Biopsy Results in Celiac Disease Pre-Diagnosis, Testing & Symptoms Posted April 16, 2015 · Report to Admin I just wanted some other opinions about some testing I have had done, about a year ago I had blood tests which showed low IgA but positive IgG for celiac, I then had a biopsy which was negative but I went on the gluten free diet anyways (after all testing was complete). About 6 months after going gluten free I had to follow up with a hematologist about the low IgA and elevated IgG. After 6 months gluten fee and follow up blood tests my IgG had returned to normal, but my IgA was still very low and he diagnosed me with IgA deficiency. I have been gluten free for about 8 months now and I feel amazing, much better than I have felt in years, no diarrhea, no headaches, I am significantly less fatigued, i used to nap every day and now I almost never need a nap, I am no longer losing weight and I have not had GERD since changing my diet, which was a weekly occurrence before. So basically the blood tests were positive for celiac, and from my understanding IgA deficiency is far more common in those with celiac than those without, and I have definitely responded well to the diet, the only thing that was negative was the biopsy. Is it possible that the Biopsy was a false negative? Has anyone here been diagnosed despite a negative biopsy, or is this just a gluten sensitivity? My gastro seems convinced it is not celiac and called it IBS and said that the IgA deficiency could be a root cause of food sensitivities. Thank you all for your input and advice!