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Jefferson Adams posted an article in Celiac Disease Diagnosis, Testing & TreatmentCeliac.com 12/31/2018 - Rates of celiac disease are about triple for patients who also suffer from cystic fibrosis, compared to those without cystic fibrosis. A team of researchers recently investigated the molecular similarities between celiac disease and cystic fibrosis. Specifically, they set out to examine the role of mutations of the gene coding for cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel pivotal for epithelial adaptation to cell‐autonomous or environmental stress. The study was led by Luigi Maiuri, Valeria Raia, and Guido Kroemer. They are variously affiliated with the San Raffaele Scientific Institute in Milan, Italy, the University of Naples Federico II in Italy, and the Paris Descartes University in France. Their research shows a connection between celiac disease and cystic fibrosis, and suggests that a compound developed for cystic fibrosis may also treat celiac disease. The results might bring us closer to a treatment for celiac disease. Failure of the cystic fibrosis transmembrane conductance regulator in cystic fibrosis patients triggers the accumulation of mucus in the patients’ lungs and intestine. By activating the immune system, the mechanism underlying CFTR malfunction causes several reactions in the lungs and other organs. These reactions are very similar to immune responses to gluten in celiac patients. Intrigued, Maiuri, Kroemer, and their colleagues took a closer look at the molecular underpinnings of these similarities. For people with celiac disease, eating gluten triggers the immune system to attack the mucus inside the small intestine. This immune attack presents as classic celiac symptoms, such as bloating, nausea, vomiting, diarrhea, and upset stomach. The team's findings appear in The EMBO Journal, and point to possible new therapies and treatments for celiac disease. The most promising part of the team's data indicate that CFTR potentiators, used to treat cystic fibrosis, may also be effective in treating celiac disease. With researchers revealing new connections between celiac and numerous other diseases, it's a very exciting time for celiac research. As researchers learn more about the connection between celiac disease and cystic fibrosis, look for new treatments for celiac disease in the not too distant future. Read more at: Medicalnewstoday.com
Jefferson Adams posted an article in Celiac Disease Diagnosis, Testing & TreatmentCeliac.com 12/11/2018 - In most people without celiac disease or other gluten sensitivities, the gut does a pretty good job of processing gluten, and helps to prevent local inflammatory and immune responses. However, in about one percent of the population, gluten proteins from wheat and related cereals trigger an HLA DQ2/8‐restricted TH1 immune and antibody response, which triggers celiac disease. A team of researchers recently set out to assess the role of the cystic fibrosis transmembrane conductance regulator (CFTR) in orchestrating gliadin activities in celiac disease. The research team included Valeria R Villella, Andrea Venerando, Giorgio Cozza, Speranza Esposito, Eleonora Ferrari, Romina Monzani, Mara C Spinella, Vasilis Oikonomou, Giorgia Renga, Antonella Tosco, Federica Rossin, Stefano Guido, Marco Silano, Enrico Garaci, Yu‐Kai Chao, Christian Grimm, Alessandro Luciani, Luigina Romani, Mauro Piacentini, Valeria Raia, Guido Kroemer, Luigi Maiuri. Researchers understand that epithelial stress and innate immune activation are necessary for overcoming oral tolerance to the gluten gliadin. However, exactly how gliadin subverts host intestinal mucosal defenses is poorly understood. In their study, the research team shows that the α‐gliadin‐derived LGQQQPFPPQQPY peptide (P31–43) reduces the activity of cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel pivotal for epithelial adaptation to cell‐autonomous or environmental stress. P31–43 binds to, and reduces ATPase activity in, the nucleotide‐binding domain‐1 (NBD1) of CFTR, thus interferes with CFTR function. This process creates epithelial stress, tissue transglutaminase and inflammasome activation, NF‐κB nuclear translocation and IL‐15 production, all of which can be blocked by potentiators of CFTR channel gating. The CFTR potentiator VX‐770 reduces gliadin‐induced inflammation and increases tolerance in gluten‐sensitive mice and cells from celiac patients. The team’s study shows that CFTR plays a central role in orchestrating gliadin activities, and presents potentially powerful new treatment direction for celiac disease. Source: The EMBO Journal (2018) DOI 10.15252/embj.2018100101 | Published online 29.11.2018 The researchers are variously affiliated with the European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy; the Department of Comparative Biomedicine and Food Science, University of Padova, Padova, Italy; the Department of Molecular Medicine, University of Padova, Padova, Italy; the Department of Health Sciences, University of Eastern Piedmont, Novara, Italy; the Department of Experimental Medicine, University of Perugia, Perugia, Italy; the Pediatric Unit, Department of Translational Medical Sciences, Regional Cystic Fibrosis Center, Federico II University Naples, Naples, Italy; the Department of Biology, University of Rome “Tor Vergata”, Rome, Italy. Department of Chemical, Materials and Production Engineering, Federico II University Naples, Naples, Italy; the Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Roma, Italy; the University San Raffaele and IRCCS San Raffaele, Rome, Italy; the Department of Pharmacology and Toxicology, Faculty of Medicine, University of Munich (LMU), Munich, Germany; the Institute of Physiology CH, University of Zurich, Zurich, Switzerland; the National Institute for Infectious Diseases IRCCS “L. Spallanzani”, Rome, Italy; the Centre de Recherche des Cordeliers, Equipe labellisée Ligue Nationale Contrele Cancer, Paris, France; the Centre de Recherche des Cordeliers, INSERM U, Paris, France; the Université Paris Descartes, Paris, France; the Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; the Pôle de Biologie, Hôpital Européen Georges Pompidou, AP‐HP, Paris, France; and the Department of Women's and Children's Health, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
RobinB28 posted a topic in Food Intolerance & Leaky GutOkay, so I am 28. I was diagnosed with Cystic Fibrosis at 6 months old and struggled to maintain weight and stay out of the hospital all my life. At 26 I went in for a endoscopy to look at my angry pancreas and found out I had Celiacs. I went gluten-free and saw some symptom improvement and then after two years and a wicked struggle with reactive arthritis I figured out I was having the same reactions to dairy that I was gluten. I also eliminated soy at this time because it seemed to irritate me too. Now, folks with CF routinely take prescription strength pancreatic enzymes because our pancreas doesn't produce them, (pancreatic insufficiency). I felt this masked my Celiacs symptoms, possibly for years. These enzymes periodically need to be increased as a CF person ages but the main reason I'm posting this is 1.) If you have Celiacs and aren't improving even with eliminating other foods you should get tested for CF. Yes, some docs still say "Oh that's a disease usually diagnosed as a child." but the oldest person to be diagnosed with CF was in her 60's and the vitamin deficiencies and stomach issues as well as other health problems are the same for CF as they are Celiacs. 2.) Since going Gluten-Dairy-Soy free I've not had a normal BM and I was wondering if anyone had repeat endoscopies that showed healing or gave them any insight cause I'm considering that. At first after eliminating the dairy and soy I felt a little better but I was having several normal BMs a day. Now I'm either not going or going too much. If I go to my CF docs they will say it's probably my Celiacs issues because they know nothing about Celiacs and they don't really want to make it their problem because God forbid they earn the money my insurance company pays them, or they'll just go to their old stand by and raise my enzymes which could cause all sorts off issues (imagine a bunch of enzymes designed to break down food running out of food in your tummy to nom- they turn to your stomach lining and it's painful.) So If anyone has any tips or tricks here that might help me get back to regular again let me know. I've done the elimination diet and tomatoes and potatoes are thankfully my friends and fruits and veggies are nice to me as well, I avoid Quinoa and stick to rice and potatoes for my starches. Anyone tried Cultrel or something like that?