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Found 4 results

  1. Celiac.com 03/05/2019 - Doctors commonly suggest celiac screening for anyone with a family history of celiac disease, or of disorders such as thyroid disease, anemia of unknown cause, type I diabetes or other immune disorders or Downs syndrome. Otherwise, patients are generally screened on a case by case basis according to individual symptoms. Genetic Testing Celiac disease is influenced, but not determined, by genetics. That means that susceptibility to celiac disease can be inherited, but the disease itself is not inherited. At least two genes, HLA-DQ2, HLA-DQ8, play a major role in celiac disease susceptibility. About 95% of people with celiac disease have the HLA-DQ2 gene and most of the remaining 5% have the HLA-DQ8 gene. A number of genetic testing services can tell you whether you have these genes. Some will test specifically for celiac genetics, others will test for celiac genetics as part of a general test. Genetic testing can help to indicate whether you might have a greater risk for celiac disease. Antibodies Point to Celiac Disease People with celiac disease have abnormally high levels of associated antibodies, including one or more of the following: anti-gliadin, anti-endomysium and anti-tissue transglutaminase, and damage to the villi (shortening and villous flattening) in the lamina propria and crypt regions of their intestines when they eat specific food-grain antigens (toxic amino acid sequences) that are found in wheat, rye, and barley. Antibodies are the specialized proteins the immune system uses to break down and eliminate foreign substances from the body. In people with celiac disease, the immune system treats gluten as a foreign invader and produces elevated levels of antibodies to get rid of it, causing symptoms and associated discomfort. Testing for Celiac Antibodies A blood test, such as anti-tissue transglutaminase and anti-endomysial antibodies, can detect abnormally high antibody levels, and is often used in the initial detection of celiac in people who are most likely to have the disease, and for those who may need further evaluation. Since the immune system of a person with celiac treats gluten as a foreign substance and increases the number of antibodies, elevated levels of these antibodies are a sign of celiac disease. Clinical Celiac Testing Typically, initial blood screening for celiac disease is done at a doctor’s office or at a clinic. Typically, such tests are ordered by a physician for patients who show symptoms, and/or a family history of celiac disease. If the results are positive, doctors will usually seek to confirm the diagnosis with a biopsy. Home Test Kits for Celiac Disease In the last several years, a number of accurate, reliable home test kits for celiac disease have come onto the market. Some of these kits deliver quick results in the home, while others require the consumer to mail the sample to a lab and receive the results later. Some mail-in kits use the same tests and labs as clinics do. Home test kits can offer convenience, confidentiality, and savings to consumers. They can also provide confidence for people, with or without symptoms, who believe they may have celiac disease. It’s not a good idea to use home test kits to diagnose celiac disease. As with clinical test results, positive results from home test kits should be confirmed by a doctor, and proper diagnosis and care should be initiated. Confirming Celiac Diagnosis To confirm a diagnosis of celiac disease, your doctor will likely want to do a biopsy. That’s where they visually examine a the small intestine to check for celiac-related damage. To do this, your doctor inserts an endoscope, a thin flexible tube, through your mouth, esophagus and stomach into your small intestine. The doctor then takes a sample of intestinal tissue to look for damage to the villi, the tiny, hair-like projections in the walls of the small intestine that absorb vitamins, minerals and other nutrients. If the biopsy shows celiac-associated damage, the doctor will confirm the diagnosis and encourage you to adopt a gluten-free diet.
  2. Celiac.com 02/22/2019 - Celiac disease, an autoimmune reaction caused by exposure to gluten, a protein found in wheat, barley, and rye, is estimated to affect one in a hundred Americans, however, only three percent of the celiac population has yet been properly diagnosed. The diagnostic process usually requires several tests, including antibody blood tests and a biopsy of the small intestine. Antibody testing is usually the first step, and positive biopsy results are required for the diagnosis of celiac disease, while genetic testing is often used as a preliminary test to determine whether an individual is at risk of developing celiac disease. Studies are showing, however, that celiac genetic test results may not always be accurate. According to the University of Chicago Celiac Disease Center, genetic testing has a couple of uses. After an individual tests positive for the disease, his relatives can be given the genetic test in order to determine if they are at risk of developing the disease later on. Secondly, it is used to help diagnose individuals who are already on a gluten-free diet, for whom an intestinal biopsy would be useless because there would be no damage to assess without gluten exposure. Genetic tests for celiac disease are easy to administer, using either blood or mouth swab samples, but the testing, usually ordered through a gastroenterologist, can be expensive. Home testing is also available now from many online sites. In celiac genetic testing, the DQ genetic patterns DQ2 and DQ8 are sought. The genetic test can indicate not only the risk of developing the disease, but also how severe it is, depending on which DQ types turn up and the number of copies there are. It’s important to understand, however, that just because the risk genes aren’t present doesn’t indicate that there’s no gluten intolerance or sensitivity. In such a case, an individual may not have celiac disease but would still require a gluten-free diet. Gastroenterologist Dr. Lewey, who published an article on Celiac.com entitled, “Ten Facts about Celiac Disease Testing,” reports that studies by Dr. Ken Fine of Enteroloab have indicated that just because DQ2 and DQ8 are absent doesn’t mean that there is no risk for gluten intolerance or sensitivity. Another study has indicated that the absence of DQ2 and DQ8 doesn’t exclude risk of the celiac disease, particularly among men. According to Dr. Lewey, “The absence of any portion of the high-risk genetic patterns DQ2 and DQ8 nearly excludes the possibility of celiac disease with an approximate accuracy of 99.9%. However, there is a big caveat about relying on ‘negative celiac genetic testing’.” In order to accurately establish that there is no celiac genetic factor, very complex genetic testing would have to be performed, which Dr. Lewey says is “complicated and difficult to understand even by physicians and scientists.” Despite the small chance of false negatives in celiac genetic testing, it is widely considered reliable. Carol Shilson, the executive director of the University of Chicago Celiac Disease Center, says, “The gene test, performed at a reliable lab, is very accurate,” Furthermore, the gene test results aren’t affected by environmental variables such as diet, which isn’t the case with other tests such as antibody blood tests and the intestinal biopsy. According to Dr. Lewey, celiac disease is arguably the most common of the autoimmune diseases, calling it “very common,” yet at the same time the diagnosis rate is alarmingly low. The celiac community currently has an effective arsenal of tests for the diagnostic process in order to turn this statistic around. Genetic testing, despite the fact that it may not be 100% accurate, appears nevertheless to be generally reliable. It has helped many people determine their own and their children’s risk of developing celiac disease. Resources: Ten Facts About Celiac Disease Genetic Testing Everyday Health: Genetic and Blood Tests for Celiac Disease Gluten Free Society: Genetic Testing for GS University of Chicago Celiac Disease Center: Antibody Blood Tests University of Chicago Celiac Disease Center: Genetic Testing
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