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Jefferson Adams posted an article in Celiac Disease Diagnosis, Testing & TreatmentCeliac.com 10/10/2018 - The Technical University in Vienna has announced a new remedy for celiac disease symptoms that they say can “alleviate or even completely eliminate the symptoms of celiac disease.” It should be available commercially in only a few years. Because most current efforts to treat celiac disease affect the immune system, possible side effects must therefore be fully assessed. This means years of study, and a long approval process. However, the TU Wien research team worked in collaboration with the industrial partner Sciotech Diagnostic Technologies GmbH to create a different approach. Their team based its approach for a celiac disease treatment on using only the part of the antibody that binds to gluten, which allowed them to create a product that works extremely well, but does not rely on triggering an immune response. Instead of a drug that works on the immune system, TU Wien created a simple medical product that directly attacks the gluten molecules to render them harmless. This makes the approval process much simpler, meaning that the product should be available in ordinary pharmacies as early as 2021. According to Professor Oliver Spadiut, head of the Integrated Bioprocess Development Research Group at TU Wien, “bodies produce antibodies that fit intruding antigens precisely, like a key to a lock. This immune response makes these antigens harmless.” He goes on to say that “If a new antibody fragment is found and produced that docks to and blocks the invading gluten molecule without triggering the immune system, the symptoms of celiac disease can be suppressed." The goal of their research project was to produce a complex of two such antibody fragments that envelop the gluten molecule at a molecular level, so that it can no longer have any further effects in the intestines. The result is a groundbreaking treatment for celiac disease and gluten intolerance. The process is complicated, and requires the team to re-program certain bacteria so that they produce exactly the desired antibody fragment. The full process took a while to iron out, but, says Spadiut, it “can be easily reproduced, can be scaled up to industrial application and delivers a very good yield of the desired product." This is very exciting news. Aside from efforts toward an outright vaccine, this is the first news of a potential treatment that can negate the effects of gluten without affecting the immune system itself. If all goes well, Spadiut says, the product “will be available in ordinary pharmacies in a few years.” Stay tuned for news about ongoing developments of this interesting treatment for celiac disease. Read: Additional scientific information Source: TUWien.ac.at
Celiac.com 06/22/2017 - Once upon a time, bananas were thought by many doctors to possess tremendous healing properties. Bananas were used to help diabetics to use weight. Doctors told mothers to feed bananas to their infants starting at 4 weeks. And for a long time, the diet seemed to help people "recover" from celiac disease. Invented by Dr. Sidney Haas in 1924, the high-calorie, banana-based diet excluded starches, but included bananas, milk, cottage cheese, meat and vegetables. The diet was so effective in celiac disease patients that it was adopted by numerous doctors, and endorsed in the 1930s by the University of Maryland, according to pediatric gastroenterologist Alessio Fasano, chair of pediatrics at Harvard Medical School and a specialist in celiac disease. The general public picked up the trend, and embraced bananas as one of the great health foods. But, whatever the medical and public perception about bananas may have been, Dr. Haas was wrong about the curative powers of bananas, and that seemingly honest mistake had long-term consequences for numerous patients with celiac disease. That's because the bananas did not cure the condition, as was commonly thought. The bodies of the patients involved did not become tolerant to wheat. So, when they reintroduced wheat into their diets, as many did, assuming they were cured, they suffered physical consequences. One such patient was Lindy Redmond, whose celiac disease was “cured” with the banana diet as a child. "All my life I have told doctors I had celiac as a child," says Lindy Redmond, "and that I grew out of it. And all my life I have eaten wheat." Thinking she was cured, but suffering years of symptoms, Redmond, at 66 years old, finally underwent a gluten-antibody test and and received an intestinal biopsy. "My intestine was very damaged," she reports. "My doctor said she didn't know if it would ever recover." It was then that Redmond wondered about the possible connection between lifelong, untreated celiac disease and her two miscarriages, frequent bouts of colds and bronchitis, and interminable constipation. Now 74 and off gluten, Redmond says the colds and constipation are gone. It wasn't until 1952 that Dutch pediatrician, Willem Karel Dicke, and his colleagues identified gluten as the trigger for celiac disease, and the gluten-free diet was born. But Haas railed against the gluten-free diet and went on promoting his banana-based cure, claiming that only the banana diet could achieve "a cure which is permanent." The European medical community quickly adopted Dicke's gluten-free diet treatment, but in the United States, at least partly due to these erroneous medical beliefs, celiac disease remained under-diagnosed, and many patients suffered needlessly. Reda more at NPR.org
Celiac.com 06/23/2017 - Dr. Alessio Fasano from the University of Maryland's Celiac Research Center published a paper in Clinical and Developmental Immunology last month. It focused on a new drug developed by Dr. Fasano that has shown promising results in both animal and human trials. But is this the 'magic pill' that will cure celiac disease and gluten sensitivity? Let's take a look. The new drug, formerly called AT1001 but now renamed Larazotide Acetate, is a zonulin inhibitor. For those who have never heard the word 'zonulin', you might think it's a term from a science fiction movie. But zonulin is the protein that causes the 'gates' or openings between the cells making up the lining of the small intestine to open and close. These openings are called tight junctions and when zonulin gets excessive, a leaky gut ensues. Dr. Fasano has made great inroads to prove that a leaky gut is a problem that must be handled with gluten intolerance. The leaky gut perpetuates gluten's negative impact on other parts of the body. It can also initiate autoimmune disease. One key point to keep in mind is that 'leaky gut' occurs because molecules can pass between cells when they shouldn't. In addition, molecules can pass through cells which they also shouldn't. Unfortunately this new drug only impacts the former, not the latter. So, the drug Larazotide Acetate is a zonulin inhibitor. Now that we've reviewed what zonulin does as regards opening the gates, the purpose of inhibiting its action should make sense. How well does it work? In the recent human trials that were double-blind, randomized placebo-controlled (the best type of study, but I would expect no less from the stellar Dr. Fasano), a gluten exposure created a 70% increase in intestinal permeability (leaky gut) in 57% of the placebo group but only 28.6% of the patients receiving the drug (4 out of 14 patients) experienced such increased permeability. Further, gastrointestinal symptoms were significantly more frequent among patients of the placebo group as compared to the group that received the Larazotide. A pro-inflammatory substance known as interferon gamma was also evaluated. This is manufactured by the body when a specific foreign/toxic agent is recognized by the body's immune system. As expected, levels of interferon gamma increased in 4 out of 7 of the placebo patients (57%) but only 4 out of 14 larazotide patients (28.6%) saw any increase. The good news is that this drug seems well tolerated and it does reduce the leaky gut response that gluten ingestion normally creates. Further, it also reduces the percentage, by about half, of the production of interferon gamma. These are all excellent results. But, and it's unfortunately a very big 'but', we have a very long way to go before such a drug would be useful for your typical celiac or gluten sensitive patient. Will Dr. Fasano and his team be able to tweak this drug such that it functions at a higher level of efficacy? I certainly hope so, but let's analyze exactly what this drug does in its present state: The drug still resulted in almost 30% of the patients experiencing a 70% increase in permeability (leaky gut) – Not good. A highly pro-inflammatory (this means that it creates degenerative disease) substance known as interferon gamma was also produced in nearly 30% of the drug-consuming patients tested – Not good. Leakiness, or the passage of negative substances through cells is not affected by this drug – Not good. Of course on the plus side, over 70% of those tested DID have a very good result with apparently no untoward side effects – Very good. At what point is the efficacy high enough that you'd be willing to subject yourself to a possible reaction? Do realize that any gluten ingested increases your chance of disease, chief amongst them cancer and autoimmune disease. Is there a level of function of the drug that you would chance taking it? Is it 90%, 99%? Does any drug ever get that good? Well, as a big fan of Dr. Fasano's, I would say that if anyone can do it, he and his team can. But at the same time, I cannot help but think of all the other drugs I have encountered. As 'wonderful' as they sometimes seem initially, they almost always fall from grace when some horrible side effect is realized. Would I guinea pig my own health that I've fought so hard to regain? Would I recommend taking such a chance to my children just so that they could consume some white flour product? I don't think so. How about you? What do you think? If the drug were available right now at its efficacy of 71%, would you take it and hope you weren't in the 29% for whom it didn't work? I'd love to hear your thoughts. If you are wondering if you're gluten intolerant or know that you are but still aren't enjoying good health, consider calling us for a free health analysis: 408-733-0400. We are here to help! Our destination clinic sees patients from across the country and internationally so you do not need to live locally to receive assistance. To your good health! Reference: Alessio Fasano, Clinical and Developmental Immunology, Published online 2012 October 10. "Novel Therapeutic/Integrative Approaches for Celiac Disease and Dermatitis Herpetiformis."
Hi! WARNING! EXTREMELY HIGH ICK-FACTOR! I'm new to Celiac Disease, and thus this site as well. Though I'm still waiting on blood work to come back, I'm nearly a week into a gluten-free diet and can already tell a major difference. My doctor told me to do some research on a gluten free diet and I must admit that I have been experiencing an amalgamation of excitement for a conclusion to a 15 year search, a fear of the implications of having celiac disease, and an intense dread of having a lifetime of a gluten-free diet. All that said, in researching cure research progress, I came across several inferences and references to a cure. Unfortunately, however, that cure is a fecal transplant from a perfectly healthy donor. Here is a starter link to one article, if anyone is curious: http://www.mayoclinic.org/medical-professionals/clinical-updates/digestive-diseases/quick-inexpensive-90-percent-cure-rate It seems to take a good bit of research to piece together tidbits from here and there to get an idea of where this procedure is headed. There is also a video on YouTube of a woman showing how to do this from home. The only drawback I am aware of, so far and beyond the obvious ICK-factor, is that antibiotics could necessitate another transplant. I am wondering if anyone has any experience or insight into this. If a fecal transplant really can cure celiac disease, what an equally gross and amazing thing! What could this mean for those with celiac, and what can we do to further this along?