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Jefferson Adams posted an article in Irritable Bowel Syndrome and Celiac DiseaseCeliac.com 12/30/2013 - Irritable bowel syndrome (IBS) and fibromyalgia syndrome (FMS) often occur together, and research indicates that many people with IBS plus FMS (IBS/FMS) might actually suffer from undiagnosed celiac disease. To better understand the potential connection between the two, a team of researchers recently conducted an active case finding for celiac disease in two IBS cohorts, one constituted by IBS/FMS subjects and the other by people with isolated IBS. The research team included L. Rodrigo, I. Blanco, J. Bobes, F.J. de Serres. They are affiliated with the department of Gastroenterology at the Central University Hospital of Asturias (HUCA), Celestino Villamil in Oviedo in the Principality of Asturias, Spain. For their study, the team included 104 patients (89.4% females), fulfilling the 1990-ACR criteria for FMS and the Roma III criteria for IBS classification, along with 125 unrelated, age and sex matched IBS non-FMS patients. All patients underwent the following studies: hematological, coagulation and biochemistry test, serological and genetic markers for celiac disease (i.e., tissue-Transglutaminase-2, tTG-2, and major histocompatibility complex HLA-DQ2/DQ8); multiple gastric and duodenal biopsies; FMS tender points (TPs); fibromyalgia impact questionnaire (FIQ), health assessment questionnaire (HAQ), short form health survey (SF-36), and visual analogue scales (VAS) for tiredness and gastrointestinal complaints. Overall results showed that IBS/FMS patients scored much worse values in quality of life and VAS scales than those with isolated IBS (p These seven patients showed substantial improvement in digestion and symptoms once they adopted gluten-free diets. The findings of this screening indicate that a significant percentage of IBS/FMS patients actually have celiac disease. These patients can improve symptoms and possibly prevent long-term celiac-related complications with a strict lifelong gluten-free diet. Source: Arthritis Res Ther. 2013 Nov 27;15(6):R201.
Jefferson Adams posted an article in Celiac Disease & Gluten Intolerance ResearchNon-celiac wheat sensitivity (NCWS) is a newly described clinical condition marked by symptoms which may affect the gastrointestinal tract, the nervous system, the skin, and other organs. There is little data regarding the origins of NCWS, and it is likely that numerous factors influence the various clinical manifestations of the condition. The one common thread in NCWS is wheat consumption. Symptoms disappear when wheat is eliminated from the diet, and reappear when wheat is consumed. Looking into the possibility that their NCWS patients might in fact be suffering from non-immunoglobulin E (IgE)-mediated wheat allergy, a team of researchers conducted a review their own earlier data regarding NCWS, with a corresponding review of relevant medical literature on NCWS. The research team included Antonio Carroccio, Pasquale Mansueto, Alberto D'Alcamo and Giuseppe Iacono. Together, they reviewed data on 276 patients diagnosed with NCWS by means of double-blind placebo-controlled (DBPC) wheat challenge. They then examined data indicating a possible wheat allergy diagnosis, and reviewed other study data, along with the role of serum immunoglobulin G antibodies and the basophil activation assay in food allergy, and the histology findings in the food allergy diagnosis. By comparing patients with NCWS and irritable bowel syndrome (IBS) against controls with non-IBS-related NCWS, the team determined that NCWS was marked by: food allergy in the pediatric age (0.01); coexistent atopic diseases (0.0001); positive serum anti-gliadin (0.0001) and anti-betalactoglobulin (0.001) antibodies; positive cytofluorimetric assay revealing in vitro basophil activation by food antigens (0.0001); and a presence of eosinophils in the intestinal mucosa biopsies (0.0001). Patients with NCWS and multiple food sensitivity show several clinical, laboratory, and histological characteristics that suggest they might actually be suffering from non-IgE-mediated food allergy. This is potentially very interesting news regarding NCWS, but the team does note that other pathogenic possibilities need to be considered and investigated before this can be confirmed. Source: The American Journal of Gastroenterology, 5 November 2013. doi:10.1038/ajg.2013.353