Search the Community
Showing results for tags 'flora'.
Found 3 results
Jefferson Adams posted an article in Bacterial Overgrowth and Celiac DiseaseCeliac.com 03/17/2014 - Researchers know a great deal about the function of human digestive proteases in gluten proteins, but they know very little about the role of intestinal microbes in metabolizing those proteins. A team of researchers recently set out to examine the isolation and characterization of human gut bacteria involved in the metabolizing gluten proteins. The researchers include Alberto Caminero, Alexandra R. Herrán, Esther Nistal, Jenifer Pérez-Andrés, Luis Vaquero, Santiago Vivas, José María G. Ruiz de Morales, Silvia M. Albillos, and Javier Casqueiro. They are variously affiliated with the Instituto de Biología Molecular, Genómica y Proteómica (INBIOMIC), and the Instituto de Biomedicina (IBIOMED) at the Campus de Vegazana of the Universidad de León, with the Área de Microbiología, Facultad de Biología y Ciencias Ambientales at the Universidad de León, with the Departamento de Inmunología y Gastroenterología, Hospital de León, León, Spain, and with the Instituto de Biotecnología (INBIOTEC) de León, all in León, Spain. For their study, the team cultured 22 human fecal samples, with gluten as the principal nitrogen source, and isolated 144 strains belonging to 35 bacterial species that may play a role in gluten metabolism in the human gut. They found that 94 of the isolated strains were able to metabolize gluten, 61 strains showed an extracellular proteolytic activity against gluten proteins, while several strains showed a peptidasic activity toward the 33-mer peptide, which is an known peptide trigger in celiac disease patients. Most of the isolated strains belong to the phyla Firmicutes and Actinobacteria, mainly from the genera Lactobacillus, Streptococcus, Staphylococcus, Clostridium and Bifidobacterium. They found that the human gut hosts a wide variety of bacteria capable of using gluten proteins and peptides as nutrients. These bacteria could play an important role in gluten metabolism and could offer promising new treatment possibilities for celiac disease. Source: Onlinelibrary.wiley.com. DOI: 10.1111/1574-6941.12295
Jefferson Adams posted a topic in Publications & PublicityView full article
Celiac.com 10/13/2011 - While certain immunologic risk factors have been identified for celiac disease, it is still unclear why some develop the disease and others do not. One possibility is that some people are more able to digest gluten than others. Those who cannot break down the gluten into smaller proteins higher in the digestive tract, in the mouth and stomach, could develop an immune reaction to the full, unaltered protein. Maram Zamakhchari and other researchers at Boston University and collaborating sites investigated whether bacteria present in the mouth can play a role in breaking down gluten. The authors reported in the journal PLoS ONE, published by the Public Library of Science, that two bacterial species present in the normal oral flora were able to degrade gluten. The species are Rothia mucilaginosa and Rothia aeria, as the authors reported in the online version of the publication on September 21, 2011. This finding raises the question of whether people with celiac disease have different levels of these bacteria than those without celiac disease. The species R. mucilaginosa is found in the mouth and the intestines while R. aeria is only found in the mouth. The authors attempted to answer this question by looking at saved intestinal biopsy specimens from patients with and without celiac disease. They found no difference in the presence of the intestinal bacteria between celiacs and healthy patients. This study supports the idea that bacteria in the digestive tract may play a role in the development of celiac disease. While there was no difference in gluten-digesting bacteria in the intestines of celiac patients, the study did not evaluate the bacteria levels in the mouth. Patients with celiac disease have an increased incidence of Sjogren's syndrome, which features decreased mouth saliva, and suggests that oral digestion could be related to developing celiac disease. Assessing the presence of these bacteria in the mouths of celiacs versus the general population will be an important next step in the research. Source: Identification of Rothia Bacteria as Gluten-Degrading Natural Colonizers of the Upper Gastro-Intestinal Tract. PLoS ONE 6(9): e24455. doi:10.1371/journal.pone.0024455