Egd Without Sedative? in Celiac Disease Pre-Diagnosis, Testing & Symptoms Posted July 24, 2007 · Report to Admin I had a friend that had it done without sedation and had a terrible time of it. No way would I even attempt it. I just had one the other day - totally knocked out, along with a flex sig and don't remember a thing, thank God. I didn't even feel that groggy afterwards, although I was very weak from not having eaten in over 24 hours. I didn't experience any throat pain or irritation either.