Feeling Good On Gluten? in Celiac Disease Pre-Diagnosis, Testing & Symptoms Posted July 6, 2014 · Report to Admin "Leaky gut " when mentioned in terms of celiac disease and autoimmunity is not at all "nonscientific". Have you read anything by Dr. Alessio Fasano? Here are just two of many pub med articles. http://www.ncbi.nlm.nih.gov/pubmed/22109896 http://www.ncbi.nlm.nih.gov/pubmed/21248165 An hypothesis is defined as "an idea or theory that is not proven but leads to further study or discussion". Not sure why you are arguing the meaning of these two words, but I am still sticking with the leading celiac researchers who say there is no scientific evidence that gluten is additive (like a drug) in humans. Evidence of the effects of opioids on rat brain tissue does not seem to support "gluten acts like an opioid " and causes "gluten addiction." Thanks for the links. I have seen various definitions and descriptions of the term leaky gut depending on the context in which it is being discussed, some of them based on solid science, others wild conjecture, which is why it is a term that I try to avoid using simply to avoid muddying an issue. In science, the term hypothesis means an educated guess based on observation. The term theory means a hypotheses that is supported with scientific tests and is valid as long as there is no evidence to dispute it. As far as I know, there are studies that show that opiod peptides are addictive while there aren't any that prove they are not. Again, I'm not disputing that gluten is not addictive in the same way as heroin. This would be such a leap that it isn't even one that I would presume anyone would make which is why I didn't clarify more carefully in my original comment. I didn't realize that I was stepping on such a landmine that would get so many people's feathers ruffled. But none of the links you shared said that gluten was not addictive or that opiod peptides weren't the cause of the addiction. One said that there wasn't enough study to fully understand, another said that the opiod peptides looked like likely culprits. So we aren't in disagreement. I'm also aware that many of the claims made in the book Wheat Belly don't hold up to scientific review, which is why I chose not to read it.