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Genetics Nutrition and Stress the Threeway Model of How Gluten Triggers an Immune Reaction in Severely Malnourished IE Vitamin Deficient Individuals consuming a High Calorie Diet This blog post is WTL again....I tried breaking it into to two Posterboy Blog posts but decided to go ahead.... And post it instead as one due to other things IRL that are taking up most of my time these days..... So thanks in advance to every one who actually completes it! I truly believe it will help everyone who reads it and UNDERSTANDS! This Posterboy blog post is for everyone who got lost in the “Forest of Data” and never found their way out! As I am fond of saying “To Educate is to truly free!” Where there is a free exchange of knowledge there is health and peace for one’s soul and body! The journey of a thousand miles begins with the first step….that step back to health for me was my seemingly rare and not well understood Celiac disease diagnosis… I then began my journey….to learn at least what the doctor’s knew about this diagnosis….and exceed it if I could… But I got lost in the forest of data….for years…going around in circles…or so it seemed at the time… See my first attempt to hack/machete my way out of this sad forest (of illness) I was in… https://www.celiac.com/celiac-disease/a-differential-diagnosis-how-pellagra-can-be-confused-with-celiac-disease-r3989/ But I soon learned to spot clues as I read more and more studies….trends, patterns…in the data begin to emerge… one tree (study) at a time…I was able to blaze a trail back out of the forest… I can honestly say I am out of the forest now….and by blazing this trail….I hope I have left enough markers (IE posterboy blog posts/articles etc.) to help the next person out of this forest of symptom’s….. I had over focused on every shiny thing I found (individual Vitamin Deficiency one tree at a time)…. I begin to identify each Vitamin (tree of health) in this vast forest… I had settled on the 3 alarm fire of Pellagra….I didn’t know how wrong and right I was at the same time… It would take years to figure this out (as I walked around in circles)….it is what others had concluded before… The IJCD had concluded the same thing a couple years earlier… http://pubs.sciepub.com/ijcd/3/1/6/ They confirmed for me…it was possible… They noted: on how Pellagra occurred in Celiac disease… Pellagra and celiac disease “The two diseases can be connected in two aspects. 58% of pellagra patients were shown to have malabsorption and many had intestinal pathology on biopsies [36, 37]. Alternatively, Pellagra was described in celiac disease [38]. The skin manifestations in pellagra might have some additional etiologies, since multiple nutrient deficiencies are at the origin of the cutaneous manifestations in celiac disease. The following nutritional deficiencies inducing skin rashes, were describe in celiac disease: Zinc, Iron, Vitamin A, E, B12, niacin, folate, selenium and essential fatty acids [39, 40].” So Eureka! I had found what was being misdiagnosed as Celiac disease instead… 58% was good….I was more than halfway there….being right and wrong all at the same time! Then I found that there was another disease that explained these connections even better! https://www.celiac.com/celiac-disease/how-low-thiamine-can-thin-villi-old-research-rediscovered-and-its-clinical-significance-in-celiac-disease-r5100/ Now I had found out what was really causing my problems! I thought…and once again I was right and wrong all at the same time…. While my aim was dead on….it was nutrients (or lack thereof more correctly) causing my health problems… I had become too myopic only seeing individual trees and the not the forest ….for what it was a healthy place to live and thrive and fruit for meat and leaves for medicine… It was all the trees (at least 3 in particular)….together forming a Web of Life… To pivot from the metaphor to hard science (in real life aka IRL) ….how do know this analogy is true….or truer than not! To see if this is true we have to dig deep in the forest of data….and see what it tells us… See this research entitled “Pellagra in the USA: unusual manifestations of a rare entity” https://casereports.bmj.com/content/12/9/e230972 On the surface….it is just as we would suspect…Pellagra is rare in the USA…right only in Alcoholic’s right…. But we if we dig a little deeper….we learn something from this good research… Quoting from their abstract… “They/She had adrenal function testing which revealed adrenal insufficiency. Vitamin testing revealed normal B12 and folate levels but undetectable levels of thiamine, riboflavin and niacin. Her symptoms and signs resolved entirely with appropriate vitamin supplementation. Niacin (vitamin B3) is essential for multiple metabolic pathways, and severe deficiency may cause clinical syndrome of pellagra, which is most commonly associated with diarrhoea, delirium and dermatitis.” Notice the bolded Vitamin Deficiencie(S)….not one deficiency but many deficiencies culminating the a “Capstone” disease diagnosis…. Now why did this researcher not say the patient had Beri Beri (B1 deficiency), or Pellagra Sine Pellagra (B2 deficiency) instead…they/she had ALL these deficiencies…. Because B-Vitamins don’t occur alone or uncomplicated….so I was right to say I had gone on to develop (mostly) Pellagra ….except I didn’t have Skin (dermatitis) problems like DH etc….so I had only developed Pellagra Sine Pellagra instead…(so far)… But I had already gone on to develop Thiamine deficiency aka Beri Beri and the doctor’s had already missed it…. So why should I be surprised they missed me having a Riboflavin deficiency too! What most people don’t know (even doctor’s) don’t realize today….and I have recently found out that Pellagra has been incorporated into Celiac disease today….. Celiac disease is a three alarm metabolic (deficiency syndrome/disease) ramped up by each B-Vitamin you become low in …..in time…. It is a Cascade….like falling domino’s….one falling triggers the others too fall as well… Let’s see if there is research to backup this claim…. See this research published before 1950 (15+ years) before DH was associated with Celiac disease…. https://www.jidonline.org/article/S0022-202X(15)50482-X/pdf They show that DH was successfully being treated with Nictonic Acid aka Niacin more than 15 years before DH was described in the Skin of Celiac patients… Quoting from their summary “In a series of 12 patients with dermatitis herpetiformis of various degrees of severity, the oral administration of niacin in doses of 50 to 200 mgm. four times daily relieved the pruritus (Itching) and improved the cutaneous manifestations.” Yet today we exclusively “see” through50+ years of error(s)…having forgotten that DH can be treated with Niacin…. thus confirming a Pellagra diagnosis in a Celiac patient… It is the third phase (3 alarm stage) of the Vitamin Deficiencies you have now developed…. Don’t be surprised if the doctor’s don’t see your Vitamin Deficiency even then… Because in classic genetics….the environment and nutrition is discounted as limited factors….in disease… But other researchers are now rejecting this myopic view realizing Environment (Viruses etc.) and Deficiencies IE (Vitamins and Minerals) ALSO play a part in the pathogenesis of disease in an equal 50/50 mix…. See this 2 year old research that summarizes such an hypothesis entitled… Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease Here is the link…to this seminal and groundbreaking research… https://science.sciencemag.org/content/356/6333/44 /tab-e-letters Where Doctor Leslie M. Klevay , Prof. Emeritus, Department of Internal Medicine University of North Dakota School of Medicine and Health Sciences says quoting “In the original classification scheme, Celiac disease would have been considered a toxic deficiency (3) similar to Wernicke’s encephalopathy in which excessive ingestion of ethanol induces thiamine deficiency. Now some celiac disease can be considered a three-way cooperation among an infection, a toxin and a deficiency. Other three- and four-way cooperations have been identified.” Here is longer and probably better description how Virus's (Environment) or IE Epigenetics could/can trigger an Genetic disease like Celiac disease... https://www.gutmicrobiotaforhealth.com/virus-may-lead-celiac-disease-disruption-intestinal-immune-homeostasis/ The research is a couple years old.....also the Epstein Barr Virus has also been associated with Celiac disease. Dr. Londsdale says we need a “new Model” for Medicine… https://www.hormonesmatter.com/new-model-medicine/ I say we need a better one that acknowledges the environment and deficiencies as important or as important as genetics…. Other researchers have noticed the same thing….your environment and deficiencies are not being taken into account for Celiac’s. See this recent research that says the same thing entitled “Genetic risk factors for disease can be affected by environment” https://www.upi.com/Health_News/2017/08/16/Genetic-risk-factors-for-disease-can-be-affected-by-environment/4251502820421/ Not only are genetic risk factors for Celiac disease being affected by your environment…. they are effected by your deficiencies like Thiamine, Riboflavin and Niacin…. We know this because they have been studied (these three B-Vitamins) for toxic overload in Sepsis…. where the Auto-immune system goes haywire and results in death… See this research in Rats https://pubmed.ncbi.nlm.nih.gov/30903555/ It will take a few years for this study to be confirmed in humans….while more studies are performed more people will be dying of Vitamin Deficiencies…. Despite 8+ years ago Riboflavin has been proven to treat (MADD) disorder resulting in acute Renal Failure…. https://www.jstage.jst.go.jp/article/internalmedicine/50/21/50_21_2663/_pdf/-char/en People still think it is 70/30 genetics or even 80/20 genetics… Recent research for Celiac disease proves it is no more than 50/50 percent Genetics/Environment IE (Vitamins deficiency etc. AKA malnutrition) It is my hope that clinical practice will quickly catchup with the newest/latest research proving DNA/Genetics usually has less than 50pct of the risk factors for Celiac disease and accept many Vitamin deficiencies are prevalent as co-morbidities and need to be addressed before a Valid Celiac diagnosis can be accepted/confirmed…. See this studied that confirms this in Celiac’s https://www.genengnews.com/news/dna-has-relatively-little-say-in-disease-risk-usually/ Where they say quoting “It is becoming increasingly clear,” explained Wishart, “that the risks for getting most diseases arise from your metabolism, your environment, your lifestyle, or your exposure to various kinds of nutrients, chemicals, bacteria, or viruses.” And though Celiac disease is a disease consider to have a higher genetic factor it is now believed to be no more than 50% of the risk factor …..as once commonly believed… quoting again “There are diseases, however, for which the genetic contribution is about 40–50%. These diseases include Crohn’s disease, Celiac disease, and macular degeneration.” But I don’t believe they (doctor’s/Clinicians) will……memory has a “longtail” of approximately 18 years from new research reaching clinical practice on average… Appropriate supplementation is consider a key part of “Aftercare” for Celiac’s ….it needs to be part of appropriate disease diagnosis (IMHO)….so you don’t continue to suffer from the avoidable and treatable diseases that often in as many as 80pct of patients are found out Post-Mortem….as is the case in Wernicke Encephalopathy (WE)… etc.…and it should be NOTED 80% of WE is not diagnosed in Alcoholics….. it is happening in Celiac’s today and/or passed off as other GI diseases like Chrons, IBS, UC etc. and psychiatric or neurogenerative diseases today…. https://www.hormonesmatter.com/beriberi-the-great-imitator/ see this current research on Thiamine Deficiency and Benfotiamine Therapy in Brain Diseases https://biomedgrid.com/fulltext/volume3/thiamine-deficiency-and-benfotiamine-therapy-in-brain-diseases.000621.php You will fell half-dead if you continue to have these deficiencies if they doctor don’t also treat you for these co-morbidities despite being on a gluten free diet! I know I did….Ignorance kills!....but It maims us first! I hope this is helpful but it is not medical advice…. Posterboy by the Grace of God At this point I am only making one Posterboy blog post....see following/below for more technical studies...... Showing how and why this is true and how the doctor's missed it! Note to Self::::::))))) Put this a Part 1 of the Blog post and then link the Smoking Gun research on Tryptophan… ADDENDUM IF this analysis is true and a good working Theory and not just a good hypothesis we would find research that shows Tryptophan is important in the pathogenesis of Celiac disease and new research in 2020 confirmed this analysis. Celiac.com ran a summary of the research but I will link a good synopsis for others to read for themselves showing how Celiac’s have impaired metabolism of Tryptophan. https://www.celiac.com/celiac-disease/tryptophan-in-turkey-meat-can-speed-gut-healing-in-celiac-disease-r5338/ This good synopsis of this working theory shows how Tryptophan speeds gut healing in Celiac IMHO proving Pellagra is happening in Celiac’s. I would recommend reading it ALL when you get a chance. https://www.gutmicrobiotaforhealth.com/gut-microbes-in-celiac-disease-show-impaired-metabolism-of-dietary-tryptophan-according-to-researchers-at-mcmaster-university/ And like most “All” good medical research….they always conclude “more research/study” is needed…. Well people can’t want another 10 or 15 years until this research is again confirmed (and again) See this research entitled “Kynurenine pathway metabolites in humans: disease and healthy States” https://pubmed.ncbi.nlm.nih.gov/22084578/ This connection was established at least 10+ years ago….and now we can say for SURE IMHO that this metabolic breakdown is triggering inflammation in Celiac’s leading, in time, to a Leaky Gut! Again, I want to say (make note) that the International Journal of Celiac disease aka IJCD first noticed this connection 5 years ago…will it take another 10 or 15 years before it is “accepted” medical research??? I hope not: but I AM honestly not encouraged!!! This was meant to be a 2 part blog post….so It doesn’t get too long and too technical…but I have decided to publish it all at once now that I am working through some other health issues at the moment! If this is true….there should be studies about these facts….and there is…. I have argued IT is ONE immune system with multiple presentations of the difference Phases of Vitamin Deficiencies…. We see how this works in the LUPUS Inflammation Model I wrote a Posterboy blog post about these connections…. https://www.celiac.com/blogs/entry/2709-the-lupus-inflammation-model-for-sickness-beginning-with-b-vitamin-deficiencies-in-celiacs-and-other-inflammation-triggered-diseases…/ Here is the recent research it is based on…describing how IL-2 and IL-6 combine to help control the immune system…. We see this Alcoholic’s too…in how Niacin can help Leaky guts… See this Celiac.com thread about this topic… https://www.celiac.com/forums/topic/126496-intestional-permability-could-a-vitamin-deficiency-cause-it/?tab=comments#comment-1009633 And that is exactly what we want to fix in Celiac’s right….well B-Vitamins do that! And we see B-Vitamins are low in other chronic inflammation GI diseases like IBS, Chron’s and UC…because there is ONE Immune System! See this research entitled “Blood Concentrations and Renal Clearance of Water-Soluble Vitamins in Outpatients With Ulcerative Colitis” https://pubmed.ncbi.nlm.nih.gov/30906550/ Quoting “The blood concentrations of vitamins B2, C, niacin and folate were markedly lower in the patients with UC than those in the control group, and the renal clearance of vitamins B1, B6, B12 and folate was notably higher in the UC cohort. It was concluded that vitamins B2, C, niacin and folate were at significantly lower concentrations in patients with UC following adjustment for coexisting factors. The lower levels of niacin may be partially due to impaired reabsorption. Chronic inflammation, common in patients with(my words and/or chrons, IBS etc. and Celiac disease), with UC may contribute to the lower levels of other vitamins by rendering amino acid and carbohydrate metabolism into a hypermetabolic state. As the role of vitamins in metabolic activity is constant and pervasive, nutritional management including the application of water-soluble vitamins appears important for patients suffering from UC.” It is me again….why wouldn’t we think this would be the same in Celiac’s…..and why I believe the new research that shows Tryptophan helps heal Celiac Villi is key to understanding/proving Celiac is Pellagra in disguise in the 21st Century! It is time testing is done to confirm these same B-Vitamin deficiencies in Celiac’s is all I am saying so the Co-morbidities can be treated…leaving a true diagnosis… If not the same Vitamin Deficiencies could be confused for Celiac and you will never be sure if you ever received the proper diagnosis…. I have had to figure this out on my own….this is written so you won’t have t o suffer like I did for year’s going undiagnosed despite a Celiac diagnosis…. Two front wars are rarely winnable. Disguise is a great trick of the enemy. For if you get the wrong diagnosis then the symptom’s never getting better and the battle/war rages on. But What If you have the wrong disease? Would you get better? This is dedicated to those still suffering who are willing to ask why? am I still suffering GI symptom’s on a Gluten free diet? Since (auto-immune) or disease in general rarely occur alone it only makes sense to tackle the easiest one’s first. There are two camps/type of people. (It is true in many things of life). Supplementing or not to supplement is the 64K dollar question. The one’s who believes in supplementing readily attack the front (symptom’s) on/from whatever artillery (vitamins and minerals) they can find to shore up their defenses. The other camp prefers to hunker/bunker down and wait for reinforcement/symptom’s to get better and the battle/siege to pass. But in war there is an old saying. “A city besieged is a city taken”. I know there is a lot of confusion out there. … I have been YOU! I am just trying to help those who are still suffering (losing the war). For a battle the war was lost. And many battles’ are lost from confusion…. Knowledge is power …..know you have to power to move forward! It is been said Doctor’s miss Celiac’s in 90% of their patients… https://www.celiac.com/articles/24919/1/Are-Doctors-Missing-90-of-Celiac-Disease-Cases/Page1.html It is equally true about how often Vitamin Deficiency are missed in Celiac’s… “How could this be? One reason is that even classic Celiac disease symptom, such as abdominal pain, bloating, gas, diarrhea, anemia and weight losscan mimic other conditions. Less classic symptoms such as fatigue, low vitamin C, D and calcium levels can be misleading.” Lupus is known as the great imitator disease. And Celiac or is it Pellagra could be called the same in 87% of cases if you are lucky. And so is Beri Beri… https://www.hormonesmatter.com/beriberi-the-great-imitator/ Imitation is the sincerest form of flattery — Unless it is medicine then it is the unkindest cut. . . How do we know this is true…we can predict that Pellagra would develop in Sorgen’s disease aka SLE or LUPUS and it does…where they ask how confident are you of your diagnosis…explaining DH in detail (IF) you did not know it also described Pellagra instead (Rough Skin)… https://www.dermatologyadvisor.com/home/decision-support-in-medicine/dermatology/pellagra/ Dermatology doctor’s get it because a Niacin deficiency is 90% classically described as a skin disorder first and foremost…. But Beri Beri and Pellagra GI’s problems are a forme fustre of WE’s….FIRST a Thiamine deficiency and finally a Niacin deficiency when it present’s as DH today! See this research that explains how the first signs of these Vitamin Deficiencies are GI related… .entitled“Gastrointestinal Beriberi: A Forme Fruste of Wernicke's Encephalopathy?” https://pubmed.ncbi.nlm.nih.gov/29982183/ I can only hope what I have shared here has lifted the tide of knowledge a little and your boat/that has been lifted enough for you to freely sail again. Learn from my mistakes! No body is so dumb who won’t learn from other people’s mistakes! A valid I dare say standard “process” of modern/good medicine is the differential diagnosis. If it is not the doctor has not done justice for you or YOU for yourself . … A “differential diagnosis” makes more sense. They have not done YOU justice. Isn’t that what we all want – to know just what we need to do to get better that is justice/peace and good medicine. We are our own best advocate! I share that other’s may know to look for these Vitamin Deficiencies if you too received a Celiac diagnosis and the Doctor’s don’t “See” it in your face….like those of nearly 70 years ago who were treated for DH by Niacin(amide)…… 15+ years before DH was ever linked to Celiac disease Remember **** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your regimen. 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included. As I am fond of saying “To Educate is to truly free!” Where there is a free exchange of knowledge there is health and peace for one’s soul and body! Let’s all make peace for to educate is to empower to change. Change is not easy . . especially if you have a bunker mentality I grant . . . but possible with education for with education comes understanding! 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble (starfish/sufferer), by the comfort wherewith we ourselvesare comforted of God.” Posterboy by the Grace of God, EPILOGUE We know this is a good working theory because both B1 (Thiamine) and B3 (Niacin) are used in the production of stomach acid. Quoting from the Celiac.com article on How Low Thiamine Can Thin Villi How Low Thiamine Can Thin Villi: Old Research Rediscovered and its Clinical Significance in Celiac Disease - Celiac.com “Via the Parasympathetic Nervous System (PNS) the neurotransmitter "acetylcholine" regulates our organ functions throughout the body, and could be why both undiagnosed celiac disease and Beri Beri affect so many organs in the body. Without enough thiamine our body can’t synthesize enough acetylcholine to regulate it’s organs, which may cause the body to go into high alert mode and trigger a runaway auto-immune reaction like celiac disease. Another study shows a connection with the microvilli that line organs and how they can trigger auto-immune reactions throughout the body.” B3 aka Niacin via Histamine is used to trigger stomach acid production and why an H2 Blocker is used to treat stomach acid issues….and can be used for other immune mediated conditions like allergies etc… Low Thiamine (B1) triggers the Auto-Immune Cascade….leading to low B2 (Riboflavin) and finally resulting in Low B3 (Niacin)…. who’s production in the body is regulated by Tryptophan via the Knyneurine Pathway and why Tryptophan recently was shown to help heal Villi in Celiac’s. And why just over 7 years ago PPIs were shown to be able to trigger a Celiac diagnosis. Do Proton Pump Inhibitors Increase Risk of Celiac Disease? - Celiac.com See my previous Posterboy blog post about why this so. Is there a Type I and Type II Celiac Disease IF so what is your Type: What the Diabetic Model can tell us about Celiac Disease Subtypes? - Celiac.com Niacin (B3) and Thiamine both help control the Biofeedback loop in the body and why being low in either one will trigger an auto-immune cascade! And Note: it is not just humans who need Thiamine to live/survive ALL animals need it even Bacteria and Fungus. See this latest research from 2020 entitled "Born to be wild: Fungal highways let bacteria travel in exchange for thiamine" that shows/explains how Bacteria and Fungi or Fungus use Thiamine as "Currency" along "Life's" highway.... https://www.sciencedaily.com/releases/2020/09/200924114128.htm Dr. Lonsdale called Thiamine the "Spark of Life".....I have called it the "Currency of Life"....because your health will be poor without IT! So we know this is true! Even at the microscopic level! You will feel half-dead if you continue to have these deficiencies if they doctor don’t also treat you for these co-morbidities despite being on a gluten free diet! I know I did….Ignorance kills!....but It maims us first! Lord willing it has been helpful and will it will help someone before the medical community catches up with the latest research on the topic. As always 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God
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Why did I call this post “Time for a Vitamin Reformation”? I see this a lot. So I wanted to write more about it. I share/write these posterboy blog post’s so that others might not have to suffer the same things’ I have. As always I hope you find it helpful to learn how/what someone else did to help their own selves in this journey/road we all walk/or have walked on as a Celiac Disease/NCGS patient. I know this post is way too long (again) as usual but I had a lot of ground to cover. So hang on if you can and will and if you have an interest in learning how I became the posterboy for Celiac and Pellagra. Learn from my mistakes! Quoting the Celiac and now Pellagra Posterboy “No man is so dumb as the man/woman who won’t learn from other people’s mistakes.” I have made too many (mistakes) to count. Take as much honey (knowledge) as you can from my mistakes so bad (lack of knowledge) health will not sting your quality of life. Is it any wonder God’s promised’ land was described as a land flowing with milk and honey? Where knowledge (truth) flows there is health of mind and body. Truth of the right diagnosis can free us from the error of a wrong diagnosis. SADLY! Few listen. But some (Pellagrins’) who have received a Celiac diagnosis co-morbid have heard (listened to) the good news that Pellagra is reversible (when it is mimicking Celiac disease in a clinical setting) and have gotten better. Don’t be the Last! Tell others! So again Why did I call this post “Time for a Vitamin Reformation”? Most people (in the US anyway if you are reading this in some other country) are aware of the Protestant Reformation but most people are not as aware of the Catholic Reformation. Where basically the Catholic’s got smart? If you will and said all these Protestant’s are writing books (fresh off the invention of Gutenberg’s printing press (the internet of their day)) and the Catholic church said let us start printing our own books about how great the Catholic church is plus some minor changes essentially stopped the reformation in it’s tracks. And today there is still 1 Billion (with a Bee Catholics in this world. (I am not against either by the way) this is only by the way of illustration. I had recently wrote a blog post about this why Supplementation wins the War but I wanted to take another stab at it again. And even though I will have only used Vitamin(s) in this post. I want it to be clear this is for Vitamins and Minerals . . . like Iron, Magnesium, Calcium etc. It is just easier to type/write colloquially to use Vitamins to stand in for both Vitamins and Minerals together. See any of my comments or Ennis_Tx’s about Magnesium taken as Magnesium Citrate or Magnesium Glycinate. And why it is easy for the Protestant’s to claim a victory of sorts (there are Protestants still right) it is a pyrrhic victory at best because according to answers.com Catholics outnumber Protestant’s 2 to 1. https://answers.yahoo.com/question/index?qid=20070213184757AAHuhGz If you don’t still don’t believe me visit some of the old Cathedral’s of Europe you guessed it nearly all of them are Catholic Cathedral’s. Back to our point about Vitamins needing a Reformation. Such is the reign of Genetics today we blame it (our Genes) for everything today. Yet new research indicates maybe less than 1/3 of cancer’s day has anything to with Genetics at all. http://www.foxnews.com/health/2015/01/02/study-concludes-that-many-cancers-caused-by-bad-luck-in-cell-division.html Why this research is old it highlights my point that lifestyle (nutrition/vitamins etc) can and do help prevent Cancer today even in this GENETIC age we live in. http://www.cbsnews.com/news/lifestyle-changes-can-prevent-40-of-cancers-study/ To quote them from cbsnews “”We didn’t expect to find that eating fruit and vegetables (VItamin rich foods my words) would prove to be so important in protecting men against cancer,” Parkin said in the statement. … “This adds to the now overwhelmingly strong evidence that our cancer risk is affected by our lifestyles,” Dr Rachel Thompson, deputy head of science for the World Cancer Research Fund, told The Guardian. “ We hope this study helps to raise awareness of the fact that cancer (sickness) is not simply a question of fate (it’s in our genes my words) and that people can make changes today that can reduce their risk of developing cancer in the future.” My point is we need to be saying. Nutrition (Vitamins’ make us healthy) and not let Genetics get all the credit these day’s this includes our GI health too! I believe. It is actually probably more true too realize/say the balance is 50/50 because stress/environment effect both our health and yes even Genes. I think of it in these terms. A Vitamin is a substance we need in a “Min”ium” amount without which we become sick. I understand completely there is a lot of confusion about this topic. I will provide you some of the sources that lead/helped me come to my conclusions. Dr Prousky’s research is what I based my conclusion’s on and helped me to realize my Celiac Disease with/where he concluded “Niacin treats digestive problems” could also be confused for Low Stomach Acid. http://www.yourhealthbase.com/database/a124b.htm This is the link to the abstract. I realized this was going to be a future post when I saw Ennis_Tx muse about this question in a previous thread. Digestion is a north south process and it begins to make much more sense when you begin to understand the stomach protects your Small Intestine and if your defense are low (low stomach acid) when it is commonly thought to be high invading proteins like lactose, soy, and gluten etc. get through. http://divinehealthfromtheinsideout.com/2012/03/digestion-101/ Try a low carb (i.e. and also gluten free) diet for about a month and see if you flare ups don’t improve I think you will find your trigger is gluten and carbs. If so this will work but you will have to come to this conclusion on your own. It took me 3 years of study to understand these things God being my help. 2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. If you are now taking an acid reducer/proton pump inhibitor (I can’t lie) there will be a transition period. They all have a wall effect (burning when stopped) that often lock people in to using them for years and years when they were only intended to be used for 6 weeks or less to let ulcer’s heal. Actually on the OTC kind people usually buy without a prescription. It is even less than that. Only 14 days is recommended. . . . not 14 months ++ as is so often the case for people when they begin an acid reducer. See the FDA box warning. https://www.fda.gov/drugs/drugsafety/ucm245011.htm It will take courage and conviction on your part to take a Vitamin when all you hear these days’ that the “average” person doesn’t need a Vitamin. (see link below about why all the hate for Celiac’ drug/medicine treatment?/ trials?) by Jefferson Adams which inspired my title. https://www.celiac.com/articles/24099/1/Why-All-the-Hate-for-Celiac-Disease-Drug-Treatments/Page1.html Or put another way why ‘all the hate” for Vitamins? these days” instead of “Time for a Vitamin Reformation” (though I believe it is. .. I am also convenienced) it will take another generation to realize Pellagra is now being diagnosed as Celiac disease today instead. It takes a generation to make a change unless there is Education. This posterboy blog post is about that education process/the things I have learned from studying this subject myself. Do not change any of your supplementation/medical regime unless you have consulted with a doctor. . . but I found it helped me. The ignorance of this fact that Pellagra can occur with/in/as part of a Celiac diagnosis is so strong that so much so the “average joe” won’t take a Vitamin for their health? Well an IBS/NGCS patient/ Celiac Patient is not the average patient. They are known to develop malabsorption syndromes and B Vitamins are known to help celiac patient’s why wouldn’t you at least try a B-Vitamin or B-Complex to see if could help your GI symptom’s. https://www.celiac.com/articles/21783/1/B-Vitamins-Beneficial-for-Celiacs-on-Gluten-Free-Diet/Page1.html (though this study does not include the effects of full spectrum B-complex) it would have been nice if it did. I ask again “Who’s Afraid of a B Vitamin” See my earlier posterboy blog post about this topic Or to ask it rhetorically why all the hate for Vitamins these day (reader)? Or you (reader) afraid of a Vitamin? Or have you been too (reader) taught to hate Vitamins? And it isn’t just Niacinamide by the way (which is the focus of this post) it is most B-Vitamins. See this article about how B-1 Thiamine can help reverse Kidney Damage in Type 2 Diabetes http://news.bbc.co.uk/2/hi/health/7796073.stm Entitled “Thiamine ‘reverses Kidney Damage’ in Type 2 Diabetes” As usual this research is almost 10 years old and doctor’s clinical practices have not caught on to this fact proven by research. Instead the standard reply is “you don’t need Vitamins” or at least the average person does not. People who have TD2 or Celiac disease should not be considered the average person. Let me say at this point. Why is this not on the front page of every newspaper in the US and the UK and the world. Here we have a Vitamin that reversed Kidney Damage but no one is talking about it. What is not considered or well understood that these same vitamins that can help these patients – a deficiency in these same vitamins can also cause these same symptom’s. http://glutenfreeworks.com/blog/2010/06/23/niacin-vitamin-b3-deficiency-in-celiac-disease/ Now back to Niacinamide for a few minutes. What if had a Vitamin that was known to treat GI problems? We do but clinical practice has not yet again caught up with the research. That is why Prousky’s research is so ground breaking and misunderstood because the same vitamin (commonly misunderstood) associated with these problems has been proven to help the same problems it (Vitamin B3) has been thought to cause … though not commonly (well) understood Niacin treats digestive problems. http://www.yourhealthbase.com/database/a124b.htm *****I must say at this point this is not medical advice only my experience with Niacinmaide See my previous posterboy blog post about how the average clinical delay is 17 years in implementing new research into doctor’s protocols’/treatment regimens. This clinical gap is a devastating delay. And also I want to make this disclaimer. The default (thought) here is you are not taking Niacin or any version of B-3 (in its many forms) or have either not taken it for Cholesterol management previously or are now taking it for your GI problems. If you are now taking Niacinamide/Niacin etc. this post does/is not directed at you (or other Vitamins/Minerals) for that matter . . . like Magnesium or Iron etc. Also see my posterblog post about how supplementing can help you fight a two front war. Any Vitamin or Mineral can be taken to excess . . . contributing to a worsening of your conditon.. . including Niacinamide, Iron, Calcium etc. This comment/thread is directed to those who have not yet considered supplementation previously. And with the intent you will only take this for a cycle of time. Say 4 to 6months for most people or 6 to 12 months max for the most severe forms of this disease. See this link where it explains how “up to 12 months” B-Vitamins helps improved/improves moods for those who are depressed. https://www.ncbi.nlm.nih.gov/pubmed/7477807 Reader, Do some of the research of I have listed here and if you still feel the same way. I get it. I have been on that same journey. But this is not as uncommon or unplausible as it might sound. The “House TV” show/medical drama noted this fact in their episode on Celiac Disease. Google House season 2 episode 22 on Celiac disease entilted “Forever” and you will find articles about it and probably a link to watch it. I think it would be enlightening to see how these two diseases are entangled like Siamese twins. When digestion works properly the God given burp is produced (not soda’s) but you burp like a healthy child at 6 months of age so too will an adult when they take Niacinamide (the nonflushing form of Vitamin B-3) for 6 months 2/day (especially if you are not taking PPIs currently). Your results might be different but you won’t know unless you try it. When I began my journey I was/became known as the posterboy for Celiac disease. What it has turned into unexpectedly is me being/becoming the posterboy for Pellagra too! It (Pellagra in Celiac’s) is not as rare as people think it is today especially 2ndary Pellagra caused by your original Celiac diagnosis since Vitamin absorption is frequently compromised in Celiac’s. I always have to say. **** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your medical regimen. But I have found (and my friends have found) if you take it (Niacinamide) like an antibiotic (UNTIL BURPING) then 95% of your GI stress will be in remission. And I don’t mean twenty minutes after you have eaten but 2+ hours later when burping has replaced burping and bloating that start’s almost as soon as you take you first bite. Or burping that occurs with drinking soda or a carbonated drink. Again I say 2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” I hope this is helpful. Posterboy by the Grace of God, That is all for now until the next post. (Whenever that is) but the intent of this/theses post’s is “Too Educate” and anyone of my posterboy blog posts could help you without the need to read all my posterboy blog posts??? So I am sorry if I run a little long some times. . . but people need to know if this is the only blog post they read. . . Pellagra in Celiac’s can be successfully treated with supplementation or AKA a Vitamin Reformation (in the way we think) about GI problems according to Prousky who almost 17 years ago proved Niacinamide can help those with low stomach acid misdiagnosed. Will you listen? and take the Niacinamide Challenge taking it until you are burping 2 hours after you finish a meal. This usually takes 3 to 4 months taken it 3/day or morning and evening and (one hour before) bedtime (if it is not convenient to bring to work) works well for most people. This tends to be one 300 count bottle for most people. Though a smaller amount might work I want you to have a positive experience and thus recommend conservatively a 3 month to 4 month cycle – the amount your body can typically store in your liver – thus helping to reset your body’s stress clock (my words). This schedule works well for Magnesium as well. . . and usually it (Magnesium Citrate/Glycinate) causes restful dreaming in the first month of taking it. The power to change is in your hand for “To Educate is to Free” As always remember **** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your medical regimen. But I have found (and friends have found) if you take it (Niacinamide) like an antibiotic (UNTIL BURPING) then 95% of your GI stress will be in remission. It is time for a Vitamin Reformation (a change in the way we think about Vitamins – a shift in our paradigm) praise bee to God! Back to when in the 20th century they understood Vitamins make us healthy! They even gave Nobel Prizes for discovering these substances called Vitamin(s) and rightly so! If this is the case for you – you the reader also have/had developed 2ndary Pellagra due to your primary diagnosis of Celiac disease. See my earlier posterboy blog post where I talked about my experience of developing Pellagra 2ndarly to my Celiac diagnosis. All those who have ears to hear may they listen! Feel free to read all my posterboy blog post’s if this pique’s your curiosity/interest but there is only so much in a/one blog post than can be explained but it really Is not necessary or visit the website/blog in my profile where I have told the same story hundreds of time that ONE fellow sufferer like myself may/might be helped by the same wisdom, I found God being my help, when I learned Pellagra and Celiac disease are Siamese twins and separating one (supplementing one to death) will kill the other (cause the other to go into remission). Also see my posterboy blog post of how I supplemented Pellagra to death/into remission. Noted above (earlier) in this post but provided here again for easy reference. And I believe you can too! Praise bee to God! 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them (fellow sufferer) which are in any trouble, by the comfort wherewith we ourselves are comforted of God.” Posterboy by the Grace of God, 2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. As always it is in this spirit of truth that I share so that others like my-self might not have to suffer the same things I did.
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