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Celiac.com 11/11/2024 - Celiac disease is an autoimmune condition triggered by gluten, a protein found in wheat, barley, and rye. While gastrointestinal symptoms are common, many individuals, especially children, may present with non-specific or atypical signs, making diagnosis challenging. This study sought to explore whether certain oral manifestations, such as recurrent aphthous stomatitis (commonly known as canker sores) and molar incisor hypomineralization (MIH), could be early indicators of celiac disease in children. By identifying these signs in dental examinations, healthcare providers might have a better chance of diagnosing celiac disease in children who otherwise lack typical symptoms. Purpose of the Study The primary goal of the study was to investigate whether celiac disease could be diagnosed through certain oral manifestations in children, specifically focusing on recurrent aphthous stomatitis and MIH. The research aimed to highlight the role dentists could play in the early diagnosis of celiac disease by recognizing these signs during routine dental examinations. Study Design and Methods Participants Sixty children aged 7 to 13 participated in the study, all of whom initially presented with complaints of recurrent aphthous stomatitis. These children were divided into two groups: MIH group: 40 children who had been diagnosed with MIH, a condition that causes developmental defects in the enamel of molars and incisors. Control group: 20 children who did not show any signs of MIH lesions. Oral Examination Two pediatric dentists conducted detailed oral examinations, during which they noted signs of MIH and recorded data such as decayed, missed, or filled teeth (DMFT). MIH lesions were diagnosed based on guidelines from the European Academy of Paediatric Dentistry. To ensure consistency, the dentists re-examined the children one week later to confirm the presence of MIH lesions. Medical History and Testing Following the dental examination, the parents of the children were asked to complete a questionnaire regarding their child's medical history, specifically looking for any symptoms or conditions related to celiac disease, as defined by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Blood samples were then taken from all children to conduct serological and genetic tests, which included: Serological tests: Tissue transglutaminase IgA (tTG-IgA), endomysial antibody IgA (EMA), and total IgA. Genetic testing: Human leukocyte antigen (HLA) typing for HLA-DQ2 and HLA-DQ8, which are genetic markers associated with celiac disease. Results The study found no significant differences between the groups when comparing their medical history or serological and genetic test results. However, six children in the MIH group showed borderline or positive results for the celiac disease-specific antibody tTG-IgA. Of these, two children had both positive tTG-IgA and EMA results and were also positive for the HLA markers associated with celiac disease. After a biopsy, these two children were formally diagnosed with celiac disease. While only 5% of the children in the MIH group were diagnosed with celiac disease, the findings suggest that MIH lesions and recurrent aphthous stomatitis may serve as early oral indicators of the condition. Importance of Oral Manifestations in Celiac Disease Diagnosis Recurrent Aphthous Stomatitis (RAS) Recurrent aphthous stomatitis, or canker sores, are small, painful ulcers that commonly occur in the mouth. While these sores are typically benign, their presence in children, particularly when recurrent, may be linked to underlying systemic conditions like celiac disease. In this study, all participants initially presented with RAS, suggesting that it could serve as an early warning sign, particularly when combined with other dental or medical symptoms. Molar Incisor Hypomineralization (MIH) MIH is a developmental condition that affects the enamel of the first permanent molars and incisors. The study found that MIH lesions are similar in appearance to the enamel defects commonly seen in celiac disease patients. This resemblance, along with the high prevalence of enamel defects in individuals with celiac disease, points to a potential overlap between the two conditions. MIH could be an important clinical clue for dentists when assessing children who may have undiagnosed celiac disease. Limitations and Considerations Although the study provides valuable insights, it has several limitations. The sample size was relatively small, and the study was conducted over a short period. Larger, long-term studies are needed to validate these findings and determine the true prevalence of celiac disease in children with MIH and recurrent aphthous stomatitis. Additionally, the genetic tests for HLA-DQ2 and HLA-DQ8, while helpful, are not always necessary for diagnosing celiac disease. The presence of these genetic markers does not confirm celiac disease but indicates a predisposition to it. On the other hand, the absence of these markers makes celiac disease highly unlikely. In this study, the two children diagnosed with celiac disease both had positive results for HLA-DQ2 or HLA-DQ8, but the utility of genetic testing remains a subject of debate. The Role of Dentists in Celiac Disease Diagnosis The findings of this study highlight the important role dentists can play in diagnosing celiac disease. Since many children with celiac disease do not present with the typical gastrointestinal symptoms, dentists are often in a unique position to spot the first signs of the condition through oral manifestations like RAS and MIH. Early detection of celiac disease is crucial for preventing long-term complications such as malnutrition, growth delays, and increased risk of certain cancers. Dentists should consider referring children for further medical testing if they observe persistent oral issues like RAS or MIH, especially when accompanied by a family history of autoimmune diseases or other risk factors for celiac disease. A multidisciplinary approach, involving both dental and medical professionals, can lead to earlier diagnosis and treatment, improving outcomes for children with celiac disease. Conclusion This study underscores the potential link between certain oral manifestations, such as recurrent aphthous stomatitis and molar incisor hypomineralization, and celiac disease in children. While the sample size was small, the results suggest that dentists could play a pivotal role in diagnosing celiac disease, especially in children who do not exhibit typical symptoms. Early detection through dental examinations can lead to timely interventions, helping to prevent the serious complications associated with undiagnosed celiac disease. The study's findings emphasize the need for further research and greater awareness among dental professionals regarding the systemic implications of oral health conditions. Read more at: bmcgastroenterol.biomedcentral.com

Celiac.com 07/04/2024 - Celiac disease is an autoimmune condition where the ingestion of gluten causes an immune reaction that damages the small intestine in genetically predisposed individuals. This disease can lead to various systemic and localized health issues, including those affecting the oral cavity. One significant oral manifestation linked to celiac disease is dental enamel defects. A new study explores the connection between celiac disease and dental enamel defects, the potential mechanisms behind these defects, and the role of dentists in early diagnosis and management. The Relationship Between Celiac Disease and Dental Enamel Defects Dental enamel defects are abnormalities in the structure of the tooth enamel, often presenting as discoloration, pitting, or grooving of the teeth. These defects can occur due to several reasons, including genetic factors, nutritional deficiencies, and systemic diseases like celiac disease. Research has shown a high prevalence of dental enamel defects among individuals with celiac disease, ranging from 50% to 94.1%. These defects are often symmetrical and occur in a chronological pattern, which can be categorized using Aine’s classification system. Pathophysiological Mechanisms The development of dental enamel defects in individuals with celiac disease is thought to be due to multiple factors. One primary factor is the malabsorption of essential nutrients caused by the damage to the intestinal villi in the small intestine. This damage impairs the body's ability to absorb nutrients critical for proper enamel formation, such as calcium and vitamin D. Additionally, the autoimmune response triggered by gluten ingestion may directly affect the cells responsible for enamel formation. Clinical Implications for Oral Health The presence of dental enamel defects can significantly impact oral health. These defects can increase the susceptibility to dental caries, lead to aesthetic concerns, and cause sensitivity. Research indicates that individuals with celiac disease often have higher decayed, missing, and filled teeth (DMFT) scores, indicating more severe dental decay. They are also more likely to experience recurrent aphthous stomatitis and symptoms of dry mouth, which can further exacerbate oral health issues. The Role of Dentists in Early Diagnosis Dentists play a crucial role in the early diagnosis of celiac disease. Since dental enamel defects can be an early indicator of celiac disease, dentists can identify potential cases through routine dental examinations. By recognizing the patterns of enamel defects and considering patient history, dentists can refer patients for further investigation, including serological testing and intestinal biopsy. Aine’s classification of enamel defects provides a structured approach for dentists to categorize and suspect celiac disease. Interdisciplinary Collaboration Effective management of celiac disease and its oral manifestations requires a collaborative approach between dentists and gastroenterologists. This interdisciplinary collaboration ensures comprehensive care, addressing both the systemic and oral health aspects of the disease. Regular dental check-ups are essential for monitoring and managing dental enamel defects in celiac patients, helping to prevent further complications and improve overall health outcomes. Conclusion This study underscores the significant association between celiac disease and dental enamel defects. Early recognition of these oral manifestations by dentists can lead to timely diagnosis and management of celiac disease, even in the absence of gastrointestinal symptoms. Understanding this relationship emphasizes the importance of integrated care involving both dental and medical professionals. This holistic approach can enhance the quality of life for individuals with celiac disease, ensuring better health outcomes and effective management of both their oral and systemic health. Implications for Celiac Disease Patients For individuals with celiac disease, this study highlights the importance of regular dental visits and the need for heightened awareness of potential oral health issues. Early detection of dental enamel defects can prompt further investigation into underlying celiac disease, facilitating timely intervention and adherence to a gluten-free diet. This proactive approach can help prevent further health complications and improve overall well-being for those with celiac disease. By recognizing the critical role of dentists in the early diagnosis and management of celiac disease-related oral manifestations, this research paves the way for improved interdisciplinary collaboration and comprehensive patient care. Further large-scale studies are recommended to deepen our understanding of the link between celiac disease and dental enamel defects, ultimately contributing to better health outcomes for affected individuals. Read more at: mdpi.com

Celiac.com 08/04/2022 - We get a lot of questions from celiac community members wondering if certain products are gluten-free. Lately, we've seen a lot of questions about which top brands of home dental products are gluten-free and safe for people with celiac disease. Specifically, what brands of dental whitening products are gluten-free and safe for people with celiac disease? Here's the rundown. Not all dental whitening products are usually formulated to be gluten-free. Some are, some are not. Many brands of dental whitening products don't bother to specifically label their products as gluten-free. Others do. It can be tricky to figure out which brands of dental whitening products are gluten-free. For many people, especially those with celiac disease, it's best to specifically look for products labeled gluten-free. For dentists working in a clinical setting, and for people using products at home, it's important to look for the gluten-free label on packaging for dental whitening products and systems, including any patient samples. As always, read labels, avoid gluten ingredients, and choose carefully. Here's a list of dental whitening products brands that are made without gluten ingredients, and are regarded as gluten-free and safe for people with celiac disease. Colgate Optic White Crest Crest Whitestrips GLO Science Professional GLO Whitening System Ultradent All Ultradent products Read more about avoiding gluten in dental products in rdhmag.com

Celiac.com 03/09/2022 - Many people, and even dental professionals, are not aware that gluten can also be present in some types of oral prostheses and appliances, specifically those made with a popular acrylic resin called methyl methacrylate (MMA). Being exposed to gluten at the dentist's office is a common complaint on our celiac disease and gluten-free forum. A number of readers have asked for a list of gluten-free dental products. Orthodontic retainers, fixed and removable dentures, temporary crowns, and denture repair material are types of products typically made with MMA. It was discovered in recent years that the non-dietary gluten found in MMA can trigger symptoms in patients with celiac disease and should be avoided. Since many companies do not label products as gluten-free, it is important to seek out products which are labeled or certified gluten-free. Consult your dental professional regarding gluten-free dental products for use by professionals. The list of gluten-free dental products for use by dental professionals includes: Gluten-Free Dental Whitening Colgate Optic White Crest Crest Whitestrips GLO Science Professional GLO Whitening System Ultradent All Ultradent dental whitening products Gluten-Free In-Office Fluoride Crosstex Zap Gel Crosstex International Sparkle V Varnish ProGard Varnish DMG America Kolorz Sixty Second Gel Kolorz Foam Kolorz Varnish Keystone Industries Gelato Gel Medicom Duraflor Halo Varnish Oral-B Labs Oral-B Varnish Patterson Dental Patterson Premier Dental Products Enamel Pro Varnish Ross Healthcare PCxx One Minute Foam Sunstar Americas Butler Monsterz Varnish Ultradent Enamelast Varnish Voco Profluorid Varnish Young Dental Zooby Foam D-Lish Varnish Zooby Varnish Gluten-Free Prophy Paste Phophy paste is short for Prophylaxis or prophylactic paste, prophy paste is the stuff dentists use to polish your teeth. Gluten-Free brands of trophy paste include: Benco Dental PRO-SYS PRO-SYS Premium Biotrol Trophy Gems Crosstex Zap Gel Crosstex International Sparkle Sparkle Free Dentsply Nupro Nupro Extra DMG America Kolorz Glitz Glitz Harry Schein Acclean Keystone Industries Gelato Mydent International Defend Patterson Dental Patterson Premier Dental Products Enamel Pro Glitter Zeroxide Preventative Technologies NEXT Sultan Healthcare Topex Sunstar Americas Monsterz Ultradent UltrPro Tx Voco CleanJoy Water Pik Technologies Water Pik Water Pik Soft Shine Cosmetic Young Dental Zooby D-Lish Smart Select Vera Advanced Bright Oral-B Gluten-Free Therapeutics Benco Dental Gibson Healthcare Chlorhexidine Rinse Colgate PreviDent Mouth Rinse IoTech International iO Rinse Mouth Rinse Patterson Patterson Dental Chlorhexidine Rinse Do you know of any professional dental products that are gluten-free that we have missed? Share them in the comments below. Stay tuned for a list of gluten-free home dental care products.

Celiac.com 02/23/2022 - Anyone who knows about trying to live gluten-free with celiac disease can likely cite chapter and verse about the wide variety of products that can contain hidden gluten. The list is long, and contains numerous non-food items, like makeup and cosmetics, shampoos and conditioners, lotions, drugs, and more. To that list, we can now add dental products, including both professional dental products and home dental products. Hidden gluten in dental products could be an issue for people with celiac disease, who need to remain gluten-free if they want to remain healthy. We know that dentists can play an important part in protecting people with celiac disease. But maybe there's even more your dentist can do to protect patients with celiac disease. Here's why you and your dentist should talk about gluten in dental products. We did an article a while back on gluten in orthodontic retainers made with a chemical resin called methyl methacrylate (MMA), which contains gluten. We've also had some good information exchanged about gluten in dental devices on our gluten-free and celiac disease forum. Gluten Found in Numerous Dental Products As awareness has grown that the non-dietary gluten found in MMA can trigger symptoms in celiac patients, attention has turned to a number of other oral prostheses and dental appliances that are also made with MMA, and can contain gluten. The list includes orthodontic retainers, fixed and removable dentures, temporary crowns, and denture repair materials. Since the FDA still does not require manufacturers to specifically label whether these products contain gluten, the safest bet for celiacs is to assume possible gluten presence in any unlabeled products. In response to this conundrum, a number of dental manufacturers have begun to clearly label their gluten-free products. For dentists working in a clinical setting, and for people using products at home, it's important to look for the gluten-free label on packaging for prophylactic pastes, therapeutic agents, fluoride products, whitening systems, and patient samples. Look for Dental Products Labeled Gluten-Free If no such label is found, dentists may want to consider purchasing a small amount of a certified gluten-free options for their celiac patients, while those using products at home might want to look for a comparable product that is clearly labeled gluten-free. Until we have comprehensive gluten-free labeling for dental products, it's important for patients to look for the gluten-free label, and to work with your dentist to make sure you're getting products labeled gluten-free. Please search the brand of any prescription medications and other dental products here, but know many will not be found in the prescription medication database: https://dailymed.nlm.nih.gov/dailymed/ Stay tuned for a list of advertised gluten-free home and professional dental products. Read more in rdhmag.com

Celiac.com 03/15/2019 - A number of studies have shown a correlation between dental enamel defects and the presence of celiac disease. The connection opens up a possible avenue for dentists to help diagnose celiac disease by noticing dental symptoms and making a referral for celiac evaluation. Celiac.com has done a few articles on this subject over the years. Now, periodontal teams looking to remain on the cutting-edge of comprehensive dentistry are taking course-work on the impact of celiac disease on dental health. One such team, board-certified periodontists, Drs. Sam Bakuri and Mark J. Weingarden of Pittsburgh, PA, recently completed a course on the impact of celiac disease and dental health with members of their team at Greater Pittsburgh Dental Implants & Periodontics. Led by Cynthia Kupper, RD, celiac disease, CEO of the Gluten Intolerance Group (GIG), the training helped Drs. Bakuri and Weingarden to learn about dental issues commonly associated with celiac disease, such as enamel defects, cavities and frequent canker sores. The training will help these dental professionals spot the dental effects of celiac disease early, before they can cause health or cosmetic issues later in life. It will also allow them to suggest appropriate dental options to improve the dental and general health of their patients. Anyone in the Pittsburgh area who wishes to discuss the dental health implications of celiac disease, along with possible treatment options, can contact Drs. Bakuri and Weingarden by phone at 412-201-0633. Learn more about the team at Greater Pittsburgh Dental Implants & Periodontics. Do you know of any other dentists or dental professionals who are up to speed on celiac disease and dental health? Please share your information below.

Celiac.com 08/09/2017 - There have been a number of studies showing a strong connection between celiac disease and dental enamel defects (DEDs), however, the exact relationship is still unclear. To get a better understanding, a team of researchers recently set out to evaluate DEDs in people with celiac disease by looking at how long it took them to begin a gluten-free diet (GFD). The research team included AM de Queiroz, J Arid, FK de Carvalho, RAB da Silva, EC Küchler, R Sawamura, LAB da Silva, and P Nelson-Filho. They are variously affiliated with the Department of Pediatric Dentistry, University of São Paulo - School of Dentistry of Ribeirão Preto, Ribeirão Preto, SP, Brazil, and the Department of Childcare and Pediatrics, University of São Paulo School of Medicine of Ribeirão Preto, Ribeirão Preto, SP, Brazil. For their study, the team had a pediatric dentist examine forty-five children with celiac disease. The dentist then classified DEDs by the type of teeth affected. The study team divided celiac disease patients into two groups, those with and those without DEDs. They then tested the differences between these groups using chi-square or Fisher´s exact tests and t-test to compare differences between means. They used the Pearson coefficient test to determine the correlation between the age at gluten-free diet introduction and number of teeth with defects. They found that patients with Molar Incisor Hypomineralisation (MIH), a condition affecting the enamel of permanent teeth, were more often introduced earlier to the GFD (p = 0.038). They also saw a connection with molar DED (p = 0.013). Their study suggests that enamel defects in the molar are connected with the time that celiac disease patients were introduced to a gluten-free diet. What this means for patients with celiac disease remains to be seen. Source: Spec Care Dentist. 2017 Jul;37(4):194-198. doi: 10.1111/sceliac disease.12227.