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Found 1,859 results

  1. Hello. My youngest daughter (8 y/o) was recently diagnosed with Celiac Disease, thorough labs and biopsies. It was suggested that our who family be tested and so I immediately began that process. My middle daughter (15 y/o) labs came in with a positive IGA of 13 but the transgluten was negative. What could this mean? My middle daughter is being referred to the pros GI specialist that my youngest goes to but her pediatric doctor is running a great deal more labs to look into other autoimmune disorders as well. I am being told, regardless of the negative portion that she does have Celiacs and obviously they'll need to confirm with biopsies, but both the labs and the pediatrician say its celiac...Can anyone clarify this more for me because I can't seem to find the correct search online to find the answers that I am looking for and my anxiety is through the roof right now! TIA
  2. Celiac.com 09/01/2018 - Celiac disease is a common disease triggered by gliadin exposure in genetically sensitive individuals. It has long been known that untreated celiac disease is associated with intestinal malabsorption, but it is also associated with ongoing inflammation. This inflammation may have adverse effects on the uptake of important nutrients. This is probably the underlying reason for the increased risk of osteoporosis demonstrated in patients with celiac disease. Malabsorption and ongoing inflammation in untreated celiac disease could also potentially have a negative effect on fetal development. Several reports have indicated an adverse effect of untreated celiac disease on pregnancy outcome. We set out to use the national registers of Sweden to: Evaluate the association of untreated celiac disease and birth weight, pregnancy duration and intrauterine growth. Evaluate the same association in treated celiac disease. Compare the risk of the above two groups with a reference group of 2.8 million births to mothers who never had a diagnosis of celiac disease. A fourth objective was to evaluate placental weight to see if lower placental weight was more frequent in women with celiac disease. We found that untreated celiac disease (women diagnosed after pregnancy, but most likely having untreated celiac disease at time of pregnancy) was associated with a two-fold risk of low birth weight, pre-term birth, intrauterine growth retardation and cesarean section. The low birth weight and intrauterine growth retardation may have been mediated through malabsorption, since placental weight was lowest in women with untreated celiac disease. This study was published in Gastroenterology Aug 2005. A link to this paper can be found here: gastrojournal.org After that we set out to evaluate the association between adverse pregnancy outcome in males with untreated and treated celiac disease. In a previous paper, we had found an increased risk of adverse pregnancy outcome when the father had celiac disease (Ludvigsson et al, Gut, 2001). Now, taking advantage of the large Swedish national registers (all births since 1973 and onwards are recorded), we found no increased risk of low birth weight, pre-term birth or cesarean section in infants to fathers with untreated or treated celiac disease. This study was published in the Scandinavian Journal of Gastroenterology in Feb 2006.
  3. Celiac.com 07/19/2018 - Maintaining a gluten-free diet can be an on-going challenge, especially when you factor in all the hidden or obscure gluten that can trip you up. In many cases, foods that are naturally gluten-free end up contain added gluten. Sometimes this can slip by us, and that when the suffering begins. To avoid suffering needlessly, be sure to keep a sharp eye on labels, and beware of added or hidden gluten, even in food labeled gluten-free. Use Celiac.com's SAFE Gluten-Free Food List and UNSAFE Gluten-free Food List as a guide. Also, beware of these common mistakes that can ruin your gluten-free diet. Watch out for: Watch out for naturally gluten-free foods like rice and soy, that use gluten-based ingredients in processing. For example, many rice and soy beverages are made using barley enzymes, which can cause immune reactions in people with celiac disease. Be careful of bad advice from food store employees, who may be misinformed themselves. For example, many folks mistakenly believe that wheat-based grains like spelt or kamut are safe for celiacs. Be careful when taking advice. Beware of cross-contamination between food store bins selling raw flours and grains, often via the food scoops. Be careful to avoid wheat-bread crumbs in butter, jams, toaster, counter surface, etc. Watch out for hidden gluten in prescription drugs. Ask your pharmacist for help about anything you’re not sure about, or suspect might contain unwanted gluten. Watch out for hidden gluten in lotions, conditioners, shampoos, deodorants, creams and cosmetics, (primarily for those with dermatitis herpetaformis). If your child has celiac disease be sure to avoid Play-Doh because it contains wheat flour. Be careful about hidden gluten in toothpaste, lipstick and mouthwash. Be careful about common cereal ingredients, such as malt flavoring, or other non-gluten-free ingredient. Be extra careful when considering packaged mixes and sauces, including soy sauce, fish sauce, catsup, mustard, mayonnaise, etc., as many of these can contain wheat or wheat by-product in their manufacture. Be especially careful about gravy mixes, packets & canned soups. Even some brands of rice paper can contain gluten, so be careful. Lastly, watch out for foods like ice cream and yogurt, which are often gluten-free, but can also often contain added ingredients that can make them unsuitable for anyone on a gluten-free diet. Eating Out? If you eat out, consider that many restaurants use a shared grill or shared cooking oil for regular and gluten-free foods, so be careful. Also, watch for flour in otherwise gluten-free spices, as per above. Ask questions, and stay vigilant.
  4. Celiac.com 08/22/2018 - There’s been some data to support the idea that local pharmacists might have an important role to play in helping people with celiac disease to remain gluten-free by providing information about possible gluten in drugs, and even liaising with manufacturers for gluten information on the patient’s behalf, as needed. But how solid is your local pharmacist when it comes to celiac disease awareness? A team of researchers recently set out to evaluate pharmacists' knowledge of celiac disease, and to look for areas where further information may be beneficial. The research team included Carmela Avena-Woods, PharmD, BS Pharm; Robert A. Mangione, EdD; and Wenchen Kenneth Wu, PhD, MBA. They are all with St. John's University in Queens, New York. To gather data for their evaluation, their team sent a survey to community pharmacists who practice in a national chain pharmacy in one region of New Jersey and New York. A total of 418 pharmacists, just under 40%, responded to the survey. Sixty percent of the responses correctly noted that there are currently no federal regulations requiring manufacturers to designate medications as gluten-free. Still, forty percent got that wrong. Perhaps most alarmingly, of the pharmacists who claimed a basic or advanced understanding of celiac disease, only 27% correctly indicated that celiac disease is both an autoimmune and a chronic lifelong disease. Interestingly, twenty percent of pharmacists said they often suggested a change of diet to people with suspected celiac disease before a clinical diagnosis was made. This study suggests that community pharmacists have some understanding of celiac disease, but that additional celiac education is advisable if they are to play an integral role in helping people with celiac disease to maintain a gluten-free diet. Read more at: Am J Pharm Educ. 2018;82(2)
  5. Celiac.com 08/28/2018 - There have been a number of studies that tried to estimate risk levels for celiac disease in patients with osteoporosis, but the data has been highly variable and inconclusive. To address this, a team of researchers recently set out to investigate rates of celiac disease among individuals with osteoporosis. The research team included M. Laszkowska, S. Mahadev, J. Sundström, B. Lebwohl, P. H. R. Green, K. Michaelsson, and J. F. Ludvigsson. They are variously affiliated with the Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York, NY, USA, the Department of Medical Sciences, Uppsala Clinical Research Center, Uppsala University in Uppsala, Sweden, the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet in Stockholm, Sweden, the Department of Paediatrics, Örebro University Hospital in Örebro, Sweden, and with the Division of Epidemiology and Public Health, School of Medicine, University of Nottingham in Nottingham, UK. The team conducted a systematic review of articles that appeared in PubMed, Medline or EMBASE through May 2017 to find studies on rates of celiac disease in patients with osteoporosis. Search terms included “coeliac disease” combined with “fractures”, “bone disease”, “bone density”, “densitometry”, “osteoporos*”, “osteomal*”, “osteodys” or “dexa” or “dxa” or “skelet”. Non‐English papers with English‐language abstracts were included. To confirm their data, the team used fixed‐effects inverse variance‐weighted models, and tested heterogeneity through both subgroup analysis and meta‐regression. They found a total of eight relevant studies, containing data from 3,188 people with osteoporosis. From this group, the team found 59 individuals, or just under 2%, with celiac disease. A weighted pooled analysis showed biopsy‐confirmed celiac disease in 1.6% of osteoporosis patients. The team found moderate heterogeneity (I2 = 40.1%), which was influenced by the underlying celiac disease rates in the general population. After adding four studies covering a total of 814 people with celiac disease, based on positive tissue transglutaminase or endomysial antibodies, the pooled rate was comparable (1.6%; 95% CI = 1.2%‐2.0%). About 1.6% of people with osteoporosis have biopsy‐verified celiac disease. That’s about the same rate as the general population. Based on this data, the team sees no need to routinely screen osteoporosis patients for celiac disease, contrary to current guidelines. They suggest additional studies to assess the benefits and desirability of such screening programs. So, it looks like there’s no reason for people with osteoporosis, or their doctors, to be concerned about celiac disease unless patients shows some physical symptoms or signs. Read more in: Alimentary Pharmacology & Therapeutics
  6. 08/21/2018 - Does celiac disease have any kind of adverse effect on ovarian reserve levels in women of reproductive age? To get an answer, a team of researchers recently conducted a study of ovarian reserve in patients of reproductive age with celiac disease using anti-Müllerian hormone (AMH) levels, antral follicle counts (AFCs), and ovarian volume. The research team included Erol Cakmak, Savas Karakus, Ozlem Demirpence, and Banu Demet Coskun. They are variously affiliated with the Department of Gastroenterology, the Department of Obstetrics and Gynecology, the Department of Biochemistry, Cumhuriyet University Faculty of Medicine, Sivas, Turkey, and with the Department of Gastroenterology, Kayseri Training and Research Hospital in Kayseri, Turkey. For this study, their team included 46 female celiac patients and 40 healthy female subjects of reproductive age, 18–45 years of age. The team drew blood samples from both groups on days 2–4 of the menstrual cycle, and measured follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), and AMH levels. On the same day, the team measured AFCs and ovarian volume for each patient. They also recorded patient body mass index (BMI), gravidity/parity/abortions/alive counts, disease duration, and Marsh histological classification. The results showed no statistically significant differences between celiac disease patients and control groups in terms of mean age, BMI, or median gravidity/parity/abortions/alive counts. Also, there were no statistically significant differences between the groups in terms of average FSH, LH, E2, PRL levels, right and left ovarian volumes, and median right and left ovarian AFCs. The team found AMH levels to be markedly lower in the celiac group. The Spearman correlation test showed no significant connection between AMH levels and age, BMI, FSH, LH, E2, PRL levels, right and left ovarian volumes, right and left ovarian AFCs, or Marsh histological classification. However, the team did find that, compared to healthy controls, female celiac patients of reproductive age showed decreased AMH levels and ovarian reserves that reflected the length of celiac duration; the longer the celiac disease, the greater the decrease. It appears that, especially over time, celiac disease can reduce ovarian reserves, which could have an adverse affect on fertility. Read more at: Med Sci Monit. 2018; 24: 1152–1157.
  7. Celiac.com 08/23/2018 - With the market for gluten-free goods and ingredients going like gang-busters, the proliferation of new flours made from previously unavailable ingredients is helping to change the product manufacturing landscape and to open up whole new avenues of nutrition, health benefits and flavor for people with celiac disease. One of the latest gluten-free flours to hit the market is banana flour, an alternative to wheat flour that has gained popularity for its light, fluffy baking results. Made of 100% dried, ground green bananas, banana flour is not only gluten-free but also paleo, Whole30-approved, and vegan. Highly nutritious banana flour also touts numerous health benefits. In addition to being naturally gluten-free, banana flour is similar in calories to regular white flour, but is made from a completely different type of carbohydrate. While white flour is made from simple starches that are quickly absorbed and turned into energy, banana flour contains high levels of what is called “resistant starch.” Resistant starches are so-called, because they work a bit like soluble fiber, slowing the digestion of carbohydrates, and resisting absorption by the gut. Resistant starches are also found in foods such as whole grains, vegetables, and legumes. “Resistant starch has been found to be beneficial for colon health, increasing satiety levels, and lowering blood sugar,” said registered dietitian Amy Margulies. “Banana flour also contains high levels of phenolic acid, a type of phytochemical found in many plant foods, which works like an antioxidant and supplies both potassium and vitamin B6.” Banana flour not only produces light, fluffy baked goods with a good nutrition profile, it is also easy to use. When substituting banana flour for wheat flour in a recipe, simply use about 30% less banana flour.
  8. Celiac.com 08/27/2018 - Imagine the difficulty of diagnosing celiac disease without the associated blood antibodies, with seemingly normal blood tests. Seronegative celiac disease is one of the most common causes of seronegative villous atrophy, so a biopsy is crucial in such cases, but it can be hard for doctors to justify a biopsy in the face of seemingly normal blood tests. How can researchers learn more? Seronegative celiac disease seems like a simple enough condition. It's just the presence celiac disease without the celiac-associated blood antibodies typically found in people with the disorder. Isn't it? Well, not exactly. For one thing, seronegative celiac disease is rare, and the little data that exist are contradictory. Some data has even indicated that seronegative enteropathies have lead to higher rates of death than standard celiac disease. Yet, seronegative celiac disease remains poorly defined, partly from an absence of consensus on an exact definition, and partly due to an imprecise use of specific celiac serology. Due to these factors, accurate celiac diagnosis can be extra difficult in patients with seronegative celiac disease. Even when doctors spot seronegative villous atrophy, they still need to exclude other enteropathies as a potential cause. To try to shed some light on the nature of seronegative celiac disease, a team of researchers recently set out to provide a critical summary of the most recent work on this topic, along with a working definition of seronegative celiac disease. The research team included A Schiepatti, DS Sanders, and F Biagi. They are variously affiliated with the Coeliac Centre/First Department of Internal Medicine, University of Pavia, Pavia, Italy, and with the Academic Department of Gastroenterology, Royal Hallamshire Hospital & University of Sheffield, UK. Finding an accepted definition of seronegative celiac disease is crucial in order to ensure that patients receive a correct diagnosis, and thus avoid inappropriate treatment, and the perils associated with long-term untreated celiac disease. Since cases of seronegative celiac disease are commonly dealt with individually, it is important to establish strict criteria for the diagnosis of seronegative celiac disease to ensure prompt identification and treatment of these celiac patients. Doing so will require further study, along with input from the scientific community. Source: Curr Opin Gastroenterol. 2018 May;34(3):154-158.
  9. Celiac.com 08/14/2018 - Occasionally, Celiac.com learns of an amusing gluten-free story after the fact. Such is the case of the “Gluten-Free Fireworks.” We recently learned about a funny little event that happened leading up to Fourth of July celebrations in the town of Springdale in Northwest Arkansas. It seems that a sign advertising "Gluten Free Fireworks" popped up near a fireworks stand on interstate 49 in Springdale. In case you missed the recent dose of Fourth of July humor, in an effort to attract customers and provide a bit of holiday levity, Pinnacle Fireworks put up a sign advertising "gluten-free fireworks.” The small company is owned by Adam Keeley and his father. "A lot of the people that come in want to crack a joke right along with you," Keeley said. "Every now and then, you will get someone that comes in and says so fireworks are supposed to be gluten-free right? Have I been buying fireworks that have gluten? So then I say no, no they are gluten-free. It's just a little fun." Keeley said that their stand saw a steady flow of customers in the week leading up to the Fourth. In addition to selling “gluten-free” fireworks, each fireworks package sold by Pinnacle features a QR code. The code can be scanned with a smartphone. The link leads to a video showing what the fireworks look like. We at Celiac.com hope you and your family had a safe, enjoyable, and, yes, gluten-free Fourth of July. Stay tuned for more on gluten-free fireworks and other zany, tongue-in-cheek stories. Read more at kark.com
  10. Celiac.com 08/20/2018 - Following a gluten-free diet is critical for people with celiac disease. However, the factors that influence gluten-free diet success for people with celiac disease are not well understood on a population-wide scale. A team of researchers recently set out to assess the factors that influence gluten‐free diet adherence in patients with celiac disease. The research team included E. P. Halmos, M. Deng, S. R. Knowles, K. Sainsbury, B. Mullan, and J. A. Tye‐Din. The team asked celiac patients to complete an online survey that included the validated Celiac Dietary Adherence Test, along with questions on demographics, details of diagnosis and management and assessment of diet knowledge, quality of life and psychological distress. The team then reviewed the survey data for predictors of adherence and quality of life. There were a total of 7,393 survey responses, with 5,310 people completing the Celiac Dietary Adherence Test, and 3,230 of whom were following a gluten‐free diet. Multivariate regression showed that predictors of gluten-free dietary adherence included older age, being male, symptoms severity after gluten consumption, above average gluten-free food knowledge, and lower risk of psychological distress. People with celiac disease who followed a gluten-free diet also reported better quality of life. Respondents who reported having poor food knowledge were more likely to wrongly identify gluten‐free foods, though they could still recognize gluten‐containing foods. This indicates that poor overall food knowledge may lead people with celiac disease to over‐restrict their diet. Poor understanding of gluten‐free diet and stressful psychological well-being were the main modifiable risk factors for failure to follow a gluten‐free diet in patients with celiac disease. From these responses, the team concluded that access to a dietitian and mental health care professional, in cases of psychological stress, is likely necessary to improve gluten-free dietary observation, and thus to improve overall patient health and well-being. Read more at: Alimentary Pharmacology & Therapeuticsdoi.org/10.1111/apt.14791 The researchers in this study are variously affiliated with the Department of Gastroenterology, The Royal Melbourne Hospital in Parkville, Victoria, Australia, the Department of Gastroenterology, Central Clinical School, Monash University in Melbourne, Victoria, Australia, the Cartovera Pty. Ltd. in Adelaide, SA, Australia, the Department of Psychological Sciences, Faculty of Health, Arts and Design, Swinburne University of Technology in Hawthorn, Victoria, Australia, the Department of Mental Health, St Vincent's Hospital in Fitzroy, Victoria, Australia, the Department of Psychiatry, University of Melbourne in Parkville, Victoria, Australia, Institute of Health and Society, Faculty of Medical Sciences, Newcastle University in Newcastle Upon Tyne, UK, the Health Psychology & Behavioural Medicine Research Group, School of Psychology, Curtin University in Bentley, WA, Australia, the Immunology Division, The Walter and Eliza Hall Institute of Medical Research in Parkville, Victoria, Australia, and the Department of Medical Biology, University of Melbourne in Parkville, Victoria, Australia.
  11. Celiac.com 08/16/2018 - What is the significance of vitamin D serum levels in adult celiac patients? A pair of researchers recently set out to assess the value and significance of 25(OH) and 1,25(OH) vitamin D serum levels in adult celiac patients through a comprehensive review of medical literature. Researchers included F Zingone and C Ciacci are affiliated with the Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy; and the Celiac Center, AOU San Giovanni di Dio e Ruggi di Aragona, University of Salerno, Department of Medicine and Surgery, Salerno, Italy. Within the wide spectrum of symptoms and alteration of systems that characterizes celiac disease, several studies indicate a low-level of vitamin D, therefore recent guidelines suggest its evaluation at the time of diagnosis. This review examines the data from existing studies in which vitamin D has been assessed in celiac patients. Our review indicates that most of the studies on vitamin D in adult celiac disease report a 25 (OH) vitamin D deficiency at diagnosis that disappears when the patient goes on a gluten-free diet, independently of any supplementation. Instead, the researchers found that levels of calcitriol, the active 1,25 (OH) form of vitamin D, fell within the normal range at the time of celiac diagnosis. Basically, their study strongly suggests that people with celiac disease can recover normal vitamin D levels through a gluten-free diet, without requiring any supplementation. Source: Dig Liver Dis. 2018 Aug;50(8):757-760. doi: 10.1016/j.dld.2018.04.005. Epub 2018 Apr 13.
  12. Celiac.com 08/13/2018 - It’s not uncommon for people to have psychiatric reactions to stressful life events, and these reactions may trigger some immune dysfunction. Researchers don’t yet know whether such reactions increase overall risk of autoimmune disease. Are psychiatric reactions induced by trauma or other life stressors associated with subsequent risk of autoimmune disease? Are stress-related disorders significantly associated with risk of subsequent autoimmune disease? A team of researchers recently set out to determine whether there is an association between stress-related disorders and subsequent autoimmune disease. The research team included Huan Song, MD, PhD; Fang Fang, MD, PhD; Gunnar Tomasson, MD, PhD; Filip K. Arnberg, PhD; David Mataix-Cols, PhD; Lorena Fernández de la Cruz, PhD; Catarina Almqvist, MD, PhD; Katja Fall, MD, PhD; Unnur A. Valdimarsdóttir, PhD. They are variously affiliated with the Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland; the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Reykjavík, Iceland; the Department of Rheumatology, University Hospital, Reykjavík, Iceland; the Centre for Rheumatology Research, University Hospital, Reykjavík, Iceland; the National Centre for Disaster Psychiatry, Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden; the Stress Research Institute, Stockholm University, Stockholm, Sweden; the Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; the Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden; the Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden; the Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. The team conducted a Swedish register-based retrospective cohort study that included 106, 464 patients with stress-related disorders, 1,064 ,640 matched unexposed individuals, and 126 ,652 full siblings to determine whether a clinical diagnosis of stress-related disorders was significantly associated with an increased risk of autoimmune disease. The team identified stress-related disorder and autoimmune diseases using the National Patient Register. They used Cox model to estimate hazard ratios (HRs) with 95% CIs of 41 autoimmune diseases beyond 1 year after the diagnosis of stress-related disorders, controlling for multiple risk factors. The data showed that being diagnosed with a stress-related disorder, such as post-traumatic stress disorder, acute stress reaction, adjustment disorder, and other stress reactions, was significantly associated with an increased risk of autoimmune disease, compared with matched unexposed individuals. The team is calling for further studies to better understand the associations and the underlying factors. Source: JAMA. 2018;319(23):2388-2400. doi:10.1001/jama.2018.7028
  13. Hello everyone, i will try my best to keep this short but it may not work that way as it’s a long ish story. For about a year I’ve been having some awful stomach issues, diarrhea mostly and weight loss. I had an elevated calprotectin but blood work was normal. I had a colonoscopy, they found some inflammation near the rectum but they gave me a follow up for months later and no one seemed all that concerned, I was told it went well and that I was fine. Finally I was sent for blood work to determine if I have a gluten allergy. I got a call and was told that based on my blood work they want to do an endoscopy to confirm a Celiac diagnosis. I’m an emetphobe (I have an extreme phobia of vomiting which I’ve been in therapy for my whole life) so naturally I decided to forego the endoscopy and just go gluten free. I also had read that the blood work tends to be fairly indicative of a gluten allergy and that endoscopies can produce false negatives. Either way 2 months later here I am, totally gluten free but unsure if I’m improving. I have good days and I have bad days and because I started taking Imodium every day and haven’t been able to stop without experiencing withdrawal (which apparently happens since it’s an opiate...I was clueless to this) I literally don’t know how I’m doing, I ont have diarrhea anymore but I’m taking an anti diarrheal so who knows. The people around me are telling me I seem better (more energized, sick less often, generally happier). As someone who struggles with a lot of mental health issues (depression, health phobias, anxiety) I honestly can’t tell. I’m still experiencing issues with going to the bathroom. Sometimes my stool is mucousy or seems to be full of undigested food. I’m not gaining weight or losing it (at least). On the other hand I I have days where I feel very well. I’ve continued to consume dairy, soy and really everything else. I guess I’m just looking for some advice, I’m so tired of feeling sick, I don’t feel like the person I used to be and I don’t feel like I have the support of my doctors or really any resources for this. I’m happy to never consume gluten again if it means I’ll feel generally well. Also, how long should it normally take for me to feel well again on the gluten free diet? If anyone has any tips, personal stories of success or really any insight for me that would be immensely helpful. Id also like to mention so you guys have all the info that some of my initial symptoms included headaches (often), mouth sores (canker sores), more hair coming out in the shower (I thought I was crazy but seriously I was losing hair), skin issues, and just a general malaise as well as bloating, gas and nausea. Thank you you so much in advance and sorry for the kinda gross information I shared. Regards, Kathryn.
  14. Celiac.com 08/03/2018 - Do you know that there are numerous sites on the web to help you with the symptoms of getting glutened, and other suggestions to prevent you from ever getting "glutened". There are tips to help heal gluten exposure even for the gluten sensitive or person with dermatitis herpetiformis to speed up the process of getting the gluten out of your system. The dermatitis herpetiformis sores can be assisted with some simple home remedies that can ease you through to the scabbing and eventual disappearance, save for the scarring which is slower to heal.. First, we need to really "get" the fact that this is a disease that you will not grow out of despite what some advertisers attest. There are fewer people being mis-diagnosed today because of the blood test being readily available. Most physicians have crawled into the 21st Century and know about the symptoms of celiac disease, but some are still at a loss when looking at a severe outbreak of dermatitis herpetiformis. The United States and Canada have different laws concerning allergy labeling. A recent survey presented at the AAAAI Allergists' Convention in Los Angeles in March revealed that 40 percent of consumers avoiding one or more allergens when buying foods "Manufactured in a facility that also processes allergens.” Beyond buying habits the researchers also found a lack of awareness of labeling. Another problem occurs with differences in the food laws between the United States and Canada, and with the fluctuating Canadian dollar many Americans close to the border are taking advantage of the savings and shopping in Canada. 45% of people were unaware that precautionary labeling is not required by law. In Canada, labeling regulations require manufacturers to clearly indicate if major allergens are ingredients of a product. But there are no legal guidelines on how companies should identify products that may have come into contact with food allergens during manufacturing. I did a survey of six bakeries this past month that baked gluten free products. Out of the six, four cleaned their ovens and pans by pressure washing and only baked gluten-free on one particular day a week. Even their gluten-free home made noodles were made on a separate day and had to be ordered ahead of time. Recently Health Canada recommended companies limit the advisories to the phrase "May contain", but even that is not yet a legal issue, just a precautionary one I was told. A recent study tested 186 products with precautionary peanut labels and found 16 (just under 9%) contained the allergen. It becomes very serious after a 22 year old Minnesota man, with a peanut allergy died in January of anaphylaxis after eating a chocolate candy with a label that it had been made in a plant that also processed peanuts. "Not the same', you say but it brings to the foreground the fact that there are too many different types of wording, says author Dr. Susan Waserman, a professor of medicine in the division of allergy and immunology at McMaster University in Hamilton, Ontario. "Patients assume that differences in wording imply a lower level of risk, which they don't. " Gupta and Waserman would like to see precautionary labels reduced to one or two clearly defined phrases. For instance, Dr. Gupta says if a "May Contain" label meant that the food might have up to 100 milligrams of an allergen, then the patient could work with their doctors to find out just how much of their allergen may be safe to consume and purchase foods accordingly. The study shows that there is already research "underway to develop thresholds for such labels." Did you know that the outward manifestations of getting glutened may be different for everyone, and can cause a variety of symptoms such as brain fog, diarrhea, constipation, headache, rash, weakness, joint pain, swelling, vomiting and fatigue. Inside your body gluten is perceived as a toxin that causes inflammation and damage to the intestines. Ridding yourself of this toxin, reducing inflammation and healing your gut from the damage are essential to recovering as quickly as possible. Did you know that digestive enzymes help speed up the breakdown and absorption of micronutrients. Be sure to take an enzyme that includes dipeptidyl peptidase (DPP-IV) and or AN-PEP, both of which help to break down gluten. In fact several sites recommend that those with celiac and gluten intolerance take enzymes with DPP-IV and/or AN-PEP when dining out. Activated charcoal and bentonite clay rid toxins and help reduce gas and bloating. It is best to increase water intake when taking either of these to avoid constipation, which will only delay healing. Speaking of water intake, it is one of the biggest ways of removing gluten from your body. Cleanse, don't drown yourself, but drink as much water or a pure juice, (not pop) is one of the fastest ways of doing a body cleanse from a celiac outbreak, whether a diagnosed celiac, gluten sensitive, or those afflicted with dermatitis herpetiformis. I have been nagged so many times to drink more water when experiencing a dermatitis herpetiformis outbreak. You can try coconut water, which contains electrolytes that may have been lost through vomiting or diarrhea. Decreasing inflammation occurs naturally in our body when there has been an insult or inflammation to it. Decreasing inflammation is essential in healing your gut. 10 tips may help you reduce inflammation and recover quickly should you accidentally ingest gluten: Omega-3 fatty acids, fish oils, flax and chia seeds are full of anti-inflammatory omega 3 fatty acids. It is recommended to take 1 - 2 grams of omega 3 oils daily. You can go up to 4 grams a day for a week after an accidental gluten ingestion. Never play guessing games with celiac disease, or cheat. In the scheme of things it is NOT worth it, and deep inside when you are really suffering you know that sneaking a regular donut is definitely not worth it. The man that said to me, "Every time I come back from Japan to the U.S.A. I have to have Kentucky Fried Chicken and to heck with the consequences", I noticed the last sabbatical when he came over for a visit he did not succumb to his favorite Kentucky Fried Chicken. He now had dermatitis herpetiformis, which is basically celiac disease of the skin. I have been told it can often be caused by extreme stress or constantly cheating on the gluten-free diet. If you think being a celiac is "The Poor Me Syndrome" think again! Dermatitis herpetiformis on your scalp can give you an extreme desire to shave your hair off, and pick the itchy sores off your legs until they not only scar, but look like a shark attack. Don't do it! And I am not even telling you about what it does to the lining in your bowel and the nutrients that are flowing through your body right down the toilet. Ginger has high levels of gingerol, which gives it a natural spicy flavor and acts as an anti-inflammatory in the body. It also has potent anti-nausea properties and can ease stomach cramping, Drinking warm ginger tea is a great idea. Turmeric is a member of the ginger family that contains the active ingredient curcumin, which is known for its antioxidant and anti-inflammatory properties. Try an anti-inflammatory smoothie with turmeric. It is a great drink to help you quickly recover from getting glutened. Did you know that nearly 70% of our immune system is in our gut? Having a healthy gut is crucial for optimal health. Probiotics. Many researchers suggest or recommend taking a highly concentrated probiotic (24-100 billion units a day). Amy Myers, M.D., is a renowned leader in functional medicine and a New York Times best selling author of "The Auto-Immune Solution".She received her doctorate in Autoimmune Diseases and has several books on celiac disease and its mystifying complex symptoms. Celiac disease reacts differently with each person, and childhood celiac disease symptoms are often different than adult onset celiac disease. L-Glutamine. It is an amino acid that is great for repairing damage to the gut, helping the gut lining to regrow and repair, undoing the damage caused by gluten. Dr, Myers recommends 3 -5 grams a day for a week after exposure. *MY ADVICE to you all is to write these suggestions down and show them to your general practitioner, research them on the internet, Do not take my word for it or the words of these authors; check and re-check your facts. It is your body, and just like you would change grocery stores if they sold you a bunch of out-dated food products, you would complain and possibly shop somewhere else. You have a right to read about new things and be heard. Slippery Elm. It contains mucilage, which stimulates nerve endings in he gastrointestinal (GI) tract to increase its secretion of mucus. Mucus forms a barrier in the gut to protect it and promote healing. Deglycyrrhizinated licorice (DGL). DGL is a herb that is being used for more than 3,000 years in Marshmallow root is a multipurpose supplement that can be used for respiratory or digestive relief. Like slippery elm, it contains mucilage, which eases the inflammation in the stomach lining, heals ulcers and treats both diarrhea and constipation by creating a protective lining on the digestive tract. Bone Broth is very high in the anti-inflammatory amino-acids glycine and proline. The gelatin in bone broth protects and heals the mucosal lining of the digestive tract that may et disrupted by being glutened. Baking Soda Remember, be your own researcher and look into each of these before trying them.
  15. Celiac.com 08/08/2018 - A number of studies have cataloged the numerous challenges faced by adolescents with celiac disease attempting to comply with a gluten-free diet. A team of researchers recently set out to reevaluate gluten-free dietary compliance and the current clinical condition of 123 now teenage celiac patients, who were diagnosed in the first three years of life and were followed up for at least 10 years to determine whether a less strict approach to a gluten-free diet can actually increase gluten-free dietary compliance. The research team included M Mayer, L Greco, R Troncone, S Auricchio, and M N Marsh. They are variously affiliated with the University Department of Medicine, Hope Hospital, Salford, Manchester, UK. The team used computerized image analysis to assess mucosal structure and lymphocytes in small intestinal biopsy specimens obtained from 36 subjects. Of these adolescents with celiac disease, 65% were adhering to a strict gluten free diet, 11.4% followed a gluten-free diet with occasional gluten intake, while nearly 25% ate a gluten containing diet. Patients on a gluten containing diet had more frequent clinical gluten-related symptoms, while patients on a semi-strict diet did not. Occasional intake of small amounts (0-06-2 g/day) of gluten did not produce increased concentrations of anti-gliadin antibodies, but did result in a substantially greater crypt epithelial volume and expanded crypt intraepithelial lymphocyte numbers. So, could a semi-strict gluten-free diet benefit celiac teenagers who eat a gluten containing diet? These numbers suggest that a semi-strict gluten-free diet may be better than no gluten-free diet at all. Of course, the best choice would always be a 100% gluten-free diet. Source: Gut
  16. Celiac.com 08/07/2018 - A new drug designed to reduce symptoms of accidental gluten ingestion in celiac disease sufferers has yielded some encouraging data. The drug in question is a monoclonal antibody designed to reduce adverse reactions in celiacs who are accidentally exposed to gluten. The results, presented at Digestive Disease Week, held in Washington DC from 2–5 June 2018, suggest that monoclonal antibodies could provide protection for people with celiac disease. Celiac patients on a gluten-free diet who randomly received six injections of a monoclonal antibody, called AMG 714, over a ten-week period, enjoyed a substantial reduction in intestinal inflammation. Over a ten week study period, celiac patients on a gluten-free diet received six randomly assigned injections of either a placebo, or of AMG 714 at a dose of either 150mg or 300mg. Patients then underwent a dietary gluten challenge from week through until week twelve. As tested, the drug did not reduce damage to intestinal villi for either treatment group, which was the trial’s primary goal, but it did significantly reduce celiac-related inflammation and symptoms in response to gluten consumption. Patients receiving the highest dose of AMG 714 had no clinically active disease at week twelve of the study, and also had a significant improvement in self-reported outcomes, compared with the placebo group. No matter how diligently people with celiac disease follow a gluten-free diet, they can still suffer accidental gluten exposure ingestion. Treatments like AMG 714 could become important adjunct to gluten-free diet in for people with celiac disease, including non-responsive celiac disease. Read more in Pharmaceutical-journal.com
  17. 08/01/2018 - A federal appeals court has ordered a new trial for a terminated worker who sued a staffing company for allegedly violating the Americans with Disabilities Act by not accommodating her celiac disease. Laurie Peterson suffers from celiac disease, and worked as a staffing supervisor for Troy, Michigan-based Kelly Services Inc. until her termination in January 2014 according to court papers filed in Laurie Peterson v. Kelly Services Inc. Peterson had originally sued Kelly in U.S. District Court in Spokane, Washington, alleging failure to accommodate, discrimination and retaliation under the ADA. The original court issued a partial summary judgment granting Kelly’s motion on Ms. Peterson’s claims that the company had failed to accommodate her celiac disease and had fired her in retaliation for protected activity, but allowed related charges in the case to proceed. A jury later found that Kelly had not retaliated against Ms. Peterson. A three-judge panel of the 9th U.S. Circuit Court of Appeals recently issued a unanimous reversal of the district court’s original ruling. The panel wrote that the district court had “failed to construe the facts in the light most favorable to Peterson as the non-moving party as required on summary judgment.” The case originally arose out of Peterson’s work as interim district manager in fall 2013 while Kelly Services was looking for a new district manager. According to the complaint in the case, when the new district manager learned Ms. Peterson had celiac disease, he began treating her differently than other employees, including changing her work schedule. The change in work schedule allegedly caused Ms. Peterson stress and anxiety, which aggravated her celiac-related condition. Ms. Peterson sought to return to her previous 8 a.m. to 5 p.m. shift. According to the complaint, the district manager told Ms. Peterson to take unpaid leave under the Family Medical Leave Act instead of seeking an accommodation from the company. Peterson and the supervisor were later fired. In reversing the lower court and remanding for trial the claims decided on summary judgment, the court found that the district supervisor’s statement “is direct evidence of retaliatory intent.” The ruling added that the supervisor’s declaration “also raises a genuine issue of material fact as to whether Kelly Services engaged in the interactive process in good faith.” Ms. Peterson’s battle against Kelly Services, Inc., has important implications for how companies treat people with celiac disease under the ADA. To find out how the retrial turns out, keep an eye on Celiac.com Source: businessinsurance.com
  18. Hi all, I was diagnosed with both Celiac and Microscopic Colitis (Callogenous) last year, and while I'm feeling largely better, I've never been able to find a succinct and ready-to-go guide for people with MC and Celiac, and am having an especially hard time finding one that is friendly for vegetarians. Any advice, links, or reads that anyone might have would be greatly appreciated!
  19. I'm not exactly sure what to do at this point if what I am reading is correct. I don't want to go into too much detail right off the bat but I can tell you more if needed. I had an allergy test done, they messed up the first time and did a small panel, but my Whey Allergin, IgG came back as 32.20. Ref range: 0-88.60 mcg/mL In the notes it says "values less than 2.00 mcg/mL represent absent or undetectable levels of allergen-specific IgG anitibody. Values 2.00 mcg/mL and above indicate progressive increases in the relative concentration of allergen-specific IgG." This is where my doctor sent back for a full 96 allergy test, but he was concerned about any cross-reactivity due to the Whey results so he requested a Celiac panel as well. Everything on the food allergies came back as negative, besides some environmental allergies that were already tested previously and noted before. Could you please tell me your thoughts on the results? I think they might be negative. But if so, what do I do now? Should I request some other testing? Let it go? I would love to get some relief though and find out what is wrong with me. I fell like I have many of the symptoms that have been attached with Celiac disease. Not that I'm saying I would like to be diagnosed with something but if I were diagnosed it would make my medical history make much more sense. If you would like more detail on symptoms I can outline them. For Gluten Allergen, IgG, Casein Allergen, IgG and Whey Allergen, IgG (The Whey was the one on the first set of tests though) it says "Request Credited -- ORDINC; Test ordered incorrectly" Here are the results for Celiac Disease Panel: IgA - Result - Sufficient Gliadin IgA Ab - Result - 10.3 -- Ref Range - 0.0-14.9 Tis.Transglut.Ab IgA - Result - <0.5 -- Ref Range - 0.0-14.9 the notes section is not helpful at all. And I guess they didn't do the IgG so should I be asking them to do that? The doctor has to send it to a different lab than the one they use due to insurance. Thank you all in advance!
  20. Celiac.com 07/26/2018 - Currently, the only medically proven treatment for celiac disease is a life-long gluten-free diet. That’s been true for many years, but that doesn’t stop people from making curious or questionable celiac disease claims. Today in the arena of likely bogus medical claims, we ask ourselves if long-distance energy channeling can help people with their celiac disease symptoms? The obvious answer is that it’s highly unlikely. According to the group's recent press release titled, Trivedi Global, Inc. and Su-Mei Liu Announce Research Results on the Impact of a Biofield Energy Treated Nutraceutical for Decreasing Inflammation and Autoimmune Disorders, such treatments do help. The company is called Trevedi Global, Inc., and claims that "tests" conducted in the research laboratory of Dabur Research Foundation, near New Delhi, India, show that just 5 minutes of Biofield Energy Treatment, conducted using the “healers' unique Biofield Energy Transmission process remotely to the test samples under laboratory conditions” improves celiac disease and numerous other conditions for people using nutraceutical supplements. Whatever their appeal may be, there’s reason to be skeptical of such claims. The press release claims that “Human Biofield Energy has subtle energy that…can be harnessed and transmitted by the gifted into living and non-living things via the process of a Biofield Energy Healing Treatment or Therapy.” Of course, this process involves paying money for both nutraceuticals and for the self-labeled “energy healers” working from a remote location. These “healers” then use their “unique” abilities to “channel energy” to the afflicted person for about five minutes. Again, as per the press release, these “healing” sessions were conducted by someone called “Sui-Me Liu as part of a group of 20 energy healers. Eighteen were remotely located in the U.S.A and two in Canada.” It goes on to add that “Lui, along with another 19 Biofield healers participating in this research never visited the laboratory in person, nor had any contact with the nutraceuticals samples.” The release calls Liu “an evidence-based energy healer, today announces research based on the impact of a biofield energy treated nutraceutical to improve overall immunity and to combat inflammation and autoimmune disorders.” Without addressing any alleged clinical significance the press release goes on to claim the following results: “Up to 260% increase overall immunity as seen by elevation of antibody levels" "Over 50% increase in delayed hypersensitivity reaction" "Over 30% decrease in uric acid levels" "Over 25% increase in blood cell counts” The press release claims that these “research findings suggest that the biofield energy treatment enhanced the nutraceutical's anti-inflammatory and immunomodulatory properties with a safe therapeutic index. Another promising indication for the supplement is improvement of overall health and quality of life.” So the company is basically selling their nutraceuticals as a cure-all that, coupled with remote energy channeling treatments, allegedly translates into improvements for people with celiac disease. They go on to claim that their product “can be used to combat autoimmune diseases and inflammatory disorders like Celiac Disease (gluten-sensitive enteropathy), Irritable Bowel Syndrome (IBS), Parkinson’s Disease, Graves’ Disease, chronic peptic ulcers, Hepatitis, Addison's Disease, Multiple Sclerosis (MS), Tuberculosis, Rheumatoid arthritis, Chronic periodontitis, Crohn's disease, Ulcerative colitis, Lupus, Vitiligo, Hashimoto Thyroiditis, Chronic sinusitis, Type 1 Diabetes, Asthma, Rheumatoid Arthritis, Sjogren Syndrome, Alopecia Areata, Dermatitis, Psoriasis, Fibromyalgia, Diverticulitis, Chronic Fatigue Syndrome, Alzheimer’s Disease, Atherosclerosis and more.” Aside from the addition of the strange energy channeling claim, the claims made by Trevedi Global about their nutraceuticals are pretty standard pseudo-medical hype. It’s common for companies to make vague, unsupported health claims while hawking products that are unlikely to have any impact at all upon particular health problems, including celiac disease, and any other serious disorder. So, take these claims, and any other claims such as this, with a grain of salt, and don’t give up your gluten-free diet just yet.
  21. Celiac.com 07/25/2018 - Several recent research articles have emphasized the connection between intestinal autoimmune diseases, such as Crohn's disease with dysbiosis or an imbalance in the microbiota composition in the gut. However, little is known about the role of the microbiota in autoimmune pathologies affecting other tissues than the intestine. A team of researchers recently set out to examine the role played by gut microbiota in the pathogenesis of non-intestinal autoimmune diseases, such as Grave's diseases, multiple sclerosis, Type-1 diabetes, systemic lupus erythematosus, psoriasis, schizophrenia, and autism spectrum disorders. They wanted to see if microbiota can influence and determine the function of cells of the immune system. In their report, the team discusses how metabolites derived from bacteria could be used as potential therapies for non-intestinal autoimmune diseases. The report was reviewed by Richard Eugene Frye of Phoenix Children's Hospital, United States, and Matej Oresic at the University of Turku in Finland. The report was edited by Marina I. Arleevskaya of Kazan State Medical Academy in Russia. The authors conclude: "The current evidence supports the notion that changes or alterations of the microbial species that form part of the intestinal microbiota will affect the balance of Tregs and Th17 cells at the intestine, which could modify the immune response of non-intestinal autoimmune diseases. The experimental evidence suggesting that the cytokines secreted from Treg and Th17 will determine and influence non-intestinal autoimmune responses. It could also be possible that cells of the immune system located at the intestine could to move other organs to establish or modify an autoimmune response. The major message of this review is that the abundant data support the notion that the intestine is a critical organ the appropriate immune balance and for the prevention of non-intestinal autoimmune diseases. The key point is that by modifying the intestinal microbiota of a patient that suffers non-intestinal autoimmune disease it might be possible to improve the outcome of such illness." For more on the role of microbiota in influencing immune cell function and promoting individual wellbeing, read the full report in Frontiers in Microbiology. The research team included Maria C. Opazo, Elizabeth M. Ortega-Rocha, Irenice Coronado-Arrázola, Laura C. Bonifaz, Helene Boudin, Michel Neunlist, Susan M. Bueno, Alexis M. Kalergis, and Claudia A. Riedel. They are variously affiliated with the Laboratorio de Biología Celular y Farmacología, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Universidad Andres Bello, Santiago, Chile; Facultad de Medicina, Millennium Institute on Immunology and Immunotherapy, Universidad Andres Bello, Santiago, Chile; Laboratorio de Inmunobiología, Facultad de Medicina, Departamento de Biología Celular y Tisular, Universidad Nacional Autónoma de México, Mexico City, Mexico; Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile; Unidad de Investigación Médica en Inmunoquímica Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico; Institut National de la Santé et de la Recherche Médicale U1235, Institut des Maladies de l'Appareil Digestif, Université de Nantes, Nantes, France; and the Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad, Metropolitana, Chile.
  22. Celiac.com 07/24/2018 - The UK is in the midst of a national evaluation and reshaping of gluten-free prescription practices for people with celiac disease. Meanwhile, local health authorities in Calderdale, UK, are catching heat for a plan to consult with local people on proposed prescription cuts for gluten-free foods, branded medications and over the counter supermarket items. Critics, including leading charity, Coeliac UK, strongly oppose cutting gluten-free prescriptions for patients in Calderdale and elsewhere. They say the plan is a pointless waste of time and money, as results are due in from a nationwide consultation. Chief executive Sarah Sleet described the move by the NHS Calderdale Clinical Commissioning Group (CCG) as a poor use of public money. The Commissioning Group claims that consulting with local people over the plans could save £800,000 a year, while Sleet warns that, if approved, the move will result in “health inequality.” The Commissioning Group is proposing to eliminate funding of certain gluten-free products on prescription, thus saving £120,000. The plan would affect all people who receive gluten-free foods on prescription. Coeliac UK contends that any reduction or elimination of gluten-free prescriptions will negatively impact the ability of celiac patients, to access needed gluten-free foods. The consultation exercise in Calderdale is slated to run through December 4. Meanwhile, Results are forthcoming from a recently concluded national consultation on gluten-free prescription practices in the UK. Stay tuned for more on what these decisions mean for UK residents living with celiac disease. See the CCG's online consultation survey.
  23. I just came across this article with some very credible evidence on the link between the pesticide Roundup developed by Monsanto and the increase in Gluten Intolerance and Celiac disease. You can find more about this study here, with a link for downloading the whole article: http://sustainablepulse.com/2014/02/19/roundup-linked-global-boom-celiac-disease-gluten-intolerance/#.UxBTGV5z-sQ Now, my question, is when and how a class action suit by people suffering from Celiac Disease and GI can proceed. I know legal action against Monsanto is normally an exercise in futility, but for symbolic value I would very much like to participate in some response to these findings.
  24. Celiac.com 07/17/2018 - What can fat soluble vitamin levels in newly diagnosed children tell us about celiac disease? A team of researchers recently assessed fat soluble vitamin levels in children diagnosed with newly celiac disease to determine whether vitamin levels needed to be assessed routinely in these patients during diagnosis. The researchers evaluated the symptoms of celiac patients in a newly diagnosed pediatric group and evaluated their fat soluble vitamin levels and intestinal biopsies, and then compared their vitamin levels with those of a healthy control group. The research team included Yavuz Tokgöz, Semiha Terlemez and Aslıhan Karul. They are variously affiliated with the Department of Pediatric Gastroenterology, Hepatology and Nutrition, the Department of Pediatrics, and the Department of Biochemistry at Adnan Menderes University Medical Faculty in Aydın, Turkey. The team evaluated 27 female, 25 male celiac patients, and an evenly divided group of 50 healthy control subjects. Patients averaged 9 years, and weighed 16.2 kg. The most common symptom in celiac patients was growth retardation, which was seen in 61.5%, with abdominal pain next at 51.9%, and diarrhea, seen in 11.5%. Histological examination showed nearly half of the patients at grade Marsh 3B. Vitamin A and vitamin D levels for celiac patients were significantly lower than the control group. Vitamin A and vitamin D deficiencies were significantly more common compared to healthy subjects. Nearly all of the celiac patients showed vitamin D insufficiency, while nearly 62% showed vitamin D deficiency. Nearly 33% of celiac patients showed vitamin A deficiency. The team saw no deficiencies in vitamin E or vitamin K1 among celiac patients. In the healthy control group, vitamin D deficiency was seen in 2 (4%) patients, vitamin D insufficiency was determined in 9 (18%) patients. The team found normal levels of all other vitamins in the healthy group. Children with newly diagnosed celiac disease showed significantly reduced levels of vitamin D and A. The team recommends screening of vitamin A and D levels during diagnosis of these patients. Source: BMC Pediatrics
  25. Celiac.com 07/23/2018 - Celiac disease has been associated with several conditions influencing female reproduction and pregnancy outcomes including spontaneous abortion and stillbirth. To determine how celiac disease influences women’s reproductive lives, both prior to and after diagnosis, a team of researchers recently set out to assess the risk of adverse pregnancy outcomes, both before and after diagnosis. The research team included L Grode, B H Bech, O Plana-Ripoll, M Bliddal, I E Agerholm, P Humaidan, and C H Ramlau-Hansen. They are variously affiliated with the Department of Medicine, Horsens Regional Hospital, Sundvej 30, DK-8700 Horsens, Denmark; the Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000 Aarhus C, Denmark; the National Center for Register-based Research, Aarhus University, Fuglesangs Allé 26, DK-8210 Aarhus V, Denmark; with OPEN, Odense Hospital and Department of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 9 a, 3. etage, DK-5000 Odense C, Denmark; and with the The Fertility Clinic, Horsens Regional Hospital, Sundvej 30, DK-8700 Horsens, Denmark Faculty of Health, Aarhus University, Palle Juul-Jensens Boulevard 82, DK-8200 Aarhus N, Denmark. By linking several Danish national health registers, the research team was able to identify all women diagnosed with celiac disease between 1977 and 2016. To make their assessment, the team compared 6,319 women diagnosed with celiac disease with 63,166 age- and sex-matched non-celiac women. For both groups, the team identified reproductive events between the ages of 15 and 50 years. The team used adjusted stratified Cox and logistic regression models to estimate differences in reproductive outcomes between women with and without celiac disease. They found that women with diagnosed celiac disease had about the same chances as non-celiac women of pregnancy, live birth and risk of stillbirth, molar and ectopic pregnancy, spontaneous abortion and abortion due to fetal disease. However, prior to being diagnosed, celiac disease women had an excess risk of spontaneous abortion equal to 11 extra spontaneous abortions per 1,000 pregnancies (adjusted odds ratio (OR) = 1.12, 95% CI: 1.03, 1.22) and 1.62 extra stillbirths per 1,000 pregnancies (adjusted OR = 1.57, 95% CI: 1.05, 2.33) compared with the non-celiac disease women. In the period 0–2 years prior to diagnosis fewer pregnancies occurred in the undiagnosed celiac disease group, equal to 25 (95% CI: 20–31) fewer pregnancies per 1,000 pregnancies compared to the non-celiac disease group and in addition, fewer undiagnosed celiac disease women initiated ART-treatment in this period, corresponding to 4.8 (95% CI: 0.9, 8.7) fewer per 1000 women compared to non-celiac disease women. Overall, these findings suggest that undiagnosed celiac disease can influence female reproduction, and that doctors should focus on early celiac detection in at-risk groups. The team adjusted their results for numerous confounding factors, but cannot rule out residual confounding. The team stresses several limitations of the study. For example, they could not confirm the validity of the diagnoses in the registers. They also note that some spontaneous abortions will go unnoticed or unregistered, while live-births, stillbirths, ectopic and molar pregnancies, and abortion due to fetal disease, are likely to be registered. For these reasons, they urge caution in interpreting these results. Stay tuned for more news on the relationship between celiac disease and female reproduction. Source: Human Reproduction
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