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Hi All, My son is a 28 year old type 1 diabetic with celiac disease. He is currently in the hospital after becoming very ill 2 days ago, then moved to ICU. They have not determined exactly what the cause of his illness, but it sounds like they are leaning toward gastroparesis. I am doing what I can to research and be informed so I can be a support system for him. He has really been struggling, especially the past couple of months, with nerve pain down his legs, anxiety and panic attacks, fatigue, weight loss, light-headedness, very pale, etc. Are these symptoms that any of you had prior to your diagnosis? Deep down I have felt there was some underlying cause. Any input would be helpful. It is really hard right now because of Covid-19, I can't even visit him. Thanks!
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Celiac.com 01/21/2020 - Hockey fans might know Kaapo Kakko as the NHL's number two draft pick, now playing for the New York Rangers. Diagnosed with both celiac disease and type 1 diabetes while in his early teens, Kakko has had to adapt his diet and training regimen accordingly. Of course, he avoids gluten and follows a strict gluten-free diet. Because Kakko's home country of Finland boasts an excellent socialized health system, Kakko not only received early testing, but also received supervised instruction from medical professionals on following a gluten-free, and diabetic-friendly diet, and adjusting his lifestyle as needed to thrive in the face of his medical challenges. Like many people diagnosed with celiac disease, Kakko says he didn't feel sick and didn't have any clear symptoms, so popping in to the doctor for a routine check-up and testing positive for both type 1 diabetes and celiac disease came as a bit of a shock. After nearly a week of medical supervision and instruction, Kakko was released with a good feel for what he needed to do to remain healthy, courtesy of Finland's good medical system. Joining the NHL as the number two draft pick is a strong indication that Kakko has done a good job of managing his celiac disease and diabetes. What's his secret? Read more about Kaapo Kaako's gluten-free diet at GQ.com Learn more about the ins and outs of a gluten-free diet at Celiac.com. Learn more about Kaapo Kakko's diet at GQ.com.
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Celiac.com Article:The Gluten-Free Diet Powering New York Rangers' Kaapo Kakko
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Celiac.com 04/18/2019 - Cases of type 1 diabetes have been on the rise in western countries, which suggests an environmental role in the development of the disease. Still, after decades of study, researchers have yet to nail down the factors driving the increase, and so they have no clear way to prevent new cases. A potential association that deserves closer scrutiny is one of environmental causes as a driver of diabetes, including dietary factors, such as gluten. At the moment, there is a great deal of focus on maternal and childhood dietary factors. To remedy the current impasse, researchers Maija E Miettinen and Suvi M Virtanen of the National Institute for Health and Welfare in Helsinki, Finland, cite the need for comprehensive prospective studies with carefully collected data to define and confirm associations. Only with such data can effective solutions be devised and tested. In a linked article, also in the BMJ, Antvorskov and colleagues investigated the association between maternal gluten intake during pregnancy and risk of type 1 diabetes in offspring. The authors analyzed data from the large Danish National Birth Cohort, covering about a third of all pregnancies in Denmark during the recruitment period of 1996-2002, in which more than 70,000 pregnant women reported their diet with a food frequency questionnaire. That analysis revealed that risk of type 1 diabetes in offspring increased proportionally with maternal gluten intake during pregnancy per 10 grams per day increase of gluten. Compared to women with the lowest gluten intake of under 7 grams per day, those with the highest gluten intake, who consumed 20 or more grams a day, had double the risk for type 1 diabetes development in their children. Basically, higher gluten intake during pregnancy meant higher diabetes risk for the children. However, that’s one study with good data. The authors stress the urgency to understand what is driving alarmingly fast-rising diabetes rates. People’s health, well-being, and lives are at stake. For that, further study is needed, and soon. Read more at BMJ 2018; 362
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I have been living with a diagnosis of Celiac for 10 years and now also am type 2 diabetic. My question is: is there anyone else out there with these two conditions and how do they navigate making and buying and eating food for both conditions? Thank you for your help!
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Celiac.com 10/23/2019 - Autoimmune therapy company ImmunoMolecular Therapeutics (IM Therapeutics) has received $10 million in Series A financing to support its new HLA-targeted treatment approach to autoimmune diseases, and to develop its lead HLA-targeted drug candidate for type 1 diabetes. Founded by physician scientists at the University of Colorado's Barbara Davis Center for Diabetes, IM Therapeutic creates personalized therapies for autoimmune diseases. The company's research has shown that blocking certain high risk human leukocyte antigen (HLA) genes also blocks the subsequent autoimmune response, which offers a possible way to prevent autoimmune triggering in a number of autoimmune diseases. Based on that research, the company is creating personalized therapies against HLA targets in various autoimmune diseases, including type 1 diabetes and celiac disease. The company has clinically proven that treating patients based on HLA-DQ8 status can reduce the autoimmune response in type 1 diabetes. With a technology platform that integrates computational chemistry, bioassays, and rational drug design, IM Therapeutics is developing a series of HLA targets for a number of autoimmune diseases. IM Therapeutics' personalized therapy approach to treating autoimmune disorders has proven effective in a Phase 1b human study of recently diagnosed type 1 diabetes patients who were positive for the HLA DQ8 variant. The Company is moving forward on its lead oral drug, IMT-002, through IND development for type 1 diabetes, and expanding its therapeutic HLA blocking treatments to other targets of autoimmune disorders, including celiac disease. IM Therapeutics’ HLA is currently focused on HLA-DQ8 and DQ2 gene variants, which are known to greatly increase individual risk to both type 1 diabetes and celiac disease. HLA-DQ8 is present in three out of five type 1 diabetes patients, and in one out of ten celiac disease patients. However, about 90% of celiac patients have DQ2, and nearly 100% of celiac patients have DQ2 and/or DQ8. “Our value has been clear since day one – getting to the root cause of autoimmunity with a targeted therapy approach and making an impact on diseases such as type 1 diabetes,” said Nandan Padukone, Ph.D., CEO of IM Therapeutics. Read more at Businesswire.com
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Celiac.com 09/30/2019 - We know from recent studies that high gluten intake in infancy can raise risk for celiac disease, and we know that the amount of gluten eaten by infants at 18 months heavily influences their risk of developing type 1 diabetes later in life. An earlier study conducted in Denmark suggested that a high maternal gluten consumption during pregnancy increased the risk of type 1 diabetes in the child. Until now, researchers have not looked at levels of gluten intake by both the mother during pregnancy and the child in early life, and how that influences risk of developing type 1 diabetes in childhood. Now, a new study shows that every 10 grams of extra gluten eaten at age 18 months is associated with a 46% increased risk of developing type 1 diabetes. The researchers recently conducted a Norwegian population-based nationwide study of 86,306 people to examine the association between the mother's intake of gluten during pregnancy, child's gluten intake at age 18 months, and the risk of type 1 diabetes in the child. The research team included Dr Nicolai Lund-Blix, and colleagues at Oslo University Hospital, and the Norwegian Institute of Public Health in Oslo, Norway. Their research was presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Barcelona, Spain from September 16-20. The outcome was clinical type 1 diabetes cases in the nationwide childhood diabetes registry. The team calculated increased risk using statistical modeling for maternal gluten intake during pregnancy and child's gluten intake at 18 months. The authors estimated grams per day of gluten intake based on a semi-quantitative food frequency questionnaire at week 22 of pregnancy, and from a questionnaire completed by the guardian when the child was 18 months old. Researchers are not calling upon expectant mothers to reduce gluten content in the infant diet at this point in time. According to the authors, "This study suggests that the child's gluten intake at 18 months of age, and not the maternal intake during pregnancy, could increase the risk of type 1 diabetes in the child." Read more at: Diabetes Times and at Celiac.com: High Childhood Gluten Intake Increases Risk of Celiac Disease and Celiac Autoimmunity
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Celiac.com 08/26/2019 - Does the amount of gluten consumed during the first 5 years of life influence the risk of celiac disease autoimmunity and celiac disease in at-risk children? A new study says it does. There's been some previous study data to suggest that high gluten intake during childhood may increase risk of celiac disease. A team of researchers working for The Environmental Determinants of Diabetes in the Young (TEDDY) study group recently set out to investigate if gluten intake levels are associated with celiac disease autoimmunity and celiac disease in genetically at-risk children. The TEDDY group is a prospective observational birth cohort study designed to identify environmental triggers of type 1 diabetes and celiac disease. The research team included Carin Andrén Aronsson, PhD; Hye-Seung Lee, PhD; Elin M. Hård af Segerstad, MSc; et al Ulla Uusitalo, PhD; Jimin Yang, PhD; Sibylle Koletzko, MD, PhD; Edwin Liu, MD, PhD; Kalle Kurppa, MD, PhD; Polly J. Bingley, MD; Jorma Toppari, MD, PhD; Anette G. Ziegler, MD; Jin-Xiong She, PhD; William A. Hagopian, MD, PhD; Marian Rewers, MD, PhD; Beena Akolkar, PhD; Jeffrey P. Krischer, PhD; Suvi M. Virtanen, MD, PhD; Jill M. Norris, MPH, PhD; Daniel Agardh, MD, PhD; for the TEDDY Study Group For their multinational prospective birth study, the team looked at gluten consumption in 6,605 genetically predisposed children in 6 clinical centers in Finland, Germany, Sweden, and the United States. The team defined celiac disease autoimmunity as positive tissue transglutaminase autoantibodies found in 2 consecutive serum samples. The team defined celiac disease as cases confirmed by intestinal biopsy or persistently high tissue transglutaminase autoantibody levels. The team estimated gluten intake from 3-day food records collected at ages 6, 9, and 12 months and biannually thereafter until the age of 5 years. Their results showed that children with higher gluten intake levels had a significantly higher risk of celiac disease autoimmunity, with an absolute risk difference of 6.1%. Children with higher gluten intake levels also had a significantly higher risk of celiac disease, with an absolute risk difference of 7.2%, for every gram increase of gluten intake per day. This study shows that genetically predisposed children with higher gluten intake during the first 5 years of life face an increased risk of celiac disease autoimmunity and celiac disease. Read more at JAMA. 2019;322(6):514-523. doi:10.1001/jama.2019.10329 The researchers are variously affiliated with the Department of Clinical Sciences, Lund University, Malmö, Sweden; the Health Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa; the Dr von Hauner Children’s Hospital, Ludwig Maximilians University, Munich, Germany; the University of Warmia and Mazuri, Olsztyn, Poland; the Digestive Health Institute, University of Colorado Denver, Children’s Hospital Colorado, Denver; the Tampere Centre for Child Health Research, University of Tampere, Tampere University Hospital, Tampere, Finland; the School of Clinical Sciences, University of Bristol, Bristol, England; Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland; the Institute of Diabetes Research, Helmholtz Zentrum München, Klinikum rechts der Isar, Technische Universität München, and Forschergruppe Diabetes eV, Neuherberg, Germany; the Center for Biotechnology and Genomic Medicine, Augusta University, Augusta, Georgia; Pacific Northwest Diabetes Research Institute, Seattle, Washington; the Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora; the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; the National Institute for Health and Welfare, Department of Public Health Solutions, Helsinki, Finland; the Faculty of Social Sciences/Health Sciences, University of Tampere, Tampere, Finland; the Research Center for Child Health, Tampere University, University Hospital, Science Center of Pirkanmaa Hospital District, Tampere, Finland; and the Colorado School of Public Health, Department of Epidemiology, University of Colorado, Aurora, Colorado.
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Celiac.com 07/04/2019 - There's been some data to suggest that gluten may play a role in diabetes, but there really isn't much data on the role of gluten in type 1 diabetes (T1D), so a team of researchers recently set out to test whether gluten plays a role in type 1 diabetes onset. Specifically, the team wanted to know if a gluten-free diet can decelerate the decline in beta-cell capacity in newly diagnosed non-celiac children with T1D. The research team included Vít Neuman, Stepanka Pruhova, Michal Kulich, Stanislava Kolouskova, Jan Vosahlo, Martina Romanova, Lenka Petruzelkova, Barbora Obermannova, Ondrej Cinek, and Zdeněk Šumník. They are variously affiliated with Charles University in Prague, and the University of Chemistry and Technology in Prague, Czech Republic. For their non-randomized self-selected intervention trial, the team recruited forty-six children, from about 6-13 years old. One group of 26 began a gluten-free diet, while 20 continued on a standard non-gluten-free diet. Main outcomes were the decline in C-peptide area under the curve (AUC) in mixed-meal tolerance tests and the differences in insulin dose, insulin dose adjusted A1c (IDAA1c) and HbA1c at 12 months. Data were analyzed as intention-to-treat by linear regression models adjusted for baseline parameters. The adherence to a gluten-free diet was tested by immunoreactive gluten in stool. Average decrease in C-peptide AUC was 293 vs.484 pmol/L (p=0.3) at 6 months, and 567 vs. 919 pmol/L (p=0.1) at 12 months in the gluten-free diet and control group, respectively. The group that ate a gluten-free diet had a lower insulin dose by 0.22 U/kg/day, lower IDAA1c by 1.5, and lower average HbA1c by 7.5 mmol/mol (p=0.01) after 12 months. Daily carbohydrate intake between the groups was the same. Researchers found immunoreactive gluten in the stool of just 3 patients. Children with type 1 diabetes who ate a gluten-free diet for their first year after diagnosis lower insulin demand and lower HbA1c, although C-peptide dynamics were similar for each group. This is the first study to provide solid data on the connection between gluten intake and type 1 diabetes. The fact that children who follow a gluten-free diet need less insulin is intriguing. Read more at Diabetes 2019 Jun; 68(Supplement 1).
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A Breath Test for Celiac Disease? Yes Please!
Jefferson Adams posted an article in Diagnosis, Testing & Treatment
Celiac.com 05/20/2019 - A stuffy and obscure-sounding scientific paper has more than a few people excited about a breakthrough breath test to help manage diabetes, celiac disease and other conditions. Celiac is one of the most common and misdiagnosed disease. The process of getting a proper diagnosis can be long and convoluted. In part, that's because people with celiac disease may have few or no symptoms. In fact, these days, most people diagnosed with celiac disease report few or no symptoms. In fact, it's not at all uncommon for a person with celiac disease to suffer for up to 10 years before getting a proper celiac diagnosis. In diabetes, glucagon increases blood glucose levels. In diabetes treatment, DPP-4 inhibitors are used to reduce glucagon and blood glucose levels. According to Wikipedia, they do this by increasing levels of incretin, GLP-1 and GIP, "which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels." The excitement arrises because a team of scientists has developed a selective, non-invasive breath test that could be used to diagnose and treat celiac disease and Type-II diabetes. The development team set out to develop a selective, non-invasive, stable-isotope 13C-breath test that can detect dipeptidyl peptidase-4 inhibitors (DPP4i), a class of orally available, small molecule inhibitors for the management of Type-II diabetes. The team included Roger Yazbeck, Simone Jaenisch, Michelle Squire, Catherine A. Abbott, Emma Parkinson-Lawrence, Douglas A. Brooks & Ross N. Butler. The team's paper carries the very weighty title: Development of a 13C Stable Isotope Assay for Dipeptidyl Peptidase-4 Enzyme Activity A New Breath Test for Dipeptidyl Peptidase Activity. If you read that title, and understood only the words "breath test," you are not alone. The title and the paper are highly scientific. The takeaway is that the test they developed could be useful in diagnosing, treating, and managing diabetes and gastrointestinal diseases, including celiac disease. The team's paper describes in detail their development process for the stable-isotope 13C-breath test for DPP4. The test could potentially help to treat and manage diabetes, celiac disease, and other conditions, including certain cancers. "Furthermore," the paper reads "the significant pool of DPP4 in the small bowel and in inflammatory conditions suggests that a DPP4 breath test could also have potential application as a non-invasive method to measure intestinal function/integrity and immune status. Certain cancers also exhibit high expression of DPP4 as exemplified by the adenocarcinoma cell line in this study and this may provide a measure of cancer activity and response to therapy." Imagine a quick non-invasive breath test that can do all that. That's exciting stuff. Among other things, it could mean better treatment, and less unnecessary suffering. We say: Yes, please! Do you find the idea of a breath test for diabetes and celiac disease an exciting prospect? Share comments below. Read more in Nature.com Scientific Reports; volume 9, Article number: 4906 (2019. Also of interest is D Detel, M Persic, & J Varljen's paper titled "Serum and intestinal dipeptidyl peptidase IV (DPP IV/CD26) activity in children with celiac disease," and published in the Journal of Pediatric Gastroenterology and Nutrition; 45, 65–70- 10 comments
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Celiac.com 03/07/2019 - Researchers don’t have much good data on the distribution of the related alleles in the type 1 diabetes Iranian population. In an effort to generate better data, a team of researchers recently set out to assess the frequency of HLA DQ2 and DQ8 haplotypes in patients with type 1 diabetes, with and without celiac disease, and to compare them to the healthy population. The research team included Ali Moheb-Alian, Flora Forouzesh, Amir Sadeghia, Kamran Rostami, Elham Aghamohammadi, Mohammad Rostami-Nejad, Mostafa Rezaei-Tavirani, and Mohammad Reza Zali. The team looked at 70 type 1 diabetes patients who did not have celiac disease, 60 type 1 diabetes cases with celiac disease, and compared them with 150 healthy individuals. They collected ten milliliter Gheparinized blood samples, extracted genomic DNA, and genotyped alleles in Real-time PCR using SYBR Green as a low-resolution method. They found HLA-DQ2 genotypes in 51% of type 1 diabetes patients without celiac disease, and HLA-DQ8 in 23% of such patients. Just over twenty percent of those patients carried both alleles, while 5% carried neither allele. More than 70% of type 1 diabetes patients with celiac disease had DQ2, while nearly 12% carried DQ8. Compared to diabetes patients without celiac disease and the control group, 14% carry both alleles, and 3% carrying neither allele. The frequencies of DQ2 and DQ8 alleles in Iranian healthy population were 19 and 5% respectively. The similarities in genetic background for celiac disease and type 1 diabetes show that HLA-typing can be serve as a helpful tool for spotting celiac disease in people with type one diabetes. Read more in the Journal of Diabetes and its Complicationshttps://doi.org/10.1016/j.jdiacomp.2018.10.001 The researchers are variously affiliated with the Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; the Department of Gastroenterology MidCentral District Health Board, Palmerston North Hospital, New Zealand; the Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran; and the Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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Celiac.com 03/01/2019 - About 30,000 new cases of type 1 diabetes are diagnosed annually in the US, typically in children. If a serious disease affected up to 10% of all type 1 diabetics, wouldn’t you agree that it’s time to sit up and take notice? Perhaps screening for this disease would also make sense. Celiac disease affects 1% of the population, making it a common disease. In the celiac population there is an increased prevalence of type 1 diabetes and this association is well established. Despite celiac disease affecting a much greater percentage of the general population than type 1 diabetes, 90% of the patients suffering from both conditions are first diagnosed with diabetes.[1] Study results vary, but the prevalence of celiac disease among children with diabetes ranges between 4.5% (over 25 studies),[2] to 10%[3] and 12.3%[4] respectively. Opinions on whether screening of all diabetic patients should become part of the medical model are controversial, but fortunately, we are seeing increased support [5,6,9]. It is difficult to overestimate the stress associated with the diagnosis of a severe illness in a child. And perhaps the last thing that a parent wishes to hear is that a second severe illness may be involved. I understand that. But consider the fact that both type 1 diabetes and celiac disease are autoimmune diseases. When a patient has one autoimmune disease they are much more likely to develop another. And obviously the greater the number of such conditions that affect a single individual, the lower their vitality and life expectancy are likely to be. I would recommend to any parent of a child with type 1 diabetes, as well as any adult with the disease, that they get tested for both celiac disease and gluten sensitivity as soon as possible. In my clinical experience we have seen excellent changes when a gluten-free diet was implemented. The facts are these: when celiac disease is diagnosed in diabetics it often occurs within a couple of years of the diabetes diagnosis, but after 5 years the cumulative numbers revealed an estimated 10% incidence of celiac.[3] This is just too common to ignore and the ill effects it creates in these individuals can be dramatic. While it may seem overwhelming to consider, in the long run it could mean the difference between a stable health condition and life-long health challenges. Please let me know if I can be of any assistance. I am here to help. Sources: Ludvigsson JF, “Celiac disease and risk of subsequent Type 1 diabetes” Diabetes Care 29(11), 2483–2488 (2006). Holmes GK. “Screening for coeliac disease in Type 1 diabetes”. Archives of Disease in Childhood. 87(6), 495–498 (2002). Larsson K, et al. “Annual screening detects celiac disease in children with Type 1 diabetes”. Pediatric Diabetes 9(4 Pt 2), 354–359 (2008). Hansen D, et al. “Clinical benefit of a gluten-free diet in Type 1 diabetic children with screening-detected celiac disease” Diabetes Care 29(11), 2452–2456 (2006). Holmes GK. “Coeliac disease and Type 1 diabetes mellitus – the case for screening”. Diabetic Medicine 18(3), 169–177 (2001). Narula P, et al. “Gastrointestinal symptoms in children with Type 1 diabetes screened for celiac disease”. Pediatrics 124(3), E489–E495 (2009). Sanchez-Albisua. “Celiac disease in children with Type 1 diabetes mellitus: the effect of the gluten-free diet. Diabetic Medicine 22(8), 1079–1082 (2005). Goh C. “Prevalence of coeliac disease in children and adolescents with Type 1 diabetes mellitus in a clinic based population”. Postgraduate Medical Journal 83(976), 132–136 (2007). Frohlich-Reiterer EE, et al. “Screening frequency for celiac disease and autoimmune thyroiditis in children and adolescents with Type 1 diabetes mellitus” Pediatric Diabetes 9(6), 546–553 (2008).
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Celiac.com 01/30/2019 - Children who receive the rotavirus vaccine may be less likely to develop type 1 diabetes than children who remain unvaccinated, a recent Australian study suggests. Rotavirus can cause severe watery diarrhea, vomiting, fever, and abdominal pain. In some cases, the virus can leave kids with dehydration that is serious enough to require a hospital visit. There is some data to indicate that rotavirus infections can accelerate the development of type 1 diabetes, though researchers don’t yet know why. In May, 2007, health officials introduced a routine oral rotavirus vaccine for infants six weeks and older. In the most recent study, the research team compared rates of type 1 diabetes in the eight years before and the eight years after the vaccine was introduced. The data showed that cases of type 1 diabetes cases declined 14 percent among children age four and younger in the period after the vaccine. The same data showed no significant change in type 1 diabetes cases among older kids. The study wasn’t set up to prove that rotavirus causes type 1 diabetes or how vaccination might help minimize this risk. The findings are only preliminary, lead study author Dr. Kirsten Perrett of the University of Melbourne says that “rotavirus vaccination may be one of possibly many as yet unknown protective environmental and modifiable factors against the development of type 1 diabetes in early childhood.” Perrett stresses that diabetes “has not been clearly linked to other modifiable lifestyle factors and cannot be prevented.” Rotavirus can interfere with insulin production in the pancreas, which could promote type 1 diabetes, Perrett said. The study does add more data to support the idea that viral infections likely contribute to autoimmune disorders like type 1 diabetes and celiac disease in otherwise susceptible people, said Dr. Federico Martinon-Torres a researcher at Hospital Clínico Universitario de Santiago and Instituto de Investigacion Sanitaria de Santiago in Spain. All infants who do not have severely compromised immune systems or a history of bowel obstruction should receive the rotavirus vaccine, says Martinon-Torres. The good news about this study is that a vaccine that is routinely given to most infants seems to offer protection against type 1 diabetes. Source: JAMA Pediatrics, online January 22, 2019.
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So, where to begin... I was officially diagnosed with Celiac Disease about 2.5 years ago and have been trying to fully heal since then. I knew prior that I had celiac disease but didn't know how serious being gluten free needed to be if you have it. My intestines got so damaged that I had no energy (needed about 12 hours of sleep a day when I normally would sleep 8) and could barely function. I ended up having to quit my job because of how much time I had missed (had used all FMLA, vacation, etc) and spent about 5-6 months recovering till I had enough energy to work a 32 hour/week job but even then was calling out because of gluten exposure. The biggest problem for me has been Rx medication. Food has been hardly an issue at all, at least in comparison. I currently take 2 types of prescriptions and have had problems with both over the past 2.5 years; Hypothyroid medication (T3/T4) & SSRI for depression/energy. I used to go between Paxil and Cymbalta. I would be on one for about 9 months, switch to the other, and repeat (because of the immune system's "short term memory"). I've had a lot of trouble with generic brands and more recently have been using only name brands because they are the only ones now that are listed as Gluten Free on glutenfreedrugs.com, but, now I seem to be having problems with them as well. My doctor has told me that I'm very sensitive to gluten (I think she said I've ranged from an 8-12?). I'm not sure what scale she was referring to, but I know I'm very sensitive based on how my body's reacted to the smallest amount of gluten. When I ingest gluten, my body seems to react by my gallbladder producing a lot more bile (this is most noticeable about 8 hours after I consume gluten), which causes me to have severe diarrhea for about a week (it's basically all liquid). I take my Rx medications everyday, so it's non-stop diarrhea, which makes it hard to stay hydrated. The more water I drink, the more I just end up ****ing it out. I've been taking Benadryl at night because I heard it can help with upset stomach for people with celiac disease. Before I started taking the Benadryl at night I was waking up after about 6 hours of sleeping with extreme stomach pain (too much bile in my stomach?) and having to rush to the bathroom, and would be in there for about an hour. I'm very in tune to knowing when I'm getting gluten exposure for 2 reasons: 1) the slightest amount will cause my stool to get softer and I can smell a difference when I go to the bathroom (my guess is it's from the bile, which has a strong odor), and 2) the amount of long acting insulin required for me per day is less depending on how damaged my small intestines are (I have type 1 Diabetes). I started taking Cymbalta 60 mg about 2 weeks ago and notice severe gluten exposure. I was on it for about 5 days and stopped taking it for a day to see if the symptoms lessened and I couldn't see a difference from only a day. I tried to stop taking it for 2 days but the withdrawl symptoms were too severe (intense sadness/hopelessness, strong suicidal thoughts, etc) and I don't even remember if the gluten exposure symptoms lessened because I could barely function mentally. I'm pretty sure that's where the gluten is coming from because it was the biggest change at the time. I had actually switched from a generic Cymbalta (duloxetine by Mylan) slightly early from my 9 month usual switch because I was having gluten symptoms (at the time, glutenfreedrugs.com listed it on their list but soon changed it to "now questionable"). I'm currently trying Zoloft (been on it for about 3 days now) and the gluten symptoms seem to be slightly less but I won't know for at least another few days. Plus, I don't know if it's actually going to work for me (depression wise). I was going between Paxil & Cymbalta for about 15 years and they were working for me very well (as far as depression) up until recently (because of gluten). I know I've tried Celexa, Lexipro, & Wellbutrin in the past and cannot take them because they either make things worse or the negative side effects outweigh the benefits. I may have tried another type or two of SSRI but it's been so long that I can't remember for sure. I'm making this post to try and get some advice, or even just words of encouragement, on any generic Rx versions of Cymbalta (and Paxil as well, but I won't be taking it for a while so it's less relevant at this point) that people have recently had success with. I've searched online & this site but haven't been able to find anything recent about these medications (most of the posts I've found are from many years ago). I'm scared. Scared of all the times I want to kill myself in any given day because of not taking an SSRI to try and reduce the gluten exposure. Scared that things will get as bad as they've gotten before and I will have to quit my job again. Scared to cry because I'll become even more dehydrated and may not be able to keep fluid in me because of my body is currently not being able to absorb water the way I need it to. The past 3 years have been really tough and I don't really know where to turn at this point. Sorry if this post isn't the most organised. I'm currently an emotional wreck while typing this and at least trying to get out all the important info. Here is a list of new things I've been eating in case someone reads this and sees something they've had problems with that might (also?) be causing gluten issues: Schär Gluten Free Artisan Baker Multigrain Bread (to try and soak up some of the bile, but with constant gluten exposure this doesn't help much) Ensure Original Nutrition Shake (says Gluten Free on it) Pedialyte Advanced Care+ Benadryl
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Celiac.com 12/20/2018 - Patients with monoglandular and/or polyglandular autoimmunity, and their relatives, have higher rates of celiac disease than those without such autoimmunity. Somewhere between 10 and 30% of patients with celiac disease test positive for thyroid and/or type 1 diabetes antibodies, while around 5 to 7% of patients with autoimmune thyroid disease and/or type 1 diabetes test positive for IgA anti-tissue transglutaminase antibodies. A team of researchers recently set out to examine the relationship between celiac disease and endocrine autoimmunity. The research team included George J. Kahalya, Lara Frommera, and Detlef Schuppan. They are variously affiliated with the Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany, the Institute for Translational Immunology and Research Center for Immunotherapy (FZI), Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany, and the Division of Gastroenterology and the Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. Celiac disease and endocrine autoimmunity do share a common genetic background, which definitely explains some of the relationship. The main common denominators are HLA antigens DQ2 (DQA1*0501-DQB1*0201) and/or DQ8 (DQA1*0301-DQB1*0302), that are tightly linked to DR3 and DR4, respectively. Researchers have identified functional single nucleotide polymorphisms of various genes involved in immune regulation as susceptibility genes for both celiac disease and monoglandular or polyglandular autoimmunity. This is a promising hypothesis, but exactly how the effects of a gluten-free diet might prevent or ameliorate glandular autoimmunity remains unclear. Based on their results, the research team does recommend that all patients with celiac disease be tested for type 1 diabetes and/or autoimmune thyroid disease. They also recommend that patients with the above autoimmune endocrine disorders be checked for celiac disease. Read more at: Sciencedirect.com https://doi.org/10.1016/j.autrev.2018.05.013
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