-
Welcome to Celiac.com!
You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
-
Celiac.com Sponsor (A1):
Celiac.com Sponsor (A1-M):
-
Get Celiac.com Updates:Support Our Content
Search the Community
Showing results for tags 'crohns disease'.
-
Celiac.com 11/25/2024 - The relationship between intestinal diseases and anal diseases has long been observed in clinical settings. Many patients with intestinal diseases, such as Crohn's disease or ulcerative colitis, also suffer from anal complications like hemorrhoids or fissures. However, the exact causal connection between these conditions is still unclear, due to limitations in previous observational studies. This study sought to clarify these relationships using Mendelian randomization, a method that uses genetic data to help determine causal effects and reduce bias caused by other variables. Methodology and Data Collection In order to explore the link between different types of intestinal diseases and anal diseases, researchers used genome-wide association study data. Seven types of intestinal diseases were examined, including inflammatory bowel disease, Crohn's disease, ulcerative colitis, irritable bowel syndrome, colorectal cancer, celiac disease, and constipation. Five types of anal diseases were also investigated: anorectal abscess, hemorrhoidal disease, fissures and fistulas of the anal and rectal regions, benign neoplasm of the anus, and malignant neoplasm of the anus. Using the Mendelian randomization technique, genetic variations were analyzed to determine whether these intestinal diseases have a direct influence on the development of anal diseases. This approach allowed researchers to control for confounding factors and focus on potential causal relationships. Key Findings The results of the analysis showed a significant link between several intestinal diseases and anal conditions. Inflammatory bowel disease, Crohn's disease, and ulcerative colitis were all found to increase the risk of three anal conditions: anorectal abscess, fissures and fistulas, and hemorrhoidal disease. These findings reinforce what has been noted in clinical practice—patients with these chronic inflammatory bowel conditions often experience anal complications. For celiac disease, the study identified a significant association with an increased risk of malignant neoplasm of the anus, a rare but serious form of anal cancer. This suggests that people with celiac disease may need to be more vigilant about monitoring for anal cancers. Other interesting findings include a potential link between irritable bowel syndrome and hemorrhoidal disease, and between colorectal cancer and benign neoplasm of the anus. While these associations need further exploration, they provide new avenues for research and clinical attention. Implications for Celiac Disease The link between celiac disease and anal cancer is particularly noteworthy. Celiac disease is characterized by an autoimmune response to gluten, which can lead to chronic inflammation in the gut. This chronic inflammation could contribute to the development of cancerous conditions, including in areas beyond the intestines, such as the anal canal. While more research is needed to fully understand the connection, this study highlights the importance of regular monitoring and early detection efforts for patients with celiac disease, especially concerning malignancies. Conclusion This study is significant in that it provides robust evidence supporting the causal relationship between certain intestinal and anal diseases. The use of Mendelian randomization strengthens the findings by reducing potential biases that have complicated earlier studies. For patients with celiac disease, Crohn's disease, ulcerative colitis, or other intestinal conditions, these findings emphasize the need for regular screening for anal diseases. The ability to understand these risks better may lead to improved prevention strategies and tailored medical advice for individuals with these chronic conditions. Read more at: nature.com Watch the video version of this article:
-
Celiac.com 08/19/2024 - Erectile dysfunction is defined as the inability to achieve and maintain an erection sufficient for satisfactory sexual performance. It affects a significant portion of the male population, with prevalence rates varying globally but generally high. Research has shown a strong link between erectile dysfunction and several chronic health conditions, including gastrointestinal diseases. However, establishing a clear causal relationship has been challenging. Research Design This study used Mendelian randomization to investigate the potential causal links between various chronic gastrointestinal diseases and erectile dysfunction. Mendelian randomization leverages genetic variants as instrumental variables to infer causality, minimizing confounding factors and reverse causation that often plague observational studies. Data on chronic gastrointestinal diseases, such as Crohn's disease, inflammatory bowel disease, ulcerative colitis, liver cirrhosis, and colorectal cancer, were sourced from large public datasets. Erectile dysfunction data were obtained from three distinct sources, including the FinnGen study and the UK Biobank. The genetic correlations between these diseases and erectile dysfunction were explored using linkage disequilibrium score regression. Mendelian randomization analysis followed, along with meta-analysis to determine the ultimate causal effect. Genetic Correlation Findings The study found significant genetic correlations between Crohn's disease and erectile dysfunction. Inflammatory bowel disease and ulcerative colitis showed potential genetic correlations with erectile dysfunction, while liver cirrhosis exhibited a negative genetic correlation. These findings suggest a genetic link between these gastrointestinal conditions and erectile dysfunction, warranting further investigation. Causal Relationship Findings The Mendelian randomization analysis revealed significant causal relationships between inflammatory bowel disease and Crohn's disease with erectile dysfunction. Colorectal cancer also demonstrated a potential causal effect on erectile dysfunction. These results were consistent across multiple analyses, strengthening the evidence for these associations. Conclusion The study underscores the importance of considering gastrointestinal health when addressing erectile dysfunction. Chronic gastrointestinal diseases can impact sexual function through various mechanisms, including inflammation, psychological stress, and hormonal changes. The findings highlight the need for comprehensive care in patients with these conditions, addressing both their gastrointestinal and sexual health. This study provides robust evidence supporting a causal relationship between chronic gastrointestinal diseases and erectile dysfunction. For patients with celiac disease, understanding these links can be particularly meaningful. It emphasizes the need for healthcare providers to consider and address potential sexual health issues in patients with chronic gastrointestinal diseases, ultimately aiming for improved overall health and quality of life. Read more at: frontiersin.org
-
- crohns disease
- erectile dysfunction
- (and 6 more)
-
Celiac.com 05/23/2023 - In recent years, there has been a rapid decline in the cases of Helicobacter pylori gastritis, particularly in developed countries. However, amidst this decline, an intriguing phenomenon has emerged: Helicobacter pylori-negative chronic gastritis. This condition is marked by chronic inflammation of the stomach lining in the absence of the notorious Helicobacter pylori bacterium, and has gained increasing recognition among experts as an important histological finding. Despite the growing awareness of this condition, the rates and clinical significance of Helicobacter pylori-negative chronic gastritis in children remain poorly studied. To shed more light on this condition, a team of researchers set out to learn more about this peculiar type of gastritis in the younger population. The research team included Anni Virkkula, Laura Kivela, Pauliina Hiltunen, Antti Sotka, Heini Huhtala, Kalle Kurppa, and Marleena Repo. They are variously affiliated with theTampere Centre for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; the Celiac Disease Research Centre, Faculty of Medicine and Health Technology, Tampere university, Tampere; the University of Helsinki and Helsinki University Hospital, Children's Hospital, and Paediatric Research Center, Helsinki; the Department of Pediatrics, Tampere University Hospital, Tampere; the Department of Pediatrics, South Karelia Central Hospital, Lappeen-ranta; the Faculty of Social Sciences, Tampere University, Tampere; the University Consortium of Seinajoki and Seinajoki Central Hospital, Seinajoki, Finland; and the Department of Pediatrics, Central Finland Central Hospital, Jyvaskyla, Finland. The team began their investigation by gathering data from 1,178 consecutive children who underwent diagnostic esophagogastroduodenoscopy (EGD). By comparing the baseline characteristics and long-term outcomes of children with active and inactive Helicobacter pylori-negative chronic gastritis, as well as those with normal gastric histology, they sought to discern patterns and draw meaningful conclusions. They then tracked follow-up data for up to 13 years. What the team discovered was nothing short of remarkable. Helicobacter pylori-negative chronic gastritis, it turns out, is a rather common finding in children undergoing EGD. Intriguingly, the active type of this form of gastritis was found to be particularly associated with Crohn's disease, an inflammatory bowel condition, while the inactive form exhibited links to celiac disease. In addition to shedding light on these associations, the study uncovered another fascinating revelation—Helicobacter pylori-negative chronic gastritis can serve as a predictor of gastrointestinal diagnoses, most notably inflammatory bowel disease and celiac disease. This finding carries significant implications for early detection and subsequent management of these conditions. Furthermore, the researchers examined the long-term prognosis of patients diagnosed with Helicobacter pylori-negative chronic gastritis who did not receive an initial diagnosis. Encouragingly, they found that the prognosis for these individuals is generally favorable. With valuable insights into prevalence, clinical significance, and potential implications for gastrointestinal health, this study marks an important evolution in our understanding of Helicobacter pylori-negative chronic gastritis. Read more in the Journal of Pediatric Gastroenterology and Nutrition 74(5):p 949-955, May 2022
-
- celiac disease
- children
- (and 5 more)
-
Celiac.com 05/10/2018 - Most people who suffer from inflammatory bowel diseases (IBD) have either Crohn’s disease or ulcerative colitis. Some research has suggested that patients with Crohn's disease have an altered response to vitamin D, among other issues. The exact mechanism behind this is not well understood. To get a better picture of the problem, a team of researchers recently set out to investigate disease-specific gene expression profiles of peripheral blood mononuclear cells (PBMCs) from Crohn’s disease patients in clinical remission. The research team included Holger Schäffler, Maria Rohde, Sarah Rohde, Astrid Huth, Nicole Gittel, Hannes Hollborn, Dirk Koczan, Änne Glass, Georg Lamprecht, and Robert Jaster, with the Department of Medicine II, Division of Gastroenterology, Rostock University Medical Center in Rostock, Germany. The team began by genotyping patients with Crohn's disease in clinical remission or with very low disease activity according to nucleotide-binding oligomerization domain 2 (NOD2), and PBMCs from wild-type (WT)-NOD2 patients, and patients with homozygous or heterozygous NOD2 mutations. Meanwhile the team isolated healthy donors for further analysis. The team then cultured the cells with vitamin D, peptidoglycan (PGN) and lipopolysaccharide (LPS) for defined periods of time before RNA was isolated and subjected to microarray analysis using Clariom S assays and quantitative real-time PCR. They assessed the NOD2- and disease-specific gene expression profiles with repeated measure ANOVA using a general linear model. The team used microarray assays to find 267 genes that were significantly up- or downregulated in PBMCs of WT-NOD2 patients, compared to healthy donors after challenge with vitamin D and/or a combination of LPS and PGN (P < 0.05; threshold: ≥ 2-fold change). For further analysis by real-time PCR, the team selected genes with known impact on inflammation and immunity that fulfilled predefined expression criteria. In a larger group of patients and controls, the team found a disease-associated expression pattern, with higher transcript levels in vitamin D-treated PBMCs from patients, in three of these genes, CLEC5A (P < 0.030), lysozyme (LYZ; P < 0.047) and TREM1 (P < 0.023). The team found six genes that were expressed in a NOD2-dependent manner (Crohn's disease101, P < 0.002; CLEC5A, P < 0.020; CXCL5, P < 0.009; IL-24, P < 0.044; ITGB2, P < 0.041; LYZ, P < 0.042). Interestingly, the team saw the highest transcript levels in patients with heterozygous NOD2 mutations. This study identifies CLEC5A and LYZ as Crohn's disease- and NOD2-associated genes of PBMCs and supports the need for further studies on their pathomechanistic roles. The team found that PBMCs of patients with Crohn's disease display alterations in their response to vitamin D and PAMPs. Disease-associated and NOD2-dependent gene expression profiles are preserved even during clinical remission. The team’s data identifies CLEC5A, LYZ and TREM1 as good candidates for follow-up study. The researchers propose that these genes may act in a common network relevant to celiac disease development. The research team remains committed to the longterm goal of biomarkers to that will accurately predict the clinical course of celiac disease. Source: World J Gastroenterol. 2018 Mar 21; 24(11): 1196–1205. doi: 10.3748/wjg.v24.i11.1196
-
- crohns disease
- genetics
-
(and 2 more)
Tagged with:
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8-M):