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Celiac.com 06/12/2018 - A life-long gluten-free diet is the only proven treatment for celiac disease. However, current methods for assessing gluten-free diet compliance are lack the sensitivity to detect occasional dietary transgressions that may cause gut mucosal damage. So, basically, there’s currently no good way to tell if celiac patients are suffering gut damage from low-level gluten contamination. A team of researchers recently set out to develop a method to determine gluten intake and monitor gluten-free dietary compliance in patients with celiac disease, and to determine its correlation with mucosal damage. The research team included ML Moreno, Á Cebolla, A Muñoz-Suano, C Carrillo-Carrion, I Comino, Á Pizarro, F León, A Rodríguez-Herrera, and C Sousa. They are variously affiliated with Facultad de Farmacia, Departamento de Microbiología y Parasitología, Universidad de Sevilla, Sevilla, Spain; Biomedal S.L., Sevilla, Spain; Unidad Clínica de Aparato Digestivo, Hospital Universitario Virgen del Rocío, Sevilla, Spain; Celimmune, Bethesda, Maryland, USA; and the Unidad de Gastroenterología y Nutrición, Instituto Hispalense de Pediatría, Sevilla, Spain. For their study, the team collected urine samples from 76 healthy subjects and 58 patients with celiac disease subjected to different gluten dietary conditions. To quantify gluten immunogenic peptides in solid-phase extracted urines, the team used a lateral flow test (LFT) with the highly sensitive and specific G12 monoclonal antibody for the most dominant GIPs and an LFT reader. They detected GIPs in concentrated urines from healthy individuals previously subjected to gluten-free diet as early as 4-6 h after single gluten intake, and for 1-2 days afterward. The urine test showed gluten ingestion in about 50% of patients. Biopsy analysis showed that nearly 9 out of 10 celiac patients with no villous atrophy had no detectable GIP in urine, while all patients with quantifiable GIP in urine showed signs of gut damage. The ability to use GIP in urine to reveal gluten consumption will likely help lead to new and non-invasive methods for monitoring gluten-free diet compliance. The test is sensitive, specific and simple enough for clinical monitoring of celiac patients, as well as for basic and clinical research applications including drug development. Source: Gut. 2017 Feb;66(2):250-257. doi: 10.1136/gutjnl-2015-310148.
lesley42 posted a topic in Celiac Disease - Pre-Diagnosis, Testing & SymptomsMy first post. Have just had blood tests for celiac (family history and symptoms). My query is every website mentioning the tests say you should have some gluten in your diet beforehand. My doctor ordered the test for next day, though I pointed out I'd been avoiding gluten for two months (and felt much better and had seen improvements in blood tests since then). GP says it isn't important and won't affect results. I had an endoscopy (?) about ten years ago - I was also gluten free then, and the results showed gastritis and reflux, an SeHCAT test showed malabsorption but no celiac. Am worried that another clear test will cause false negative. Can anyone advise please\/
Vesnamil posted a topic in Celiac Disease - Pre-Diagnosis, Testing & SymptomsI'm new in forum and you people my only hope. First i ask to be excuse for my English but i hope you or some of you will understand my question. My road with gluten is long but the main problem is that in my country is not well understood and hard to get tested. I always thought that i have gluten issue and my problems looked like this: diharea very common almost every day bloating nausea ITC... My first test step was antigliadin antibodyes and results were Antigliadin igg 4 an normal was <6 Antigliadin IGA 5.5 normal <5 so borderline (but i was gluten-free for3 mounts before the test) Than ige for wheat allergy weak positive I did genetic test with results DQ 5 and DQ7 Can someone please tell me does it ruleout celiac definitely Sorry for long post and i hope to find answers