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Hi all, Before I was diagnosed my cholesterol was always low and my Dr's were so impressed with me! Now, the past 2 physicals it is high according to my Dr. The LDL was 141 last year and 116 this year. This year my Dr ordered an ultrasound of my carotid arteries after seeing the numbers. Because I'm 45 and have high cholesterol he wants to look for buildup. I didn't think too much of it at the time, but I got a call yesterday to come in to discuss my results. That means there is an issue. If test results are normal they tell you over the phone. If not, they make you come in. I'm freaking out. He already said that if there is buildup they want to get the LDL below 70 and I am pretty sure that involves a statin. I don't want that at all. I know that they can cause a variety of issues. My appointment is at the end of the month...I'm looking for any experience that any other celiac has. Thanks! ?
Roy Jamron posted an article in Celiac Disease & Gluten Intolerance ResearchCeliac.com 09/12/2006 - Symptoms of celiac disease prominently include fat malabsorption. One would expect this to impact levels of essential fatty acids in celiacs. The omega-3 essential fatty acids, especially eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids available in fish oil supplements have been demonstrated to have numerous health benefits. However, there are almost no studies on the effect of celiac disease on essential fatty acid levels. I am currently in the process of writing an article on essential fatty acids that will appear in Celiac.coms Scott-Free Newsletter, so a new study on lipid profiles in celiac disease caught my eye with promise. I was disappointed to find the study only measured cholesterol levels in celiacs, which showed an improvement in the "bad" to "good", LDL to HDL, ratio and an increase in "good" HDL cholesterol in patients on a gluten-free diet. The opportunity to study essential fatty acid levels in celiacs was again missed. However, omega-3 fatty acids have a proven beneficial effect on cholesterol levels, and improved fat absorption of omega-3 fatty acids due to a gluten-free diet may be responsible for the results presented in this new celiac disease lipid profile study. Below are the abstract of this study and two studies on the effects of omega-3 fatty acids on cholesterol levels: Am J Med. 2006 Sep;119(9):786-90. Change in lipid profile in celiac disease: beneficial effect of gluten-free diet. Brar P, Kwon GY, Holleran S, Bai D, Tall AR, Ramakrishnan R, Green PH. Am J Cardiol. 2006 Aug 21;98(4 Suppl 1):71-6. Clinical overview of omacor: a concentrated formulation of omega-3 polyunsaturated Fatty acids. Bays H. Am J Clin Nutr. 2000 May;71(5):1085-94. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Mori TA, Burke V, Puddey IB, Watts gluten-free, ONeal DN, Best JD, Beilin LJ. New Fatty Acid Celiac Disease Study No sooner do I complain there arent any studies of essential fatty acid levels in celiac disease then, at least, a limited pediatric study of essential fatty acids appears! The results of this study on 7 pediatric patients with active celiac disease, 6 with celiac disease in remission, and 11 controls, show serum levels of fatty acids are similar between celiac disease and control patients, but abnormal fatty acid levels exist in intestinal mucosa tissue of active celiac disease patients. Results suggest an omega-6 fatty acid deficiency, at least in the mucosa. Not too surprising because prostaglandin E2 secretion increases in the intestines of active celiac disease patients, and prostaglandin E2 is produced from omega-6 fatty acids. It should be noted that fatty acid profiles may prove to be different in adult celiac disease patients. Also while omega-6 fatty acids may be deficient, increasing intake of omega-3 fatty acids may help reduce inflammatory processes in celiac disease. J Pediatr Gastroenterol Nutr. 2006 Sep;43(3):318-323. Abnormal Fatty Acid Pattern in Intestinal Mucosa of Children with Celiac Disease is Not Reflected in Serum Phospholipids. Steel DM, Ryd W, Ascher H, Strandvik B. Abstract: "Objective: Celiac disease (celiac disease) is characterized by chronic inflammation of the small intestinal mucosa with disturbed epithelial transport. The fatty acid (FA) composition of intestinal membranes is important for epithelial function, and disturbances may contribute to the pathophysiology of the disease. We aimed to evaluate whether the intestinal mucosal FA status was reflected in serum phospholipids of patients with celiac disease." "Patients and Methods: Samples were obtained from 7 pediatric patients with active celiac disease showing mucosal atrophy, 6 pediatric patients with celiac disease in remission, and 11 control pediatric patients with morphologically healthy intestinal mucosa. Small intestinal biopsies were obtained using a Watson biopsy capsule under fluoroscopic control. Blood samples were collected on the same morning after an overnight fast. Tissue phospholipids were isolated by high-performance liquid chromatography, and FAs were analyzed by capillary gas-liquid chromatography." "Results: Serum phospholipid FA showed marginal differences between the patients with celiac disease and the controls. Significant differences were observed in mucosa with active celiac disease compared with controls. Linoleic acid (18:2n-6) level was decreased, whereas those of its derivatives were elevated, indicating increased transformation of n-6 FA. Mead acid (20:3n-9) level was increased, with an increased ratio of Mead acid to arachidonic acid (20:4n-6) levels, suggesting essential fatty acid deficiency. The n-3 FA levels were not significantly changed. During remission, the FA pattern of the intestinal mucosa was mainly similar to that in controls." "Conclusions: The FA abnormality of intestinal mucosa in patients with active celiac disease was not reflected in serum values. Altered FA content may contribute to the pathophysiology of the disease because FAs are important for enzymes and for the transport and receptor functions of epithelial membranes."
Jefferson Adams posted an article in Schizophrenia / Mental Problems and Celiac DiseaseCeliac.com 07/13/2009 - Doctors are recommending that kids with mental and behavioral disorders, and with low cholesterol be tested for celiac disease. This, after findings from a recent study suggest that low plasma cholesterol levels might have a role in the development and pathogenesis of certain behavioral disorders such as schizophrenia, depression, and obsessional neurosis in people with celiac disease. It is well documented that children with celiac disease face higher rates of certain behavioral disorders such as schizophrenia, depression, and obsessional neurosis. Still, not much is known about the development and pathogenesis of celiac-related mental and behavioral disorders. A team of researchers made up of Italians Luca Mascitelli, M.D., Francesca Pezzetta, M.D., and American Mark R. Goldstein, M.D. set out to investigate the matter. A large scale study of patients aged 6–16 years showed that most people with celiac disease harbored illness of low-grade intensity that was often associated with "decreased psychophysical well-being." Furthermore, a recent study found that adolescents with celiac disease face higher rates of depressive and disruptive behavioral disorders, especially before adopting a gluten-free diet. 2 For some, psychiatric symptoms appear to improve after the patients started a gluten-free diet. Interestingly, children with malabsorption and steatorrhea due to celiac disease often have lower concentrations of blood cholesterol. Moreover, people with celiac disease, but who show no signs of overt cholesterol malabsorption, often show low levels of blood cholesterol, while normal to high cholesterol levels have been shown effective in ruling out celiac disease. Add to that the fact that low cholesterol has been tied to other mental disorders. In particular, a national sample of non-institutionalized, non-African American children of school-age found a statistically significant association between low cholesterol and aggressive behavior. Low cholesterol has also been tied to the onset of conduct disorder during childhood among male criminals. Therefore, they recommend that screening for celiac disease be considered in children and adolescents with mental disorders and low cholesterol. Psychosomatics 50:300-301, May-June