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Found 9 results

  1. Hi Im new here. I've been suffering from GERD and IBS for past two years. I have done several courses of different medicines including PPIs to no avail. I have been researching on celiac desease and gluten sensitivity for past few weeks and out of curiosity I took the tTG and DGP antibodies test. My results are as follows, tTG-igA: 8.29 U/ml tTG-igG: 20.0 U/ml normal: values less than 12 U/ml equivocal: values between 12 -18 U/ml positive: values greater than than 18 U/ml ------------------------------------------------------------------------------------------ DGP-igA: 21.7 AU/ml DGP-igG: 14.75 AU/ml normal: values less than 15 AU/ml equivocal: values between 15-30 AU/ml positive: values greater than than 30 AU/ml ------------------------------------------------------------------------------------------ so basically my tTG-igG is positive and DGP-igA is equivocal. how would this result be interpreted?
  2. Hello! Can anyone give me your opinion on my celiac test results? The nurse on the phone said everything looks okay, but I got a copy of the report and a few things were flagged! I am beyond confused and frustrated. I have been struggling over the last 2 years with TERRIBLE fatigue, headaches, joint pain, bloating, and constant stomach pain with weekly diarrhea. I've tested negative for RA as well as other autoimmune disorders. My doctor thinks I may have celiac and ordered a test, however I do not have a follow up appointment for another month. Here are my results: **IGM, QN, Serum: Ref Range (26-217); 270 (high) IGG, QN, Serum: Ref Range (600-1600); 961 IGA, QN, Serum: Ref Range (86-252); 248 **Deamidated Gliadin Abs, IGA: Ref Range (0-18); 20 (high) **Deamidated Gliadin Abs, IGG: Ref Range (0-18); 58 (high) tTG IGA: Ref Range (0-3); 2 tTG IGG: Ref Range (0-5); 1 Any insight at all will be greatly appreciated!
  3. My internist (for over 8 years) has just refused to order the tTg and DGP for my annual follow-up. I have never had the DGP; and my tTg has never dropped below 20. He says he "never heard of the DGP and doesn't know why these tests would be recommended". I showed him a printout from the U. of Chicago Celiac Center showing these 2 tests being recommended for annual follow-up. I'm shocked, confused, frustrated, and angry. He knows how sick I continue to be and how hard I'm trying to get well. Suggestions?
  4. ahhh as soon as I think I'm a step closer to knowing what is wrong I get thrown another curve ball! So here is a little bit of info about me.. 27 year old female with Hashimoto's thyroiditis. I've suddenly developed iron deficiency anemia. After doing some research and seeing my doctor I learned that a lot of people with Hashimoto's can also have celiac disease so we ordered some celiac blood tests TTG (IgG/IgA) both came back normal (however total IgA wasn't tested..) DGP IgA negative, and DGP IgG positive (3.59 IV anything above .90 IV considered positive). After getting my blood test results back I made an appointment with my GI doctor and had the endoscopy done yesterday.. I also work in the hospital laboratory so I know the pathologists and all so I called today and he said he didn't see any signs of celiac but wants to pass it around to the other pathologists to make sure, he did say I have gastritis tho with no signs of H. pylori...told me to come talk to him tomorrow but now I'm stressed out and confused!! :/ any advice?
  5. Hi, I went gluten-free three years ago without any celiac testing at the recommendation of an (obviously ill-informed) doctor when I was experiencing severe GI distress with no known cause after the birth of our first son. My GI symptoms disappeared (until a few months ago, but more on that in a moment). I always just assumed I was gluten-intolerant and told people so, and I assumed that having celiac disease was very unlikely due to the low incidence rate. Additionally, I knew I'd have to consume gluten to get tested for celiac disease, and I wasn't willing to put myself through that. Then within the last six months I started having recurring GI problems again. I thought I was on a decent gluten-free diet so assumed that something else must be going on, such as a soy issue. Last week an allergist requested to run the celiac tests on my blood, and I said ok despite telling him that I knew it would come back negative regardless of my disease status since I had been on a gluten-free diet for years. Shockingly, the DGP IgA came back positive. My question is, should I just assume that I have celiac disease, or should I go through with a gluten challenge and getting an endoscopy? I get SO sick from consuming gluten, and as a result of last week's blood tests I've realized that I was obviously consuming hidden gluten and that it was likely the cause of my recent GI distress. However, I doubt it's been enough gluten to result in a positive biopsy. And I just can't imagine consuming large amounts of gluten for the biopsy considering how sick I've been lately with only consuming trace amounts of gluten. Prior to starting the gluten-free diet three years ago, I was having severe bloating and cramping and diarrhea 4 to 5 times per day alternated with days of constipation. I would imagine that my reaction would be even worse now that I've been (attempting) gluten-free for three years. What are everyone's thoughts? Label myself as celiac or try to do a gluten challenge?
  6. Had positive DGP IGG... 3.59IV positive is GT .90 Biopsy says A. Duodenal mucosal biopsies with no significant microscopic abnormality. No diagnostic histology all features of celiac are appreciated. B. Gastric antral and oxytocin mucosal biopsies showing chronic gastritis. Reactive foveolar hyperplasia is present. H. Pylori is negative The material present is partly tangentially sectioned. The villous crypt ratio is about 3.5. There are intraepithelial lymphocytes but they don't seem to be significantly increased in most of the villi. There are inflammatory cells in the lamina propria including plasma cells and lymphocytes with an occasional germinal center. They are normal to slightly increased in number. No histologically diagnostic features of celiac are appreciated Opinions anyone??? I'm confused see. Lymphocytic gastritis can be associated with celiac plus my positive blood test!! Ahh maybe I'll just give up the gluten and see how I feel
  7. every so often I like to see if there are any new studies added related to DGP, and here's an interesting abstract I found: http://gut.bmj.com/content/62/Suppl_2/A31.2 it says that 55 patients with known celiac disease, though it doesn't say biopsy proven, were tested for compliance to GFD. It would have been great if it was said whether these patients previously tested positive for both DGP and TTG before going on a GFD. Results after a GFD: 24/55 of those tested positive for DGP Out of those results: 12/24 had an elevated ttg iga serum above the normal reference range of <10 9/24 had a ttg iga result between 3-9 3/24 had a ttg iga result of <1 All patients who tested negative for DGP were also ttg iga negative: 31/55 The paragraph of self reporting reads as follows: "If serum IgA anti tTG is used as a measure of compliance to GFD, then the sensitivity of anti-DGP in predicting dietary compliance was 100%, with a specificity of 72% and a negative predictive value of 100%. When compliance was determined based on patients' self-reporting during the consultation, 11 (20%) patients were documented as not fully compliant to GFD. 8 (72.7%) of these were anti-DGP positive and had elevated serum IgA anti tTG, and 3 were anti-DGP positive with IgA anti- tTG level in the normal range (with their IgA anti tTG level ranged between 3 to 9 U/ml). Four (7.3%) patients reported compliance to GFD but had positive anti-DGP tests and elevated IgA anti tTG levels." Looks like DGP still out performs ttg iga in dietary compliance!
  8. Hello Forum Members, I'd like to introduce myself... I've been coming to the forum for about 2 months to learn about the tests. I saw I wasn't the only one who was puzzled...thank you for all the information. It is amazing how little doctors know in contrast to you all. I don't know where to start but here it goes... (sorry for the long intro) As a kid I had the chronic D, I was underweight and sickly. I had a colonoscopy at around 12 years old; the gastro-doctor found nothing. In my 20's I controled the dreaded D by eating cheeze. At 30 I was diagnosed with fibromyalgia. In 2010 my fibromyalgia got really bad. That year, I kept hearing on TV that the gluten free diet helped people with chronic pain and fatigue. So in October 2010 I went gluten free. Of course there was a learning curve of a few months. After about 2 weeks of going gluten free my pain and fatigue vanished. I was in hyper mode with insomnia, and I had so much energy that able to exercise and lose weight. About a month after going gluten free, I went to see my doctor much thinner. She didn't want me to get the Celiac blood tests but she told me to stay on the gluten free diet. In retrospect this was the worse medical advice I received. After seeing her, I read 2 library books on Celiac and everything I read made sense from childhood D, having been underweight, dental enamel defects, and as an adult: broken foot bones, kidney stones, fatty liver, neurological problems, Lactose intolerance. During my gluten free period of 2 years, my pain returned on and off and quite hard. At first I was was phoning companies to find out if they were putting gluten in their food but later I was eating only produce and cheeze, meat, eggs. I got my carbs from rice and potatoes. Then I noticed that beans and lentils gave me pain so that got me thinking. The doctor that didn't want to test me for Celiac had moved and I found a better doctor by chance. Eventually the new doctor agreed to have me tested with a Celiac blood test or a food intolerance test. But I procastinated another year as I was so afraid of even having even more pain if I returned to eating bread-gluten. In December 2012 I did a tTG blood test - it was negative. I did an IgG food intolerance panel in January 2013. The IgG food intolerance test showed several foods that I was intolerant to such as Wheat (very high), Casein, Eggs, Peas and several others. Months ago my doctor booked to see a gastroenterologist (which I'm seeing next week) to check several issues as some auto immune problems are a reflection of what is happening in the gut. While on the long waiting list, I continued to eat bread daily and with daily pain cranking up after January. I stopped the eggs and the cheeze so the bread must be the cause of my pain. I will need to see a Rheumatologist to re-evaluate my fibromyalgia as my PCP and an Internist suspects it developed into something worse but as others have said on this forum, I'd rather solve the problem by finding the food cause vs just taking pills. I did the Celiac panel last week and got the disapointing results yesterday. I'm listing the results below and I welcome some of your expert opinions... Thank you for reading this far. ............................................................................................................................ Gluten challenge: October 2010 to November 2012 gluten free November 6 to December 6 - 2012 about 4 slices of bread / daily December and January 2 slices daily February 2 to 6 slices daily March 4 to 6 slices daily up to April 18 10 slices daily (yes I gained weight) ............................................................................................................................. December 6 - 2012 result reference range Total IgA : 0.92 0.69 - 3.82 g/L Tissue Transglutaminase IgA AB 1 < 4.0 ku/L negative 4 to 10 kU/L weak pos. > 10 ku/L positive ............................................................................................................................. January 2013 IgG food intolerance test: Wheat 59 (Elevated when >30 U/ml) ................................................................................................................................ April 18 - 2013 (done at a different lab than the first time) result reference range Total IgA: 0.83 0.69 - 3.82 g/L Transglutaminase IgA AB 2.2 < 10 U/mL Deaminated Gliadin IgA 0.6 < 10 U/mL Deaminated Gliadin IgG 2.5 < 10 U/mL ................................................................................................................................
  9. Hi, I have stalked around on this forum for a while and finally decided to sign up today and ask all of you seasoned celiacers a question about my lab work. I have had some serious neurological issues, mainly my eyes being very sensitive to light and feeling dizzy, so my neurologist ran a panel of blood work on me and besides a low Vit. D, a slight titer of dsDNA which is so low considered neg. only one came back positive. This was the Deamidated Gliadin Peptide IgG. It was weakly positive at 24. 30 being strong postive. So I googled what Deamidated Gliadin Peptide was and a whole slew of celiac articles popped up. I had a biopsy in 2008 which I was told was negative for celiac disease, but I think my Gastro only took one biopsy. I want to be realistic here and not keep barking up the same tree if I don't have celiac disease, but I was shocked to see the DGP IgG positive. Do you guys think this test could correlate with other possible diseases? They did do other celiac tests like the IgA and Ttg test which were in normal ranges.Endomysial test also normal. I guess what I want to know is, with this one test being positive, should I look further into celiac disease or should I not worry about it? Thanks for any input in advance.
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