She often talks about Beri Beri and/or a Thiamine deficiency because Thiamine is where the body's "Energy Producing Machine" better known as the Krebs Cycle breaks down.....it is essentially (for animals) the same as Photosynthesis is for plants....

We can't make energy without Thiamine, and Magnesium and Niacin etc.....and why we wither away with out these critcal B-Vitamins and the Mineral Magnesium for example......being low in any three of these Nutrients will cause the Krebs Cycle to break.....

Niacin can reset the cycle.....by restoring the Kynurenine Pathway....it does this Via Trytophan.

It is trytophan is essential to development of IBS etc.

See this article about it....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266036/

When they Kynurenine Pathway breaks......Illness follows you around.....because you can no longer produce enough energy to maintain or repair your cells....

See this article about it entitled "Kynurenine pathway metabolites in humans: disease and healthy States"

https://pubmed.ncbi.nlm.nih.gov/22084578/

IN the strictest since......Niacin acts like a hybrid between a Vitamin and an (Essential) Amino Acid.....by the strictest definition......we can't synthesize Vitamins and why Knitity Kitty focusing on Thiamine......it is where the link breaks intially (and we can't synthesize) internally Thiamine......it can only be obtained from our food our Bacteria/Biome etc...

But Niacin is soooooooo important we will die (the 4th D of Pellagra) without it if our body can't synthesize it......if this Pathway breaks.....you will be haunted by Illness!

Our body will use Vitamin B2 (Riboflavin), B6 and Tryptophan to synthesize Niacin.....so our Mucus Membranes can stay healthy......which includes our GI tract and our Skin as examples.....approx. 80% of our Niacin is produced this way....and why we often don't have Skin issues right away....beause our back up pathways.....keep it under control (Mostly).....BUT

Wherever HIGH turnover of cells are invovled Pellagra or a Niacin deficiency will rear its "Ugly Head" like with Low/NO stomach Acid or Skin issues etc...(Especially when we are STRESSED OUT).....hence our Flares!

(and is exactly what we find in GERD/Heartburn).....

6 months before we get STRESSED Out of our B-Vitamins and Heartburn/GERD Develops....

See this rearch about it... Entitled "The effect of life stress on symptoms of heartburn"

https://pubmed.ncbi.nlm.nih.gov/15184707/

(I explain how Stress effects us negatively more in this thead) so I wont' have to retype everything again.....and So I don't get too far off topic....

Back to the main question at hand....so to speak...

Essentially every body knows Stress KILLS right.....well it MAIMS Us First!

BUT With High Stress our deficiency Shines through (shows up or becomes more evident)....you might say...

OR High energy activities where we burn alot of energy......Like our Brains to manage our body (Dementias of the brain) and our GI tract etc.....to make Stomach acid.

 Combine them both, High Energy and High Cell turnover and  BINGO!......Almost always Pellagra or a Niacin deficiency mainly (though not always) shows up first as GI problems.....

If you read the Acne Vulgaris full citation.....he explains welll why this is....

Quoting From Paragraph 4.

"4. Pellagra, Acne and Dyspepsia Chronic or recurrent diarrhea is a symptom of dyspepsia in the pellagra.Other gastrointestinal disturbances include anorexia, nausea, and epigastric discomfort [33]. Acne vulgaris and acne rosacea are also frequently accompanied by gastrointestinal disturbances, of which constipation is most frequently recorded, and less often, (so-called dyspepsia or indigestion) [34-37]. Approximately 68.5% of acne patients display symptoms of functional dyspepsia or gastrointestinal disorders, including halitosis, distension, pain, belching, acid reflux, diarrhea, and constipation [38]"

I am sorry I rambled again (in the electic way I am knonw for) (sorry for the long reply I didn't expect to be this long!!!).....maybe it will help someone else....

In summary......Beri Beri (happens in a Pellagra Diagnosis first) and why Knitty Kitty focuse on it first!)

I didn't know about Beri Beri.....happened first (in the beginning)......but Knitty Kitty is highlighting the Cornerstone nutrient, I am highlighting the Capstone nutrient.....or vice Versa (depending on how you look at it /or  think about it)....

In summary......Pellagra doesn't happen in an Uncomplicate way.....IT will always happen as/with Beri Beri FIRST!!!

Most of us (see blog post below) never go past Pellagra Sine Pellagra but those who develop Skin Issues such as DH......the Kyneurine Pathway has broken and we can no longer synthesize enough Niacin naturally to kee our Mucus Membranes IE our Skin (as the final straw) that breaks the Camels back and the Doctor's can SEE Acne, Ezcema, Psorsias and yes DH as Pellagre IF and WHEN they are made aware of these connections.....

"But don't kid (ourselves/youself) they will laugh you out of their offices.....if you mention it ......because you are not Homeless or an Alcoholic".......just trial the Niacinamide for 3 months and let the results speak for t hemselves....

See Dr.  Haneys' nice article about this topic as well......

http://blogs.creighton.edu/heaney/2013/11/18/pellagra-and-the-four-ds/

Where he says quoting....at least in North America...IE the US and Western Medicine etc.

"In the United States, at least, pellagra is a disease of the past – fortunately – and it is doubtful today that most health professionals would recognize it if a case happened to come to their attention."

And is exactly what the research on Acne and Pellaga showed.....unless Pellagra is in its most advanced state....

The Dermatitis State.....Pellagra is often overlooked.....even when Niacinamide supplementation has proven it is effect in 80% of those who take Niacinamide for 3 months.

I summarized all of this in this blog post......if you have the interest....it is kind of long winded but it should answer most if not all of your questions....

Rogol72,  this blog post might be of help to you too!

It explains why you would want to take Niacin/Niacinamide and how to for best your best results when you take it...

I  need to stop for a while but I hope this is helpful but it is not medical advice.

As always I hope you “Consider what I say; and the Lord give thee understanding in all things” this included.

2 Timothy 2:7

Posterboy by the Grace of God,

Hb333,

These couple of threads might help you.

You can trial some Niacinamide it has shown to help certain certain skin conditions including Acne and up to and including DH...

I've said this before and stand by it.....more studies need to be done about this topic, IE the Niacin connection for skin issues in Celiac disease presenting....as DH.

Here is fairly recent research on Niacinamide being used to treat DH in Celiac's...

Entitled "Two Cases of Dermatitis Herpetiformis Successfully Treated with Tetracycline and Niacinamide"

https://pubmed.ncbi.nlm.nih.gov/30390734/

It would only be "antedotal" information if you take Niacinamide for 3 months and it helps your Skin flare ups.....but it would/could help you know.....until more studies are done on this topic.....Don't take the Tetracycline......IF it is the Pellagra causing the flare up.....then the Niacinamide will help it in about 3 months or less!

It sounds like you need help now and cant' wait another 13 years to get/be better!

See the research on Acne as a "Sub-Type" of Pellagra....

https://www.sciencepublishinggroup.com/journal/paperinfo?journalid=254&paperId=10063819

Duration and frequency is important with any B-Vitamin....it takes about 3 months of Niacinamide to put many types of Skin issues into remission.

From the full citation and be accessed by clicking on the PDF link undere the abstract (top right of citation)....

quoting

"A pilot study shows that the effective rate of high dose niacin in 3 month treatment of acne vulgaris up to
80% [60]. The therapeutic effect of niacin on acne is an important basis for acne to be diagnosed as pellagra"

You can only confirm if you have developed Pellagra presenting as DH in Celiac's by trialing Niacinamide for approx. 3 months.

If the Skin rash goes into remission then the low nutrient levels triggered by your Celiac disease has triggered Sub-Clinical Pellagra....and the doctor's don't SEE it.....

I suggest you take it with meals for 3 months and SEE what happens!

I have a friend IRL now (acquantence really)......friend is an over used term....that had terrible acne and who trialed Niacinamide after I bought her a bottle and gave it to them......and now after about 6 weeks of taking Niacinamide her Acne IS much improved and she IS very happy I gave her some Niacinamide to take.

I hope this helpful but it is not medical advice.

2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things”

Posterboy by the grace of God,

Scott,

I will be glad too......as a moderator (I just though he would be on here often enough) to see the thread since he has mentioned migraines in threads before and piqued in interest enough to read....

By the way my following is still not working.....which doesn't matter so much.....but it does limit what I see about who commented on what etc....

For example, I did not get your response.....I had just happened to check in....because Fridays is once of  my normal days (these days) and I was by happenstatnce online when you responded....

I just wonder who else....it might be affecting beside(s) me....

I haven't got a follow up email except for this thread (for whatever reason)....

I think,......it was from before when my following feature broke....

Posterboy,

Trents,

@trentsyou might enjoy this article

I saw it and thought of you....

Posterboy,

To All,

I saw this reseasrch recently and I thought it was worth sharing!

https://www.sciencealert.com/spicing-up-your-meals-could-be-one-simple-way-to-build-a-healthier-gut

Posterboy,

To All,

I don't have as much time as I once did.....to focus on the forum but I wanted to share this new research that I came across that explains (summarizes)  perfectly (IMO) all the research I have done on this topic over the years.

Entitled "Acne Vulgaris Is a Special Clinical Type of Pellagra"

https://www.sciencepublishinggroup.com/journal/paperinfo?journalid=254&doi=10.11648/j.ajcem.20210906.13#:~:text=Foam cells are an important pathological change in,that patients with acne are deficient in niacin.

This is “SMOKING GUN” research that proves that Acne Vulgaris is sign of Pellagra…..or as they say is a “Sub-Type” or Special Clinical form of Pellagra!

And I would say (IMHO) that the DH of Celiac disease is a special "Sub-Type" of Pellagra that shows up in Celiac patients......or if you prefer their terminolgy....

that DH is a "Special Clinical" form of Pellagra in Celiac's....

Now to be fair.....I wasn't the first to seize on this idea.....the International Journal of Celiac Disease more than 7 years ago now.....I was just the one....who has beat the drum the most.....I agree!

Here is the original researsch.

http://pubs.sciepub.com/ijcd/3/1/6/#:~:text=Celiac Disease%3A Intestinal%2C Heart and Skin Interconnections The,versa%2C multiple cardiac manifestations exist in celiac disease.

Here is the article Scott graciously agreed to publish on this topic...

If someone wants to read the whole article just click on the PDF link.....which I highly recommend you do if you have DH....the special form of Pellagra in Celiac disese (IMHO)....

Where they make a great point!!!! and this is the same in Beri Beri (to a great degree as well).....unless you are an alcoholic or homeless you can't have Beri Beri or Pellagra in America (it commonly thought and taught)....but what if the wrong people got.....like GI patients.....then the doctor's can't see it....they are EYE Blind too it!

quoting

"The current diagnostic approach to pellagra does not provide a basis for early warning, definitive diagnosis, timely treatment, nor prevent pellagra from
deteriorating and aggravating. Medical doctor cannot diagnose a patient as mild and moderate pellagra clearly."

Until a doctor can SEE Pellagra they can't diagnosis it......and if they see Acne, Psorsias, Ezcema, DH etc.....then they can't see the forest for the trees!

As a matter of fact a/this link between Ezcema (skin issues) in babies has been tied to Niacin levels in the Mothers Children has been established but the doctors can't SEE it today.....beause this form of Niacin deficiency is subclinical and being diagnosed as a seperate skin disease.....totally unaware of these established connections...

Not surpisinlgy this research is 5+ years old.....but mothers and babies still suffer from low Niacin levels going clincially unregnozied as metabolic Pellagra....

https://www.thehealthsite.com/news/high-levels-of-vitamin-b3-during-pregnancy-may-lower-the-risk-of-eczema-in-babies-ag0916-436755/

Which I think this research conclusively proves IMO!

Where they summarize it well...

"Summary: Based on an analysis of the clinical feature of acne patients, pathological changes in acne lesions and the therapeutic effects of niacin on acne, we propose that acne can be diagnosed as a specific clinical type of pellagra, and niacin is the first choice for the treatment of acne vulgaris."

Note: Similar studies have been found in the study of DH in Celiac disease as well.....but these conditions are no longer assoicated......and therefore it goes un/misdiagnosed too this day!

I hope this is helpful as always but it is not medical advice.

2 Timothy 2:7  As always, “Consider what I say; and the Lord give thee understanding in all things”

Posterboy by the grace of God,

Trents,

I saw this reseach and thought of you......I hope it is helpful.

https://www.eatthis.com/migraines-eating-habits-new-study/

Posterboy,

On 11/25/2022 at 5:18 AM, grossi said:

Hello guys, a few weeks later I had positive EMA and in January I am going to have biopsy. If Its connected my symptoms are mostly mental. I have fatigue, brain fog, sometimes depression and anxiety. 
 

Weird thing is that. When I have for example summer vacation and minimum stress I feel better. But when the school starts and I become feel more stressful. I will strart feel foggy and have low energy again. Its hard to study with this. I think the brain fog also give me social anxiety. 
 

Do you think that stress can make celiac symptoms worse and give me social anxiety? Thank you for your reply

 

Grossi,

Stress can make many medical symptom's worse....

Stress has been tied to GERD/Heartburn in the  6 months prior to it's development.

See this research about it....

Entitled "The effect of life stress on symptoms of heartburn"

https://pubmed.ncbi.nlm.nih.gov/15184707/

Higher stressors burn more energy and why you have more fatigue, and brain fog especially from low Thiamine levels….

The production of stomach acid is HIGH Energy activity and why stress will trigger your GI symptom's to be worse when yout STRESS is High.

A Canadian research studied these same connections when it comes to healhty stomach acid and low Niacin levels....

I will cite the whole article because it will be instructive too you.....Students who were studying for their "Finals" developed more GI problems......just as the above researsch proved!.....first comes your stress then comes your heartburn....

Entitled "Is Vitamin B3 Dependency a Causal Factor in the Development of Hypochlorhydria and Achlorhydria?" aka Low or NO Stomach Acid and his answer was yes! it was.

http://orthomolecular.org/library/jom/2001/pdf/2001-v16n04-p225.pdf

Stress has also been shown to be a potential trigger for Long COVID Symptoms'....

https://medicalxpress.com/news/2022-11-severely-stressful-events-worsen-symptoms.html

Not suprisingly.....because Stressful events burn through our B-Vitamins!

B-Vitamins (and especially Magnesium) are critical for your body to produce energy.....and we need more B-Vitamins to help use manage/produce more energy when we are STRESSED OUT!

As I like to say everybody knows STRESS Kills us right.....but It MAIMS us first!

I wrote a blog post that might help you.

I hope this is helpful but it is not medial advice.

Good luck on your continued journey(s) in life and dont' let it (life) stress you out too much!

Take some B-Vitamins for your heartburn!

2 Timothy 2:7 "Consider what I say; and the Lord give thee understanding in all things.", this included.

Posterboy by the Grace of God,

To All,

A recent thread asked about this (What could be the cause of their Low Vitamin D levels) ..and the someone was taking Seroquil.....so that set off the researscher in me to see if the medicine they were taking could of been the cause of their low Vitamin D levels......and indeed it could!

As most know (on this forum) I have had my own bad reactions in the past from medicines I had been taking at the time......

Well it turns out.....recent medicine I begin to take again was also affecting my Vitamin D levels (I really shouldn't be surprised by now)......but somehow I still am...

@knitty kittyprobably can find you the original research on this topic......I haven't had the time lately.

But here is the article from Pharmacy times that talks about a whole class of drugs than can make someone low in Vitamin D.

https://www.pharmacytimes.com/view/drug-interactions-with-cyp3a4-an-update

It turns out my new BP medicine I had recently started does interfere with my (your) Vitamin D levels.

I had taken it in the past.....but it had begin to bother me after  a couple years (as most drugs do)......so I was cycling back to it.....because my other BP medicine I had been transferred too.....Ramipril was causing a "Chronic Cough" instead.....it did both as Linsopril and Ramipril.....so I was looking for shelter from Amlodopine.....(little did I know it.....I was going from the frying pain and into the fire again).....see below for more information about how it was affecting me)

So it was back on the Norvasc etc....

Sometimes you can't win for loosing....

I probably don't need it anyway.....but was just taking it for a maintenance medicine as  a precaution....

Turns out it caused me to feel a little "Glum" shortly after taking it.....it wasn't until I recently found out this connection between Norvasc aka Amlodopine Besylate could also be causing my low Vitamin D levels.....which I have struggled with before.....from time to time.....and you guessed it was when I was on Amlodopine but I didn't put 2+2 together until now.....

So I am back on the Vitamin D again......and my moods has perked up again already....

Medicine mugs us of our Vitamins!

I hope this is helpful but it is not medical advice.

Posterboy,

On 11/29/2022 at 9:55 AM, theOk said:

Thank you!

I take Emgality for migraines, Viibryd and Seroquil for mental health, Pantoprazole to slow down damage to my stomach. (New prescription) and promethazine or zofran for nausea. I also take a multivitamin and 5000 IU vitamin D daily. 

theOk,

Pantroprazole is a powerful acid blocker.....and could be leading to your low Vitamin D....and the need to supplement.

When we block our stomach acid it is not  uncommon to be low in our Minerals and our Fat Soluble Vitamins like Vitamin D.

I also suspect your Seroquil as a potential drug that could be interfering with you Vitamin D levels.

See this article about how Seorquil (along with many other medicines) can cause Low Vitamin D levels....

https://www.pharmacytimes.com/view/drug-interactions-with-cyp3a4-an-update

Also the use of PPI's are thought to be able to trigger Celiac disease.

I am not suprised you are still having horrible symptom's.....

By taking a B-Complex frequently you can help cut back on your need for you PPIs.....

I am trying to help my brother with the same issue now....

It is the PPI's that causing your horrible symtpom's to linger despite being gluten free all these years IMO.

HHMI debunked the idea of it is High Stomach that is the problem.....that leads to ulcers....almost 20 years ago.....

When all along it is low stomach acid instead.....causing most of your horible GI problems...but it is still a common trope  you hear when it comes to stomch issues.

https://www.hhmi.org/news/excessive-growth-bacteria-may-also-be-major-cause-stomach-ulcers

IN FACT, acid blockers will often make your GI symptom's worse as you are experincing....

It is called NERD instead of GERD....

Not suprisingly this was found to be true almost 10 years ago.....but PPIs are as popular as ever.

http://www.foxnews.com/health/2012/11/13/gerd-or-nerd-new-type-acid-reflux-doesnt-respond-to-drugs.html

I hope this is helpful but it is not medical advice.

Posterboy,

On 11/30/2022 at 12:42 AM, mwalum said:

I have had Celiac Disease for over 10 years with good tolerance.  However, this last year I developed Urtecia (horrible hives) that Zi have not been able to control even with Rx from allergist doctor.  Has anyone had success with any treatment?

Mwalum,

I haven't had time to respond until now.....

I am always doing research for one thing or another......and this topic has come up before...

So I have some information that might help you.

Urticaria commonly known as hives can be a sign of Low Vitamin D levels.

Here is some research that might help you.

Entitled "Relationship between vitamin D and chronic spontaneous urticaria: a systematic review"

https://ctajournal.biomedcentral.com/articles/10.1186/s13601-018-0234-7

Hives can be a sign of a thyroid disorder as well.

Cold Urticaria has been studied in Celiac disease.

Here is the research about it.

https://pubmed.ncbi.nlm.nih.gov/18447142/

See also this nice article about how Vitamin D treats Hives...

Entitled "UNMC study: Vitamin D provides relief for those with chronic hives"

https://www.unmc.edu/newsroom/2014/02/17/unmc-study-vitamin-d-provides-relief-for-those-with-chronic-hives-2/

You might also try taking a B-Complex, Magneisum (which is a Co-Factor for Vitamin D) and some Zinc which is an important immune regulator.

All the above play a role in how our immune system works and can help down regulate inflammation in the body.

I hope this is helpful but it is not medical advice.

2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the grace of God,

To All,

I saw this article this week and I thought it would be a fun article to share.

https://www.msn.com/en-us/health/wellness/farts-say-more-about-your-health-than-you-think-now-scientists-are-listening/ar-AA14Jova?ocid=msedgntp&cvid=8279994d703a47c28f5baecf62b56516

One of our regulars would often say...."A little farting never hurt anybody"......so I thought at least they would enjoy it...

I don't think the "Machine" they are creating actually existsts yet.....at least commercially anyway....

More a proof of concecpt idea.....but it seems to have some merit....at least according to the research reported in this article.

I hope this is helpful and maybe a little enteraining.....ha ha ha ha funny.....because we all need a good laugh from time to time!

Posterboy,

4 hours ago, Scott Adams said:

I also had H Pylori at the time of my diagnosis, and it was likely caused by the severe gut damage that I had at that time, although it's not exactly clear which came first, the H Pylori or celiac disease.

Scott Et Al,

Here is some research that might answer the "Chicken and Egg" issue....

Entitled "Helicobacter pylori infection in patients with celiac disease"

https://pubmed.ncbi.nlm.nih.gov/16780559/

Quoting

"Results: At baseline, 30 patients had H. pylori infection and 50 did not; at follow-up five new (H. Pylori) infections were detected"

This was over a 12 to 18 months timespan.....

Because Low Stomac Acid can be the trigger for H.Pylori the continued Low Stomach acid allowed more H. Pylor infections to occur as time went on...

See this research approx. 20 years ago that "Debunked" the commonly held belief that High Stomach Acid triggers Ulcers...

Entitled "Excessive Growth of Bacteria May Also Be Major Cause of Stomach Ulcers"

https://www.hhmi.org/news/excessive-growth-bacteria-may-also-be-major-cause-stomach-ulcers

going back to the other study on H.Pylor in Celiac disease entitled "Helicobacter pylori infection in patients with celiac disease"

quoting again...

"The higher prevalence of milder duodenal lesions in celiac disease patients with H. pylori infection suggests that lymphocytosis induced by H. pylori gastric infection becomes less obvious as profound inflammatory and structural changes alter the mucosal architecture. This study also provides further support for a pathogenetic relationship between celiac disease and lymphocytic gastritis."

Essentially saying to me....the Low stomach acid triggers the H. Pylori infection.....progressing to NCGS and finally your Celiac disease diagnosis......and in it's (the gastritis) later stages the progressive damage done by being low in stomach over a certain period time says 1 to 2 years progress to a NCGS and/or your Celiac disease diagnosis.

The Biderectional link between IBS, GERD etc and NCGS and/or Celiac disease has recently been established in the lastest research on this topic.....but it will take a few years to incorporate these latest findings into the latest models on Celiac disease.

I hope this is helpful but it is not medical advice.

2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the Grace of God,

Scott Et Al,

I alluded to this earlier......when drug companies started blocking the "natural action" of Niacin aka Nicotinic Acid to flush us.....it looses/limits some of the benefits people seek to get from taking Niacin in the first place.

Here is the summary of the findings...

https://www.nbcnews.com/health/health-news/niacin-doesnt-stop-heart-attacks-major-study-finds-flna1C9459707

It was called the "Thrive Study" and before it Niacin as the Patented Slow Release "Niaspan" form failed to lower heart risk......and since that time Niacin has been looked down on in the medical community.

It is because it blocks the natural healthy flushing of Niacin.....if you want the benefit of taking Niacin.....you will have to take the Nicotinic Acid form......and titrate it up....or take the Naturally flush free form of Niacinamide....

Here is a great overview artcle of why you want to "Invite the Flush" of Niacin.

https://life-enhancement.com/pages/why-the-niacin-flush-may-be-surprisingly-beneficial-to-your-health

This article explains how to tritrate up your levels of Naicin so the flushing is not too intense.....so you don't stop it before it does you any good....

http://getwellstaywellathome.com/blog/2015/06/seasonal-allergies-and-the-niacin-flush/

Once you know how healthy the flush is too you......then it is an easy thing to tolerate....and with each succeeding flush.......the flush is a little less intense each time.....until it just goes away naturally!

It happens like clockwork in higher does of Nicotonic Acid say 100mg to 200 mg etc... after 30 minutes you start the flush and after an hour (or so) depending on the original dosage amount.....the flush subsides....

IF it is not Niacinamide or the flushing kind of Niacin......you are not doing it right!

Essentially, NO Flush equals NO Benefit.....or at least the kind you are looking for by taking Niacin aka Vitamin B3 in the first place.

Note: Niacinamide because it does not flush you will not help your Cholesterol levels but the flushing Nicotinic Acid (NA) form will and that is why it helps your elevated Cholesterol levels......and is also, in part, why Non-Flushing Niacin does not help the way the naturally flushing kind will/does!

I hope this is helpful but it is not medical advice.

Posterboy by the grace of God,

P.S. Here is the full STRIVE Study if someone want to read it.....and note the effect of "NO Heart" Benefit was the from the Flush Free Form.....the exact same kind that you are taking now....

https://www.nejm.org/doi/full/10.1056/NEJMoa1300955

Rogol 72 and Knitty Kitty Et Al,

I saw the discussion about high Vitamin D......and how much is too much.

Chris Masterjohn is an experienced researcher and he says you should take Vitamin D and Vitamin K together to keep from getting Vitamin D toxicity from getting too much Vitamin D at one time.

Here is the summary article about this topic

Entitled "Is Vitamin D Safe? Still Depends on Vitamins A and K! Testimonials and a Human Study"

https://www.westonaprice.org/is-vitamin-d-safe-still-depends-on-vitamins-a-and-k-testimonials-and-a-human-study/#gsc.tab=0

Here is the pure research article about this topic.

Entitled "Vitamin D toxicity redefined: vitamin K and the molecular mechanism"

https://pubmed.ncbi.nlm.nih.gov/17145139/

I hope this is helpful but it is not medical advice.

Posterboy,

Scott and Knitty Kitty,

This backs up Knitty Kitty’s assertion about the attempt to patent NAD+ as a drug……taking it off the available supplement list…

It is a interesting read…..and shows how Vitamins and supplements compete with “Patentable Drugs” in the marketplace….

https://www.lifespan.io/news/fda-purges-nmn-from-the-list-of-supplements/

Entitled  "FDA Purges NMN From the List of Supplements: The rationale is that it is being investigated as a drug."

And probably why Nicotinamide Riboside (NR) is not widely available as a supplement anymore.....because it has been declared as a possible "Drug Candidate"......I always wondered why I couldn't find it anymore.....and this article explains why?

Note: both the NR and NMN forms are precursors of NAD+ and open for "Patenting" as drugs but Niaciamide or Niacin is not because they are actually different forms of Vitamin B3 itself aka Nicotinic Acid in its flushing form or Niacinamide in the naturally flush free form!.....so they invented a "patentable" drug form called Niaspan which had "Side Effects" not caused by the "Natural Form" of Niacin......and too this day the Naturual form of Niacin is confused for the Synthetic from which cause side efffects...

They have KNOWN about this affect for 10 years now.....and drug companies are still trying to go around the natural healthy form of Niacin.......and they almost always  have to deal with the side effects from not using the natural, healthy forms of Vitamin B3.

Entitled "New study cautions use of drugs to block 'niacin flush'"

https://medicalxpress.com/news/2012-04-cautions-drugs-block-niacin-flush.html

Interestingly Vitamins can’t be patented as Knitty Kitty noted but their precursors can etc…. NMN and NR are precursor for NAD+ etc….

Lucky natural NAD+ precursor are available in foods and no supplements are needed to boost NAD+ levels….

Quoting from the article…

“NAD+ levels can be boosted via its precursors, which include nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). NMN-containing supplements have been gaining popularity in the longevity community, even though not everyone agrees on their effectiveness or safety. NMN naturally occurs in foods such as edamame, broccoli, cabbage, cucumber, and avocado.”

I still remember this same kind of  "Brough Ha Ha" over Red Rice yeast back in the day.....it too was asked to be banned as a supplement because it had a patentable natural form of Statins.....

And the drug companies didn't want the competiton!

I hope this is helpful.

Posterboy,

Scott,

My nephew actually showed/shared with me this research recently.

Here is a couple links that will explaing the difference between Niaicinamide and Niacinamide Riboside aka NR.

Form matters......and Niacinamide Riboside is not commonly available because of it's high price.....IN FACT it can't be found on the Vitamin Shoppe's website to even order......they are conflating one supplement (form) with the other....and transferring the potentinally harmful altered form to the natural Vitamin healing form of Vitamin B3.....because it does indeed unaturally promote cell NAD+ levels....which the cancer cells use to grow.....Niacin and/or Niacinamide by themselves do not do that....

https://www.thorne.com/take-5-daily/article/meet-the-vitamin-b3-family-nr-nmn-niacin-explained

See their chart (I couldn't copy it over)......Niacinamide does not promote NAD+ the substance that promotes the cancer link the way the Niacinamide Riboside aka NR form does.

See also this link

https://htfd6.org/is-niacinamide-the-same-as-nicotinamide-riboside/

That explains the difference between the two forms.....quoting

"What is the difference between niacinamide and nicotinamide riboside?

The way that your body converts dietary vitamin B into NAD makes all the difference. Nicotinamide, also known as niacinamide, is an amide of nicotinic acid, which is commonly known as niacin. Nicotinamide riboside (NR), on the other hand, is a chemically altered form of nicotinamide that has unique attributes." that promotes the cancer link connection found in the latest research.....

The non NAD+ promoting form of Niacin and/or Niacinamide alone can actually help promote Cancer healing!

See this recent research that bears this out....

Entitled "Study: Niacin may help immune system battle a deadly brain tumor"

quoting from this article where Niacin actually tripled survival rates in brain tumors...

"The results published in Science Translational Medicine found the lifespan of mice with glioblastoma that received combination therapy tripled, increasing to 150 days from 40 days."

IN FACT after studying over 1,000 plus subtances they found Vitamin B3 promoted cancer survival better than any other substance screened.

Quoting again...

"We were able to help immune cells do what they're supposed to do, attack and kill cancer cells," says Dr. Susobhan Sarkar, Ph.D., first author on the study. "We screened 1,040 compounds and found niacin had the properties needed to activate immune cells, specifically myeloid cells, and inhibit the growth of brain tumor initiating stem cells."

The NAD+ stimulating affects of NR is the problem and not the natural Niacin or Niacianmide form....

IN FACT the Niacin therapy alone was able to extend life of the most dangerous brain cancers!

quoting again...

"In the study, the researchers found that niacin therapy alone extended survival and that the combination therapy with temozolomide (a chemotherapy drug commonly used against glioblastoma) markedly prolonged survival by stimulating and re-educating immune cells to stop helping the cancer and instead, destroy it."

Wrong form......wrong results.....in the right (Natural) forms you have wonderful, healthy, healing results!

I hope this is helpful but it is not medical advice.

Posterboy by the grace of God,