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Showing results for tags 'asthma'.
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Hello, I am a PhD student in integrative and functional nutrition hoping to examine the effects of a 14 day wheat free diet on asthma signs and symptoms. Currently no studies on asthma and wheat exist from an intervention standpoint. I am wondering if anyone on this forum with asthma noticed improvements in asthma sign/symptoms once going on a wheat-free diet? If it did help you, would you mind sharing how long it took for asthma signs to improve? For instance, did you notice an improvement only days into a wheat free diet or did it take months? I will not use any of this information in my research but it may help me to tweak the length of my intervention. Thank you.
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Celiac.com 04/07/2011 - People with celiac disease are 60 percent more likely to develop asthma than people without celiac disease, according to a new study, which appears in the Journal of Allergy and Clinical Immunology. Moreover, the study results show that those with asthma are also more likely to eventually develop celiac disease. Indeed, for every 100,000 people with celiac disease, 147 will have asthma that would not have occurred in the absence of the digestive disorder. To assess possible links between celiac disease and asthma, Dr. Jonas Ludvigsson of Orebro University Hospital and the Karolinska Institutet in Sweden and colleagues compared more than 28,000 Swedes diagnosed with celiac to more than 140,000 similar people without the disease. Ludvigsson cautions that the study merely shows an links between the two diseases, it does not establish that asthma causes celiac disease, or vice versa. The exact nature of the association between the two diseases is unclear, but Ludvigsson told reporters that he thinks "the role of vitamin D deficiency should be stressed." Ludwigsson points out that people with celiac are more likely to develop osteoporosis and tuberculosis, both diseases in which vitamin D plays a role. If a person with celiac also has low levels of vitamin D, this could in turn affect the immune system, which could increase the risk of developing asthma. Another possibility, he points out, is that "asthma and celiac disease share some immunological feature. If you have it, you are at increased risk of both diseases. Ludvigsson also addresses the fact that the study did not establish levels of compliance with a gluten-free diet among the participants with celiac disease by noting that general "dietary compliance is high in Sweden," so he believes that "patients with good adherence are at increased risk of asthma." Source: Journal of Allergy and Clinical Immunology, 2011. doi:10.1016/j.jaci.2010.12.1076
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Celiac.com 11/30/2016 - Trials using hookworm as a possible treatment for celiac disease are already underway in Australia, but they latest hookworm news indicates that they might also be useful for treating asthma. The New World hookworm, aka necator americanus, is long and slender as an angel hair noodle. Adults are large enough to be seen with the naked eye. Seen up close, they look more like the sand worms in the movie Dune than anything people are used to seeing here on earth. Researchers are reporting that a protein produced by hookworms reduces the symptoms of asthma in mice, and could one day be used to treat asthma in humans, says the journal Science Translational Medicine. These parasites are some of the most maligned creatures in the animal kingdom. They chew into the human intestinal wall and suck blood to survive, but they just might be the key to making millions of people healthier. Says Severine Navarro, the paper's lead author and a senior research fellow at James Cook University in Australia, data from immunological studies shows that populations with no parasites also have "the highest incidence of autoimmune diseases and allergies." The data in this study arose from an effort by Navarro and her fellow researchers to look for a connection between success of de-worming programs around the world and the rise of immune system problems like asthma and celiac disease. Among other things, when hookworms infect humans, they secrete chemicals that turn off the immune alarm bells and repair the tissue around it. The worms limit blood consumption to a few drops a day and keeps its own numbers in check by plants offspring in the host's poop to ensure an orderly exit from the body. Navarro and her team wonder if the hookworm's stealthy adaptations also benefit their host by controlling in adverse immune reactions. The team's initial small study of one dozen trial participants showed that the hookworm did improve their tolerance of gluten. Since infecting large numbers of patients directly with hookworm might lead to other issues, the team isolated the active ingredient in hookworm spit - a compound called AIP-2 - and injected it into asthmatic mice on a daily basis for five days. Results showed a sharp decline in asthma symptoms, and reduced inflammation in airways. These benefits persisted for 10 weeks after the mice stopped getting the treatment. The researchers also noticed that AIP-2 seemed to have a calming effect on the body's dendritic cells - a part of the immune system responsible for processing threats. According to Navarro, the drug works by "basically rewiring the cells in that tissue into promoting very efficient regulatory T cells." This suggests that AIP-2 might also help humans, since dendritic cells have the same function in us that they do in mice. Navarro said the team's next step is a phase one clinical trial, which would test the effectiveness of an AIP-2 pill. Successful phase one trials will lead the way toward a safe drug that could help tens of millions of asthma sufferers. As seen in earlier studies using hookworm, the compound might be useful in treating autoimmune disorders, like celiac disease, inflammatory bowel disease and multiple sclerosis. Read more on hookworms and celiac disease. Source: ChicagoTribune.com.
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Celiac.com 05/20/2011 - Over the years, researchers have been discovering more and more about celiac disease, an autoimmune disease which is caused by gluten, a protein found in wheat, barley, and rye. Studies have linked the disease to a variety of other medical conditions, such as irritable bowel syndrome, rheumatoid arthritis, and osteoporosis. Researchers have now found a connection between celiac disease and asthma. Asthma is chronic lung disease that causes the passages of the lungs to become inflamed and narrowed, resulting in wheezing, shortness of breath, tightness in the chest area, and coughing. It often begins in childhood, and according to the U.S. Department of Health and Human services, more than 22 million people suffer from the condition. Many studies have linked asthma to airborne allergens, but doctors have begun to look into food culprits as well. One such study shows a connection to celiac disease, which isn’t an allergy but rather an autoimmune response to gluten. In a study published in the Journal of Allergy and Clinical Immunology, European researchers found that celiac individuals were 60 percent more likely to develop asthma than those without the condition. Celiac disease affects approximately one percent of the population and without treatment, which is a gluten-free diet, can cause a variety of physical and mental symptoms including chronic fatigue, headaches, malnutrition, chronic headaches, and stomach problems. Dr. Jonas Ludvigsson of Orebro University Hospital and the Karolinska Institutet in Sweden and his colleagues compared more than 28,000 Swedish celiac patients to more than 140,000 similar people without the disease. The study concluded that only a link between the two could be demonstrated, not that one condition causes the other; the researchers weren’t able to identify the reason for the association. One possible factor may be Vitamin D. According to Reuters Health, Dr. Ludvigsson said in an email, "Personally, I think the role of vitamin D deficiency should be stressed." Vitamin D has been demonstrated to be a factor in the development of tuberculosis and osteoporosis, both of which celiacs are more likely to develop. In celiac disease, gluten causes an autoimmune reaction that causes the immune system to attack the small intestine, specifically the villi, the finger-like structures that absorb the nutrients from food; thus celiac patients usually exhibit deficiencies in vitamins and minerals. If a celiac patient isn’t getting enough vitamin D into their system, according to Dr. Ludvigsson, the risk for asthma disease may be increased. According to Dr. Ludviggson, Swedish celiac patients adhere well to the gluten-free diet. The study didn’t determine how closely the 28,000 subjects were sticking to their diets, but Ludviggson told Reuters health, "Generally dietary compliance is high in Sweden, so I actually believe that also patients with good adherence are at increased risk of asthma.” It is recommended that people who suspect they may have celiac disease or asthma should consult with a qualified medical practitioner for testing, diagnosis, and treatment. Resources: U.S. Department of Health & Human Services: http://www.nhlbi.nih.gov/health/dci/Diseases/Asthma/Asthma_WhatIs.html Gluten Free Society: Gluten Sensitivity Increases the Risk for Asthma: http://www.glutenfreesociety.org/gluten-free-society-blog/gluten-sensitivity-increases-the-risk-for-asthma/ Reuters: Asthma linked to celiac disease: http://www.reuters.com/article/2011/02/24/us-asthma-linked-celiac-disease-idUSTRE71N4WF20110224
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Celiac.com 03/11/2009 - I recently had an unfortunate health experience related to celiac disease. I learned long ago that it’s my responsibility to manage my own health, so I came up with a strategy that was successful. Along the way, I also learned some important information that really helped me understand the problem and the eventual solution. Perhaps this information will help you avoid a similar health crisis. I’ve included links that can give you additional information. Disclaimer: I’m not a medical doctor. This is information that I have gathered based on my own experiences and research. Celiac Disease I have celiac disease. I manage it quite well through my diet. However, if I ingest anything with gluten, for instance a wayward crouton in a restaurant salad, I have a severe reaction that starts within five minutes. All or some of the following will occur: hives from head to toe, stomach cramps, uncontrollable diarrhea, vomiting, asthma, severe lethargy. I fall into an uncontrollable sleep that takes about four hours to run its course. Needless to say, I avoid gluten at all costs. A Bit of History Although I am a remarkable person (like all of us), my health history has been quite unremarkable. Nothing was ever wrong with me and I wasn’t allergic to anything. I can count on one hand how many times I’ve taken antibiotics in my entire life. In the past 30+ years, I never went to the doctor for an illness. I’ve had colds, various and sundry viruses and infections, but they ran their course with slowing down, plenty of rest and fluids. I believe that the primary strategy should be to give your body the time to heal itself first, and if that fails look for an alternative strategy from your doctor. Imagine my surprise when about six years ago the symptoms of celiac disease manifested themselves. (Note: I was going through an acute stressful time in my life when this occurred.) Along the way, other unexpected food allergies have presented themselves as well. One of my favorite foods was peanut butter. Since I was a little girl, I loved feasting on “peanut butter on spoon”. Out of the blue one day, a typical teaspoon of one of my favorite foods sent me into an anaphylactic reaction. And then a few months after that incident, a bite of a granola bar with cashews sent me on my first ambulance ride with a rapidly constricting throat to the emergency ward. My favorite food is now a deadly poison. I’ve had mild intestinal reactions to all vinegars and vinegar products (a little balsamic is OK), more than three glasses of red wine (not white wine or champagne), milk and cream (not cheese, thank the Universe!). I’ve also realized that I’m thirsty all the time. It seems that no matter how much water I drink, I can’t seem to quench my thirst. I even sleep with water next to my bed and drink several glasses throughout the night and still wake up thirsty. The water goes right through me and doesn’t seem to be absorbed. (I have recently been prodded, poked, examined and tested by a battery of doctors as a result of my once in 50-year checkup and they all agree that I’m the picture of health.) Both my mom and my grandmother suffered from asthma; my grandmother dealt with it her whole life. When I have an asthmatic reaction, my wheezing and coughing sound just like theirs! I remembered them being armed with their inhalers and their steroids at all times. I also remembered that these medical weapons didn’t stop the asthma attacks or the wheezing or uncontrollable coughing. They only dealt with the symptoms, not the underlying problem. Mom’s asthma went away when she started eating a gluten free diet. The Incident So I’ve come to enjoy cooking. Regardless of the disastrous results of my past cooking experiences well documented by my children, close friends and family, this new hobby relaxes me at the end of the day, is creative, saves money and insures a truly gluten and allergy free diet. I recently made a delicious French Onion and Ham Cream Soup. It was inspired by some wonderful French spices I bought from Penzey Spices. I made a big pot of the soup and had it for different meals throughout the week. I didn’t notice at the time an increased feeling of lethargy, intestinal rumblings and increased thirst that got progressively worse through the week. And then it happened. About five minutes after devouring the last of my delectable French Onion and Ham Cream Soup, the tell-tale signs of an oncoming asthma attack occurred: mucous pouring into my lungs, wheezing, airways closing up, unrelenting coughing. In addition, I had horrible abdominal cramping. I was tremendously thirsty, but the water just seemed to go through me and make me even thirstier. At about 4:00 am just as I was about to get myself to the hospital, I started to slowly stabilize, meaning I wasn’t getting worse. I slept for a little bit, then woke up coughing uncontrollably. My throat was so parched it felt like sandpaper. I dragged myself through a day of work exhausted, not being able to really get a good breath and feeling so very thirsty. That night I literally coughed all night long sitting straight up in a chair; I couldn’t lie down because of the coughing. I couldn’t go to work the next day. I needed to discover why this happened, how I can prevent it from happening again and implement an immediate strategy for managing this health crisis. Hypothesis I realized there was a relationship between several factors: celiac disease, since I had no allergies until it manifested itself; cow’s milk, which I knew was a highly allergic food; asthma, as the allergic reaction, and dehydration, because of the incessant thirst. By understanding how all of these factors related to each other, I thought I could figure out a strategy to 1) get myself into a healthy state quickly and 2) prevent this health crisis from happening again. (Even thought I knew this was an asthma attack, I wanted to make doubly sure it wasn’t pneumonia or something similar. I had no fever, chills, aches or pains, headache, or upper respiratory infection. I was fine one minute and not fine the next.) Research Asthma is a disease in which inflammation of the airways causes airflow into and out of the lungs to be restricted. When an asthma attack occurs, mucus production is increased, muscles of the bronchial tree become tight, and the lining of the air passages swells, reducing airflow and producing the characteristic wheezing and coughing. Asthma symptoms are usually worse at night. There is high correlation between people who have celiac disease and people who have sensitivities to proteins found in cow's milk. Milk is one of the most common food allergens in the American diet. And most cows eat a lot of grain and perhaps there’s a link here. Milk allergy symptoms can occur within minutes or hours after consuming the dairy product. They can be triggered by a very small amount of milk protein in the system. There is also a relationship between celiac disease, asthma and dehydration. People with celiac disease are often very thirsty even after drinking lots of water. And so are people with asthma. If fact, many doctors now think that asthma is a symptom of the body managing its water supply. This is how it works… Water is needed for every function of the body. Our bodies are 75% water and our brains are 85% water. Because of the water used in breathing, digestion, enzyme and hormone production, immune function, toxin removal and so on, we need to replace that water frequently throughout the day or our health will suffer. When we start to dehydrate, histamine production increases to conserve water in our bodies. This is vital since our lungs must remain moist to work properly. Excess histamine, a defense against losing more water, makes it difficult to breath and triggers an asthma attack. Histamine also stimulates mucous production to help seal in moisture, but that also leads to increased breathing difficulties. Histamines are also important for immune function, but during dehydration they are mostly used to look for water. If dehydration becomes chronic, the immune system will suffer; allergies, both inhalant and food allergies, will result because histamine is important for the proper balance of Tcells, antibodies and so on. Elevated histamine in the lungs causes the spasm of the bronchioles. This conserves moisture that would normally be lost during breathing. The mucus that clogs up the airways is the body’s attempt to keep the airways from completely drying out. Inflammation in the airways is the result of the body bringing more “micro-circulation” to the lungs as a result of dehydration. Common problem foods for people with asthma are dairy and gluten. Both are very hard to digest and require a lot of water to break down. If there is not enough water in the digestive tract when food is taken in, water will be pulled from other parts of the body and localized dehydration will result. This can lead to asthma, among other problems. Allergy symptoms of any kind are a sign that we need to drink more water. Antihistamines and most medicines, either directly or indirectly, actually are counterproductive for the body because they further dehydrate the body and shut off the body’s search for water. Pain, inflammation and digestive problems are also typically signs of dehydration. Dehydration is a common cause of migraines, for example. And then I unexpectedly learned about salt… Salt is the other half of the hydration equation. Salt is vital for the generation of hydroelectric energy and transmission of nerve impulses in all the cells. Salt acts as a natural antihistamine through salt-sensing nerves on the tongue and plays a major role in regulating water. Without enough salt, water is not absorbed. My Strategy The first step was to get myself in a healthy state. My re-hydration plans included continually drinking filtered water even through the night, teaspoons of honey to soothe my raw throat when needed and pinches of pink Australian sea salt (a Christmas gift from my wonderful mom) on my tongue throughout the day and night when I felt I needed it, although any sea salt would do. I also had vegetable juice and fruit juice for additional fluids. I noticed the salt working in a couple of hours. I was beginning to absorb the water (I didn’t have to pee every time I drank some water). It took about two days before the thirst went away. It was great waking up without a parched throat. The coughing was still uncontrollable, especially at night, but instead of a constant, non-productive coughing and horrible wheezing, the mucus was beginning to become looser. It took another three nights before I could sleep lying down, but the mucus had really broken up. The coughing was actually allowing the mucus to get out of my lungs. It took about six days to feel like myself again. I did gain about five pounds. But I lost it quickly and it was fat lost, not precious water. Besides, there’s nothing glamorous about walking around in a dehydrated, sickly state. The second step is to not let this happen again. I’m now drinking no less than 10 eight-ounce glasses of water every day with a pinch of salt on my tongue if I feel I need it. I need about ¼ teaspoon of salt for every quart of water I drink. After a lifetime of poor medical advice, I now know that salt is my friend. If I drink coffee or wine or if I get the nutty idea to exercise, I have to drink more water. And no more milk and cream - at least until I’m stabilized for awhile. If I feel an asthma attack coming on, the best treatment is to drink 2-3 cups of water and put a pinch of sea salt on my tongue. This will provide my body with the water it needs and the salt will send a signal to my brain to relax the bronchioles by letting it know relief is coming. Conclusion As difficult as this last health adventure was, I learned something that has changed the way I feel and has optimized my health. I found the root of the problem and fixed it instead of following mainstream medical thinking and putting a band aid on the symptoms. It’s really scary when it feels like your body is turning on you, and very empowering when you use science and knowledge to get yourself back. I’ve always said when it comes to business, “the market speaks, just listen.” I now need to take that advice for myself. My body speaks; I just have to listen!
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Celiac.com 03/21/2011 - Two recent population-based studies, both performed in Sweden by Dr. Jonas Ludvigsson, have concluded that people who have had biopsies that reveal villous atrophy are at increased risk of both ischemic heart disease and asthma. But at least regarding heart disease, the bulk of the risk may simply be attributable to inflammation. The team of researchers looked at biopsy data collected from all twenty-eight of Sweden’s pathology departments between 2006 and 2008. The data included biopsies performed as far back as 1969, and represented 44,446 individuals: 28,190 with celiac disease, as ascertained by small intestine morphology; 12,598 with duodenal/jejuna inflammation lacking villous atrophy; and 3,658 with latent celiac disease, defined as those with positive celiac serology but normal mucosa. 219,392 healthy controls who had never had biopsies were included as controls. They concluded that celiac disease and inflammation of the small intestine were both modestly associated with ischemic heart disease, whereas latent celiac disease was not. Although these findings agree in kind, if not in degree, with reports previously published by others, this study had a number of flaws. First of all, the researchers lack data on individual adherence to a gluten free diet. The authors note that “low dietary adherence is associated with persistent inflammation and therefore might explain the increased risk of ischemic heart disease observed in patients with celiac disease.” They also lack data on blood pressure, smoking status, body mass index, lipid levels, exercise routines, and other established risk factors for ischemic heart disease. Because they found the highest risk in the first year following biopsy, they cede that this risk could be attributable to enhanced inflammation, enhanced stress surrounding a diagnosis with celiac disease, or even an increase in reporting rather than incidence due to more vigilant medical care immediately following the diagnosis with celiac disease. They even note that gastrointestinal and cardiac symptoms are easily confused, further confounding their analysis. The second study compared the same 28,190 Swedes with villous atrophy to 140,000 controls. It reported that people with celiac disease were 60% more likely to develop asthma than those without it, and conversely, that people with asthma are more likely to develop celiac disease. “A potential mechanism could be that asthma and celiac disease share some immunological feature,” said Dr. Ludvigsson. “If you have it, you are at increased risk of both diseases.” He also noted that vitamin D deficiency can play a causative role in both diseases, and should be assessed on both celiac patients and asthmatics. Sources: Circulation 2011; 123: 483-490 Journal of Allergy and Clinical Immunology February 11, 2011 / doi:10.1016/j.jaci.2010.12.1076
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