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fox23 posted a topic in Celiac Disease - Pre-Diagnosis, Testing & SymptomsHello! Im very new to all of this and honestly feeling overwhelmed. Just received my results from Entrolab and was wondering if someone with more experience in all this wouldn't mind helping me analyze what exactly they mean. Any help/advice is very much appreciated! Here are my results: B-1) Gluten Sensitivity Stool Panel Fecal Anti-gliadin IgA 191 Units (Normal Range is less than 10 Units) Fecal Anti-tissue Transglutaminase IgA 59 Units (Normal Range is less than 10 Units) Quantitative Microscopic Fecal Fat Score 1048 Units (Normal Range is less than 300 Units) TEST INTERPRETATION(S): Interpretation of Fecal Anti-gliadin IgA: The level of intestinal anti-gliadin IgA antibody was elevated, indicative of active dietary gluten sensitivity. For optimal health; resolution or improvement of gluten-induced syndromes (mainly falling into six categories abbreviated as NAAAGS – neuropsychiatric, autoimmune, asthma, abdominal, glandular deficiencies/hyperactivity or skin diseases); resolution of symptoms known to be associated with gluten sensitivity (such as abdominal symptoms - pain, cramping, bloating, gas, diarrhea and/or constipation, chronic headaches, chronic sinus congestion, depression, arthritis, chronic skin problems/rashes, fibromyalgia, and/or chronic fatigue); and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well. For additional information on result interpretation, as well as educational information on the subject of gluten sensitivity, please see the "FAQ Result Interpretation," "FAQ Gluten/Food Sensitivity," and "Research & Education" links on our EnteroLab.com website. Interpretation of Fecal Anti-tissue Transglutaminase IgA: The level of intestinal anti-tissue transglutaminase IgA antibody was elevated, indicative of an autoimmune reaction to the human enzyme tissue transglutaminase. This is almost always due to clinically significant gluten sensitivity. In rare cases, anti-tissue transglutaminase antibody appears in the absence of clinically significant gluten sensitivity, either as a marker of latent gluten sensitivity, as a consequence of an autoimmune reaction to a different stimulus (either dietary or otherwise), or possibly from liver disease. Tissue transglutaminase is an intracellular enzyme present in virtually all human tissues and organs, and is secreted extracellularly in response to tissue damage (such as occurs with trauma, surgery, pregnancy, infections, or inflammation-induced tissue damage). It is this extracellular release that allows the enzyme to become antigenic, especially when underlying gluten sensitivity is present. The fact that dietary gluten sensitivity so often induces a subsequent and secondary autoimmune reaction to this important human enzyme explains why autoimmune reactions and diseases so often accompany clinically significant gluten sensitivity. Interpretation of Quantitative Microscopic Fecal Fat Score: A fecal fat score greater than or equal to 300 Units indicates that an abnormally high amount of dietary fat has passed undigested and/or unabsorbed into the stool. Malabsorption of dietary fat almost always is associated with malabsorption of all other nutrients as well (protein, carbohydrates, vitamins, etc.). When associated with gluten sensitivity, elevated fecal fat usually is due to gluten-induced small intestinal functional damage and subsequent malabsorption; this does not require there be villous atrophy present. However, deficient production of enzymes by the pancreas can also be associated with celiac disease or non-celiac gluten sensitivity with autoimmune attack on the pancreas, causing maldigestion and malabsorption of dietary fat and other nutrients. Some other causes of exocrine pancreatic insufficiency include chronic pancreatitis from any cause (alcoholism being the most common), pancreatic resection, pancreatic cancer, or common bile duct obstruction. Pancreatic insufficiency as the primary cause of fat malabsorption usually causes significant elevations of fecal fat values, usually into the moderate (600-1000 Units) or severe (>1000 Units) ranges. To distinguish between small intestinal malabsorption and pancreatic maldigestion, a fecal pancreatic elastase test is necessary, which is now available from our laboratory. Other possible causes of elevated fecal fat (steatorrhea) include - another inflammatory bowel disease (such as Crohn’s disease which can be associated with gluten sensitivity); deficiency in the production or secretion of bile salts; overgrowth of bacteria in the small intestine; diarrhea from any cause which can, in turn, cause dietary fat to rush through the intestine unabsorbed; consuming very large amounts of dietary fat; eating unabsorbable synthetic dietary fat substitutes; or taking “fat blockers;” and resection of the small intestine causing “short bowel syndrome” (if you have had an intestinal resection). Any elevated fecal fat value should be rechecked in one year after treatment to ensure that it does not persist, because chronic fat malabsorption is associated with osteoporosis and other nutritional deficiency syndromes.