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Showing results for tags 'colon'.
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Celiac.com 04/10/2023 - The association between celiac disease and the development of small bowel lymphoproliferative disorders and esophageal adenocarcinoma is well-established, but there is limited evidence of an increased risk of colorectal cancer in these patients. Cross-sectional Population-based Study To evaluate the risk of developing colorectal cancer in patients with celiac disease a team of researchers recently conducted a cross-sectional population-based study using a commercial database that contains the electronic health records from 26 major integrated US healthcare systems. The team included patients aged 18-65 years of age, and excluded those with inflammatory bowel disease. They used multivariate analysis to calculate the risk of developing colorectal cancer, adjusting for potential confounders. The Researchers The research team included Somtochukwu Onwuzo; Antoine Boustany; Mustafa Saleh; Riya Gupta; Chidera Onwuzo; Jessy Mascarenhas Monteiro; Favour Lawrence; Chinenye Emeshiobi; Juliana Odu; and Imad Asaad. They are variously affiliated with the departments of Internal Medicine and Department of Gastroenterology at the Cleveland Clinic Foundation in Cleveland; the Faculty of Medical Sciences at Lebanese University in Beirut, LBN; the Faculty of Medicine in Kasturba Medical College, Mangalore in Mangalore, IND; the department of Internal Medicine and the General Hospital Lagos Island in Lagos, Nigeria; the department of Internal Medicine at the Ross University School of Medicine in Bridgetown, Barbados; the department of Internal Medicine at Mercy Hospital in Fort Smith, USA; and the department of Public Health at the University of Toledo in Toledo, Ohio, USA. Their Findings: Patients with Celiac Disease Face an Increased Risk of Developing Colorectal Cancer The team's cross-sectional population-based study showed that patients with celiac disease face an increased risk of developing colorectal cancer, even after adjusting for common risk factors. Their findings suggest that patients with celiac disease are frequently diagnosed with colorectal cancer, indicating that the disease may involve other parts of the gastrointestinal tract besides the small bowel. The results highlight the importance of screening patients with celiac disease for colorectal cancer, even in the absence of traditional risk factors. These findings could help to improve the management and follow-up of patients with celiac disease, especially with regard to diagnosis and prevention of colorectal cancer. Read more at Cureus.com
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hi all, i am a newbie on here and still a bit confused about the hole thing! i suffered with constipation and tiredness for a long time and put on weight real easy even tho i eat really healthy! i went to the doctor on numberous occasions and they always told me to drink more water! eat more fruit and veg! anyway long story short a new doctor suggested doing a blood test for wheat and sure enough, it came back high! TTG 150 +,, i was shocked to say the least, so i was booked in for a gastro and colon test.... However, the person doing the gastro test asked me a few questions of what i was in for and why the test, i told her for coeliac and she asked about symptoms, told her mine and she told me in a near condescending way that thats not coeliac symptoms and kinda laughed at me and shock her head! at the time i didnt realise my bloods where high or did not know much about the blood results or the hole thing really! When she finished she said just as i though they look normal, i felt a bit stupid as i was half drugged too! Anyway, 4 weeks later i went for my colon test and the doctor (a different one) asked me a few questions again!! i was reluctant to say i was being tested for coeliac and i had a gastro test a couple of weeks before hand, he pulled out the file and had a look through it and said, yes you arecoeliac,,, not sure how this happened or why i wasnt told properly or even what happens next??? now this was only last week. Has anyone else had my symtoms?? alot of people i spoke to seem to have the opposite effect?? and if so, has the diet made a difference to them? How, long did it take? and will this tiredness go away!! Anyway thanks in advance!!
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Celiac.com 02/17/2009 - Texas AgriLife Research scientist Dr. Nancy Turner has recently discovered that a microscopic compound commonly found in plant-based foods reduces inflammation and prevents the formation of cancerous lesions in the colon. The tiny molecule, called quercetin, is easily absorbed when people eat fruits and vegetables, and so requires no specialized supplements or drugs. Quercetin is a tiny, but powerful compound that is easily absorbed from onions, peppers, tomatoes and most other common produce. According to Turner, nearly all plant-based foods offer "some level of quercetin," including "fun things like wine." Previous laboratory research has shown quercetin to be effective in reducing rates of colon cancer, but Turner's study is the first to illuminate the mechanism by which quercetin works its magic. These results offer researchers another line of inquiry into other inflammatory bowel diseases such as Crohn's and celiac disease, as it's quite likely that quercetin can offer some measure of protection against those conditions as well. According to Turner, the levels of quercetin used in the study are comparable to those "achieved in diets around the world such as...the Mediterranean-style diets." As such, reaching such levels in American diets is "not an unachievable goal," she said. In the study, Turner's research team observed the responses of rats to quercetin-supplemented diets. Some of the rats were in the early stages of colon cancer formation, while others were cancer-free. In people, as in animal models, early colonic lesions represent some of the very first pre-cancerous changes that can be seen visually. These so called "aberrant crypts," are thought to mark or predict tumor formation. Earlier studies have shown quercetin to reduce the number of these crypts, but Turner "wanted to know how it might be protecting." Cancer is commonly understood as uncontrolled cell growth, but researchers are now realizing that the normal action of cell death, a process called "apoptosis," plays a crucial role in allowing cancer to develop. Healthy bodies generally maintain equilibrium between the generation of new cells and sloughing off cells that have completed their job. Quercetin seems to play a beneficial role in both cases. It decreases the number of cells being generated in the colon [and] increases the number of cells that were undergoing apoptosis. In all, quercetin helps to maintain a normal number of cells. The research team then turned its attention to the relatively new discovery that inflammation is one of the prime instigators of colon cancer. The team focused on two enzymes, called Cox-1 and Cox-2. Cox-1 is a standard protein that the body usually exhibits. But Cox-2 has a potential role in a number of diseases. Turner explains that Cox-2 is an "inducible protein that is expressed in the body when there is some kind of external stimulus to a cell." Scientists consider high levels of Cox-2 "as being a bad thing." Research shows that not only are elevated levels of Cox-2 present in colon cancer, but that the Cox-1 levels become elevated before Cox-2 levels rise. According to Turner, it seems that Cox-1 exerts some sort of influence over whether Cox-2 expression. Both the control groups and the carcinogen-injected groups that consumed dietary quercetin had lower levels of both Cox-1 and Cox-2, suggests that there may be chance for quercetin to prevent tumor growth. Clearly, further study is needed to better understand the links. But Turner encourages people to consume lots of fruits and vegetables. She points out that, in addition promising benefits for colon cancer, quercetin has demonstrated positive influence in fighting other chronic ailments such as cardiovascular disease. *Turner's research was funded by the U.S. Department of Agriculture . Source: http://agnews.tamu.edu/showstory.php?id=972
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Scand J Gastroenterol. 2002 Sep;37(9):1054-6. Related Articles, Links Celiac.com 08/27/2004 – The following abstract demonstrates the importance of follow up exams with your doctor, and also the importance of regular colon screenings for those with celiac disease. BACKGROUND: Coeliac disease and colorectal neoplasia are both common, present most often in patients over 40 and cause similar symptoms. Greater awareness and early use of serological tests have improved the diagnosis of coeliac disease, but raise the concern that co-existing colorectal neoplasia may be missed. This study assessed the prevalence of colorectal neoplasia among patients with coeliac disease diagnosed after the age of 40 who presented with altered bowel habit or iron deficiency. METHODS: All patients meeting the above criteria underwent colonoscopy unless this or barium enema had been performed shortly before. RESULTS: Of 69 patients with coeliac disease undergoing colonoscopy, 7 (10%) had colon neoplasia: 5 had tubulovillous polyps, and 2 had carcinoma. The prevalence figures for coeliac patients undergoing colonoscopy with iron deficiency and altered bowel habit alone were 11% (5 of 47) and 10% (2 of 22), respectively None of a further 13 who had undergone previous colon investigation (all by barium enema) had neoplasia, although these were probably a selected population. The seven patients with colorectal neoplasia had not reported rectal bleeding. The prevalence of colorectal neoplasia was not significantly higher than in two series of non-coeliac patients undergoing colonoscopy for investigation of iron deficiency (12%) or altered bowel habit (8%). CONCLUSIONS: There is a high prevalence of colorectal neoplasia among older patients with coeliac disease who present with iron deficiency or altered bowel habit, though this is no higher than for non-coeliac patients with these presentations. The possibility of dual pathology should be considered and excluded by colon investigation.
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