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Showing results for tags 'alopecia areata'.
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Celiac.com 01/06/2025 - A recent study sheds light on the potential link between alopecia areata, a hair-loss condition caused by the immune system, and celiac disease, an autoimmune disorder triggered by gluten. Both conditions are rooted in immune dysfunction, and researchers aimed to determine whether individuals with alopecia areata are at greater risk of developing celiac disease. The Study's Approach The study analyzed data spanning from 2005 to 2019 and included a large sample of patients with alopecia areata alongside a matched group of healthy individuals. Specifically, the researchers examined medical records of 33,401 patients diagnosed with alopecia areata and compared them to 66,802 healthy controls. The focus was to identify whether celiac disease occurred more frequently in patients with alopecia areata compared to the control group. Key Findings Prevalence Rates of Celiac Disease - Among those with alopecia areata, 1.1% were found to have celiac disease, compared to 0.6% of the control group. - This nearly doubled the risk, suggesting a strong association between the two conditions. Odds of Developing Celiac Disease - Statistical analysis revealed that individuals with alopecia areata had close to a twofold increased likelihood of having celiac disease. - The odds ratio of 1.95 confirmed the significance of this connection, and the findings were consistent across all age groups. Higher Risk in Older Adults - The study highlighted that the association was particularly pronounced in patients over 40 years of age. This demographic showed the highest prevalence of celiac disease among the alopecia areata population. Implications of the Findings The study emphasizes the importance of recognizing the increased risk of celiac disease in individuals with alopecia areata. For healthcare providers, these findings underscore the potential benefits of early screening for celiac disease, particularly in older adults with alopecia areata. Detecting celiac disease early can help prevent complications such as nutrient deficiencies, intestinal damage, and other associated health issues. Why This Study Matters for People with Celiac Disease For those already living with celiac disease or concerned about its onset, this study adds to the understanding of how autoimmune conditions can overlap. People with alopecia areata may benefit from discussing their risk with their healthcare providers and considering screening for celiac disease if symptoms arise. By highlighting the connection between these two conditions, the study encourages proactive management and improved quality of life for individuals at risk. Read more at: academic.oup.com Watch the video version of this article:
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Celiac.com 08/05/2024 - Psoriasis is a prevalent chronic inflammatory skin condition characterized by its autoimmune etiology. Affecting both men and women equally, this disease is often associated with other autoimmune disorders, increasing the complexity of its management. This study aims to explore the prevalence of autoimmune diseases in patients diagnosed with psoriasis at King Abdulaziz Medical City in Riyadh, Saudi Arabia. By identifying these associations, the study provides valuable insights into the interconnected nature of autoimmune conditions. Study Methods and Patient Selection The research was conducted as a retrospective, cross-sectional chart review. Patients with confirmed psoriasis diagnoses were identified through the dermatology clinic's electronic medical records. The charts were meticulously reviewed to document the presence of other autoimmune diseases, including hypothyroidism, hyperthyroidism, alopecia areata, vitiligo, atopic dermatitis, and inflammatory bowel diseases such as Crohn's disease and celiac disease. Ethical approval was granted by King Abdullah International Medical Research Center's Institutional Review Board. Key Findings and Demographic Data A total of 839 patients were included in the study, with a female majority of 56.4%. The age group with the highest prevalence of psoriasis was between 31 and 50 years, comprising 37.1% of the patients. The study found that 6.8% of the patients had hypothyroidism, making it the most common associated autoimmune disease. This was followed by alopecia areata (3.6%) and atopic dermatitis (2.9%). Rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel diseases were notably less common in this cohort. Discussion on the Association Between Psoriasis and Autoimmune Diseases The study reveals that a significant number of psoriasis patients also suffer from other autoimmune diseases, with thyroid disorders being the most prevalent. The findings are consistent with other research that suggests a higher susceptibility to autoimmune conditions among psoriasis patients. For instance, autoimmune skin disorders such as alopecia areata and vitiligo were frequently observed. The commonality in immune response mechanisms across these diseases might explain their co-occurrence. In particular, the role of T-cell-mediated processes and cytokine release, such as tumor necrosis factor-alpha and interleukins, is critical in both psoriasis and other autoimmune conditions. Limitations of the Study Despite its valuable findings, the study has several limitations. Being a single-center, retrospective study, the results might not be generalizable to other populations. Additionally, the reliance on documented diagnoses in medical records could lead to underreporting or missing data. A larger, multicenter approach would provide a more comprehensive understanding of the prevalence and association of autoimmune diseases with psoriasis. Implications for Celiac Disease Patients This study underscores the high prevalence of autoimmune diseases among psoriasis patients, with thyroid disorders and skin autoimmune conditions being the most common. For individuals with celiac disease, these findings are particularly relevant. Understanding the interconnected nature of autoimmune disorders can aid in better managing their health and anticipating potential complications. It also highlights the importance of comprehensive care approaches that address multiple autoimmune conditions simultaneously. By recognizing these associations, healthcare providers can improve diagnostic accuracy and treatment plans, ultimately enhancing the quality of life for patients with celiac disease and other autoimmune disorders. Further research in diverse populations and larger settings is necessary to validate these findings and expand our understanding of autoimmune disease interactions. Read more: cureus.com
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Hello everyone, I was diagnosed with celiac disease at the end of September 2023 and immediately started the gluten-free diet. Ever since I was a little girl, I've often been ill, and throughout my childhood I was underweight and severely deficient in iron and vitamin D in particular. In my pre-adolescence, I began to have difficulty standing, running etc., and after more than a year of tests and X-rays, no diagnosis could be made. Fortunately, in adolescence it went away on its own. The doctors never really understood why I was so often ill as a child. I changed doctors and treatments several times, but nothing helped. Around the age of 14, I started to lose a lot of my hair, and by the age of 18 I had severe alopecia. Several years later I had an event in my life that deeply affected me and I suffered a great deal of stress for a long time, since when I've also started to lose my eyebrows. After a major eyebrow loss this summer, I decided to do something about all this and understand what is going on with me. After a lot of research, I realized that I might have celiac disease. I was diagnosed with the disease in September and my gastroenterologist has put me on a strict diet which I follow to the letter (I eat almost no processed foods and those I do eat rarely I check for contamination). However, I don't feel that my symptoms are improving. True, I no longer have a constant gut ache or dizziness, but apart from that, my acne is still present and has even worsened, my hair and eyebrows don't seem to be improving (I still loss lots of them) and I'm constantly tired. I have a diet where I eat very little dairy, lots of protein and fruits, vegetables, oilseeds, etc.. I'm 6 months into a gluten-free diet, how long did it take you to see your skin, hair and fatigue improve for those who also had these symptoms in particular? Thank you very much
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Is Your Gut's Microbiota Making You Bald?
Jefferson Adams posted an article in Skin Problems and Celiac Disease
Celiac.com 05/14/2018 - An imbalance or defect in gut bacteria function may be a major cause of hair loss and pattern baldness. Pattern baldness (alopecia areata) affects approximately 1.7 per cent of the population and we still don’t know precisely what causes it. In addition to promoting a healthy digestive tract, our gut bacteria play an important function in our overall health. Recent experiments with antibiotics and bacteria-free mice reveal how a single a single gut bacteria, Lactobacillus murinus, could cause pattern baldness by triggering deficiencies in biotin. Biotin, vitamin B7, is a crucial vitamin. Biotin deficiency can lead to skin disease and hair loss. Some bacteria in our gut produces biotin, while other bacteria breaks down and consumes biotin. Biotin deficiency is most often seen in patients with serious conditions, such as celiac disease, but it can also be common among pregnant women. Previous research has shown that bacteria-free mice that lack biotin in their diet, develop mild hair loss (alopecia). Could an imbalance or defect in gut bacteria function be a major cause of hair loss and pattern baldness? To determine if the underlying cause of hairless might be an imbalance of our gut bacteria, a team of Japanese scientists conducted experiments with antibiotics and bacteria-free mice to see if variations gut bacteria might cause pattern baldness by influencing biotin levels. The team first fed laboratory mice a diet with and without biotin, but saw no impact on hair loss. They then repeated the experiment, but this time they also gave the mice a long course of antibiotics to destroy the balance of bacteria in their gut. The laboratory mice on a biotin-free diet coupled with antibiotics saw an increase in a particular gut bacteria that corresponded to patten hair loss, as was previously shown in bacteria-free mice. By studying what had happened in the gut bacteria of these mice, the scientists discovered that a particular type of lactic acid bacteria, Lactobacillus murinus, had expanded after the antibiotic treatment. When the team fed bacteria-free mice with Lactobacillus murinus, they saw that the hair loss became even worse and the mice became almost entirely bald. Further tests followed, in which regular mice and bacteria-free mice received a regular diet with normal levels of biotin, but added Lactobacillus murinus. These mice showed no hair loss at all. Direct injections of biotin also stopped hair loss; although the team did concede that skin bacteria could also play a role. The discovery that gut bacteria and diet to influence hair loss creates new avenues for treating baldness and hair loss simply by adjusting gut microbiota. It’s possible that probiotic dietary supplements can be used to influence gut bacteria, and prevent the biotin-eating bacteria now known to cause hair loss. Stay tuned for news on the role of gut bacteria in hair loss, and on any new treatment approaches to hair loss and alopecia that may result. Their results appear in the scientific journal Cell Reports.-
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