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Showing results for tags 'depression'.
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Is Depression Really a Chemical Imbalance?
Dr. Vikki Petersen D.C, C.C.N posted an article in Spring 2009 Issue
Celiac.com 06/06/2020 - Patients with depression are told they have a chemical imbalance. If someone else in their family is also depressed, the “gene card” is played. “Your depression is genetic”, they are told. I have been in practice for over 20 years and I find the above data to be false. Consistently we find patients who are suffering from depression and anxiety to be gluten sensitive. How could a food cause depression? Let’s take a look: After the digestive tract, the system most commonly affected by gluten is the nervous system. It is thought that depression can be caused by gluten in one of two ways, inflammation and protein absorption. The first is through the inflammatory changes caused by gluten. A gluten sensitive individual’s immune system responds to the protein gliadin. Unfortunately, that protein is structurally similar to body proteins, including those of the brain and nerve cells. A cross reaction can occur when the immune system “confuses” body proteins with gliadin proteins. This is called cellular mimicry and the result is inflammation where the body is attacking its own tissues. When inflammation happens in the brain and nervous system, a variety of symptoms can occur, including depression. Research shows that patients with symptoms involving the nervous system suffer from digestive problems only 13% of the time. This is significant because mainstream medicine equates gluten sensitivity almost exclusively with digestive complaints. In a study examining blood flow in the brain, 15 patients with untreated celiac disease were compared to 15 patients treated with a gluten-free diet for one year. The findings were amazing. In the untreated group, 73% had abnormalities in brain circulation by testing while only 7% in the treated group showed any abnormalities. The patients with the brain circulation problems were frequently suffering from anxiety and depression as well. In addition to circulation problems, other research looks at the association between gluten sensitivity and its interference with protein absorption. Specifically the amino acid tryptophan can be deficient. Tryptophan is a protein in the brain responsible for a feeling of well-being and relaxation. A deficiency can be correlated to feelings of depression and anxiety. Our society is too willing to accept “chemical imbalance” as an explanation for their symptoms. Instead of getting to the root cause of the condition, we simply swallow a pill—a pill that in the case of anti-depressants has very dangerous and sometimes lethal side effects. The frequency with which we are able to successfully taper patients off their anti-depressants is considered “unbelievable” by many mainstream doctors, yet we do it regularly. How is that possible? We actually diagnose the root cause of the depression. Frequently the culprit is gluten.- 3 comments
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Celiac.com 08/20/2020 - I am afraid that the following article might not make me very popular—if I had any popularity remaining after my last one! If you saw “The Paleo Template” here on these pages, you’ll recall that its ideas rest upon the theory that humans are healthiest when eating the types and classes of foods we’ve been consuming for the overwhelming majority of the roughly two and one half million years we’ve been on this earth. It wasn’t until very, very recently, in the grand scheme, that we’ve been consuming the products of agriculture: wheat; dairy; beans; and any foods that required more than the bare minimum of processing to make them edible. To greater or lesser degrees consuming these new foods isn’t good for us. As paleo nutritionist Ray Audette put it in his book Neanderthin (St. Martin’s Press, 2000), historically we’ve only consumed those items we could get if we were “naked with a sharp stick”: meat; certain vegetables; low glycemic; high fiber fruits; and certain nuts: hunter gatherer foods. Modern diseases are reactions to those foods that have only recently been added to our diets, gluten-containing foods being the most immediately obvious to this publication’s readership. Well, here’s one modern food that may deserve the same level of scrutiny as gluten-containing grains, even given its worship by what appears to be a totality of today’s nutritionists: our beloved chocolate. Now wait a minute. What kind of sadist would want to find fault with this giver of pleasure and apparent health panacea? Well, before we go there, let’s step back a moment to the naked with a sharp stick idea. Would chocolate, cocoa, cacao—or anything remotely similar—have been consumed by our paleo ancestors? No. Even in its purest commercial forms, it does require quite a deal of processing before it is edible: drying, fermenting, roasting, powdering, etc. Raw cacao proponents would disagree with this and, even though it is a tiny, tiny fraction of the market, there are raw, unpeeled, whole beans available for purchase. But let me get to a more important point. Chocolate, cocoa, cacao, in any form, was apparently discovered by native South Americans around 3000 years ago and didn’t make its way into the European diet until the 16th century, with widespread usage delayed until the Industrial Age a little more than 100 years ago. So if you’re a native of the tropical rainforests of South America, you’ve had a very short period of time for adaptation. If you don’t fit that description, you’ve had effectively zero time to adapt to this food. So what if it’s new? The so what is this: new foods—gluten-containing grains included—are almost always the cause of modern disease and as such deserve a closer look because of their novelty. Maybe chocolate’s ok to eat, maybe not. As mentioned above, it’s not “maybe” in current nutritional culture. Chocolate is lauded as the perfect health food. A simple search on Medscape.com yields more than 380 studies touting its benefits: they say it reduces blood pressure, decreases risk for pregnancy-induced hypertension, improves vasodilation, reduces platelet adhesion, reduces cholesterol, improves post-exercise workout recovery, improves insulin sensitivity, protects smokers’ hearts, improves endothelial function, even helps with diarrhea. And to top it off, it’s apparently a wonderful aphrodisiac. Turn on your television or radio, open a newspaper or log onto an Internet site and you’re sure to see a thousand more benefits claimed. We want this stuff to be good for us. Before we go on, I want to take another step back, change the subject entirely again, and talk about depression. Wikipedia defines it as “a mental disorder characterized by a pervasive low mood and loss of interest or pleasure in usual activities.” Ron Hoggan points out in his excellent article “Food Allergies and Depression,” that this condition is a “very common symptom of celiac disease,” and by extension gluten intolerance. Why did I suddenly change the subject to depression? Here’s why: a new study out of Australia (Gordon Parker, Isabella Parker, Heather Brotchie, Mood state effects of chocolate, Journal of Affective Disorders 92, 2006, 149-159) shows that chocolate may actually cause and/or deepen depression. The study shows a link between a worsening of depressive symptoms and chocolate consumption for those “emotional eaters” who are attempting to self-medicate. As the authors put it in the conclusion of the study: "When taken in response to a dysphoric state as an 'emotional eating' strategy it may provide some transient ”comforting” role but it is more likely to prolong rather than abort the dysphoric mood. It is not, as some would claim, an antidepressant." Now we already know that celiacs and the gluten intolerant are very prone to depression. We now know that chocolate may deepen depression. But, since there’s not a whole lot of data out there linking mood, chocolate, and gluten intolerance, I decided to do a personal experiment. Of course, the data is anecdotal, but I think informative and revealing. I regularly eat a diet free of gluten, diary, legumes, and artificial fats and had been very faithful to the regimen for a few months. For the purpose of the experiment I consumed one bar of Green & Blacks 70% Cocoa Content Dark. I quickly felt contentment, even mild euphoria. I was able to concentrate for quite a long time and actually did quite a bit of research for this article. But that evening I experienced a shallow, dream-filled sleep before awaking in a fog early the next morning. I had some gas, bloating, and was itchy with what I’ll call proto-hives. Within a few hours I had gained almost a pound of water weight and felt as if I had a hangover, mild depression. And, boy, was I irritable! I also noted mild shakes and muscular tension and some knots. Again, one guy = anecdotal evidence. But this doesn’t sound at all like a food that’s good for you! As a fellow gluten intolerant, I’d like to challenge you to the same experiment. Pick up a copy of a book I recommended in my last article, Loren Cordain’s The Paleo Diet (Wiley, 2002), and follow its dietary regimen for three weeks to eliminate from your system whatever non-paleo foods you might have floating around in your body. Then try a bar of quality dark chocolate and send me an email to tell me how it made you feel. Truth is, my reaction surprised me. But should it have? Chocolate is composed of foreign substances only very recently introduced into the human diet and apparently causes an immune system reaction similar to that caused by gluten. And, like the psychoactive effects felt when one ingests gluten, the initial euphoria and increased attentiveness caused by chocolate wears off relatively quickly and, for me at least (and I suspect for quite a few of the gluten intolerant) serious after effects remain. Maybe this isn’t the miracle food it’s purported to be.
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Celiac.com 09/01/2023 - Celiac disease, a chronic autoimmune disorder triggered by the consumption of gluten, has long been associated with gastrointestinal symptoms and malabsorption issues. However, a growing body of research has shed light on an often-overlooked aspect of celiac disease: its potential impact on mental health. The intricate relationship between the gut and the brain, known as the gut-brain axis, is garnering attention for its role in influencing both physical and mental well-being. As scientists delve deeper into the complexities of this connection, a compelling picture emerges—one that suggests that the health of the gut could play a pivotal role in shaping our mental state. In this article, we embark on a journey through the fascinating landscape of celiac disease and its intricate relationship with mental health. We'll explore the mechanisms that underlie the gut-brain axis and how they contribute to various mental health conditions. We'll delve into the scientific evidence that links celiac disease to conditions such as anxiety, depression, ADHD, autism spectrum disorders, schizophrenia, and bipolar disorder. Additionally, we'll examine how nutritional deficiencies stemming from untreated celiac disease may exacerbate these mental health issues. As we navigate this intricate web of connections, we'll address the question of whether a gluten-free diet—one that is central to managing celiac disease—could also hold the key to alleviating mental health symptoms in gluten sensitive individuals. The Gut-Brain Axis: Exploring the Connection The intricate interplay between the gut and the brain is a captivating area of scientific inquiry that has been gaining momentum in recent years. This communication network, known as the gut-brain axis, serves as a two-way highway along which information travels between these seemingly distant organs. The gut, often referred to as the "second brain," is home to a complex ecosystem of trillions of microorganisms, collectively known as the gut microbiota. These microorganisms play a pivotal role in maintaining the gut's health and influencing various bodily processes, including those related to mental well-being. The gut-brain axis operates through intricate signaling pathways that involve both direct and indirect communication. The vagus nerve, a long cranial nerve that connects the brain to the abdomen, acts as a vital conduit for this communication. In addition, a dynamic network of biochemical messengers, including neurotransmitters, hormones, and immune molecules, enables the gut and brain to send and receive messages. The gut microbiota, which includes a diverse range of bacteria, viruses, fungi, and other microorganisms, has emerged as a key player in shaping this communication. These microbes contribute to the production of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), which are not only crucial for brain function but also have a profound impact on mood regulation. A growing body of research suggests that imbalances in the gut microbiota, often referred to as dysbiosis, may contribute to mental health disorders. Understanding the gut-brain axis offers a fresh perspective on the way physical and emotional health intersect. Factors that disrupt the balance of this delicate axis, such as chronic inflammation, stress, and dietary choices, can have far-reaching consequences for mental health. As researchers unravel the intricate threads of this connection, they are uncovering insights that may pave the way for innovative therapeutic approaches to address mental health conditions, particularly in individuals with underlying conditions such as celiac disease. Celiac Disease and Mental Health: A Complex Link As we journey deeper into the realm of celiac disease and its implications for mental health, we encounter a multifaceted connection that underscores the complexity of human physiology. Celiac disease, an autoimmune disorder triggered by the ingestion of gluten—a protein found in wheat, barley, and rye—has long been recognized for its impact on the gastrointestinal system. However, the story does not end there. A growing body of research suggests that the effects of celiac disease extend beyond the gut, reaching into the realm of mental health. While the exact mechanisms that link celiac disease to mental health conditions are still being unraveled, several factors contribute to this intricate relationship. One of the key elements is inflammation. Untreated celiac disease triggers an immune response that leads to chronic inflammation within the small intestine. This inflammation has the potential to extend beyond the gut, affecting other systems within the body—including the brain. This raises the intriguing possibility that the inflammation associated with celiac disease could play a role in the development or exacerbation of mental health issues. Moreover, the gut-brain axis comes into play once again. The gut microbiota, a collection of microorganisms residing in the gastrointestinal tract, plays a significant role in influencing both physical and mental health. Emerging research suggests that the gut microbiota of individuals with celiac disease may differ from those without the condition. This dysbiosis could potentially impact the production of neurotransmitters, such as serotonin, that are crucial for mood regulation. The prevalence of mental health issues among individuals with celiac disease adds another layer of complexity to the equation. Studies have shown that individuals with celiac disease are at an increased risk of conditions such as anxiety, depression, and attention disorders. While the exact causal relationship between celiac disease and these conditions remains under investigation, the implications are undeniable. Understanding the connections between celiac disease and mental health not only sheds light on the broader impact of the disorder but also offers new avenues for therapeutic interventions. Anxiety and Celiac Disease: Breaking Down the Ties Research has revealed a compelling link between celiac disease and anxiety disorders. While the exact mechanisms remain a subject of ongoing investigation, several factors contribute to this connection. One notable element is the role of inflammation. Untreated celiac disease triggers an immune response that leads to chronic inflammation in the small intestine. This inflammation may extend beyond the gut, affecting other areas of the body, including the brain. Inflammation is increasingly recognized as a potential contributor to anxiety, as it can disrupt neurotransmitter balance and neural pathways. In addition to inflammation, nutritional deficiencies resulting from malabsorption in celiac disease could exacerbate anxiety symptoms. Nutrients like B vitamins, particularly B12 and folate, are essential for maintaining optimal neurological function. Deficiencies in these vitamins have been linked to mood disorders, including anxiety. The gut's compromised ability to absorb these nutrients can hinder their availability to the brain, potentially amplifying feelings of anxiety. As for the impact of a gluten-free diet on anxiety, findings are promising but complex. Some individuals with celiac disease report a reduction in anxiety symptoms after adopting a gluten-free diet. However, the relationship is not one-size-fits-all. It's important to note that anxiety can stem from various factors, and while dietary changes might alleviate symptoms in some cases, they may not be a standalone solution for everyone. Seeking professional guidance from both medical and mental health experts is crucial for individuals with celiac disease experiencing anxiety. Depression and Celiac Disease: Searching for Clues Among the spectrum of mental health conditions, depression stands as a particularly intricate puzzle. Its origins are multifaceted, influenced by a combination of genetic, environmental, and physiological factors. As researchers delve into the complexities of depression, a new avenue of exploration emerges—one that involves the interplay between celiac disease and this mood disorder. Depression, characterized by persistent feelings of sadness, hopelessness, and a lack of interest in activities, affects millions of individuals worldwide. Interestingly, studies have shown a higher prevalence of depression among individuals with celiac disease compared to the general population. The question that naturally arises is whether there is a genuine connection between these two seemingly unrelated conditions. One avenue of investigation lies in the realm of serotonin, a neurotransmitter known for its role in regulating mood and emotions. An estimated 90% of serotonin is produced in the gastrointestinal tract, where the gut microbiota plays a significant role in its synthesis. Here, the gut-brain axis comes into play once again. Untreated celiac disease, with its potential to disrupt the balance of the gut microbiota, could potentially impact serotonin production and utilization. This disruption may contribute to the development or exacerbation of depressive symptoms. Moreover, nutritional deficiencies associated with celiac disease could play a role in the development of depression. Nutrients such as B vitamins, folate, and iron are essential for optimal neurological function. Malabsorption in celiac disease could lead to deficiencies in these nutrients, potentially affecting mood regulation. For instance, vitamin B12 deficiency has been linked to symptoms of depression, fatigue, and cognitive impairment—symptoms that often overlap with those of celiac disease. Could a gluten-free diet offer a ray of hope for individuals with celiac disease who also grapple with depression? While the research is ongoing and the results are variable, some individuals report improvements in their mood after adopting a gluten-free diet. This phenomenon raises intriguing possibilities regarding the connection between dietary choices and mental well-being. However, it's important to note that depression is a complex condition with diverse causes, and a gluten-free diet may not be a standalone solution for everyone. Consultation with medical and mental health professionals is essential for those considering dietary changes to manage their depression. Celiac Disease, ADHD, and Cognitive Function: Insights and Considerations Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that affects both children and adults, characterized by symptoms of inattention, hyperactivity, and impulsivity. While traditionally associated with behavioral and cognitive challenges, emerging research suggests a potential link between celiac disease and ADHD. The relationship between celiac disease and ADHD is complex and multifaceted. While definitive causality has not been established, studies have highlighted intriguing associations between the two conditions. Individuals with celiac disease seem to be at a higher risk of developing ADHD-like symptoms compared to the general population. Additionally, some research suggests that individuals with ADHD might have an increased prevalence of celiac disease. One plausible connection lies in the potential impact of untreated celiac disease on cognitive function. Nutritional deficiencies, often a consequence of malabsorption in celiac disease, can affect various aspects of cognitive performance. Nutrients like iron, zinc, and certain B vitamins are essential for optimal brain function. Deficiencies in these nutrients might contribute to attention difficulties and cognitive impairments often observed in individuals with ADHD. Furthermore, the gut-brain axis plays a role in shaping cognitive function and behavior. The gut microbiota, with its influence on neurotransmitter production and immune responses, could potentially impact the neural pathways associated with ADHD. Dysbiosis or imbalances in the gut microbiota might disrupt these pathways, contributing to the development or exacerbation of ADHD symptoms. Could adopting a gluten-free diet offer potential benefits for individuals with celiac disease who also experience ADHD-like symptoms? While the research is still unfolding, anecdotal evidence and some studies suggest that dietary changes might have positive effects on cognitive function and attention in individuals with celiac disease and ADHD. However, the outcomes vary, and the efficacy of a gluten-free diet for managing ADHD requires further investigation. It's essential for individuals to work closely with healthcare professionals when considering dietary interventions for managing ADHD symptoms. Autism Spectrum Disorders and Celiac Disease: An Evolving Understanding Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by a range of challenges in social interaction, communication, and behavior. While the exact causes of ASD remain elusive, researchers have been exploring potential links between celiac disease and autism, shedding light on intriguing intersections between the two. The relationship between celiac disease and ASD is a topic that continues to evolve. Studies investigating this connection have yielded mixed findings, with some suggesting a potential association and others failing to establish a clear link. Despite the ambiguity, there are notable overlaps in genetic and immunological factors between the two conditions, prompting researchers to delve deeper into the shared mechanisms. One avenue of exploration lies in the immune system's role in both celiac disease and ASD. Both conditions involve immune dysregulation and inflammation, suggesting that disruptions in the immune response could contribute to the development of both disorders. Shared genetic markers and pathways further underscore the potential connections between celiac disease and ASD. Additionally, nutritional deficiencies resulting from untreated celiac disease may play a role in the development of ASD symptoms. Nutrients like zinc, iron, and certain B vitamins are crucial for optimal neurological development. Deficiencies in these nutrients, which are common in individuals with celiac disease, could potentially impact brain development and function, potentially contributing to ASD symptoms. The question of whether a gluten-free diet could positively impact individuals with celiac disease and ASD remains a topic of interest. Some parents and caregivers have reported improvements in certain behaviors and symptoms in individuals with ASD after adopting a gluten-free diet. However, the results are variable, and the research landscape is complex. Rigorous scientific studies are needed to establish the potential benefits of dietary interventions for individuals with both celiac disease and ASD. Navigating the relationship between celiac disease and ASD requires a comprehensive approach that takes into account genetic, immunological, and nutritional factors. As researchers continue to explore this connection, individuals with celiac disease and caregivers of those with ASD are encouraged to collaborate with healthcare professionals to make informed decisions that consider the individual's unique needs and circumstances. Schizophrenia and Celiac Disease: Investigating the Intersection Schizophrenia, a complex and often debilitating mental health disorder, challenges our understanding of the intricate workings of the brain. Characterized by symptoms such as hallucinations, delusions, disorganized thinking, and impaired cognitive function, schizophrenia remains an enigma in the field of psychiatry. Recent research has sparked interest in the potential connections between celiac disease and schizophrenia, shedding light on an intersection that warrants further exploration. The relationship between celiac disease and schizophrenia is a topic of ongoing investigation, and while the evidence is limited, it presents intriguing insights into the possible links between immune dysregulation, inflammation, and brain function. Some studies suggest that individuals with celiac disease may be at a higher risk of developing schizophrenia-like symptoms compared to the general population. Furthermore, a shared genetic susceptibility between the two conditions raises the possibility of overlapping mechanisms. One avenue of inquiry involves the potential role of inflammation in both celiac disease and schizophrenia. Chronic inflammation, a hallmark of untreated celiac disease, has been proposed as a contributor to the development of schizophrenia symptoms. Immune molecules released during inflammation could impact neural circuits and neurotransmitter balance, potentially leading to the characteristic symptoms of schizophrenia. Moreover, the gut-brain axis comes into focus once again. The gut microbiota, with its influence on immune responses and neurotransmitter production, could play a role in shaping brain function and behavior. Alterations in the gut microbiota composition, often observed in individuals with celiac disease, may influence immune responses and inflammation, potentially contributing to the development or exacerbation of schizophrenia symptoms. As for the potential impact of a gluten-free diet on schizophrenia symptoms, the landscape is complex and the research is limited. Some case studies and anecdotal reports suggest that individuals with schizophrenia and celiac disease experienced improvements in their mental health after adopting a gluten-free diet. However, these outcomes are far from uniform, and more rigorous research is needed to establish the potential benefits of dietary interventions for managing schizophrenia. Understanding the potential connections between celiac disease and schizophrenia offers a fresh perspective on the intricate interplay between the immune system, inflammation, and brain function. As the scientific community continues to delve into this complex relationship, individuals with celiac disease and those with schizophrenia are encouraged to engage in open dialogues with healthcare professionals to make informed decisions that consider their unique circumstances. Bipolar Disorder and Celiac Disease: A Complex Interaction Bipolar Disorder, characterized by extreme shifts in mood, energy, and activity levels, presents a unique challenge in the realm of mental health. Individuals with bipolar disorder experience periods of elevated mood (mania) and periods of depression, often accompanied by changes in behavior and cognition. While the origins of bipolar disorder are multifaceted, researchers are uncovering potential connections between celiac disease and bipolar symptoms, shedding light on an intricate interplay that warrants exploration. The relationship between celiac disease and bipolar disorder is multifaceted and not fully understood. Studies exploring this connection have yielded mixed results, making it difficult to establish definitive causality. However, shared genetic factors and the potential impact of inflammation on brain function suggest potential links between the two conditions. One avenue of investigation involves the role of omega-3 fatty acids, essential nutrients with anti-inflammatory properties. Individuals with celiac disease are at risk of nutritional deficiencies, including deficiencies in omega-3 fatty acids. These deficiencies could potentially contribute to neuroinflammation and impact brain function, potentially exacerbating bipolar symptoms. Furthermore, the gut-brain axis enters the spotlight once again. The gut microbiota's influence on inflammation, neurotransmitter production, and immune responses makes it a key player in the relationship between celiac disease and bipolar disorder. Imbalances in the gut microbiota, often associated with celiac disease, could potentially contribute to immune dysregulation and impact mood regulation. The potential impact of a gluten-free diet on bipolar disorder symptoms remains a topic of interest. Some individuals with bipolar disorder and celiac disease have reported improvements in mood stability and overall well-being after adopting a gluten-free diet. However, the results are variable, and the research landscape is complex. Rigorous scientific studies are needed to establish the potential benefits of dietary interventions for individuals with both conditions. As researchers continue to explore the complex connections between celiac disease and bipolar disorder, individuals with celiac disease and those managing bipolar disorder are encouraged to engage in conversations with healthcare professionals. Understanding the potential impact of dietary choices and addressing nutritional deficiencies could hold promise in the realm of mental health, offering a comprehensive approach to managing bipolar disorder symptoms. The Impact of a Gluten-Free Diet on Mental Health As the intricate relationship between celiac disease and mental health unfolds, the question that looms large is whether a gluten-free diet—an essential component of managing celiac disease—could potentially have a positive impact on mental well-being. While the research is complex and the outcomes are variable, investigating the potential effects of a gluten-free diet on mental health conditions sheds light on a promising avenue of exploration. Anxiety and Depression: A Glimmer of Hope? For individuals with celiac disease who also experience anxiety and depression, the prospect of a gluten-free diet alleviating their symptoms is an intriguing one. While studies investigating the direct impact of a gluten-free diet on anxiety and depression are limited, some individuals report improvements in their mood and overall emotional well-being after adopting such a diet. The reasons behind these improvements are not fully understood, but they could stem from a combination of factors, including reduced inflammation and improvements in nutrient absorption. Attention and Cognitive Function: Enhancing Clarity? In the realm of attention disorders and cognitive function, the potential benefits of a gluten-free diet for individuals with celiac disease and ADHD remain under exploration. Anecdotal evidence suggests that some individuals experience improvements in attention and focus after adopting a gluten-free diet. However, rigorous scientific studies are needed to establish the efficacy of dietary interventions on cognitive function in individuals with ADHD. Autism Spectrum Disorders: Navigating Complexity For individuals with celiac disease and autism spectrum disorders, the potential impact of a gluten-free diet on symptoms remains a topic of debate. Some parents and caregivers report observed improvements in behavior and communication after removing gluten from the diet. However, the results are highly variable, and research findings have been mixed. It's crucial for individuals considering dietary changes to collaborate closely with healthcare professionals to make informed decisions that consider the individual's unique needs. Schizophrenia and Bipolar Disorder: A Bridge to Explore In the realm of severe mental health conditions like schizophrenia and bipolar disorder, the evidence regarding the impact of a gluten-free diet on symptoms is limited. While some case studies and anecdotal reports suggest potential benefits, the landscape is complex and the outcomes are far from uniform. The relationship between celiac disease, inflammation, and these conditions raises intriguing possibilities, but further research is needed to establish the potential role of dietary interventions. In the pursuit of understanding the impact of a gluten-free diet on mental health conditions, it's essential to approach dietary changes with caution. While the potential benefits are promising, it's important to recognize that dietary interventions are not a substitute for professional medical and mental health care. Consulting with healthcare providers who specialize in both celiac disease and mental health is crucial before making any significant changes to one's diet. Conclusion The intricate relationship between celiac disease and mental health unveils a captivating narrative that underscores the interconnectedness of the body and mind. As we navigate the complex landscape of the gut-brain axis, immune responses, and nutritional influences, a mosaic of connections emerges—highlighting the potential impact of celiac disease on a spectrum of mental health conditions. The gut-brain axis, a bidirectional communication network, serves as a bridge between the physical and emotional realms. The gut microbiota, immune responses, and inflammation play pivotal roles in shaping mental well-being. While the mechanisms are complex and multifaceted, the emerging research paints a compelling picture—one that invites us to consider new perspectives on mental health. From anxiety and depression to ADHD, autism spectrum disorders, schizophrenia, and bipolar disorder, each mental health condition weaves a unique thread in the tapestry of celiac disease's influence. Shared genetic factors, immune dysregulation, and nutritional deficiencies intermingle to create a symphony of interactions that challenge our understanding of the mind's intricate workings. As individuals with celiac disease and mental health conditions seek answers, it's essential to approach the journey with patience, curiosity, and a commitment to holistic well-being. While a gluten-free diet holds promise for some, it's not a panacea. Collaborating closely with healthcare professionals—those who specialize in both celiac disease and mental health—offers a comprehensive approach to addressing the nuanced connections between these realms. The exploration doesn't end here. As science continues to advance, our understanding of the gut-brain connection will deepen, unveiling new insights and potential interventions. The complexities of celiac disease's impact on mental health remind us of the intricate tapestry that makes us human—a tapestry woven with the threads of genetics, environment, biology, and experience. In the journey toward unraveling the gut-brain connection, we bridge the gap between the physical and emotional, gaining a deeper appreciation for the profound interplay that shapes our lives. As we move forward, let us continue to foster open dialogue, advance scientific inquiry, and empower individuals to make informed choices that honor both their physical health and mental well-being.
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Celiac.com 07/17/2023 - Celiac disease has been associated with higher levels of anxiety, but study evidence is scant. A team of researchers recently set out to measure the frequency of anxiety and depressive symptoms in Jordanian patients with celiac disease. The Research Team The research team included Sara Haj Ali, Rahaf Alqurneh, Awni Abu Sneineh, Bandar Ghazal, Lana Agraib, Layali Abbasi, Sufian Rifaei, and Tarek Mazzawi. They are variously affiliated with the department of Medicine, Al-Balqa Applied University, Al-Salt, JOR; the department Gastroenterology and Hepatology, University of Jordan, Amman, JOR; and the department of Food Science and Nutrition, Jerash University, Jerash, JOR. Celiac disease is a condition where the immune system reacts to gluten, causing intestinal problems and other symptoms. Researchers conducted a study to understand the frequency of anxiety and depressive symptoms in Jordanian patients with celiac disease. Anxiety and Depressive Symptom Questionnaire The study involved sending a questionnaire electronically to celiac disease patients through WhatsApp. The questionnaire asked about demographics, disease-related information, and assessed anxiety and depressive symptoms using validated scales. A total of 133 patients participated in the study, mostly females with an average age of 33.9 years. About one-third of the patients were not following a gluten-free diet, and more than half were experiencing symptoms at the time of the study. 83% Report Depressive Symptoms The prevalence of anxiety and depressive symptoms among the participants was found to be high, with 85% reporting anxiety symptoms and nearly 83% reporting depressive symptoms. There were no significant correlations found between the variables and the presence of anxiety or depressive symptoms. These findings highlight the significant proportion of Jordanian celiac disease patients who experience anxiety and depressive symptoms. Considering the potential impact on their quality of life, it is important for healthcare providers to screen celiac disease patients for psychiatric comorbidities and refer them for further evaluation if needed. This can help improve their overall well-being and provide appropriate support. Read more at Cureus. 2023 Jun; 15(6): e39842
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Celiac.com 03/27/2023 - Celiac disease, a chronic inflammatory disorder of the intestines, affects about 1% of the world's population. Celiac disease causes diarrhea, abdominal discomfort, bloating, flatulence, and, in rare cases, constipation in the digestive tract. Since the identification of gluten as the disease-causing antigen, celiac patients have been treated with a gluten-free diet, which usually eliminates symptoms and restores gut health, but which also has limitations for some patients. Celiac disease is also associated with numerous neurological and psychological manifestations. A recent article details findings from the most recent study, but here we try to provide more comprehensive information. Neurological Manifestations of Celiac Disease The neurological manifestations of celiac disease are varied and can include psychiatric and neurological symptoms such as ataxia, peripheral neuropathy, seizures, headaches, cognitive impairment, and myoclonus. The specific mechanisms of celiac disease's neurological effects are still being researched, but they may involve gluten-mediated pathogenesis that can lead to antibody cross-reactions, immune-complex deposition, direct neurotoxicity, or extreme vitamin or food deficiencies. A gluten-free diet can alleviate most celiac disease symptoms, except for cortical myoclonus and dementia, which may require immunosuppressive therapy. However, there is currently no consensus on whether serological or neurophysiological data can accurately predict or monitor celiac disease-related neurological involvement. Treatment for gluten-related neurological symptoms typically involves embarking on a strict gluten-free diet as soon as possible, which can have a positive therapeutic effect for most cases. Symptomatic management may also be required. Immunosuppression is only used in cases where a gluten-free diet alone has not been beneficial or for patients with refractory celiac disease. Peripheral Neuropathy and Gluten Ataxia Peripheral neuropathy and gluten ataxia are common in celiac patients, with up to 39% of patients experiencing gluten neuropathy. Gluten-free diets have been shown to improve neuropathy and ataxia. Gluten ataxia is an uncommon immune-mediated neurological disease that can be difficult to identify. The early signs of ataxia may be subtle, but worsen if left untreated. Patients with gluten ataxia may experience structural alterations in different parts of the brain, including the cerebellum and thalamus, and have larger lateral ventricles. Higher Epilepsy Risk Celiac disease increases the risk of epilepsy, especially in children and adolescents. The presence of villus atrophy on follow-up biopsies may reduce the risk of epilepsy but does not affect hospitalizations for epilepsy emergencies. Unexplained epilepsy should prompt celiac disease screening since early identification and therapy may increase the effectiveness of anti-epileptic drugs. Celiac patients also have a higher prevalence of migraines and tension headaches. The underlying relationship between celiac disease and headache involvement is still unknown, but adherence to a gluten-free diet can alleviate neurological symptoms. Celiac disease can also cause cognitive impairment, including memory loss, clouded thinking, personality shifts, and an inability to calculate. Nutrient deficiencies, systemic inflammation, and low brain serotonin levels have been suggested as possible reasons for this. Celiac disease has also been associated with Alzheimer's and vascular and fronto-temporal dementias. Neuropsychological assessments should be conducted in celiac disease patients to assess cognitive function. Psychiatric Manifestations of Celiac Disease Celiac disease is associated with depression, anxiety, eating disorders, autism spectrum disorder, attention deficit hyperactivity disorder (ADHD), bipolar disorder, schizophrenia, and mood disorders. The relationship between celiac disease and these psychiatric disorders is not well-known or established. Particular biological aspects as well as the effect of a gluten-free diet require additional research. Depression and Anxiety Celiac disease has been associated with various psychiatric disorders such as depression, anxiety, eating disorders, autism spectrum disorder, attention deficit hyperactivity disorder (ADHD), bipolar disorder, schizophrenia, and mood disorders. However, the relationship between these disorders and celiac disease remains unclear and requires further research. Research suggests that gastrointestinal disorders have a link with depression and anxiety due to prolonged pain and inflammation, affecting specific brain targets like the anterior cingulate cortex. Gastrointestinal disorder patients have reduced cognitive and mood status, leading to anxio-depressive phenotypes, even in the absence of clear evidence of threats. Children with celiac disease may experience anxiety and depressive symptoms, and pediatric patients with celiac disease should be frequently assessed for mental health issues, especially anxiety and sadness. Adults with celiac disease have reported experiencing anxiety and depression as well, particularly due to clinical illnesses and symptoms. Following a gluten-free diet may worsen symptoms like anxiety and fatigue, leading to a diminished quality of life. Therefore, clinicians must recognize the importance of promoting both dietary adherence and social and emotional well-being in celiac disease patients. Studies have shown that individuals with celiac disease experience low quality of life, anxiety, and depressive symptoms, and nutrition plays a crucial role in reducing these effects. However, the role of motivation in the quality of life and adherence remains unclear and requires further research. Eating Disorders Eating disorders may be a comorbidity with celiac disease (celiac disease) and the need for further investigation. celiac disease patients may experience disordered eating due to the disease itself or other factors such as food neophobia. It is crucial for gastroenterology clinicians to be aware of potential risks for eating disorders in celiac disease patients. The article notes that while numerous examples of eating disorders have been described in celiac disease patients, few epidemiological studies have investigated this potential link. One study found that patients with celiac disease had higher Eating Attitude Test scores than controls when testing individuals aged 13 and up, but no clear differences were seen between patients with celiac disease and controls when using other screening measures for ED. The article suggests that further investigations with larger samples and prospective designs are needed to corroborate these results. The article also discusses how celiac disease may cause food neophobia, which is linked to sensory aversions or fears of the negative effects of eating particular foods. This fear may be more severe in celiac disease patients than in non-celiac disease patients who choose to follow a gluten-free diet and can be linked to the possibility of having an unfavorable reaction to gluten-contaminated food products. The article emphasizes the importance of gastroenterology clinicians being aware of potential risks for eating disorders in celiac disease patients. It notes that eating disorders are defined by thoughts and actions linked to physical and/or psychological problems and that it is crucial to identify past, current, and potential risks for eating disorders in celiac disease patients. Autism Disorder Autism spectrum disorder is caused by a complex interplay of genetic and environmental factors, affecting individuals in diverse ways. Recent studies suggest that immune system dysfunction could contribute to the development of autism spectrum disorder in some people [55]. While some research suggests a connection between celiac disease, an autoimmune disorder triggered by gluten consumption that mainly affects the small intestine, and autism spectrum disorder, other studies have not found a significant association between the two conditions. Attention Deficit Hyperactivity Disorder (ADHD) Research has suggested a potential link between celiac disease and ADHD, with studies showing that celiac disease is overrepresented in ADHD patients, and a gluten-free diet improved ADHD symptoms in celiac disease patients. However, routine screening for ADHD in people with celiac disease or vice versa is not recommended. Cognitive problems similar to those seen in children with ADHD, such as a lack of focus or trouble paying attention, were linked to gluten-free diet noncompliance in childhood celiac disease, as were psychosomatic symptoms and antisocial behavior. Individuals with untreated celiac disease may be at risk for engaging in ADHD-like behavior, specifically inattention. Out of 23 studies, 13 found a favorable correlation between ADHD and celiac disease. Bipolar Disorder Bipolar Disorders refer to a group of serious and long-term mental health conditions that are characterized by manic and depressive episodes. Research has shown that people with bipolar disorder have higher levels of immunoglobulin G (IgG) antibodies against gliadin than those without a history of psychiatric illness. However, there is still a need for further investigation into the specific antibody response to gluten antigens in bipolar disorder. Close associations have also been observed between celiac disease and major depressive disorder, panic disorder, and bipolar disorder, leading to reduced quality of life. Therefore, early reporting of symptoms and screening for celiac disease is recommended, especially for those with a family history of the disease or essential symptoms. Schizophrenia Schizophrenia is a severe mental illness that increases the risk of premature death 2-4 times compared to the general population. Genetic and environmental factors, including drug abuse, especially involving cannabis, are associated with an increased risk of developing schizophrenia. Research suggests an association between schizophrenia and celiac disease, although a causal link has yet to be established. Although having elevated antibodies against gliadin is a common immunological abnormality between schizophrenia and celiac disease, most patients with schizophrenia who had elevated anti-gliadin antibodies (AGA) did not have celiac disease. However, there is evidence that a gluten-restricted diet may benefit schizophrenia patients with immunological gluten sensitivity. One treatment-resistant schizophrenia patient with immunological gluten sensitivity benefited from a gluten-restricted diet improvement in both mental and physical symptoms, as well as a reduction in the plasma quantitative level of AGA-IgG. Chronic inflammation, which is thought to increase due to gluten intolerance, may worsen the symptoms of schizophrenia and make it harder for patients to respond to treatment and absorb medications. Schizophrenia patients also have a higher rate of digestive and liver problems. While removing gluten from the diet may alleviate some symptoms, it is not recommended for all patients. Gluten intolerance is believed to increase chronic inflammation, exacerbating symptoms and reducing medication absorption. However, the available data on the link between celiac disease, gluten allergies, and schizophrenia are inconsistent, and a gluten-free diet is not recommended for people with psychosis and mood disorders without further research. Other Psychiatric Disorders Previous research has shown that people with celiac disease are more likely to suffer from neuropsychiatric disorders than the general population. So far, more than 60 non-human leukocyte antigen (HLA) genes have been linked to celiac disease by genome-wide association studies; of these, it is believed that 15% have a role in neurological health. Many common neuropsychiatric disorders include celiac disease as a primary predisposing factor. It's possible that the co-occurrence of diseases is in large part due to shared molecular networks and biological processes. To determine what causes these disorders, we need to look at the underlying molecular mechanisms. Celiac disease was associated with an increased risk of psychiatric problems in children, raising their lifetime risk by 1.4 times that of the general population. Celiac disease in children has been linked to an increased likelihood of developing psychosocial difficulties later in life, including depression, anxiety, eating disorders, antisocial behavior, attention deficit hyperactivity disorder, autism spectrum disorder, and intellectual disability. It was also more common to have been diagnosed with a mood, eating, or behavioral condition prior to the celiac disease diagnosis. In contrast, no elevated risk was found for any of the psychological diseases studied in the siblings of people with celiac disease. A cohort study included nearly 20,000 children with biopsy-verified celiac disease, pairing each patient with 5 reference child controls. Approximately 16.5% of celiac children were diagnosed with a psychological condition during a median follow-up of 12.3 years, compared to 14.1% of controls. Celiac disease in childhood increased the risk of psychiatric illness by 19% and this risk increases during maturity, in particular, mood, anxiety, eating, ADHD, and autism spectrum problems. There was no statistically significant increase in psychotic disorders, psychoactive substance use, behavioral disorders, personality disorders, suicide attempts, or suicides. Celiac disease increases the use of psychiatric medication. Psychological issues associated with celiac disease were also more prevalent. As a result, the attending physician should conduct routine surveillance of potential psychiatric symptoms in patients of all ages who have gluten-related diseases, including both children and adults. Conclusions In conclusion, celiac disease has been linked to numerous neurological and psychiatric conditions, including depression, anxiety, eating disorders, autism spectrum disorder, attention deficit hyperactivity disorder (ADHD), bipolar disorder, schizophrenia, and mood disorders. Clinicians should assess mental health factors when making a celiac disease diagnosis. Overall, the relationship between celiac disease and these neurological and psychiatric disorders is not well-known or established. More research is needed to understand the pathophysiology of celiac disease's neurological and psychiatric manifestations. Particular biological aspects as well as the effect of a gluten-free diet require additional research. Read more at Cureus.com
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Topic: Celiac disease I need some serious help.. please..judge me, I don’t care…obviously, as what I’m about to say 😞 Last year 5/2022, I was diagnosed with celiac with blood test and biopsy. since then, I developed severe depression with my life and with celiac always in the back of my mind and thus Been cheating on diet and living a “yolo” lifestyle and continue to eat gluten.. well in December, I had a follow up and confessed to my doctor that I haven’t gone gluten-free, he wanted to see where my antibodies are and they came back low..he wanted to see me in 3 months and I just saw him on Monday and lied and said I’m eating more at home to avoid cross contamination but then broke down in tears because this is more psychological hell for me and he was sweet but I’ve messaged him so many times throughout the year on the portal about “could it be this instead?” Im so afraid he is going to “fire me” as a patient.. he said don’t apologize for anything. he tested my antibodies again..and they are even lower! I’m soo confused, I’m in such denial..I swear, if someone told me I had cancer, I wouldn’t believe them 😓 I was scoped 8 years ago by another doctor within the same company and my bloodwork was off the charts high but my scope came back negative. How can I accept that I have it? this is seriously a huge problem and it’s beginning to drive me to insanity.. I have two children and I just don’t care anymore about myself and just in “survival mode.” Why are my antibodies going down even if I haven’t followed a gluten-free diet?
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Celiac.com 09/26/2022 - Celiac disease is on the rise, and so are the gastrointestinal and other symptoms that go with it. A number of researchers have documented connections between various psychiatric disorders and celiac disease. However, the relationship between celiac disease, and such psychiatric disorders is not well studied or documented. A team of researchers recently set out to provide a greater understanding of the existing evidence and theories surrounding psychiatric manifestations of celiac disease. The research team included Emma Clappison, Marios Hadjivassiliou, and Panagiotis Zis. They are variously affiliated with the Medical School of the University of Sheffield, Sheffield, and the Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust and University of Sheffield, Sheffield. Their systematic review and meta-analysis appears in a special issue on gluten-related disorders, titled, Time to Move from Gut to Brain. The team conducted a search of online medical literature search using PubMed, pulling data on rates of celiac disease and psychiatric disorders from eligible articles. They then conducted a meta analysis of odds ratios. For their review, the team found a total of 37 articles that met their eligibility parameters. Compared with healthy controls, the team found people with celiac disease to have a significantly higher risk for autistic spectrum disorder, attention deficit hyperactivity disorder, depression, anxiety, and eating disorders. They found no significant differences for bipolar disorder or schizophrenia. The study revealed that celiac disease is associated with a higher risk of depression, anxiety, eating disorders, along with ASD and ADHD. The team is calling for more research into the specific biological reasons underpinning this connection, along with the potential benefits of a gluten free diet in improving these conditions. Read more in Nutrients 2020, 12(1), 142
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Celiac.com 07/06/2022 - More and more people are avoiding gluten and FODMAP food components (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) over concerns about their potential connection to celiac-like reactions in the gut. In recent years, gluten-free diets (GFD) and low-FODMAP diets (LFD) have become more popular across the globe. This is due to intolerances or allergies in some people, but also due to the direct influence of marketing movements or diet trends on eating choices. At the same time, understanding, diagnosing and treating neurological and psychiatric diseases is becoming more important in numerous countries. A number of researchers have started to examine FODMAPs for that reason. Because of this, the research team conducted a bibliographic systematic review to see if there is a pathophysiological relationship between consumption of gluten or FODMAPs and mental disorders. The research team included Egoitz Aranburu; Silvia Matias; Edurne Simón; Idoia Larretxi; Olaia Martínez; María Ángeles Bustamante; María del Pilar Fernández-Gil; and Jonatan Miranda. They are variously affiliated with the Gluten Analysis Laboratory of the University of the Basque Country, Department of Nutrition and Food Science, University of the Basque Country in Vitoria, Spain; the GLUTEN3S Research Group, Department of Nutrition and Food Science, University of the Basque Country in Vitoria, Spain; the Bioaraba, Nutrición y Seguridad Alimentaria, in Vitoria, Spain; and the Centro Integral de Atención a Mayores San Prudencio in Vitoria-Gasteiz, Spain. The team's review gathered data from clinical and randomized controlled trials, based on the PRISMA statement, published since 2012. Their analysis found that limiting or ruling out gluten or FODMAPs may improve symptoms such as depression, anxiety, or cognition deficiency, and to a lesser extent for schizophrenia and the autism spectrum. Nevertheless, further studies are needed to obtain completely reliable conclusions. Read more in Nutrients 2021, 13(6), 1894.
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Celiac.com 06/27/2022 - Consumer gluten-free diet and sales of gluten-free products have increased immensely over the last decade, fueled in part by allergies and sensitivities in some, and by the popular perception that the diet is healthier by many others. The popularity of the gluten-free diet has led a group of researchers to explore the physical and mental effects that gluten might have on young people, especially in those with existing stomach and gut issues. The research team set out to assess the effects of gluten in adolescents and young adults with existing gastrointestinal symptoms and enrolled nearly 275 eligible adolescents, with at least four different gastrointestinal symptoms, from a population-based cohort of nearly thirteen-hundred. In phase one of the study, fifty-four participants lived gluten-free for 2 weeks. Thirty-three participants who improved during phase one then moved to phase two. Phase two was a blinded randomized cross-over trial, in which participants were blindly randomized either to start with 7 days of gluten, eating two granola bars containing 10g of gluten or to 7 days on placebo, eating two granola bars without gluten, followed by the reverse and separated by a 7-day washout period. The team measured any effects of the intervention on gastrointestinal symptoms and participant mental health. Overall, just under sixty of the 273 participants entered the run-in phase, with 35 eligible for randomization. A total of 33 were randomized, while 32 completed the trial. Average age was just over 20 years old, and nearly all participants were women. The team found that, compared with placebo, adding gluten to the diet did not trigger gastrointestinal symptoms or negatively affect mental health in adolescents who participated in this trial. Read more in Alimentary Pharmacology & Therapeutics 29 March 2022 The research team included Caecilie Crawley, Nadia Savino, Cecilie Halby, Stine Dydensborg Sander, Anne-Marie Nybo Andersen, Manimozhiyan Arumugam, Joseph Murray, Robin Christensen, and Steffen Husby. They are variously affiliated with the Hans Christian Andersen Children’s Hospital, Odense University Hospital, Odense, Denmark; the Department of Clinical Research, University of Southern Denmark, Odense, Denmark; the Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; the Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; the Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark; the Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA; the Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; the Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.
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An hour or so ago I had a pretty brutal panic attack. I only just found out I was diagnosed with CeD. After getting my diagnosis, I did a lot of research. I am a biology major and so the scientific logic behind the disease has been very fascinating to me. One of the things that shed a lot of light into my personal life is the connection between neuropathy and Celiac disease. I have had pretty bad anxiety and depression for a few years now. I wasn't that set off because I definitely had a predisposition, coming from a family riddled with depression, borderline personality disorder, bipolar disorder, etc. The first couple weeks I started following my gluten free diet I saw some major progress. I actually felt happy, motivated, clear. I am a college student, so doing tests and homework with brain fog and fatigue is next to impossible. The past couple weeks, for whatever reason, all of my symptoms have come back. I have checked my cabinets two, three times over. I have checked cosmetics and made my partner pack a toothbrush in case he eats something with gluten. I have done my research, I have done seemingly everything in my power. And yet the symptoms are back, leading to a very scary panic attack. The feeling of dissociation, that I'm dying. The feeling of "I don't want to live my life if this is what it is going to be like." I remember seeing somewhere that the quality of life for people with Celiac is lower than a majority of diet related diseases. Now I understand why. I want to know if anyone else struggles with these mental ailments. My confusion now stems from the possibility that I already had these neurological disorders and CeD just exacerbates them. If that is the case, how do we tell the difference between a normal neurological response and a gluten inflicted one. I just want to go back to the week I felt healthy. Knowing that I can feel that way makes me excited. I just can't keep living this way and I'm not sure when I can get to a point where things will finally be normal.
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Celiac.com 03/29/2021 - A team of researchers recently set out to analyze the connection between celiac disease and depression in children, adolescents, and young adults with Type 1 diabetes. For their study, the team looked at nearly 80,000 patients aged 6–20 years, with Type 1 diabetes lasting at least six months, and treatment data, in the diabetes patient follow-up registry, between 1995 and 2019. The team assigned the patients to one of four groups: Type 1 diabetes patients, numbering 73,699; Type 1 diabetes + celiac disease, numbering 3,379; Type 1 diabetes + depression, numbering 1877; or Type 1 diabetes + celiac disease + depression, numbering 112 patients. The results showed a strong association between celiac disease and depression. Depression and celiac disease were more frequent in women, compared with Type 1 diabetes. Patients with Type 1 diabetes + celiac disease, and Type 1 diabetes + depression, were more likely to use insulin pumps compared with Type 1 diabetes only. HbA1c was higher in Type 1 diabetes + depression, Type 1 diabetes + celiac disease + depression, both compared with Type 1 diabetes only. Compared with Type 1 diabetes patients, patients with Type 1 diabetes + celiac disease + depression were more likely to have comorbid autism, attention deficit hyperactivity disorder, anxiety, schizophrenia, and eating disorders. The results support a strong connection between celiac disease and depression in young people with Type 1 diabetes. The team hypothesizes that the emotional weight of Type 1 diabetes and celiac disease together may increase a patient's risk for depression. Depression was also associated with additional psychological and neurological comorbidities. In addition to screening Type 1 diabetes patients for celiac disease at regular intervals, the team suggests celiac disease patients might screening benefit from regular depression screening. Read more in Acta Diabetologica (2021) The research team included Sascha René Tittel, Désirée Dunstheimer, Dörte Hilgard, Burkhild Knauth, Elke Fröhlich-Reiterer, Angela Galler, Michael Wurm, and Reinhard Walter Holl. They are variously affiliated with the Institute for Epidemiology and Medical Biometry, ZIBMT, Ulm University, Albert-Einstein-Allee 41, 89081, Ulm, Germany; the German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany; the Paediatrics and Adolescent Medicine, Medical Faculty University of Augsburg, Augsburg, Germany; the Department of Pediatrics, Witten, Germany; the Department of Pediatrics and Adolescent Medicine, CJD Berchtesgaden, Berchtesgaden, Germany; the Division of General Pediatrics, Department of Paediatrics and Adolescent Medicine, Medical University Graz, Graz, Austria; the Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; the Clinic St. Hedwig, University Children’s Hospital Regensburg (KUNO Clinics), University of Regensburg, Regensburg, Germany; the Institute for Epidemiology and Medical Biometry, ZIBMT, Ulm University, Albert-Einstein-Allee 41, 89081, Ulm, Germany; and the German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
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Celiac.com 02/15/2021 - A number of studies have tied celiac disease to psychiatric disorders, but there is still not much good data to support the connection. To get a better picture of the issue, a team of researchers recently set out to describe the epidemiology of several psychiatric disorders in celiac disease. The research team included Motasem Alkhayyat, Thabet Qapaja, Manik Aggarwal, Ashraf Almomani, Mohammad Abureesh, Omaymah Al‐otoom, Mohammad Zmaili, Emad Mansoor, and Mohannad Abou Saleh. They are variously affiliated with the Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic Foundation, Cleveland, Ohio; the Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio; the Department of Gastroenterology, University Hospitals Cleveland Medical Center, Cleveland, Ohio; the Department of Internal Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio; University of Jordan Medical School, University of Jordan, Amman, Jordan; and Department of Internal Medicine, Staten Island University Hospital, New York City, New York. For their study, the team used a multi‐center database, called Explorys Inc, which offers electronic health record data from 26 major integrated healthcare systems consisting of 360 hospitals in the US. Of the 3,746,581 patients in the database between 2016‐2020, there were 112,340 patients with celiac disease. The team identified a group with celiac disease using the Systematized Nomenclature Of Medicine ‐ Clinical Terms (SNOMED–CT). They then conducted multivariate analysis using SPSS version 25. Compared to patients with no history of celiac disease, celiac patients were more likely to have a history of anxiety, depression, bipolar, ADHD, eating disorder, and autistic disorder. Patients with celiac disease and psychiatric conditions were more likely to be smokers, and to have a history of alcohol and substance abuse , along with a history of personality disorder. This large database study shows that celiac patients have a higher risk of having multiple psychiatric diseases including anxiety, depression, bipolar, ADHD, eating disorder, and autism. The team advises clinicians to keep mental health in mind when treating celiac patients, and to make psychiatric referrals as needed. Read more in Gastroenterology
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Celiac.com 01/09/2012 - Women with celiac disease face a higher risk for depression than the general population, even once they have adopted a gluten-free diet, according to U.S. researchers. A team of researchers recently used a Web-mediated survey to assess a range of physical, behavioral and emotional experiences in 177 U.S. adult women, who reported a physician-provided diagnosis of celiac disease. The team was led by Josh Smyth, professor of biobehavioral health and medicine at Pennsylvania State University, and included members from Syracuse University and Drexel University. The survey gathered information about how closely people follow a gluten-free diet and assessed various symptoms of celiac disease from physical symptoms to the respondents' experience and management of stressful situations, along with charting symptoms of clinical depression and frequency of thoughts and behaviors associated with eating and body image. Perhaps unsurprisingly, many women with celiac disease suffer from disordered eating, given that the management of celiac disease requires careful attention to diet and food, Smyth said. "What we don't know is what leads to what and under what circumstances," Smyth said. "It's likely that the disease, stress, weight, shape and eating issues, and depression are interconnected." The findings are forthcoming in the journal of Chronic Illness. Source: http://www.upi.com/Health_News/2011/12/28/Celiac-ups-depression-risk-for-women/UPI-75401325131984/#ixzz1iQynze9k.
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Celiac Disease Tied to Depression in Adolescents
Jefferson Adams posted an article in Depression and Celiac Disease
Celiac.com 06/23/2016 - Digestive Disease Week 2016 took place in San Diego from May 21-24. Among the presentations given was one that stood out for its obvious health impacts. That presentation was given by Jonathan Cordova, DO, pediatric gastroenterologist at the University of Chicago Medical Center. His presentation tied celiac disease to major depressive disorder in adolescents, and stated that most adolescents with celiac disease have symptoms consistent with the disorder. Dr. Cordova said that "...interim analysis does suggest that a majority of adolescents living with celiac disease may have symptoms consistent with major depressive disorder," and that the depression has a negative impact on their quality of life, "but does not appear to be associated with their celiac disease state." That is, the depression does not seem to be impacted by how well their celiac disease is doing. Healthy gut and gluten-free diet, or unhealthy gut, with symptoms, it doesn't seem to matter. The depression levels seem about the same whatever the case. A number of recent studies indicate that depression and anxiety are the main reasons people with celiac disease report decreased quality of life, Dr. Cordova and his colleagues wrote. But, most of these studies were done on adults, almost none used adolescents, and adolescents may be more susceptible to depression. The research team was able to connect celiac disease with mental health disorders in adolescents by administering questionnaires to adolescents and their parents. Average age of adolescents was 14.6 years at the time of survey and 11.2 years at the time of diagnosis. The researchers found no correlation between celiac disease and depression, anxiety, ADHD, age at survey, quality of life, age at diagnosis or length of time on a gluten free diet. However, the majority of adolescents and parental reports screened positive for major depressive disorder. Interestingly, a parent's perception of the state of their child's celiac disease impacted their perception of depression in their child. Dr. Cordova says that "the data suggests that early screening for depression in any adolescent with celiac disease is crucial to help optimize behavioral health," Dr. Cordova's team plans to follow these patients into young adulthood, and aims to re-screen them again in 5 years. Reference: Cordova J, et al. Abstract #844. Presented at: Digestive Disease Week; May 21-24, 2016; San Diego- 1 comment
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Celiac.com 12/29/2020 - Early-onset depression is associated with poor health outcomes over the long term. However, researchers still don't know if early depression might be connected with specific diseases and premature death, and whether these connections are independent of psychiatric comorbidity. A team of researchers recently set out to quantify the association of youth depression with subsequent diagnoses of numerous somatic diseases and mortality. Their study shows that people who suffer from depression in youth face higher risks of subsequent disease and death. The research team included Marica Leone, BSc; Ralf Kuja-Halkola, PhD; Amy Leval, PhD; Brian M. D’Onofrio, PhD; Henrik Larsson, PhD; Paul Lichtenstein, PhD; and Sarah E. Bergen, PhD. They are variously affiliated with the Janssen Pharmaceutical Companies of Johnson & Johnson, Solna, Sweden; the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; the Department of Psychological and Brain Sciences, Indiana University, Bloomington; and the School of Medical Sciences, Örebro University, Örebro, Sweden. The team defined youth depression as having received at least 1 diagnosis of depression from inpatient or outpatient care between ages 5 and 19 years. The team's population-based cohort study of nearly 1.5 million individuals in Sweden found more than 37,000 were diagnosed with depression at least once between the ages of 5 and 19 years. Those individuals with youth depression faced higher relative and absolute risks of developing any of a wide range of medical conditions, and of early death, compared with the general population. Even after controlling for other psychiatric disorders, especially substance use and anxiety disorders, those with an early history of depression had a higher risk of being diagnosed with 66 of 69 medical conditions assessed in the study, including sleep disorders, type 2 diabetes, viral hepatitis, and kidney and liver diseases. There were differences between men and women. Men with early-onset depression faced higher risk for obesity, thyroid problems, celiac disease, connective tissue disorders and eczema. Women, on the other hand, were more likely to suffer injuries, as well as urinary, respiratory and gastrointestinal infections. These findings indicate a connection between youth depression, increased risks for numerous somatic diseases, and for mortality. They invite clinicians to consider several medical conditions when assessing depression in young people, and lay the groundwork for future study. Read more at JAMA Psychiatry
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Celiac.com 06/29/2020 - Coronavirus Disease 2019 (Covid-19) has killed nearly a half a million people globally, and over 120,000 here in the United States. People with celiac disease have to eat gluten-free in order to avoid negative health consequences. The pandemic fallout has included home lockdowns, food shortages, and disruptions. How concerned and/or anxious are people with celiac disease about the lockdowns and the possible shortages of gluten-free food? A team of researchers recently set out to to evaluate the perception of this in celiac disease patients who require a lifelong gluten-free diet as a therapy. The research team included Monica Siniscalchi, Fabiana Zingone, Edoardo Vincenzo Savarino, Anna D'Odorico, and Carolina Ciaccia. They are variously affiliated with the Celiac Center at Department of Medicine, Surgery, Dentistry of the Scuola Medica Salernitana at the University of Salerno in Salerno, Italy, and the Gastroenterology Unit of the Department of Surgery, Oncology and Gastroenterology at University of Padua in Padua, Italy. To get a picture of the concerns people with celiac disease are having during the pandemic, the team created an e-mail COVID-19 survey for adult patients from the University of Salerno in Campania, in the south of Italy, and the University of Padua in Venice, in northern Italy. After emailing 651 surveys to adult celiac patients, the team received 276 replies, for a response rate of just over 42%. Nearly 60% of celiacs said that they were not concerned about being more susceptible to Covid-19 just because they had celiac disease. Nearly 50% said that they were not concerned "at all" about the possible gluten-free food shortages during the pandemic. Of patients who were concerned about exposure and food shortages, most were older, female, and suffered from other comorbidities. Finally, celiac patients said that they were happy with remote consultations and explicitly asked to have them. The researchers point out that COVID-19 offers clinicians a chance to practice large-scale remote consultation for providing healthcare for people with celiac disease. According to the researchers, telemedicine is popular with celiacs, and should be integrated into the celiac healthcare regimen. The COVID-19 pandemic has affected numerous celiac patients, especially women, elderly patients, and those with comorbidities. Read more in Dig Liver Dis. 2020 May 16
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Celiac.com 05/30/2020 - Recently, I posted a query to ICORS Listserv’s celiac email group listing the following symptoms of hypochondria as found on the Mayo Clinic website: Excessive fear or anxiety about having a particular disease or condition. Worry that minor symptoms mean you have a serious illness. Seeking repeated medical exams or consultations. “Doctor shopping,” or frequently switching doctors. Frustration with doctors or medical care. Strained social relationships. Obsessive medical research. Emotional distress. Frequent checking of your body for problems, such as lumps or sores. Frequent checking of vital signs, such as pulse or blood pressure. Inability to be reassured by medical exams. Thinking you have a disease after reading or hearing about it. Avoidance of situations that make you feel anxious, such as being in a hospital. The response from people on the Listserv was immediate and most of them reflected my own experience on the long road to diagnosis. Some responded with gratitude and relief that they were not alone and named their “symptoms” by number. “I too am guilty of 1, 2, 3, 4 sort of, 5 still am, 6-even my friends thought I was a little over the top, 7-still to this day, 8 never goes away, 11 wondering if the doctors actually have the right diagnosis. After all it took them this long to come up with it.” “As far as the hypochondria list—I’m guilty of: 3 4 5 6 11 & 13.” “I have not been treated for hypochondria, but I know people who were beginning to say it was all in my head. I suffered from 3, 5, 11 and 12. It took me nearly 8-10 years before they finally diagnosed me with celiac disease. My mother-in-law went through the same thing until they diagnosed her thyroid condition. After awhile, you’re afraid the doctors are going to see and think, “Oh, no! Not her again! What does she think she might have now?” ” There were many others who listed numbers or told their story. This is my story about the long road to a celiac disease diagnosis: I was 42 years old and had been incapacitated for thirteen years by the time I was diagnosed with celiac disease. My husband’s jobs in retail moved us so often (eight cities in thirteen years) that I had seen nearly two dozen doctors including a gynecologist, a rheumatologist and at least one family doctor in each city. At the time of my diagnosis, I’d suffered over a decade from pain, severe fatigue, and anxiety as well as cognitive trouble that made me unemployable. The question of digestive irregularity was sometimes brought up and dismissed as a nervous reaction. My biggest concern, though, by far, was the drastic loss of cognitive function. After I’d seen about a dozen doctors, I became savvy enough to quit bringing up my fibromyalgia and chronic fatigue diagnoses (the mention of which garnered responses anywhere from lip-tightening to eye-rolling, followed by anti-depressant prescriptions). I never admitted to my first diagnosis which was hypochondria. After the birth of my last child, I began my quest for relief. I saw a neurologist first, with the following complaints: My short-term memory was non-existent; I had severe fatigue; I had a severely impaired sense of direction, and; my reading and comprehension had slowed markedly. Attending art school had become difficult because my visual memory seemed to have gone missing. I could no longer hold a picture in my head between viewing the object and turning back to the paper to draw it. The bonus of a tremor made my line-quality suffer which was extremely disheartening. I couldn’t control line-width by subtle variation of pressure of the chalk on paper. At home, completing mundane tasks required an outsized effort and was extremely frustrating. I couldn’t remember a phone number long enough to dial it without referring back to it two or three times. More often than not, I became confused and had to start dialing all over. I frequently got lost in my own town while driving, and I began stammering in stressful situations. At the neurologist’s office, I was given an EEG which showed no indication of nerve impairment. Although my quality of life was annihilated, my neurologist was not impressed with my symptoms. I was a 27-year-old mother of two small children, he said, as he looked at his watch and suggested that I get some rest and a psychiatric evaluation. I was naïve. I thought that by getting an evaluation I would prove that I was earnestly looking for an answer. I made an appointment with a psychiatrist to give me the exam. The test was exhausting; it went on for hours. There was a long questionnaire that asked, several times in different ways, whether I ever heard voices or believed people were following me. I was asked many times, each time in slightly different way, what my most fervent desire was. My answer was always that I wanted to get well. After the questionnaire, I was given a round of verbal tests, that involved word recall and some non verbal tests that involved drawing pictures and assembling puzzles. I had a very hard time finding synonyms and naming objects, but my puzzles went together very quickly, I was told. When I went back to the neurologist he said that because of the psychiatric report, diagnosing hypochondria, I wasn’t a suitable patient and he could do nothing for me. I tried to believe in the possibility that I did, indeed, have hypochondria. At least that was something I could be responsible for; something over which I could take control. Raised with a belief in the ability of the mind to affect the body, I looked into the disease of hypochondriasis. I was desperate to help myself so I researched our home medical encyclopedia (this was a while before the Internet) and bought a book on the subject of hypochondria. I learned that it was then considered a fairly rare illness, and that real hypochondriacs drew some benefit from the sympathy they received due to the perception they are ill. That was far from the case with me. On the verge of a divorce because my husband hadn’t yet come around to believing that I was actually ill, I was getting no sympathy from him or his family. My siblings found it more convenient to believe I was either lazy or exaggerating my complaints than to do anything to help with my two small boys. My parents, who believed me, were too elderly and ill to help much, but my mother would send over the occasional roast beef dinner which I received with tears of gratitude. I rejected the concept of hypochondria when I saw that there was absolutely nothing in it for me, and wondered who in the world could possibly benefit from such a mindset. When I received a bill from the psychiatrist, I wrote him to insist on a copy of my test results. He was very reluctant, and told me I might not like what I found. I told him he might not get paid if I didn’t have the access to my file. His one-paragraph evaluation stated that although there was a big discrepancy between my verbal skills and sorting tests, and although I did seem to want to get well, since I still complained and nothing was found, I was a hypochondriac. In other words, the results of the hours of expensive testing were discounted and he made a diagnosis based on the fact that I had no other diagnosis. I, too, discounted the value of the test by refusing to pay for it. The weeks dragged into years. Many days I was so weak that I could only lock myself and my toddlers in my bedroom with diapers, baby food and formula and lie on the floor with them. Just trying to stay conscious to make sure they didn’t hurt themselves required a monumental effort. Often, I was too ill to prepare even a sandwich for myself. Periods lost in this type of exhaustion continued on and off for over a decade until my eighth gynecologist discovered the pain in my outer abdomen. I admitted to having long bouts of diarrhea that I had sometimes been unable to control. He insisted that before I leave the exam room that I get an appointment with a gastroenterologist whom he knew to be very competent. Before I left, I had an appointment in hand, written on a prescription sheet. I can’t express the warmth and gratitude I still feel toward this doctor who took my health so seriously when I’d come to feel so disposable. A few weeks later, I was diagnosed with celiac disease and started the arduous journey toward a completely gluten-free diet, the only treatment yet available. I saw a significant improvement just 12 hours into the diet, and thought my suffering was over. It wasn’t. I had become ill with Graves’ disease which my family doctor was unwilling to diagnose. After a few weeks with a heartbeat at 144 beats per minute, I asked to be referred to an endocrinologist who ordered new labs. I put my arm out for another prick, tried to breathe slowly, and decided to stop at Barnes and Noble on the way home to buy a book so I could read up on diagnostic criteria. By this time in my life, I’d become quite unwilling to trust my health to any one person. It may well be that I am here today because I took the initiative to do a little of my own research. My first endocrinologist misread my lab results and declared that I was getting better and suggested a “wait and see” approach. While I was on the phone, I tried to remain calm despite the hammering in my chest and the excruciating sense of urgency spreading across my throat. I calmly, if haltingly, asked for the numbers of my new test results. The man had read the results wrong. He thought they were getting better, but because he compared results from two different labs, he hadn’t perceived that both sets of lab results showed a non-existent production of thyroid stimulating hormone, a sure sign that my thyroid was in overdrive. After asking for a second opinion, I was diagnosed with Graves’ disease and finally, after four months of agony, put on anti-thyroid drugs which returned me to a state of relative normalcy. Graves’ disease, before the invention of these drugs, by the way, had a 50% survival rate. I could just as easily be dead today. Naturally, when I consider the years I lost when my boys were small, I still get angry. I wonder if my physically talented son, Patrick, would have been a baseball star had I been able to cheer him on at his games. I wonder whether more time with Stevie puttering in the garden and encouraging his extraordinary love of natural science would have invested him with more self-confidence. Perhaps that would have made his middle school years less excruciating. I would have loved to visit my older daughter in Manhattan and taken in a show once in a while, but was always too weak when it came time to live up to my plans. I wish I had been able to finish my schooling and get a job to help take the load off my husband who has been the sole breadwinner for all of our marriage. I carry all of these regrets in the pain in my back, I believe, and still look forward to the day I can lay them down. In the early stages, after the Graves’ diagnosis, a rage ran through me that burned like poison in my veins. The tens of thousands of dollars that were wasted on tests, the snide comments and the derisive looks from medical professionals, friends, neighbors and family still boil in the back of my consciousness. I started to write to every doctor that had failed me, then threw the letters away, knowing they’d just take me for a hysteric, and simply consider my case anecdotal. I started goading my friends into questioning their doctors and getting second opinions. I saw undiagnosed celiac disease or Graves’ disease in nearly everyone I met. Then something, something beyond will or intent, something deep within me broke. I realized that my trials, my ill health, my burdenhood were really not my fault. Yes, yes, all this time I’d been telling myself this truth, but now the clouds of recrimination and responsibility were actually parting. Finally, after several years of righteous anger and indignation, for the first time, I allowed myself to grieve over my lost years of health. I began to realize how, even though I fought tooth and nail against the idea that my illness was all in my head, that the very perception of me as weak-minded had the power to alter my perception of myself. This was a true epiphany. My mother had taught me that if I was doing the right thing, that the opinions of other people meant nothing, but after being told so many times that it was normal to be tired, or that I had occult depression, or lectured that I should not let myself get stressed out, I had begun to feel like someone who couldn’t be trusted no matter how trustworthy I was. I had become the mythical Cassandra’s twin sister. My story is far from unique. When the dozens of people who responded to my inquiry on the Listserv shared their stories, I began to see a pattern of systemic failure in our medical system. Some of these stories can only be described as horrific. Kat Fury, who responded with a thoughtful email, told me how she suffered agony for years before she was finally diagnosed with celiac disease and Ehlers-Danlos Syndrome type 3. She had this to say: By the time I was five I had learned to not complain about things hurting me or the dislocation of my limbs. My parents didn’t believe in doctors, but having enough of my being “lazy, depressed, and bulimic” they had me hospitalized in a psychiatric ward for said symptoms. This confirmed my worst fear, that I was crazy and that everyone felt this kind of daily pain. Even though I couldn’t keep my food down sometimes, and the pain of both disorders was unbearable, I rarely complained. During my stay in the psychiatric facility I met a girl with a diagnosis of Reynaud’s Syndrome, a circulatory disorder. When I learned about it I discovered I also had all of her symptoms, usually worse. I made the mistake of saying something and was punished by being put into solitary confinement for a week. Kat was eventually diagnosed with Ehlers-Danlos Syndrome, a rare genetic mutation that causes her to have inadequate collagen and be overly flexible. Before her diagnosis she once got dismissed from work after being caught trying to put her shoulder back into its socket. She was told not to come back without a doctor’s note. Because of her intense guilt over not being able to handle her aches and pains, she misunderstood. She thought she had been fired and she never returned to her job. The incompetent treatment she received as a medical patient left her with psychological wounds so severe she couldn’t even take her own dislocated shoulder seriously. She went on to describe how her EDS diagnosis made doctors reluctant to treat her broken back after a car accident. She is now permanently unable to walk unassisted. Her mistreatment defies comprehension. She related this insight “…my body has many things considered rare, but the more I investigate my genetic propensity for these diseases, the more I learn they are only rare because of a systemic failure to diagnose.” … If my doctors had stopped using the saying ‘When you hear hoof beats think horses not zebras’ I would’ve had a better childhood.” Unfortunately, those who have celiac disease, thyroid disease and Ehlers Danlos syndrome are not alone. Patients with difficult to diagnose autoimmune disease are all at terrible risk of permanent damage to their health because of delays in diagnosis and treatment. There seems to be no standard of care in place to look beyond the horses to find the zebras. Drug companies, who have made themselves the physicians’ source of new information and medical advancement, have no interest in talking about diseases for which there is no drug currently under patent. The current practice of confining office visits to eight-minutes, along with insurance company pressure to limit testing, it is likely that anyone who doesn’t have a popular illness with textbook symptoms is going to get shunted aside and labeled “hypochondriac.” This label serves many functions. It aids in the loss of family support, replacing it with disgust, which makes it more difficult for the patient to believe in herself, or continue to bother her doctor with her concerns. Labeling a complaining patient as a hypochondriac allows the doctor to feel antipathy instead of sympathy, which is efficient and cost-effective because it releases the doctor from any obligation to do the time-consuming research needed to follow up on her case. In the big picture, creating a culture that makes this apocryphal diagnosis so very pervasive makes patients more likely to change doctors, which results in more first-visit charges, which are usually more than double the price of a regular office visit. Hence, every doctor’s coffers are fortified. We like to think that our doctors think like Dr. House on the TV series…that they won’t give up on us until they figure out what is really wrong, that when they rule out the common diseases, they will follow the trail to the less common sources of symptoms, but this is rarely the case. Any time a patient is given a diagnosis of exclusion, that ends in the word “syndrome,” that means your doctor has given up. Fibromyalgia syndrome is one of these. No known etiology, a vague collection of symptoms, no further need to research once cancer and Crohn’s disease are ruled out. The same goes for “irritable bowel syndrome.” Although there are plenty of expensive drugs to treat it, it isn’t an actual disease, it’s a medical stalemate. Perhaps you actually have small intestinal bacterial overgrowth or an intestinal yeast infection, or God forbid, celiac disease. Most patients will never know, because there are plenty of expensive new drugs on the market that treat and mask only the symptoms. Hypochondria may be a real psychiatric condition, but its diagnosis depends on the black and white determination that there really is nothing physically wrong with the patient. Otherwise, it is perfectly understandable that a curious, pro-active person would try again and again to get help, and investigate her symptoms. To tell a patient conclusively that there is nothing wrong with her requires a burden of proof that is insurmountable, since not every disease is immediately diagnosable and not every disease is well-known. The fair thing to say would be something along the lines of: “I’m at the limits of my capability to help you,” or, more honestly, “Digging any deeper into the cause of your malaise is more than I care to do.” The cracks in the system are becoming more noticeable. Because of patient awareness and activism, conditions once thought to be rare, such as celiac disease, are now known to be common. When I was diagnosed with celiac disease in 2002, it was thought to have a prevalence of one in 4200 people in the general population. It is now known to affect around one in a hundred. Other recent examples are the greatly increased prevalence of thyroid disease, vitamin D and vitamin B12 deficiencies. Any of these can cause an array of vague but debilitating symptoms, such as generalized pain and chronic fatigue. Yet the suspicion of hypochondria is always at the forefront. This should not be the case. Such a diagnosis has a terrible impact on the patient’s mental and physical health. It should be considered with the greatest of caution instead of flung, like monkey-product, in arrogance. This egregious mistake violates both the spirit and the letter of the Hippocratic Oath, “First, do no harm.” If, as the Mayo site suggests, hypochondria diagnoses occur at a rate of between one and five percent of all patients, consider this: Celiac disease and thyroid diseases occur at rates of one percent and at least five percent respectively. These two severely under-diagnosed conditions alone pretty much take care of the alleged prevalence of hypochondria in the general population. Add to those patients anyone else with difficult-to-diagnose ailments such as lupus, multiple sclerosis or any of the dozens of other autoimmune diseases less familiar to the family practitioner, and we are easily past the full suspected five percent. For these reasons, it is high time we sent the diagnosis of hypochondria to the dust-bin of history.
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I'm new here, so I'm not sure if I'm even posting this in the right forum, but here goes. It's been about 3 months and I am at my wit's end. Forgive me for being dramatic, but I don't wanna suffer alone anymore. My gluten intolerance emerged when I hit puberty, but it was never serious: just bloating, constipation, fatigue. However, along the years, I noticed some strange symptoms come about. The weirdest being a "globus" sensation, as if something was caught in my throat. After attempting to cough it up to no avail, I decided to ignore it, assuming it was simply mucus. Once again, I continued to eat gluten, not realizing the damage it was causing. Then slowly over the course of a couple more years, I noticed that food would take awhile to go down. I didn't think much of it, just that I had to drink a lot more water than usual. Fast forward to the present time, and now I can hardly swallow my own saliva. I went to the doctor, who said I had nothing more than a mere chest cold. So I took the medicine, and only got worse. I don't know how it happened, but I stumbled upon a forum post, about a woman whose dysphagia was linked to celiac disease. It all makes sense now. After a month of starvation, my swallowing returned to (somewhat) normal, and as you can imagine, I stuffed every food imaginable down my throat: pizza, bread, ramen, my favorite foods basically. And now I'm back to step one, and I've never felt more miserable. I've avoided gluten like the plague ever since, yet I still cannot swallow. I really hope that someone out there can relate to the toll that this is taking on my mental health. I've never been suicidal, but it just seems like each day, a new symptom arises for no utter reason, and I think that being dead would be so much easier. As of now, I haven't eaten gluten in weeks, yet I have the sensation of a walnut stuck in my throat, and I am scared to death to eat a morsel of mashed potato. I've been waking up every morning choking on my saliva. No one is taking me seriously. My mom just tells me to eat less dairy and gluten. But my throat literally feels like it's the size of a straw. That's not all either. Don't even get me started on the brain fog, the random rashes, my bones aching for no reason, falling asleep while eating, the list goes on. I've managed to eat some soup now, although it takes me an hour to eat half a cup. This, along with the stress of college is beating me to a pulp right now. I hate to complain so much, but I really just want someone to tell me that they know what I'm going through, because no one in my life can relate to me right now, or even have any sympathy. Please, tell me I'm not alone.
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Hi all! I'd love your thoughts on this. I'm a 25 year old female and I've had a few different symptoms so I'm considering getting tested, but I have no family members with celiac or anything like that. I'm not sure if this actually looks like these could mean it or not! I've had these little bumps on my elbows, knuckles, and knees on and off for 5 years. They're like small blisters filled with clear liquid and are super itchy. Anti-itch cream and lotions don't do anything for them, they just sometimes disappear after a while. Wondering if it's dermatitis herpetiformis? I've been diagnosed with anxiety/panic attacks and depression and have been on and off medication for 4 years I had Mono and a Vitamin D deficiency 8 years ago and I haven't been checked for it since then...no idea if I'm still deficient or not, but I am definitely still always tired. I frequently feel sluggish physically, which is different from the mental sluggishness of my depression. I've had stomach/digestion issues for yearssss now and I've been unable to find any actual food allergies. My entire abdomen will feel incredibly bloated for 2 or 3 days at a time, but I'll also just get my stomach bloated frequently after I eat. My stomach also hurts a lot and I'm always paranoid I have appendicitis, but it never turns out to be that and goes away after a bit. I've tried being gluten free/diary free before but I wasn't incredibly strict about it and it seemed to help some? But not always. I'll often feel gross and nauseous in the morning if I eat right before going to bed. I also saw somewhere that sometimes vitiligo can be a symptom (although it's not listed on most sources) and I do have some on my face I feel like there are more things too, but they've slipped my mind at the moment. Thanks for taking the time to read this!
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