knitty kitty

@normagain,

There's a difference between Small Intestinal Bacterial Overgrowth (SIBO) and Candidiasis (Yeast Infection).  It's possible to have one or the other or both.  Celiac Disease causes damage to the small intestine.  The SIBO occurs because the bacteria take advantage of this damage to move in and multiply.  Same with Candida.  

SIBO is treated with antibiotics, while Candida is treated with antifungal agents.  Both are found in people with diets high in carbohydrates.  Both bacteria and yeast feed on carbohydrates in the intestines.  Yes, the microbiome does communicate with the brain, frequently demanding more carbohydrates be sent down to them.  

People consuming a high carbohydrate diet need extra Thiamine Vitamin B1 to process the carbohydrates into energy for the body to function.  High Calorie Malnutrition is caused by this overconsumption of carbohydrates without sufficient thiamine to process them.

Adopting a no carbohydrate diet for several weeks (not forever) can help in starving out and eradicating these organisms.  Carbohydrates can be reintroduced into the diet after the SIBO and Candida have been eliminated. 

Thiamine influences the bacteria that grow in the intestines, encouraging beneficial bacteria over SIBO bacteria. 

Thiamine is beneficial in Diabetes as most diabetics are low in Thiamine.  We lose more Thiamine through the kidneys.  

Riboflavin has been shown to eradicate Candida.  

Supplementing with vitamins helps boost our ability to absorb these essential vitamins.  

Talk to your doctors about supplementing vitamins and minerals.  

Best wishes!

References:

Small intestinal bacterial overgrowth among patients with celiac disease unresponsive to a gluten free diet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759221/

Dietary Vitamin B1 Intake Influences Gut Microbial Community and the Consequent Production of Short-Chain Fatty Acids

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147846/

Riboflavin Targets the Cellular Metabolic and Ribosomal Pathways of Candida albicans In Vitro and Exhibits Efficacy against Oropharyngeal Candidiasis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927497/

Hiding in Plain Sight: Modern Thiamine Deficiency

Dr. Chandler Marrs and Dr. Derrick Lonsdale

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/

Thiamine deficiency disorders: a clinical perspective

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451766/

Thiamine Level in Type I and Type II Diabetes Mellitus Patients: A Comparative Study Focusing on Hematological and Biochemical Evaluations

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282352/

Communication of gut microbiota and brain via immune and neuroendocrine signaling

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907780/

@Ginger38, 

Have you had a DNA test for Celiac genes?  You don't have to eat gluten with a DNA test.  

Yes, the antibodies cause damage to the intestines, and the brain, and every other organ and tissues in the body.  

Anti-transglutaminase antibodies (anti tTg IgA on blood tests) are antibodies that attack transglutaminase, a building component in the cell membranes of every cell in the body.  

The gluten may pass, but the antibodies are what can stay circulating for months.  

Some gluten containing products can contain more gluten that stimulates higher antibody production than other products.  Chewy breads with those big bubbles have more gluten than a cookie that's crumbly and not chewy like pizza dough.  Vital wheat gluten added to a product can provoke a more extreme antibody response than a product without.  

With the higher doses of gluten in the updated challenge guidelines, you don't have to stay on the gluten challenge for months.  Sufficient changes for antibodies were seen in TWO Weeks.  

No, you can't add it up that way.  

Gluten stimulates anti gluten antibodies to be made.  Those antibodies are what become cumulative.  Ten grams a day for several weeks, gets those antibodies produced in the small intestine to a level where those antibodies get into the bloodstream in a high enough level that they are measurable in the bloodstream.  

Gluten itself mostly stays in the digestive tract and is removed with bowel movements.  However, if one has leaky gut syndrome, gluten can travel to other places.  For example, joint inflammation and pain can be caused by gluten congregating in joints.  That's why it's important to heal the digestive tract so it doesn't leak.  The AIP diet and Benfotiamine are beneficial in this respect.

On average, a slice of bread contains about 2 grams of gluten.  Three grams of gluten is enough to make you feel unwell, but TEN grams of gluten gets the anti gluten antibodies into the bloodstream at a high enough level where they can be measured for blood tests for Celiac Disease and to produce noticeable damage in the small intestine.

Different breeds of wheat contain different amounts of gluten depending on breed and growing conditions.  Manufacturers blend different wheats together to get the amount of gluten required to make their products.  

The addition of vital wheat gluten to different types of bread also affects the total amount of gluten in a product.  

Can an Increase in Celiac Disease Be Attributed to an Increase in the Gluten Content of Wheat as a Consequence of Wheat Breeding?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573730/

Not that I know of, unfortunately.  

According to this recent research, updates to the gluten challenge are being implemented.

Recommended intake of gluten should be increased to 10 grams of gluten per day for at least two weeks. Or longer.

While three grams of gluten will begin the immune response, ten grams of gluten is needed to get antibody levels up to where they can be measured in antibody tests and changes can be seen in the small intestine.  

Keep in mind that there are different amounts of gluten in different kinds of bread and gluten containing foods.  Pizza crust and breads that are thick and chewy contain more gluten than things like cake and cookies.  

References:

https://www.beyondceliac.org/celiac-disease/the-gluten-challenge/

And...

Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878429/?report=reader

 "In our study, limited changes in Vh:celiac disease (villi height vs crypt depth - aka damage to the small intestine)  following 14-day challenge with 3 g of gluten were observed, in accordance with Sarna et al.  While the 3 g dose was sufficient to initiate an immune response, as detected by several biomarkers such as IL-2, the 10 g dose was required for enteropathy within the study time frame. Based on our data, we would suggest that gluten challenge should be conducted over longer durations and/or using doses of gluten of ≥ 3 g/day to ensure sufficient histological change can be induced."
Keep us posted on your progress!

@Dawn Meyers,

Thiamine has anti-cancer properties.

High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963161/

B12 is only one of the B vitamins.  

You need all eight:

Thiamine B1, Riboflavin B 2, Niacin B3, Pantothetic Acid B5, Pyridoxine B6, Biotin B7, Folate B 9, Cobalamine B12

B Complex contains all EIGHT of the B vitamins.  

White vinegar is made from grain alcohol.  Try Apple Cider Vinegar instead.  It will clean just as well.

@Dawn Meyers,

You would do much better if you took a B Complex that contains all Eight essential B vitamins.  Just taking B12 Cobalamine and Folate can cause a Pyridoxine B6 deficiency.  Pyridoxine deficiency causes Peripheral Neuropathy.  Pyridoxine is one of the vitamins that is notoriously low in celiac disease.  

Try Benfotiamine in addition to the B Complex.  Thiamine interacts with every single B vitamin.  

What kind of vinegar are you using? 

@Dawn Meyers,

Have you tried the Autoimmune Protocol Diet?  It's a Paleo Diet that cuts out processed gluten free foods, grains, legumes, nightshades, dairy, eggs and nuts.   After the digestive system calms down (about three weeks) add in one food at a time to see if symptoms reappear.  It really helped me.  

Also, get your Vitamin D level checked.  Vitamin D helps reduce inflammation.  People with psoriasis have lower Vitamin D levels than people without.

Supplementing with a B Complex and extra Thiamine in the form Benfotiamine helps, too.  Several of the B vitamins (Thiamine, Niacin, Pyridoxine, Cobalamine) can cause peripheral neuropathy which can feel like itching.  Niacin will help Dermatitis Herpetiformis.  Thiamine deficiency can cause diarrhea and nausea.  Niacin deficiency can cause diarrhea and skin rashes.

Have you been checked for nutritional deficiencies?

Have you checked any medications for Gluten?  Gluten is frequently used as a filler in many medications.  Check soaps, shampoos, etc., and pet foods for gluten.

@Rebecca Clayton,

You can click on the links and open and save the studies on your device or print them out.

@Rebecca Clayton, 

I know that doctors frequently overlook nutritional deficiencies as a cause of health problems.  

It's important to get high doses of Thiamine and the other B vitamins.  I've found some research showing several other B vitamins as well as Thiamine help with clotting.  High dose Thiamine was used in Covid patients to stop lung clots.

Association between B-group vitamins and venous thrombosis: systematic review and meta-analysis of epidemiological studies

https://pubmed.ncbi.nlm.nih.gov/22743781/

Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study

"Thiamine use as adjunctive therapy may have potential survival benefits in critically ill patients with COVID-19. Additionally, it was associated with a lower incidence of thrombosis."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242279/

Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265973/

The importance of thiamine (vitamin B1) in humans

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568373/

The influence of B-complex vitamins upon the prolongation of prothrombin time by acetaldehyde

https://pubmed.ncbi.nlm.nih.gov/23406661/

Are you following a low histamine Paleo diet to reduce inflammation and histamine levels?  How are your Vitamin D levels?  Vitamin D helps regulate and lower inflammation.

Since malabsorption and nutritional deficiencies can be so subtle and easily overlooked, supplementation to boost absorption is important.

1 hour ago, Rebecca Clayton said:

If this EATL is Lymphoma (?) then I understand that those with TYPE 2 REFRACTORY CELIAC DISEASE are at most risk. RCD is rare AND TYPE 2 is even more rare.

I was diagnosed with TYPE 1 RCD at one of only two hospitals in the UK that can do this test. (by biopsies from the duodenum and possibly bloods?!)

Have you been checked for nutritional deficiencies?  Are you currently supplementing with vitamins and minerals?

Some cancers and other illnesses occur because of nutritional deficiencies.

High dose Thiamine has been shown to be beneficial in fighting cancer.

References:

Small and Large Intestine (I): Malabsorption of Nutrients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070135/

And

High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963161/

Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet

https://pubmed.ncbi.nlm.nih.gov/19154566/

Vitamin and Mineral Deficiencies Are Highly Prevalent in Newly Diagnosed Celiac Disease Patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820055/

@Leann horne,

Flax contain Lectins.  Flax are seeds from flax plants.  

Tapioca is made from cassava, also high in Lectins.  Cassava and tapioca also contain thiaminase, an enzyme that destroys Thiamine Vitamin B1 making it unusable to the body.  

Are you boosting your intestines' ability to absorb essential nutrients?  Supplementing the essential B vitamins, Vitamin D and minerals like magnesium is very important as malabsorption and malnutrition occur due to the damage Celiac Disease does to the lining of the intestines.  

Yes, nightshades include tomatoes, potatoes, eggplant and peppers.  All contain Lectins.  

Nightshades also contain glycoalkaloids which promote zonulin production in the gut.  Zonulin promotes "leaky gut syndrome" allowing particles of incompletely digested food to pass into our blood stream causing inflammation in joints, muscles, nerves, and organs.  

@Leann horne,

Plants contain Lectins.  Lectins are proteins that bind carbohydrates together.  Lectins are concentrated in the seeds of plants.  Gluten is a lectin in wheat.  Zein is the lectin in corn (maize).  There are lectins in rice, and other edible grains and seeds.  Legumes (beans) and pulses contain lectins.  Nuts are high in lectins.  There are other plants like tomatoes and potatoes that contain high levels of lectins.  

Lectins cause inflammation in the digestive tract.  Lectins promote inflammation and can trigger the autoimmune response in Celiac Disease.  Lectins can promote irritation in the lining of the gastrointestinal tract, contributing to the development of colonic polyps.

Following a Paleo diet which excludes grains, seeds, nuts, pulses and legumes is beneficial.  Removing Lectins from the diet helps lower inflammation and allows for healing.  

Increasing the availability of vitamins and minerals for absorption by supplementation will help heal our bodies.  

Blood samples are collected in metal tubes when there's a suspicion of a seriously contagious blood borne pathogen like syphilis (in which during the later stages one goes crazy).  Happened to me, too.  Negative on my test result.  I was severely deficient in nutrients like the B vitamins (needed to heal and repair our bodies), Vitamin D (calms and regulates the immune system), and minerals like magnesium and potassium (also help heal and repair our bodies).  Vitamin deficiencies are not on most doctors' radar.  

Hope you choose a low lectin Paleo diet and supplementation of vitamins and minerals.  Talk to your doctor and nutritionist.  

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115436/

https://pubmed.ncbi.nlm.nih.gov/25599185/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036108/

https://pubmed.ncbi.nlm.nih.gov/28087670/

@Leann horne,

Welcome to the forum.  

I agree with @Wheatwacked.  Your fainting after rice sounds like a deficiency in Thiamine.  

Thiamine is needed to turn carbohydrates into energy for our bodies.  A sudden influx of simple carbohydrates like rice can cause a big demand for Thiamine.  If we don't have sufficient Thiamine, the body starts shutting down different functions in order to conserve what little Thiamine there is.  With a greater demand for Thiamine in the digestive system, other "operating systems" (like consciousness) get turned off temporarily, hence fainting.

Keep in mind that while gluten containing products are required to be enriched with vitamins like thiamine, gluten free products, like alternative grains, aren't required to be enriched.  So the gluten free diet for Celiac Disease can be deficient in essential nutrients.  

Adding to the fact that the gluten free diet can be low in essential nutrients, malabsorption due to the inflammation and damage caused by Celiac Disease compounds the problem of nutritional deficiencies.  

A subclinical Thiamine insufficiency can drag on for years.  Symptoms may mysteriously wax and wane. A twenty percent increase in dietary thiamine results in an eighty percent increase in brain function, which results in an improvement of symptoms.  

Continued Thiamine insufficiency can result in Gastrointestinal Beriberi, with symptoms that resemble "being glutened".  

High doses of Thiamine (500 mg - 1500 mg per day) are needed to correct the insufficiency.  Benfotiamine is a form of Thiamine that is beneficial in healing the digestive system.  Thiamine needs all the rest of the B vitamins and magnesium to work properly, so a B Complex, Benfotiamine and Magnesium Glycinate should be taken together.  Vitamin D and zinc also helps regulate and calm the immune system.  It's very important to supplement essential nutrients in order to boost our ability to absorb them and heal.  

Dr. Derrick Lonsdale and Dr. Chandler Marrs have studied how Thiamine deficiency is frequently overlooked.  Here's an article from their site.  

https://www.hormonesmatter.com/tag/syncope-thiamine/

Thiamine deficiency has been shown to be a factor in the development of cancer.  Sorry for your loss.  I've lost family members to cancer, too.  

Do talk to a nutritionist and your doctor about supplementing with vitamins and minerals.  Although blood tests are not accurate measurements of vitamin deficiencies, taking B vitamins are beneficial.  

Hope this helps you find peace.

@Bluesybirdie,

So sorry to hear of your sad experience with fireworks. 

Fireworks also contain some irritating chemicals that can have deleterious effects on health.  

Fireworks release Sulfites and Sulfites, as well as Nitrous Oxide.  Sulfites can destroy Thiamine and cause allergic reactions, including swollen eyes, respiratory problems, and rashes.  I have Hypersensitivity Type Four reactions to Sulfites in the air and in foods.  Nitrous Oxide binds irrevocably with Cobalamine Vitamin B12, causing metabolic problems, high histamine levels, and hives. 

It may be the exposure reduced these important vitamins and your Celiac symptoms worsened without these important vitamins needed to keep us in good health.  Have you been checked for nutritional deficiencies?  Hope this helps.

References:

Emission factors and exposures from ground-level pyrotechnics

https://www.sciencedirect.com/science/article/abs/pii/S1352231010004310

Do talk to your doctors about nutritional deficiencies that can cause all sorts of skin manifestations.

Make notes of when your rash gets worse...after eating certain foods?....after being out in sunshine?

Cutaneous signs of nutritional disorders

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721081/

And...

Infectious dermatoses that can manifest as vesicles

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781845/

Welcome to the forum, @Alkins!

Tryptophan is  derived from Niacin Vitamin B 3.  Our bodies can make tryptophan from Niacin, but supplementing with Tryptophan for better sleep is a good idea.  

Thiamine Vitamin B 1 helps with energy levels if you are feeling tired.  Along with magnesium and the other B vitamins, Thiamine can improve your energy levels.  

It highlights the impaired judgment of vitamin deficiencies that can occur in Celiac Disease.   

Be aware blood levels do not accurately reflect the level of vitamins being stored and utilized inside cells and tissues.  The vitamins inside cells can be depleted while blood levels show "normal" levels.  These are confiscated to keep the brain and heart supplied, while other organs do without.

Blood levels can reflect how much of the vitamin you've consumed in the previous day or two.  

Do Not start supplementing before you have your blood drawn for your vitamin assay.  Supplementing before testing will reflect the supplements ingested.

After testing and talking to your doctor, supplement with B Complex vitamins and look for health improvement.  If not needed, water soluble B vitamins are easily excreted in urine.  

Best wishes.

Cardiac arrhythmia can be a symptom of Thiamine deficiency.  IBS symptoms overlap with Gastrointestinal Beriberi in Thiamine deficiency.  

Benfotiamine, a form of Thiamine, has been studied and shown to promote healing in the gastrointestinal tract.  

Thiamine is one of eight water soluble B Complex vitamins.  We need all eight to live and heal.  Our bodies cannot store B vitamins for long and with damaged villi from Celiac Disease causing malabsorption, it's beneficial to supplement these B vitamins, especially Thiamine, after diagnosis.