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Showing results for tags 'associations'.
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Celiac.com 06/06/2024 - Microscopic colitis is a type of chronic inflammatory bowel disease characterized by persistent watery diarrhea, abdominal pain, cramps, bloating, weight loss, nausea, fecal incontinence, and dehydration. It comprises two distinct sub-types: collagenous colitis and lymphocytic colitis, both leading to non-bloody watery diarrhea. In contrast, celiac disease is an autoimmune disorder triggered by gluten consumption, resulting in damage to the small intestine. Despite their differences, recent studies have hinted at a potential association between microscopic colitis and celiac disease, necessitating further investigation. Utilizing National Inpatient Data for Analysis This study utilized the National Inpatient Sample (NIS) database spanning four years (2016–2019) to conduct a comprehensive analysis of the relationship between microscopic colitis and celiac disease. Through specified International Classification of Diseases, 10th Edition (ICD-10) codes, patients with and without microscopic colitis, along with the presence or absence of coexisting celiac disease, were identified. Statistical analyses, including univariate and multi-variate methods, were employed to assess the association while adjusting for various confounding factors. The study encompassed a vast dataset of over 26 million patients, providing robust insights into this intriguing link. Key Findings and Clinical Implications The analysis revealed a significant association between microscopic colitis and celiac disease, supported by both univariate and multi-variate analyses. Interestingly, celiac disease emerged as an independent risk factor for increased mortality among microscopic colitis patients, although it did not significantly impact the mean hospital stay. These findings underscore the need for heightened awareness and clinical vigilance in managing patients with coexisting microscopic colitis and celiac disease. Moreover, the study's large-scale approach and comprehensive analysis contribute valuable insights into the complex interplay between these gastrointestinal disorders, paving the way for more targeted treatments and improved patient outcomes. This study delved into the intriguing association between microscopic colitis and celiac disease using extensive population-based data from the National Inpatient Sample (NIS) database spanning four years (2016–2019). The investigation aimed to elucidate this relationship with robust statistical analyses while controlling for various confounding factors. Here's a detailed summary of the study's key aspects and findings: Exploring the Link Between Microscopic Colitis and Celiac Disease The study analyzed data from over 26 million patients, identifying those with and without microscopic colitis and assessing the presence or absence of coexisting celiac disease. Statistical analyses, including univariate and multi-variate methods, were employed to evaluate the association while adjusting for confounding factors such as age, race, hospital characteristics, and comorbidities. Association and Impact The analysis revealed a significant association between microscopic colitis and celiac disease, supported by both univariate and multi-variate analyses. Interestingly, celiac disease emerged as an independent risk factor for increased mortality among microscopic colitis patients. However, there was no significant impact on the mean hospital stay. Clinical Implications These findings highlight the clinical relevance of understanding the link between microscopic colitis and celiac disease, emphasizing the need for vigilant monitoring and appropriate management for patients with coexisting conditions. The study's population-based approach and comprehensive analysis contribute valuable insights for informed decision-making in healthcare. Future Directions The study sets the stage for further research focusing on mechanistic aspects, prospective studies to establish causality, and exploring therapeutic interventions. Addressing limitations related to data accuracy and histologic subtypes is crucial for refining our understanding and improving clinical management. This study establishes a probable association between microscopic colitis and celiac disease, backed by rigorous statistical analyses. It also identifies celiac disease as an independent risk factor for increased mortality among microscopic colitis patients. These findings provide a foundation for future research and clinical considerations, aiming to optimize patient care and outcomes in the realm of gastrointestinal health. Source: journals.lww.com
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More Links Between Celiac Disease and Osteoporosis
Jefferson Adams posted an article in Winter 2024 Issue
Celiac.com 11/20/2023 - Celiac disease and osteoporosis are known to be linked due to several interrelated factors. We recently did an article on the role of celiac disease in the development of skeletal alterations in patients with osteoporosis. In addition to the connections mentioned in that article, here are some additional connections between these two conditions: Malabsorption of Nutrients: Celiac disease, particularly when untreated or undiagnosed, can lead to damage in the small intestine. This damage impairs the absorption of various essential nutrients, including calcium and vitamin D. These nutrients are crucial for maintaining healthy bones. The malabsorption of calcium and vitamin D can contribute to the development of osteoporosis. Chronic Inflammation: Celiac disease is characterized by chronic inflammation in the gut. Prolonged inflammation can have systemic effects on the body, including the promotion of bone loss and the development of osteoporosis. Secondary Hyperparathyroidism: In celiac disease, the malabsorption of calcium can lead to secondary hyperparathyroidism. This is a condition where the parathyroid glands become overactive in response to low calcium levels in the blood. Hyperparathyroidism can further contribute to bone loss. Low Body Weight: Celiac disease can lead to weight loss and a lower body mass index (BMI), which is associated with an increased risk of osteoporosis. Low body weight can result in decreased bone density, making the bones more susceptible to fractures. Gluten-Free Diet and Nutrient Restoration: Fortunately, osteoporosis associated with celiac disease can often be managed or even reversed by adopting a strict gluten-free diet. When individuals with celiac disease eliminate gluten from their diet and allow their small intestine to heal, nutrient absorption improves. This, in turn, can lead to a recovery of bone density. Supplementation: In some cases, healthcare professionals may recommend calcium and vitamin D supplementation to help restore bone health in individuals with celiac disease. These supplements can be especially beneficial during the early stages of adopting a gluten-free diet when the body is still healing. Bone Density Monitoring: Individuals with celiac disease, particularly those who are newly diagnosed or have experienced severe bone loss, may benefit from bone density testing (e.g., dual-energy X-ray absorptiometry or DXA scans). Regular monitoring can help assess bone health and guide treatment decisions. Lifestyle Factors: Besides diet, other lifestyle factors like engaging in weight-bearing exercises, quitting smoking, and moderating alcohol intake can contribute to better bone health and help mitigate the risk of osteoporosis. It's important for individuals with celiac disease and osteoporosis to work closely with healthcare professionals, such as gastroenterologists, registered dietitians, and endocrinologists, to manage their conditions effectively. By maintaining a strict gluten-free diet and addressing nutritional deficiencies, many individuals can improve their bone health and reduce the risk of osteoporosis associated with celiac disease.-
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Celiac.com 09/21/2023 - Gluten sensitivity is a chronic intolerance to gluten in people who have a genetic predisposition. It is thought to involve the immune system and can lead to various skin conditions. Celiac disease is one common form of gluten intolerance and can affect not only the digestive system but also the skin, endocrine system, nervous system, and blood. We know that a number of skin disorders are associated with celiac disease. Psoriasis, a chronic inflammatory skin condition, has shown improvement when individuals adopt a gluten-free diet. Specifically, palmoplantar pustulosis, a variant of psoriasis, and aphthous stomatitis, which causes recurring mouth ulcers, have responded positively to gluten elimination. Dermatitis herpetiformis, another skin disorder related to celiac disease genetically, has also seen significant improvement with a gluten-free diet. However, atopic dermatitis, another prevalent long-term skin condition, has produced inconsistent results with gluten removal. Further research is needed to draw more definitive conclusions. Hereditary angioedema has shown an association with gluten intolerance in some cases, with symptomatic benefits observed after adopting a gluten-free diet. Vitiligo and linear IgA bullous dermatosis have also shown clinical evidence of improvement with a gluten-free diet. On the contrary, rosacea, a skin condition causing facial redness, has been linked to an increased risk of developing celiac disease. The Research Team A team of researchers recently set out to examine the association between gluten intolerance and skin disorders. The research team included Vaibhav Vats, Pallavi Makineni, Sarah Hemaida, Anum Haider, Sachin Subramani, Navjot Kaur, Amna Naveed Butt, Renee Scott-Emuakpor, Mohammad Zahir, Midhun Mathew, and Javed Iqbal. They include one Physician, Istanbul Okan University, Istanbul, TUR; and are otherwise variously affiliated with the department of Internal Medicine, Smt. Kashibai Navale Medical College & General Hospital, Mumbai, IND; the department of Neurosurgery, Mayo Hospital, Lahore, Pakistan; the department of Medicine/internal medicine, Allama Iqbal Medical College, Lahore, PAK; the Department of Internal Medicine, Pennsylvania Hospital, Philadelphia, USA; the department of Medicine, Ayub Medical College, Abottabad, Pakistan, Abottabad , PAK; the department Dermatology, University of Miami Miller School of Medicine, Miami, USA; the department of Medicine, Government Medical College, Amritsar, Amritsar, IND; the department of Internal medicine, ESIC medical college and hospital, Gulbarga, IND; the department of Internal medicine, Img helping hand, Karachi, PAK; and the department of Medicine, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND. Their review highlights the potential impact of gluten intolerance on various skin conditions and the potential therapeutic benefits of a gluten-free diet for managing symptoms. However, more clinical trials and observational studies are needed to fully understand the underlying mechanisms and provide definitive dietary recommendations for these conditions. Read more in Cureus.com
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